DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and MYO16

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001185879.1 Gene:MYO16 / 23026 HGNCID:29822 Length:1880 Species:Homo sapiens


Alignment Length:869 Identity:269/869 - (30%)
Similarity:431/869 - (49%) Gaps:144/869 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DLVWESATLEESYRKGAGFLKIC--------------TDSGKLKEVKLKADGSDLPPLRNPAILV 70
            |::::.||      ||     :|              :.|.|.::|||      :||..|     
Human   383 DIMFKDAT------KG-----LCKQQSQDSIPENPMMSGSTKPEQVKL------MPPAPN----- 425

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAY---RGHA 132
              :||.|||.|::..:|:.::.||...| |||:.|.||:.:|||.|:|:|...:.:.|   .|..
Human   426 --DDLATLSELNDGSLLYEIQKRFGNNQ-IYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKL 487

  Fly   133 MGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER-- 195
            ...|.||:|:..|.|:.:|.||......|:|||.|:||:.::|..:|:.....|:...|...|  
Human   488 CSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFK 552

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLF--RNQMGVMFLQGATMHTYLLEKSRVVYQAQ 258
            .|:.   |:||||:||||.||.||.|.|:.:|.|  |.|.    |.||.::||||||||:|.|..
Human   553 HVVC---ILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQ----LTGARIYTYLLEKSRLVSQPL 610

  Fly   259 GERNYHIFYQL---CAARSKYPELVLDHQDKFQFLN---MGGAPEIERVSDAEQFNETVQAMTVL 317
            |:.|:.|||.|   .:|..|| .|.|::....::||   ...|...||..:.|:.....:|:.|:
Human   611 GQSNFLIFYLLMDGLSAEEKY-GLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVV 674

  Fly   318 GFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIH-LQITADLLRVSADDL 381
            |||..::.::..|||.|||||:|:.: ..|||:        ..|.:|:. |:..|.:|:||.|:|
Human   675 GFSSLEVENLFVILAAILHLGDIRFT-ALNEGN--------SAFVSDLQLLEQVAGMLQVSTDEL 730

  Fly   382 RRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSF---- 442
            ...|.........:.::..::|:.|:..||.|||.:|::||.::|..:|..|::..:|.|.    
Human   731 ASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLD 795

  Fly   443 IGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT----------MI 497
            ||:|||:|||.|:.|.|||.|:|..|||:....|:.:|..||.|.::||:|..          ::
Human   796 IGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVL 860

  Fly   498 DFYDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGK---LIGKCNKFPHFEKPRFGT----- 554
            ||:..:|.        |.|.|||||.:|....:.::..|   |:...|....:...:.|.     
Human   861 DFFFQKPS--------GFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVAL 917

  Fly   555 ----TSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSA- 614
                |:|.|.|::..|.|||.|.:|||:|::|:.|..|:..|...:...:...:...|..:.|| 
Human   918 KDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAY 982

  Fly   615 --------KSSTLGGRVVISA--GR-----------KQQGNDT-RRRVVPSKQHRKTVGSQFQES 657
                    ||:.|..::..|:  |.           |::|..| .:|:  .:....|:.||.::|
Human   983 PSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRL--ERGDPVTIASQLRKS 1045

  Fly   658 LASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFY 722
            |..:|..|...|||::.||:||:.|:...::...:..||:..||||.|:|...|:|.|..:.||.
Human  1046 LMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFL 1110

  Fly   723 MRYQLLVYRSKLDKNDMKLS--CRNIVMK-----WIQDEDKYRFGNTQIFFRAGQVAFLEQVRAN 780
            .||:.|......:|.:...:  ||.::.:     |       :.|..::|.:......|..:...
Human  1111 SRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGW-------QMGVRKVFLKYWHADQLNDLCLQ 1168

  Fly   781 LRKKYITIVQSVVRRFVYRRQFLR 804
            |::|.|| .|.|:|.|:.|:..|:
Human  1169 LQRKIIT-CQKVIRGFLARQHLLQ 1191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 238/752 (32%)
IQ 900..922 CDD:197470
SMC_prok_B <942..1365 CDD:274008
Myo5_CBD 1424..1792 CDD:271254
MYO16NP_001185879.1 ANKYR 67..347 CDD:440430
ANK repeat 86..112 CDD:293786
ANK repeat 114..145 CDD:293786
ANK repeat 147..178 CDD:293786
ANK repeat 180..210 CDD:293786
ANK repeat 243..274 CDD:293786
ANK repeat 276..307 CDD:293786
ANK repeat 309..335 CDD:293786
MYSc_Myo16 437..1155 CDD:276844 238/752 (32%)
NYAP_N 1243..1590 CDD:464717
NYAP_C 1652..1880 CDD:464724
Blue background indicates that the domain is not in the aligned region.

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