DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myhz2

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_694514.2 Gene:myhz2 / 246275 ZFINID:ZDB-GENE-020604-1 Length:1935 Species:Danio rerio


Alignment Length:1916 Identity:496/1916 - (25%)
Similarity:852/1916 - (44%) Gaps:458/1916 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EESYRKGAGFLKICTDSGKLKEVKL--------KADGSDLPPLRNPAILVGQNDLTTLSYLHEPG 85
            :|.|.||....|   |.||:..|.|        |.|  |:.|: ||.......|:..:::|:||.
Zfish    44 KELYVKGTIKSK---DGGKVTVVTLDTQTEKVVKED--DVHPM-NPPKFDKIEDMAMMTHLNEPS 102

  Fly    86 VLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTK 150
            ||:||:.|:. ..:||||.|:....:|||..:|:|...::.||||....:..||||::::.||..
Zfish   103 VLYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQF 166

  Fly   151 LERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV---GGSESETQ--------VERKVLASSPIM 204
            :..:..|.|::::|||||||||:.|..::|||.|   ||.:.:.|        :|.:::|::|::
Zfish   167 MLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGGDKKKEQAAGKMQGSLEDQIIAANPLL 231

  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269
            ||:|||||.|||||||||||.::.|.....   |..|.:.|||||||||.:|...||.||||||:
Zfish   232 EAYGNAKTVRNDNSSRFGKFIRIHFGTSGK---LASADIETYLLEKSRVTFQLPDERGYHIFYQM 293

  Fly   270 CAARSKYPELV---LDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKI 330
            ..  :..|||:   |...:.:.| :...|...:..:.|.|:...|..|:.:|||:.::...|.|.
Zfish   294 MT--NHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGFTGEEKMGIYKF 356

  Fly   331 LAGILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRK 389
            ...:||.||::..:|..|      |:||.|.              .|.||.:::.|:.:.|...:
Zfish   357 TGAVLHHGNMKFKQKQREEQAEPDGTEEADK--------------IAYLLGLNSADMLKALCYPR 407

  Fly   390 IESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETF 454
            ::..||:|....::.....:..||:|.||.::|.::|..:|:.|:...::..|||||||.|||.|
Zfish   408 VKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQQRNFFIGVLDIAGFEIF 472

  Fly   455 EVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDL 518
            :.||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .|...||:|||..||:..:
Zfish   473 DFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSI 537

  Fly   519 LDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFGTTS--FFIKHFSDTVEYDVNGFLEKN 577
            |:|||..||.:|.|:..||    :||||.|.. .||..|...  |.:.|::.||:|:::|:|:||
Zfish   538 LEEECMFPKATDTSFKNKLYDQHLGKCNAFQK-PKPAKGKAEAHFSLVHYAGTVDYNISGWLDKN 601

  Fly   578 RDTVSKELTQVLSESNMSLAKQVM--TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRV 640
            :|.:::.:.|:..:|::.|...:.  .:||            |.||:   ..|:|:.|:      
Zfish   602 KDPLNESVVQLYQKSSVKLLATLYPPVVEE------------TGGGK---KGGKKKGGS------ 645

  Fly   641 VPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETV 705
                  .:||.|||:|:|..|::.|.:|.||:|||:.||:.|.....|...:|.|||..||||.:
Zfish   646 ------MQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGI 704

  Fly   706 RISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFR 767
            ||...|||||.||.||..||::| ..|.:.:.   |.|.:...::.....:.|:||||:|::||:
Zfish   705 RICRKGFPSRILYGDFKQRYKVL-NASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFK 768

  Fly   768 AGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREAR 832
            ||.:..||::|.......:|:.|::.|.::.||:|:                       ||.|.|
Zfish   769 AGLLGTLEEMRDEKLATLVTMTQALCRAYLMRREFV-----------------------KMMERR 810

  Fly   833 AGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRA 897
            ..:...:|.     .|.::.::|                 :..|:.:|:   |:..::.|...:.
Zfish   811 ESIYTIQYN-----IRSFMNVKH-----------------WPWMKVYYK---IKPLLKSAETEKE 850

  Fly   898 YQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNL 962
            ....:.:.:.|:.|:           .|||||.        ..||.|::::              
Zfish   851 LATMKEDFVKCKEAL-----------AKAEAKK--------KELEEKMVAL-------------- 882

  Fly   963 KHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNK---QLEAERDEKMQLLEENGHA 1024
                     |:.|.:|:..:.:|.:|:    .|.::..|.|.|   ||||:..|..:.||:....
Zfish   883 ---------LQEKNDLQLAVASESENL----SDAEERCEGLIKSKIQLEAKLKETTERLEDEEEI 934

  Fly  1025 QEEWISQKQTWRQENEELRRQIDEI------IDMAKNAEVNQ-RN------QEDRMLAEI--DNR 1074
            ..|..::|:....|..||::.||::      ::..|:|..|: :|      .:|..:|::  :.:
Zfish   935 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAKLTKEKK 999

  Fly  1075 ELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDIN 1139
            .|.||:|:.:.|.:..|       ::::.||         |:.....|..||:     :.:|:..
Zfish  1000 ALQEAHQQTLDDLQAEE-------DKVNTLT---------KSKTKLEQQVDDL-----EGSLEQE 1043

  Fly  1140 RPPDLLSKNYSYNDSTSLVVKLRSILEEEKQK----HKVLQEQYIKLSSRHKPTEDSFRVSELE- 1199
            :                   |||..||..|:|    .|:.||..:.|.:..:.:|:..:..:.| 
Zfish  1044 K-------------------KLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKIKKKDFET 1089

  Fly  1200 ------VENE-----KLRSEYDQLRTSIKHGVEINELNAQHAALQ-------------EEVRRRR 1240
                  :|:|     :|:.:..:|:..|:...|  |:.|:.||..             ||:..|.
Zfish  1090 AQLLSKIEDEQSLGAQLQKKIKELQARIEELEE--EIEAERAARAKVEKQRADLSRELEEISERL 1152

  Fly  1241 EECIQLKAVLLQQSQS--------MRSLEPESLQ----------MRGNDVNELMEAFHSQKLINR 1287
            ||.....|..::.::.        .|.||..:||          .:.:.|.||.|...:.:.:.:
Zfish  1153 EEAGGATAAQIEMNKKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQ 1217

  Fly  1288 QLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV---MFESIDEFEDSNVDTLRQ-NDRYLR 1348
            :||.|    ..|:..::.:::..:|.:...|..|:|:   :.:.:.|.:..|.:.||| ||...:
Zfish  1218 KLEKE----KSEYKMEIDDLSSNMEAVAKAKANLEKMCRTVEDQLSEIKSKNDENLRQINDLSAQ 1278

  Fly  1349 R---------------ELQKAVAQFL---------------LVQEELKLANA---KLKAYRQDGG 1380
            |               |.:..|:|..               .::||:|..||   .:::.|.|..
Zfish  1279 RARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCD 1343

  Fly  1381 QLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKI--LQRLLSALTPRTVVG 1443
            .|..:.|||      ....|::...::|..|:..|...|:.:..:.:.  |:.....|..|    
Zfish  1344 LLREQFEEE------QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQR---- 1398

  Fly  1444 LLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL-LNLM 1507
                              |..|::.:..:.||.....|...|....:|:.:|.:..:..| .||.
Zfish  1399 ------------------LQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANLD 1445

  Fly  1508 KQYGDVDEYVKFNTEK--QNQQQLKNFNLFEYRRVILDL--IVNLYQALIMQIQGL------LDP 1562
            |:..:.|:.:....:|  :.|.:|:.... |.|.:..:|  :.|.|:..:.|::.|      |..
Zfish  1446 KKQRNFDKVLAEWKQKYEEGQAELEGAQK-EARSLSTELFKMKNSYEETLDQLETLKRENKNLQQ 1509

  Fly  1563 KIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCY 1627
            :|  :.|.....:.|:..|.:.....::....:...   .|.::..|.|||              
Zfish  1510 EI--SDLTEQLGETGKSIHELEKAKKTVETEKAEIQ---TALEEAEGTLEH-------------- 1555

  Fly  1628 AEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQV 1692
                                         |...|:|..:                     .||||
Zfish  1556 -----------------------------EESKILRVQL---------------------ELNQV 1570

  Fly  1693 SQLLQSRKSEQD--VQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTE-KLNARQMQ 1754
            ...:..:.:|:|  ::.|     ..::.:|.:.|:|....:..|....:.::|..| .||..::|
Zfish  1571 KGEIDRKLAEKDEEMEQI-----KRNSQRVTEAMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQ 1630

  Fly  1755 KSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784
            .|:::....: ||.::..:...:.:.:.|:|
Zfish  1631 LSHANRQAAEAQKQLRNVQAQLKDAQLHLDD 1661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 279/745 (37%)
MYSc_Myo5 84..767 CDD:276831 269/715 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 33/132 (25%)
coiled coil 1049..1068 CDD:293879 5/31 (16%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 30/151 (20%)
Myo5_CBD 1424..1792 CDD:271254 60/378 (16%)
myhz2NP_694514.2 Myosin_N 36..74 CDD:280832 10/32 (31%)
Myosin_head 89..768 CDD:278492 272/727 (37%)
MYSc_class_II 101..768 CDD:276951 269/715 (38%)
SPEC 881..1043 CDD:295325 42/209 (20%)
Myosin_tail_1 882..1925 CDD:279860 175/956 (18%)
RILP-like <1002..1096 CDD:304877 25/133 (19%)
MIT_CorA-like <1297..>1409 CDD:294313 23/139 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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