DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh3

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_036736.1 Gene:Myh3 / 24583 RGDID:3138 Length:1940 Species:Rattus norvegicus


Alignment Length:2046 Identity:522/2046 - (25%)
Similarity:912/2046 - (44%) Gaps:470/2046 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EESYRKGA------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87
            :|.|.||.      |.:.:.|:..:...||    ..|:..: ||.......|:..|::|:||.||
  Rat    44 KEEYAKGKIKSSQDGKVTVETEDNRTLVVK----PEDVYAM-NPPKFDKIEDMAMLTHLNEPAVL 103

  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152
            :||:.|:.. .:||||.|:..|.:|||..:|:|.|.::..|||....:..||||::::.||..:.
  Rat   104 YNLKDRYTS-WMIYTYSGLFCVTVNPYKWLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFML 167

  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---------SESETQVERKVLASSPIMEAFG 208
            .:..|.||:::|||||||||:.|..::|||.:..         |:.:..:|.::::::|::||||
  Rat   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFG 232

  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273
            ||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|.:.||:||||||:.:  
  Rat   233 NAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLKAERSYHIFYQILS-- 292

  Fly   274 SKYPE-----LVLDHQDKFQFLNMGGAPEI--ERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331
            :|.||     |:..:...:.|::.|   ||  ..:.|.|:...|..|:.:|||:.::.:.:.|:.
  Rat   293 NKKPELIELLLITTNPYDYPFISQG---EILVASIDDREELLATDSAIDILGFTPEEKSGLYKLT 354

  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396
            ..::|.||::..:|..|  |:.:.|..::...      ||.|:.:::.||.:.|...:::..|||
  Rat   355 GAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------TAYLMGLNSSDLLKALCFPRVKVGNEY 411

  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQ 461
            |....:::....|.:||:|.:|.|||.::|..:|:.|:....:..|||||||.|||.||.||.||
  Rat   412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQ 476

  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRM 525
            .|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||..
  Rat   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMF 541

  Fly   526 PKGSDESWAGKL----IGKCNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582
            ||.:|.|:..||    :||.|   :|:||:.    ....|.:.|::.||:|.|:|:||||:|.::
  Rat   542 PKATDTSFKNKLYDQHLGKSN---NFQKPKVVKGKAEAHFSLIHYAGTVDYSVSGWLEKNKDPLN 603

  Fly   583 KELTQVLSE-SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            :.:..:..: ||..||....|.          |.:...||:..::   |::|:..          
  Rat   604 ETVVGLYQKSSNRLLAHLYATF----------ATTDADGGKKKVA---KKKGSSF---------- 645

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             :||.:.|:|:|..|:|.|..|.||:||||.||:.|.....|.:.::.|||..||||.:||...|
  Rat   646 -QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKG 709

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            ||:|.||.||..||::| ..|.:.:.   |.|.:|..::.....|..:|:||:|::||:||.:..
  Rat   710 FPNRILYGDFKQRYRVL-NASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGT 773

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            ||::|.....|.||..|:|                       .||:|.|...|||.:.|..:...
  Rat   774 LEEMRDERLAKLITRTQAV-----------------------CRGFLMRVEFQKMMQRRESIFCI 815

  Fly   839 KY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896
            :|       .:.|...:.:.:::..:...:|.......:.:|...:|.                 
  Rat   816 QYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE----------------- 863

  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK------YMGLENKIISMQQRIDEL 955
                               ||:.:.||.:.|.|.::.::.|      .......::..::|.|:|
  Rat   864 -------------------LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909

  Fly   956 NRDNSNLKHK--------------TSEISVLKMKL-----ELKKTLE------AEFKNVKAACQD 995
            .:....|:.|              .:|::..|.||     ||||.::      |:.:..|.|.::
  Rat   910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974

  Fly   996 K-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQ----KQTWRQENEELRRQ 1045
            |           |:.|..|.::.:|.::...|.|::. .|:|:.::.    |....|:.::|...
  Rat   975 KVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDL-QAEEDKVNSLSKLKSKLEQQVDDLESS 1038

  Fly  1046 IDEIIDMAKNAEVNQRNQE-DRMLA-------EIDNRELNEAYQRAIKDKEV------IENENFM 1096
            :::...:..:.|.|:|..| |..||       |.|.::|:|..::  ||.|.      :|:|..:
  Rat  1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK--KDFEYSQLQSKVEDEQTL 1101

  Fly  1097 -------LKEELSRL----------------TAGSFSLHARKASNASSQNEDDVGYASAKNTLDI 1138
                   :||..:|:                |....|.:||:....|.:.|:..|..|.:..|:.
  Rat  1102 SLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166

  Fly  1139 NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSE------ 1197
            .|..:.|              |||..|||     ..||.:....:.|.|..:.:..::|      
  Rat  1167 KREAEFL--------------KLRRDLEE-----ATLQHEATVATLRKKHADSAAELAEQIDNLQ 1212

  Fly  1198 -----LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNAQ 1228
                 ||.|..:.:.|.|.|.:|:      |..:|                       ::||..|
  Rat  1213 RVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQ 1277

  Fly  1229 HAALQEEVRRRREECIQLKAVLLQQSQS-----------MRSLEPE---------SLQMRGNDVN 1273
            .:.||.|......:..:.::::.|.|:|           .|.||.|         :||...:|.:
  Rat  1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCD 1342

  Fly  1274 ELMEAFHSQKLINRQLESEL-KAITE------EHNSKLVEMTQEIE--------RLNNEKDELQK 1323
            .|.|.:..::....:|:..| ||.:|      ::.:..::.|:|:|        ||.:.:::::.
  Rat  1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

  Fly  1324 VMFE--SID--------EFEDSNVDTLRQN------DRYLRRELQKAVAQFLL----VQEELKLA 1368
            |..:  |::        |.||..||..|.|      |: .:|...|.:|::..    .|.||:.|
  Rat  1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK-KQRNFDKVLAEWKTKCEESQAELEAA 1471

  Fly  1369 NAKLKAYRQDGGQLEHKIEE-----EMIRNKSNGTSADVGANVTKQKSQNPQGL---------MK 1419
            ..:.::...:..:|::..||     |.::.::.....:: |::|:|.::|.:.:         |:
  Rat  1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI-ADLTEQIAENGKSIHELEKSRKQME 1535

  Fly  1420 FHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK--FVIQIKK 1482
            ...:|:...|:...:||...         .|.::.:.:..|.:.:..|  |::..|  .:.|:|:
  Rat  1536 LEKADIQMALEEAEAALEHE---------EAKILRIQLELTQVKSEID--RKIAEKDEEIEQLKR 1589

  Fly  1483 MH-RTPHPIENRVIWLVNS----ITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF-NLFEYRRVI 1541
            .: ||...::..:...|.|    |.|...|:  ||::| ::......|:|..:.. :|...:..:
  Rat  1590 NYQRTVETMQGALDAEVRSRNEAIRLKKKME--GDLNE-IEIQLSHANRQAAETIKHLRSVQGQL 1651

  Fly  1542 LDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQ 1606
            .|..::|..||    :|..|.|...||:.       |:|:.:::....:.|:             
  Rat  1652 KDTQLHLDDAL----RGQEDLKEQLAIVE-------RRANLLQAEVEELRAT------------- 1692

  Fly  1607 LIGQLEHFYKQFQHFGLDNCYAEQIFH----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIG 1667
             :.|.|...|..:...||:....|:.|    .|::....:..:...|:.:               
  Rat  1693 -LEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSE--------------- 1741

  Fly  1668 CIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQV 1720
             :||..|..:.:.:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.
  Rat  1742 -VEDASRDARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803

  Fly  1721 LKVMKSYK-LDDYESEITNVFLE------KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYS 1778
            |.:....| :...|:.|..:..|      :.||.:...:..:....|.|...:  :..|.|.|..
  Rat  1804 LALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSE--EDRKNVLRLQ 1866

  Fly  1779 DI-------------KLEDIELPSHLNLDEF 1796
            |:             :.|:.:..::::|.:|
  Rat  1867 DLVDKLQVKVKSYKRQAEEADEQANVHLTKF 1897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 280/741 (38%)
MYSc_Myo5 84..767 CDD:276831 269/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 33/148 (22%)
coiled coil 1049..1068 CDD:293879 5/19 (26%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/175 (19%)
Myo5_CBD 1424..1792 CDD:271254 73/411 (18%)
Myh3NP_036736.1 Myosin_N 36..73 CDD:280832 6/28 (21%)
Myosin_head 88..767 CDD:278492 273/723 (38%)
MYSc_Myh3 100..767 CDD:276878 269/711 (38%)
Actin-binding 656..678 12/21 (57%)
Actin-binding 758..772 7/13 (54%)
GrpE 843..>962 CDD:295646 23/154 (15%)
Myosin_tail_1 847..1924 CDD:279860 216/1170 (18%)
RILP-like 962..1095 CDD:304877 29/135 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 6/28 (21%)
MIT_CorA-like <1296..>1408 CDD:294313 22/111 (20%)
COG6 1373..>1506 CDD:303003 26/133 (20%)
TMPIT 1739..>1828 CDD:285135 19/106 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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