DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo1g

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_006514763.1	Gene:	Myo1g / 246177	MGIID:	1927091	Length:	1039	Species:	Mus musculus

Alignment Length:	1015	Identity:	313/1015 - (30%)
Similarity:	484/1015 - (47%)	Gaps:	184/1015 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 ERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSI 160
            |:..||||.|.:||::|||.|:|||||..|..|:|..:.:..||::|:|..||..::|.:.:..|
Mouse    55 EKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCI 119

  Fly   161 IVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER---KVLASSPIMEAFGNAKTTRNDNSSRFG 222
            ::|||||||||.::|:.|:|.|||.......:|||   .:|.|:.::||||||:|.||.||||||
Mouse   120 VISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSSRFG 184

  Fly   223 KFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELVLDHQDK- 286
            |:..:.|..:...:   |..:|:||||||||:.|..||||:|.||||... |:..||...|.::
Mouse   185 KYMDINFDFKGDPV---GGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRG-SEDQELQGLHLERN 245

  Fly   287 ---FQF------LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQV 342
               :.|      ||||....::  ||.:.....::||.::|||..::..|.:|||.|||||||:.
Mouse   246 PAVYNFTRQGAGLNMGVHNALD--SDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEF 308

  Fly   343 SKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES-VNEYVLIPNSIEAA 406
            .:....|.::...:..|    :..:...|.|.....|.:.|.||.|.:.| ..|.:...:::..|
Mouse   309 VETEENGPQKGGLEVAD----EALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEA 369

  Fly   407 QAARDALAKHIYAKLFQYIVGVLNKSL--NNGSKQC----SFIGVLDIYGFETFEVNSFEQFCIN 465
            ..||||.||.:|.:||:::|..:|..:  .|...:|    :.||||||||||.|.||||||||||
Mouse   370 SYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCIN 434

  Fly   466 YANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIES-RLGVLDLLDEECRMPKGS 529
            |.||||||.|.|.:.|.|||||.:|||.|..|::::|...::|:|. ..|:|.:|||.|
Mouse   435 YCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEAC------ 493

  Fly   530 DESWAGKLIGKC---------NKFPHFEKPRFGTT--------SFFIKHFSDTVEYDVNGFLEKN 577
              |.||.:..:.         ...||:...:...|        .|.|||::..|.|.|.||::||
Mouse   494 --STAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKN 556

  Fly   578 RDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP 642
            ||::.::..::|..|                  ||    .||  |.:...|::.....|:|.:
Mouse   557 RDSLFQDFKRLLYNS------------------VD----PTL--RAMWPDGQQDITEVTKRPL-- 595

  Fly   643 SKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRI 707
                  |.|:.|:.|:.:|:..|.:..|.||||||||:||||.:.:.|....|:...|:||.||:
Mouse   596 ------TAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRV 654

  Fly   708 SAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQD---EDKYRFGNTQIFFRAG 769
            ..|||.||..||.|.:||::....:.  .|.:..|.|:.|...::.   :....||::::|.|:.
Mouse   655 RRAGFASRQPYPRFLLRYKMTCEYTW--PNHLLGSDRDAVSALLEQHGLQGDVAFGHSKLFIRSP 717

  Fly   770 Q-VAFLEQVRANL----------------------RKKYITIVQSVVRRFVYRRQFLRIQK---- 807
            : :..|||.||.|                      |.:.|..:....||...|...:.:|:
Mouse   718 RTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLRAIYTIMRWFRRHKVRAHLIELQRRFQA 782

  Fly   808 ------------------VINGIQKHARGYLARERTQ--------------KMREARAGLILSKY 840
                              |:...|...|...:|.|.:              |.:.|..| .|...
Mouse   783 ARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDMIQIKAKVAAMG-ALQGL 846

  Fly   841 ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMR--DHYRAVQIQRFVRGALARRAYQKRRR 903
            .:.|.|:|.:.| .:..|.........|...:..|:|  |.:.:|.....||  ...|..:.|.|
Mouse   847 RQDWGCQRAWAR-DYLSSDTDNPTASHLFAEQLKALREKDGFGSVLFSSHVR--KVNRFRKSRDR 908

  Fly   904 NIIICQAAIRRFLARRKFKRMKA---EAKTISHMENKYMGLENKIISMQQRIDE----LNRDNSN 961
            .:::....:.:....|:::.|:|   ||.|...:.:   |.:..::...|..|:    |:|....
Mouse   909 ALLLTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTS---GRDQLVVLHAQGYDDLVVCLHRSQPP 970

  Fly   962 LKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIE 1001
            |.::..|:..:                :.|.||.:.:.:|
Mouse   971 LDNRIGELVGM----------------LAAHCQGEGRTLE 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	263/723 (36%)
		MYSc_Myo5	84..767	CDD:276831	259/711 (36%)
		IQ	900..922	CDD:197470	3/21 (14%)
		GBP_C	<971..1086	CDD:303769	4/31 (13%)
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Myo1g	XP_006514763.1	MYSc_Myo1	52..715	CDD:276829	259/711 (36%)
Myo1g	XP_006514763.1	Myosin_TH1	836..1007	CDD:368706	35/182 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900