DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH15

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_011510861.1 Gene:MYH15 / 22989 HGNCID:31073 Length:1946 Species:Homo sapiens


Alignment Length:2072 Identity:530/2072 - (25%)
Similarity:893/2072 - (43%) Gaps:474/2072 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGA------KIWVPHADLVWESATLEESYRKGAGFLKICT-DSGKLKEVKLKADGSD 59
            |..|:|..|..      |.|:|..:..:..|.::.|...|...::... :|..:||.|::.    
Human    36 SEAELLLLQATALDGKKKCWIPDGENAYIEAEVKGSEDDGTVIVETADGESLSIKEDKIQQ---- 96

  Fly    60 LPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
                .||.......|:..|::|:|..|||.|:.|: .:.:||||.|:..|.||||..:|:|...:
Human    97 ----MNPPEFEMIEDMAMLTHLNEASVLHTLKRRY-GQWMIYTYSGLFCVTINPYKWLPVYQKEV 156

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVG---- 185
            :.||:|....:..|||||:|..|:..:.....|.||:.:|||||||||::|:.::|||.:.    
Human   157 MAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIE 221

  Fly   186 GSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEK 250
            ..:.:..:|.:::.::.|:||||||||.|||||||||||.::.| ...|:  |....:..|||||
Human   222 SRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFIRMHF-GARGM--LSSVDIDIYLLEK 283

  Fly   251 SRVVYQAQGERNYHIFYQLCAARSKYPELVL--DHQDKFQFLNMGGAPEIERVSDAEQFNETVQA 313
            |||::|..||||||||||:.:.:.:..:|:|  .:...|.|.:. ||..:|.:.|||:...|.||
Human   284 SRVIFQQAGERNYHIFYQILSGQKELHDLLLVSANPSDFHFCSC-GAVTVESLDDAEELLATEQA 347

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSA 378
            |.:|||...:.....|:...|:|.||::..:|..|  |:.::|..:      :....|.|:.:::
Human   348 MDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPRE--EQLEADGTE------NADKAAFLMGINS 404

  Fly   379 DDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFI 443
            .:|.:.|:..:|:..||||....:||....|..||:|.:|.::|:::|..:|::|:....:..||
Human   405 SELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFI 469

  Fly   444 GVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCID 507
            |:|||.|||..|.||.||.|||:.||||||.||.|:|.||||||.||.|.|..|.| .|.|.|||
Human   470 GILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACID 534

  Fly   508 LIESRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKP-----RFGTTSFFIKHFSDTV 566
            |||..:|:|.:|:|||..||.:|.::..||. ....|..|.:||     :| ...|.:.|::..|
Human   535 LIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKF-EAHFELVHYAGVV 598

  Fly   567 EYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQ 631
            .|:::|:||||:|.:::.:..|..:|:..|...:..    :.:..|||          |..|.| 
Human   599 PYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFE----NYMSTDSA----------IPFGEK- 648

  Fly   632 QGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQL 696
                 :|:...|.|   ||.|..:|:|..|::.|.:|.||:||||.||.:|:....:...::|||
Human   649 -----KRKKGASFQ---TVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQL 705

  Fly   697 RACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRS--KLDKNDMKLSCRNIVMKWIQDEDKYRF 759
            |..||||..||...|||:|..|.||..||.:|..|:  |......:.:...::.....|..:|||
Human   706 RCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLEIDHTQYRF 770

  Fly   760 GNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER 824
            |.|::||:||.:..||.:|..                       |:.||....|..|:|.|.|.:
Human   771 GITKVFFKAGFLGQLEAIRDE-----------------------RLSKVFTLFQARAQGKLMRIK 812

  Fly   825 TQKMREARAGLILSKY-------ARGWLCRRRYLRLR---------HSISGI-QTYARGMLARNK 872
            .||:.|.|..|||.::       .:.|...|.:.:::         ..::|: :..|:...|..|
Human   813 FQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEK 877

  Fly   873 FHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK 937
            ....|:..:|.|:.            ..:.:|.:|.|              ::||.:|::::|.:
Human   878 SEFQREELKAKQVS------------LTQEKNDLILQ--------------LQAEQETLANVEEQ 916

  Fly   938 -------YMGLENKIISMQQRIDELNRDNS--------------NLKHKTSEISVLKMKLEL-KK 980
                   .:.||.::..:.:|::|....||              .||.:..::..:.:|.|. |:
Human   917 CEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKR 981

  Fly   981 TLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQ 1045
            |.|.:.||:....:..::.|..||:..:..::...|.|::. |.:||.:|   :..:.|.:|.:|
Human   982 TTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL-HMEEEKLS---SLSKANLKLEQQ 1042

  Fly  1046 IDEI---IDMAKNAEVN------------QRNQEDRMLAEIDNRELNEAYQRAIKDKEV------ 1089
            :||:   ::..:.|.:|            :.|:|.....|...|.|.|..::  |:.|:      
Human  1043 VDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRK--KELELSQMNSK 1105

  Fly  1090 IENENFM-------LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSK 1147
            :|||..:       :||..:::......|.|.:.:.|..:.|      .|..|.|:   .||..:
Human  1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERE------RADLTQDL---ADLNER 1161

  Fly  1148 NYSYNDSTSLVVKLRSILEEEKQK-HKVLQEQYI-------KLSSRHKPTEDSFRVSELEVEN-- 1202
            ......|:...:::....|.:.|| |:.::|..:       .|..||   .||....|.:|||  
Human  1162 LEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRH---ADSLAELEGQVENLQ 1223

  Fly  1203 ------EK----LRSEYDQLRTSI------KHGVE-----------------------INELNAQ 1228
                  ||    |:.|.|.|.|.:      |...|                       .|:|.||
Human  1224 QVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288

  Fly  1229 HAALQEE----VRRRREECIQLKAVLLQQSQSMRSLE----------------PESLQMRGNDVN 1273
            ...|..|    :||..|:...:..:..::|...|.:|                ..:||....|.:
Human  1289 KTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCD 1353

  Fly  1274 ELMEAFHSQKLINRQLESELKAITEE-------HNSKLVEMTQEIERLNNEKDELQKVMFESIDE 1331
            .|.|.:..::.:..:|...|..:..|       :.:.:::.|:::|   :.|.||...:.|:.:.
Human  1354 LLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLE---DAKKELAIRLQEAAEA 1415

  Fly  1332 FEDSNV--DTLRQNDRYLRRELQKAV--------AQFLLVQEELKLANAKLKAYRQ--------- 1377
            ...:|.  .:|.:....|:.||..|:        |...|.|::|:...| |..::|         
Human  1416 MGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKA-LADWKQKHEESQALL 1479

  Fly  1378 DGGQLE-HKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTV 1441
            |..|.| ..:..|:::.|:....:.||....:::::|               ||..:|.||.:..
Human  1480 DASQKEVQALSTELLKLKNTYEESIVGQETLRRENKN---------------LQEEISNLTNQVR 1529

  Fly  1442 VGLLPGFPAYLIFMCIRYTDLTNADDDVRELL--SKFVIQIKKMHRTPHPIENRVIWLVNSITLL 1504
            .|.               .:||.. :.|::|:  .|..:|: .:..|...:|.      |...:|
Human  1530 EGT---------------KNLTEM-EKVKKLIEEEKTEVQV-TLEETEGALER------NESKIL 1571

  Fly  1505 NLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAI- 1568
            :...      |.::...|.:.:...|:..:..:||        ..|..|..:|..||.:....| 
Human  1572 HFQL------ELLEAKAELERKLSEKDEEIENFRR--------KQQCTIDSLQSSLDSEAKSRIE 1622

  Fly  1569 -----------LNNDEIQ---RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQ 1619
                       ||..|:|   ..||.    |.||                 :.:|||:...|..|
Human  1623 VTRLKKKMEEDLNEMELQLSCANRQV----SEAT-----------------KSLGQLQIQIKDLQ 1666

  Fly  1620 -----HFGLDNCYAEQIFHQLLYFICAVA--LNCLM------LRGDICMWETGMII--------- 1662
                 ...|::...||:         |||  .|.|:      ||......|.|..:         
Human  1667 MQLDDSTQLNSDLKEQV---------AVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEAT 1722

  Fly  1663 -RYNIGCIED---WVRSKKMSNDVLTALAPLNQVSQ------------------LLQSRKSEQDV 1705
             |.|:...::   ..:.||:..||........:|.|                  |.:..|.:||.
Human  1723 ERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDT 1787

  Fly  1706 ------------QTICDLCTSLSTAQVLKVMKSYK--------LDDYESEITNVFLEKLTEKLNA 1750
                        |||.||...|:.|:.:.:|.|.|        :.:.|.|:..........:..|
Human  1788 IAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGA 1852

  Fly  1751 RQMQK--------SNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTK 1799
            |::::        :..|:..:.:...|..|:..:..:.| :.:|: :....:::|:|
Human  1853 RRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYK-QQVEV-AETQANQYLSK 1907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 274/727 (38%)
MYSc_Myo5 84..767 CDD:276831 263/697 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 29/130 (22%)
coiled coil 1049..1068 CDD:293879 4/33 (12%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 34/169 (20%)
Myo5_CBD 1424..1792 CDD:271254 84/456 (18%)
MYH15XP_011510861.1 Myosin_N 52..90 CDD:280832 7/37 (19%)
Myosin_head 105..778 CDD:278492 267/709 (38%)
MYSc_Myh15_mammals 117..778 CDD:276892 263/697 (38%)
Myosin_tail_1 859..1935 CDD:279860 224/1181 (19%)
CENP-Q 1017..1164 CDD:289839 35/161 (22%)
DUF2317 <1487..1600 CDD:302887 24/156 (15%)
DUF4337 <1864..>1940 CDD:290935 7/46 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.