DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myo5c

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_006510998.1 Gene:Myo5c / 208943 MGIID:2442485 Length:1749 Species:Mus musculus


Alignment Length:1898 Identity:711/1898 - (37%)
Similarity:1059/1898 - (55%) Gaps:258/1898 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVG 71
            ||||..::|:|..:.||:||.:.:.||.|...|::..:.|  .|::...|...|||||||.||||
Mouse     6 LYAQYNRVWIPDPEEVWKSAEIAKDYRAGDRVLRLLLEDG--MELEYPVDPGSLPPLRNPDILVG 68

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDL 136
            :||||.|||||||.||||||:||.|.::||||.||||||:|||.::|:||.:||.||.|..|||:
Mouse    69 ENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDM 133

  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASS 201
            :|||||:|||||.::.|.|.|.||||||||||||||||:|||||||.|..|.|...||.|||||:
Mouse   134 DPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAHVEDKVLASN 198

  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLF--RNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            ||.||.||||||||||||||||:|::.|  |||     :.||.|.||||||||||:|::.|||||
Mouse   199 PITEAVGNAKTTRNDNSSRFGKYTEISFDERNQ-----IIGANMRTYLLEKSRVVFQSENERNYH 258

  Fly   265 IFYQLCAA--RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            |||||||:  :|::..|.|...::|.:..|||...||.|:|.....||.:..|:|||......|:
Mouse   259 IFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRADMVETQKTFTLLGFKKDFQMDV 323

  Fly   328 VKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES 392
            .||||.||||||:||:...||.|...:.||        ||::..:||.:....:.:||..|||.:
Mouse   324 FKILAAILHLGNVQVTTVGNERSSVSEDDS--------HLKVFCELLGLETSKVAQWLCNRKIVT 380

  Fly   393 VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVN 457
            .:|.|:.|.:...|..|||||||.|||.||.:||..:|::|:...||.:|||||||||||||:||
Mouse   381 SSETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTFIGVLDIYGFETFDVN 445

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEE 522
            |||||||||||||||||||.||||||||||:||.|.||:||||||||.|||||:::|:|:|||||
Mouse   446 SFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEE 510

  Fly   523 CRMPKGSDESWAGKLIGK-CNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELT 586
            |.:|.|:||:|..||... .||...|||||...:||.|:||:|.|||...||||||||||...|.
Mouse   511 CLLPHGTDENWLQKLYNNFVNKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVYDMLV 575

  Fly   587 QVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH-RKTV 650
            ::|..|...|.........:        .||..|..:.:.:.::.        :.|:.:| |.||
Mouse   576 EILRASKFHLCAAFFQESPV--------PSSPFGAMITVKSAKQV--------IKPNTKHFRTTV 624

  Fly   651 GSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSR 715
            |::|:.||..|:.||:||||||||||||||:|:.|::::.:|:|||||||||||:||||..:|||
Mouse   625 GNKFRSSLYLLMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIRISAQSYPSR 689

  Fly   716 WLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRAN 780
            |.|.:||.||.:|:.:.:|..:|.|..|:.::.:.|||.::|:||.|:|||||||||:||::|.:
Mouse   690 WTYLEFYSRYGILMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLD 754

  Fly   781 LRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQK------MREARAGLILSK 839
            ..::...::|..||.::.||:|||.::....||::.||   ::..:|      ::||.|.:||.|
Mouse   755 KLRQDCIMIQKHVRGWLQRRKFLRERQAALTIQRYFRG---QQTVRKAITATALKEAWAAIILQK 816

  Fly   840 YARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRN 904
            |.||:|.|..|..:|.:...||.:.||.|||.::..:...::||.:|::.|..||||.:|..||.
Mouse   817 YCRGYLVRNLYQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRF 881

  Fly   905 IIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI 969
            ::..|                               |..::..:|:::::.||:|..|..|.:.:
Mouse   882 VLNIQ-------------------------------LTYRVQRLQKKLEDQNRENHGLVEKLTSL 915

  Fly   970 SVLKM-KLELKKTLEAEFKNVKAAC----------QDKDKLIEALNK------QLEAERDEKMQL 1017
            :.|:: .||..:.||||.:  |||.          :.:|.:.|.|:|      :||.:|:...|:
Mouse   916 AALRVGDLEKVQKLEAELE--KAATHRHSYEEKGRRYRDTVEERLSKLQKHNAELELQRERAEQM 978

  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQI-DEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQ 1081
            |:|          :.:..:::.::|.||: |::          |:.::.|::.|.......:||:
Mouse   979 LQE----------KSEELKEKMDKLTRQLFDDV----------QKEEQQRLVLEKGFELKTQAYE 1023

  Fly  1082 RAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQN-EDDVGYAS--AKNTLDINRPPD 1143
            :.|   |.:..|...||:|.|:|.      |..:....:|.. :.:|...|  ||...:..:..:
Mouse  1024 KQI---ESLREEIKALKDERSQLH------HQLEEGQVTSDRLKGEVARLSKQAKTISEFEKEIE 1079

  Fly  1144 LLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRV----SELEVENEK 1204
            ||....               ::.||......:|...::|...|...:|:.:    |.|.||:.:
Mouse  1080 LLQAQK---------------IDVEKHVQSQKREMRERMSEVTKQLLESYDIEDVRSRLSVEDLE 1129

  Fly  1205 LRSEYDQL---RTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQ 1266
            ..:|..:|   ...:|....:.|   .|...|::...:..|.:..|.|.|.|             
Mouse  1130 HLNEDGELWFAYEGLKKATRVLE---SHFQSQKDCYEKEIEGLNFKVVHLSQ------------- 1178

  Fly  1267 MRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDE 1331
                ::|.|.:.|..:..||..:..|:..:|.| |..:.:..|:|..|..:|.:|:..:.|..::
Mouse  1179 ----EINHLQKLFREETDINESIRHEVTRLTSE-NMMIPDFKQQISELERQKQDLESRLKEQAEK 1238

  Fly  1332 FED------SNVDTLRQNDR--------YLR-----REL-----QKAVAQFLLVQEELKLANAKL 1372
            .|.      |:::.:|:.:|        :||     .|:     ::.|.......|.:|....:.
Mouse  1239 IEGKLEEPFSHLNRIREEERMQGRAPHPFLRAVEAQSEMHPEGKERLVGAIHEPHEAIKFPKKQP 1303

  Fly  1373 KA-------YRQDGGQL---EHKIEEE------MIR-------------NKSNGTSADVGANVTK 1408
            :|       .:|:..:|   :..:|||      |||             .|:|......|     
Mouse  1304 EAEEEVESILQQEASRLSLEKRDLEEELDMKDRMIRRLQDQVKTLTKTTEKANHVHLPSG----- 1363

  Fly  1409 QKSQNPQGLMKFHSSDLDKILQRLLSALTPR-TVVGLLPGFPAYLIFMCIRYTDLTNADDDVREL 1472
              |:...|::::...|..|::|.|:..|.|| .||.::||.||:::|||:||.|..|..:.::.|
Mouse  1364 --SREYLGMLEYKKEDEGKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLKSL 1426

  Fly  1473 LSKFVIQIK---KMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNL 1534
            ::..:..||   |.|.  ..:|....||.|:...||.:|||...:|::|:|:.:||:..|.||:|
Mouse  1427 MNSAINGIKHVVKEHF--EDLEMLSFWLSNTCHFLNCLKQYSGEEEFMKYNSPQQNKNCLNNFDL 1489

  Fly  1535 FEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ--RGRQAHGMRSRATSIGASSSPE 1597
            .|||:::.|:.:.:|...|:.::..|.|.|||.:|..:.:|  .|.:..|.|.|::||..:.:  
Mouse  1490 TEYRQILSDVAIRIYHQFIIVMENNLQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDA-- 1552

  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMII 1662
                .....::.||.:||......|||.....|...||.|.:.||.||.|:||.|:|....||.|
Mouse  1553 ----YTMTSILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLVGAVTLNSLLLRKDMCSCRKGMQI 1613

  Fly  1663 RYNIGCIEDWVRSKKMSNDVL-TALAPLNQVSQLLQSRK-SEQDVQTICDLCTSLSTAQVLKVMK 1725
            |.||..:|:|::.|.:.:.:. ..|.||:|.:.|||.:| ::.|.:.|...|||||..|::|::.
Mouse  1614 RCNISFLEEWLKDKNVQSSLAKETLEPLSQAAWLLQVKKTTDSDAKEIAQCCTSLSAVQIIKILN 1678

  Fly  1726 SY-KLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRY--SDIKLEDIEL 1787
            || .:||:|..:...|:.|:...||.|    .:|.:..:|.|::  |:|.|.:  |...||..::
Mouse  1679 SYTPIDDFEKRVNPSFVRKVQALLNNR----GDSAQLMLDTKYL--FQVTFPFTASPHALEMTQI 1737

  Fly  1788 PSHLNLDEFLTKI 1800
            ||...|. ||.::
Mouse  1738 PSSFKLG-FLRRL 1749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 399/718 (56%)
MYSc_Myo5 84..767 CDD:276831 374/688 (54%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 30/132 (23%)
coiled coil 1049..1068 CDD:293879 2/18 (11%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 23/115 (20%)
Myo5_CBD 1424..1792 CDD:271254 129/378 (34%)
Myo5cXP_006510998.1 MYSc_Myo5 81..741 CDD:276831 374/688 (54%)
DUF3584 <767..>1043 CDD:378817 87/334 (26%)
SMC_prok_A <922..1276 CDD:274009 86/420 (20%)
ERM 1220..>1354 CDD:366293 23/133 (17%)
Myo5c_CBD 1376..1743 CDD:271260 129/380 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 763 1.000 Domainoid score I81
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1254 1.000 Inparanoid score I175
Isobase 1 0.950 - 0 Normalized mean entropy S1278
OMA 1 1.010 - - QHG52542
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm43121
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X244
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.790

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