Protein Alignment didum and Myo5a

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001423326.1
• Gene: Myo5a / 25017
• RGDID: 3143
• Length: 1877
• Species: Rattus norvegicus
• Alignment Length: 1933
• Identity: 771/1933 - (39%)
• Similarity: 1122/1933 - (58%)
• Gaps: 189/1933 - (9%)

  Fly     1 MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRN 65
            |::.| ||.:.|::|:|..:.||:||.|.:.|:.|...|.:..:.||..|.:|....|:||.|||
  Rat     1 MAASE-LYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTSELPHLRN 64

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRG 130
            |.||||:||||.|||||||.|||||||||.:.::|||||||:|||||||.::|:||..||.||.|
  Rat    65 PDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 129

  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER 195
            ..|||::|||||:|||||.::.|:..|.||||||||||||||||||||||||.|.||.||..||.
  Rat   130 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEE 194

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260
            |||||:||||:.||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||:.|
  Rat   195 KVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRII---GANMRTYLLEKSRVVFQAEEE 256

  Fly   261 RNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            |||||||||||: :|.||   |.|.:.|.|.:...||:|.||.|.||::...|.||.|:||.|..
  Rat   257 RNYHIFYQLCAS-AKLPEFKMLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISES 320

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            ....|.:||||||||||:        |....|||||.|......|.|..||:.|..:::..||..
  Rat   321 YQMGIFRILAGILHLGNV--------GFASRDSDSCTIPPKHEPLIIFCDLMGVDYEEMCHWLCH 377

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFE 452
            ||:.:..|..:.|.|...|..||||||||||||||.:|||.:|::|::..||.||||||||||||
  Rat   378 RKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVGHVNQALHSAVKQHSFIGVLDIYGFE 442

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLD 517
            |||:||||||||||||||||||||.||||||||||:||.|.||:||||||||||:||||:||:||
  Rat   443 TFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILD 507

  Fly   518 LLDEECRMPKGSDESWAGKLIG-KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            ||||||:||||:|::||.||.. ..||...|||||....:|.||||:|.|||...||||||:|||
  Rat   508 LLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLEKNKDTV 572

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP---- 642
            .:|..:||..|..   |.:..|.:.|...: |..|:|..||..:          ||..|.|
  Rat   573 FEEQIKVLKSSKF---KMLPELFQDDEKAI-SPTSATSSGRTPL----------TRVPVKPTKGR 623

  Fly   643 ----SKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLE 703
                :|:|:||||.||:.||..|:.||:||||||||||||||.|..|.::..:.:||||||||||
  Rat   624 PGQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLE 688

  Fly   704 TVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRA 768
            |:|||||||||||.|.:|:.||::|: :.|....|.|.:|:|::.|.|.|:|||:||.|:|||||
  Rat   689 TIRISAAGFPSRWTYQEFFSRYRVLM-KQKDVLGDRKQTCQNVLEKLILDKDKYQFGKTKIFFRA 752

  Fly   769 GQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARA 833
            ||||:||::||:..:.....:|..:|.::.|:::|.:|:....:|::.|||.||...:.:|..:|
  Rat   753 GQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKA 817

  Fly   834 GLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAY 898
            ...:.||.|.::.||:|...|.:...:|:|.||.||||::..:...::||.||:.|||.|||..|
  Rat   818 ATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYLARNRYRKILREHKAVIIQKRVRGWLARTHY 882

  Fly   899 QKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLK 963
            ::..:.||..|...||.:|:|:.|::|.||:::...:..::|:||||:.:|:::||.|:|...|.
  Rat   883 KRTMKAIIYLQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLM 947

  Fly   964 HK--------TSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEE 1020
            .|        .||...|:..:|..:..|.|.|..........:.|..|.|.||..|.||..:.|.
  Rat   948 EKLTNLEGVYNSETEKLRNDVERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEER 1012

  Fly  1021 NGHAQEEWISQKQTWRQENEELRRQIDEI----IDMAKN-AEVNQRN--QEDRMLAEIDNRELNE 1078
            ....::|........::||..|:::.:.:    ::.||. .|..:|.  :|.:.| |:|..:...
  Rat  1013 ADKYKQETEQLVSNLKEENTLLKQEKETLNHLMVEQAKEMTETMERKLVEETKQL-ELDLNDERL 1076

  Fly  1079 AYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASA-KNTLDI-NRP 1141
            .||..:.:...:|.....||||::.:.......|.|..|..|| ||.:..::|. ..|.|| .|.
  Rat  1077 RYQNLLNEFSRLEERYDDLKEEMTLMLNVPKPGHKRTDSTHSS-NESEYTFSSEFAETEDIAPRT 1140

  Fly  1142 PDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIK-----LSSRHKPTE----------- 1190
            .:...|....:  .||.:||:..:.|.:|:.:::|::..:     |.|:.|..|
  Rat  1141 EEPTEKKVPLD--MSLFLKLQKRVTELEQEKQLMQDELDRKEEQVLRSKAKEEERPQIRGAELEY 1203

  Fly  1191 DSFRVSELEVENEKLRSEYDQLRTSI--KHGVEINE--------LNAQHAALQEEVRRRREECIQ 1245
            :|.:..|||.||:||::|.::||.::  |...|:..        |..|..|:.||:..|:||.:.
  Rat  1204 ESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTAVSEELDVRKEEVLI 1268

  Fly  1246 LKAVLLQQSQSMRS----------LEP-ESLQMRG-----------------------NDVNELM 1276
            |::.|:.|.::::.          ||. :.::.:|                       |:..||.
  Rat  1269 LRSQLVSQKEAIQPKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSAMDYQELNEDGELW 1333

  Fly  1277 EAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESID----------- 1330
            ..:...|..||.|||:|::....|.::...:..||:.|..|.:..|:::.:::.
  Rat  1334 LVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASL 1398

  Fly  1331 ------------EFEDSNVDTLRQNDRY----------LRRELQKAVAQFLLVQEELKLANAKLK 1373
                        .||:...|..::...|          |..:|:|.......::::||:...|:.
  Rat  1399 QHEITRLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIG 1463

  Fly  1374 AYRQDGGQLEH----KIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLS 1434
              ..:.||:|:    :|.:|.||          ..|:.: |.::.||::::...|..|:::.|:.
  Rat  1464 --ELEVGQMENISPGQIIDEPIR----------PVNIPR-KEKDFQGMLEYKREDEQKLVKNLIL 1515

  Fly  1435 ALTPRTV-VGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK-MHRTPHPIENRVIWL 1497
            .|.||.| |.|:||.|||::|||:|:.|..|.|..||.||:..:..||| :.:.....|....||
  Rat  1516 ELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWL 1580

  Fly  1498 VNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDP 1562
            .|:...|:.:|||...:.::|.||.:||:..|.||:|.|||:|:.||.:.:||.|:..::.:|.|
  Rat  1581 SNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQP 1645

  Fly  1563 KIVPAILNNDEIQ--RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDN 1625
            .||..:|.::.||  .|.:..|:|.|.:||...      |......::.||..|:......|:|.
  Rat  1646 MIVSGMLEHETIQGVSGVKPTGLRKRTSSIADE------GTYTLDSILRQLNSFHSVMCQHGMDP 1704

  Fly  1626 CYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSND-VLTALAPL 1689
            ...:|:..|:.|.:.|:.||.|:||.|:|.|..||.||||:..:|:|:|.|.:.|. ....|.||
  Rat  1705 ELIKQVVKQMFYIVGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPL 1769

  Fly  1690 NQVSQLLQ-SRKSEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQ 1752
            .|.:|||| .:|::.|.:.||.:|.:|:|||::||:..| .::::|..::..|:..:..:|..|:
  Rat  1770 IQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQVRLRDRK 1834

  Fly  1753 MQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTKI 1800
                :|.:..:|.|.|.|....|..|.:.||.|::|:.|.|. |:.::
  Rat  1835 ----DSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLG-FIARV 1877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	401/694 (58%)
		IQ	900..922	CDD:197470	7/21 (33%)
		SMC_prok_B	<942..1365	CDD:274008	120/532 (23%)
		Myo5_CBD	1424..1792	CDD:271254	131/374 (35%)
Myo5a	NP_001423326.1	COG5022	7..1445	CDD:227355	620/1468 (42%)
		MYSc_Myo5	83..751	CDD:276831	401/694 (58%)
		Myo5a_CBD	1503..1877	CDD:271262	134/384 (35%)