Protein Alignment didum and Myo5b

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_008770307.1
• Gene: Myo5b / 25132
• RGDID: 621347
• Length: 1854
• Species: Rattus norvegicus
• Alignment Length: 1931
• Identity: 746/1931 - (38%)
• Similarity: 1122/1931 - (58%)
• Gaps: 214/1931 - (11%)

  Fly     2 SSEEMLYA---QGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPL 63
            |:..||:.   |..::|:|..|.||.||.|.:.|:.|...|::..:...:.:..:....:.:|.|
  Rat     6 SNSSMLHCKTWQYTRVWIPDPDEVWRSAELTKDYKDGDESLQLRLEDDTILDYPIDVQNNQVPFL 70

  Fly    64 RNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAY 128
            |||.||||:||||.||:||||.|||||:|||.|...|||||||:|||||||.::|:||..:|.||
  Rat    71 RNPDILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAY 135

  Fly   129 RGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQV 193
            .|..|||::|||||:|||||.::.|:..|.||||||||||||||||||||||||.||||.|:|.:
  Rat   136 SGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASDTNI 200

  Fly   194 ERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQ 258
            |.|||||||||||.||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||.
  Rat   201 EEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHII---GANMRTYLLEKSRVVFQAD 262

  Fly   259 GERNYHIFYQLCAARS--KYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSI 321
            .|||||||||||||.|  ::.||.|...:.|.:...||...||.|.|||.|.:|.||:|:||...
  Rat   263 DERNYHIFYQLCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRE 327

  Fly   322 QQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386
            .....|.||:|.|||||::::       ..|.|.|||.|...|.||.....||.:....:..||.
  Rat   328 SHQISIFKIIASILHLGSVEI-------QAERDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLC 385

  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGF 451
            .||:.:.:|..:...|::....||:||||||||:||.:||..:||:|....||.|||||||||||
  Rat   386 HRKLVTTSETYVKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSFIGVLDIYGF 450

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVL 516
            ||||:||||||||||||||||||||.||||||||||:||.|.||:||||||||||||||::||:|
  Rat   451 ETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGIL 515

  Fly   517 DLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            |||||||::|||:|::||.||..:.:...||:|||...|:|.:.||:|.|||..:||||||||||
  Rat   516 DLLDEECKVPKGTDQNWAQKLYERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLEKNRDTV 580

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            .:|...:|..|...|...:...::......::|||.: ..::.:.:.|...       ..|:|:|
  Rat   581 YEEQINILKASKFPLVADLFRDDKDSVPATNTAKSRS-SSKINVRSSRPLM-------KAPNKEH 637

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
            :|:||.||:.||..|:.||:||||||||||||||:|:.|.::..:.:|||||||||||:||||||
  Rat   638 KKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAG 702

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKL-DKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLE 775
            :||||.|.||:.||::|:.:.:| :..|.|..|::::...|:|.||::||.|:|||||||||:||
  Rat   703 YPSRWTYHDFFNRYRVLMKKRELANTTDKKNICKSVLESLIKDPDKFQFGRTKIFFRAGQVAYLE 767

  Fly   776 QVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY 840
            ::||:..::...::|..||.::.|.::.|::.....:|:..||||||..|:.:|..||.::..|.
  Rat   768 KLRADKFREATIMIQKTVRGWLQRVKYRRLRAATLTLQRFCRGYLARRLTEHLRRTRAAIVFQKQ 832

  Fly   841 ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNI 905
            .|....||.|.|:|.:...||:|.|.|..|..:..:...::|..||::.||.:|||.:|::|...
  Rat   833 YRMLKARRAYCRVRRAAVIIQSYTRAMCVRRSYRQVLTEHKATIIQKYARGWMARRHFQRQRDAA 897

  Fly   906 IICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI- 969
            |:.|.|.||..||:..|.:|.||::..|::...:|:|||::.:|::||:.|::...|..:.|.:
  Rat   898 IVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVT 962

  Fly   970 SVLKMKLE-LKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQ 1033
            |...|::| |||.|....:|     |:.|..:: |.:::::.|.|.     :..|::...:  :.
  Rat   963 STHAMEVEKLKKELARYQQN-----QEADPSLQ-LQEEVQSLRTEL-----QKAHSERRVL--ED 1014

  Fly  1034 TWRQENEELRRQI------------------DEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAY 1080
            |..:||.|||:::                  ::|:..:| ||.:|.:.|:.:|.:.:..|....|
  Rat  1015 THNRENGELRKRVADLEHENALLKDEKEHLNNQILRQSK-AESSQSSVEENLLIKKELEEERSRY 1078

  Fly  1081 QRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLL 1145
            |..:|:...:|.....|::|  :.|.|    |.:..||.||. |.|..|.|. :|.:|....|.|
  Rat  1079 QNLVKEYSQLEQRYENLRDE--QQTPG----HRKNPSNQSSL-ESDSNYPSI-STSEIGDTEDAL 1135

  Fly  1146 SK------NYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTE-------------- 1190
            .:      ..:..|.| :.:||:..:.|.:|:.|.||.|..|.....|..:
  Rat  1136 QQVEEIGIEKAAMDMT-VFLKLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDVDQDA 1199

  Fly  1191 ----DSFRVSELEVENEKLRSEYDQLRTSI---------------KHGVEINELNAQHAALQEEV 1236
                :|.:..|||.||:||:::.::||.::               .:.:.:|:|...:    ||:
  Rat  1200 DIAYNSLKRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDSYSLLLNQLKLAN----EEL 1260

  Fly  1237 RRRREECIQLKAVLLQQSQ---SMRSLEPESLQMRGN--------DVNELMEAFH------SQ-- 1282
            ..|:||.:.|:..::...|   |.:::|| ::..|.:        |..:.:||:|      ||
  Rat  1261 EVRKEEVLILRTQIMNADQRRLSGKNMEP-NINARTSWPNSEKHVDQEDAIEAYHGVCQTNSQTE 1324

  Fly  1283 ------------------KLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFES- 1328
                              |.:.|.||::|:|...:|..::..:..::|.:..|.|:.|:...::
  Rat  1325 DWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAMKEEMDKQQQTFCQTL 1389

  Fly  1329 ---------------IDEFEDSNVD------TLRQNDRYLRRELQKAVAQFLLVQEELKLANAKL 1372
                           |....:.|:|      .|.:|::.|:::|:    .::...::|:.|.|..
  Rat  1390 LLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLK----IYMKKVQDLEAAQALA 1450

  Fly  1373 KAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALT 1437
            ::.|:     .|::..::               ..::|.::.||::::|..|...:::.|::.|.
  Rat  1451 QSDRR-----HHELTRQV---------------TVQRKEKDFQGMLEYHKEDEALLIRNLVTDLK 1495

  Fly  1438 PRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK-MHRTPHPIENRVIWLVNSI 1501
            |:.:.|.:|..|||:::||||:.|.||.|..|..|||..:..||| :.:.....|....||.|:.
  Rat  1496 PQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHNEDFEMTSFWLSNTC 1560

  Fly  1502 TLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVP 1566
            .||:.:|||...:.::..||.|||:..||||:|.|||:|:.||.:.:||.||...:|||.|.||.
  Rat  1561 RLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVS 1625

  Fly  1567 AILNNDEIQ--RGRQAHGMRSRATSI--GASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCY 1627
            |:|.|:.||  .|.:..|.|.|::|:  |.:|.       ..:.:|.|:..|:......|||...
  Rat  1626 AMLENESIQGLSGVRPTGYRKRSSSMVDGENSY-------CLEAIIRQMNFFHTVLCDQGLDPEI 1683

  Fly  1628 AEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKM-SNDVLTALAPLNQ 1691
            ..|:|.||.|.|.||.||.|:||.|.|.|.|||.:||||..:|:|:|.|.: .:..:..:.||.|
  Rat  1684 ILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLRGKNLQQSGAVQTMEPLIQ 1748

  Fly  1692 VSQLLQ-SRKSEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQMQ 1754
            .:|||| .:|:::|.:.||.|||||||.|::|::..| .|:::|..:|..|:    ..:.|:..:
  Rat  1749 AAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVSFI----RTIQAQLQE 1809

  Fly  1755 KSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTKI 1800
            :|:..:..:|.|.:.|....|..|.:.::.|.:|:.||| |||.::
  Rat  1810 RSDPQQLLLDSKHMFPVLFPFNPSALTMDSIHIPACLNL-EFLNEV 1854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	380/685 (55%)
		IQ	900..922	CDD:197470	8/21 (38%)
		SMC_prok_B	<942..1365	CDD:274008	117/540 (22%)
		Myo5_CBD	1424..1792	CDD:271254	138/375 (37%)
Myo5b	XP_008770307.1	MYSc_Myo5	91..759	CDD:276831	380/685 (55%)
		IQ	773..795	CDD:197470	4/21 (19%)
		IQ	821..842	CDD:197470	7/20 (35%)
		IQ	871..891	CDD:197470	8/19 (42%)
		SMC_prok_B	906..>1268	CDD:274008	96/388 (25%)
		Myo5b_CBD	1480..1851	CDD:271261	142/382 (37%)