Protein Alignment didum and Myo16

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_006508841.1
• Gene: Myo16 / 244281
• MGIID: 2685951
• Length: 1941
• Species: Mus musculus
• Alignment Length: 1354
• Identity: 324/1354 - (23%)
• Similarity: 570/1354 - (42%)
• Gaps: 309/1354 - (22%)

  Fly    20 DLVWESAT---LEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYL 81
            |::::..|   .::..:.|.....:.::.||.::|::      :||       ...:||.|||.|
Mouse   382 DIMFKDTTKGLCKQESQDGPPETSMTSNCGKPEQVQV------MPP-------APSDDLATLSEL 433

  Fly    82 HEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAY---RGHAMGDLEPHIFAL 143
            ::..:|:.::.||...| |:|:.|.|.:.:||:.|:|:|...:.:.|   .|.....|.||:|:.
Mouse   434 NDSSLLYEIQKRFGNDQ-IHTFIGDIFLLVNPFKELPIYSTMVSQMYLSPTGQRSPSLPPHLFSC 497

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFG 208
            ||.|:.:|.:|....:||:|||.|:|||.::|..|:|..: ..|.|.|..:.::..:..|:||||
Mouse   498 AERAFHRLFQERKPQNIILSGERGSGKTQASKQIMKYLTS-RASSSCTMFDSRLRHAIYIVEAFG 561

  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273
            :||||.|:.||...::.:|....:.  ..:.||.:.||:|||||||.|..|:..:.||..|....
Mouse   562 HAKTTLNNVSSCLIQYWELQCCQRR--KHITGARISTYMLEKSRVVAQPPGQGTFLIFSWLMDGL 624

  Fly   274 SKYPELVLDHQDKF---QFLNMGGAPEI---ERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            |...:..| |.:.|   ::::.|...::   |...:.|:......|:.|:|||..::.::..||:
Mouse   625 SSEEKCGL-HLNNFCAHRYVSQGMREDVSTAEHSLNKERLAALKHALNVIGFSTLEVENLFVILS 688

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIH-LQITADLLRVSADDLRRWLLMRKIESVNEY 396
            .|||:|:||.:     ...|.||    .|.:|:. |:..|.:|:||.|:|...|.........:.
Mouse   689 AILHIGDIQFT-----ALTEADS----AFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDV 744

  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNN----GSKQCSFIGVLDIYGFETFEVN 457
            ::..::|:.|...||.|||.:|::||.:::..:|..|.|    .|.|...||:|||:|||.|:.|
Mouse   745 IIRRHTIQMAAFYRDLLAKSLYSRLFGFLINTVNCCLQNQDEYKSLQTLDIGILDIFGFEEFQKN 809

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT----------MIDFYDNQPCIDLIESR 512
            .|||.|:|..|||:.....:.:|..||.|.::||:...          ::||:..:|.
Mouse   810 EFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPS------- 867

  Fly   513 LGVLDLLDEECRMPKGSDESWAGK---------LIGKCNKFPHFEKPRFGT---------TSFFI 559
             |...|||||      |...|:|:         |:...|....:...:.|.         .:|.:
Mouse   868 -GFFSLLDEE------SQVIWSGEPNLPRKLQGLLESSNTNAVYSPVKDGNGNVAFKGQGAAFTV 925

  Fly   560 KHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVM--TLEEIDTLCVDSAKSSTLGGR 622
            .|::..|.|::.|.:|:|:|::|:.|..|:..|...:...:.  .|.:..:| :.|..|...||.
Mouse   926 MHYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSL-ISSYPSFKFGGH 989

  Fly   623 --------------------VVISAGRKQQGNDT----RRRVVPSKQHRKTVGSQFQESLASLIS 663
                                :.:|...|::|..|    ..|..|:     |..||..:|||.:.:
Mouse   990 KSTLLSKRTASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPA-----TAASQLTKSLADITA 1049

  Fly   664 TLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL 728
            .|...:||::.|||||..::...::...:..||:..|||..||:..:|:|.|..:.||..||:.|
Mouse  1050 KLQRGSPHFILCIKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYEPL 1114

  Fly   729 --VYRSKLDKNDMKLSCRNIVMK-----WIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYI 786
              |...:......:..||.::.:     |       :.|..::|.:...|..|..:...|::|.:
Mouse  1115 ASVLLGETKGQAAEERCRLVLQRCKLQGW-------QIGVHKVFLKYWHVDQLSDLWLQLQRKIV 1172

  Fly   787 TIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYL 851
            |                 .||||       ||:|||:...:....:...:.|        .:.:|
Mouse  1173 T-----------------CQKVI-------RGFLARQHLLQRMSIKQQEVTS--------IKSFL 1205

  Fly   852 RLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFL 916
            :....:: ::|| ..::.:|.....|:|.|           |.:..:....||
Mouse  1206 QSTEDMA-LKTY-DALVIQNASDIAREHDR-----------LRKEVHTAYHRN------------ 1245

  Fly   917 ARRKFKRMKAEAK-TISHMENKYMGLENKIISMQQRI-----------DELNRDNSNLKHKTSEI 969
             |::....:||.: ...|:.:..:.:...:.|:.|.:           ...:.|:|.......:.
Mouse  1246 -RQEEGTKRAEDQGGCRHVHSNSVPVPMVVDSLAQALTGPSTRPPSLHSVFSMDDSTGLPSPRKQ 1309

  Fly   970 SVLKMKLELKKTLEAEFKNVKAACQD--KDKLIEALN------------KQLEAERDEKMQLLEE 1020
            ...|.|.:....|.|.::.| :||..  ||...|||.            |::...:.::....:.
Mouse  1310 PPPKPKRDPNTRLSASYEAV-SACLSAAKDAAGEALTRPRPHSDDYSTMKKIPPRKPKRSPHTKL 1373

  Fly  1021 NGHAQEEWISQKQT------------------WRQENE--ELRRQI------------DE----I 1049
            :|..:|.|...:.:                  |.:.:.  :...|:            |:    .
Mouse  1374 SGSYEEIWGPPRPSGTMGQGGRHQAPGTLSVQWARPDSVPQCTPQLPLHLPLPQGDYDDDAEPVY 1438

  Fly  1050 IDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEE---LSRLT----AG 1107
            |:|..||            |.....|.:...|    .:.|.|...::|.||   |..||    :.
Mouse  1439 IEMVGNA------------ARAGGSETDSPDQ----GESVYEEMKYILPEEGCGLGMLTFLPASP 1487

  Fly  1108 SFSLHARKA--SNASSQNEDDVGYASAKNTLDI---------NRPPDL------LSKNYSYNDS- 1154
            ...|..|||  ..|:..|     ...:|:|.||         :|||.|      ::::.:.::|
Mouse  1488 PLFLETRKAIILEAAEGN-----CQPSKDTCDIPPPFPNLLPHRPPLLVFPPTPVTRSPASDESP 1547

  Fly  1155 -TSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRS 1207
             |.|.||...:| |...|:.|..|....||.::...:..        :|::|.|
Mouse  1548 LTPLEVKKLPVL-ETNLKYPVQSEGSSPLSPQYSKAQKG--------DNDQLAS 1592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	214/757 (28%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	67/353 (19%)
		Myo5_CBD	1424..1792	CDD:271254
Myo16	XP_006508841.1	ANKYR	81..336	CDD:440430
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		MYSc_Myo16	436..1153	CDD:276844	214/757 (28%)
		NYAP_N	1235..1605	CDD:464717	73/402 (18%)