Protein Alignment didum and Myo16

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_008769606.1
• Gene: Myo16 / 192253
• RGDID: 621561
• Length: 1934
• Species: Rattus norvegicus
• Alignment Length: 1414
• Identity: 340/1414 - (24%)
• Similarity: 569/1414 - (40%)
• Gaps: 350/1414 - (24%)

  Fly     2 SSEEMLYAQGAKIWVPHADLVWE----------SATLEESYRKGAGFLKICTD----SGKL---- 48
            |.||||.         .|::.||          |...||.|.      :|..|    |.||
  Rat   321 SIEEMLL---------KAEIAWEERMKESPSVPSLAQEELYE------EILHDLPELSSKLSPLV 370

  Fly    49 -----------KEVKLK--------ADGSDLPP---------------LRNPAILVGQNDLTTLS 79
                       |::..|        .:..|.||               |..||   ..:||.|||
  Rat   371 LPIAKQDSLLEKDIMFKDTTKGLCNQESQDGPPETSMVSSSSKPEQVQLTPPA---PSDDLATLS 432

  Fly    80 YLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAY---RGHAMGDLEPHIF 141
            .|::..:|:.::.||...| |:|:.|.|.:.:||:.|:|:|...:.:.|   .|.....|.||:|
  Rat   433 ELNDSSLLYEIQKRFGNDQ-IHTFIGDIFLLVNPFKELPIYSTVVSQMYLSPTGQRSPSLPPHLF 496

  Fly   142 ALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEA 206
            :.||.|:.:|.:|....:||:|||.|:|||.::|..|::..: ..|.|.|..:.:...:..|:||
  Rat   497 SCAERAFHRLFQERRPQNIILSGERGSGKTQASKQIMKHLTS-RASSSCTMFDSRFKHAICILEA 560

  Fly   207 FGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCA 271
            ||:||||.|:.||...::.:|.|..:.  ..:.||.:.||:|||.|:|.|..|:.::.||..|..
  Rat   561 FGHAKTTLNNVSSCLIQYWELQFCQRR--KHVTGARISTYMLEKPRLVAQPPGQGSFLIFSWLMD 623

  Fly   272 ARSKYPELVLDHQDKF---QFLNMGGAPEI---ERVSDAEQFNETVQAMTVLGFSIQQIADIVKI 330
            ..|...:..| |...|   ::::.|...::   ||..:.|:..:...|:.|:|||..::.::..|
  Rat   624 GLSAEEKCGL-HLSNFCAHRYVSQGMREDVSTAERSLNKERLADLKHALNVIGFSALEVENLFAI 687

  Fly   331 LAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIH-LQITADLLRVSADDLRRWLLMRKIESVN 394
            |:.|||:|:||.:     ...|.||    .|.:|:. |:..||:|:||.|:|...|.........
  Rat   688 LSAILHIGDIQFT-----ALTEADS----AFVSDLQLLEQVADMLQVSTDELASALTTDIQYFKG 743

  Fly   395 EYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNN----GSKQCSFIGVLDIYGFETFE 455
            :.::..::.:.|...||.|||.:|::||.:::..:|..|.:    .|.|...||:|||:|||.|:
  Rat   744 DVIIRRHTTQIAAFYRDLLAKSLYSRLFGFLINTVNCCLQSQDEYKSLQTLDIGILDIFGFEEFQ 808

  Fly   456 VNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT----------MIDFYDNQPCIDLIE 510
            .|.|||.|:|..|||:.....:.:|..||.|.::||:...          ::||:..:|.
  Rat   809 KNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPS----- 868

  Fly   511 SRLGVLDLLDEECRMPKGSDESWAGKLIG---KCNKFPHFEKPRFGT---------TSFFIKHFS 563
               |...|||||.:.....:.:...||.|   ..|....:...:.|.         .:|.:.|::
  Rat   869 ---GFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKDGNGNVAFKGQGAAFTVMHYA 930

  Fly   564 DTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSA---------KSSTL 619
            ..|.|::.|.:|:|:|::|:.|..|:..|...:...:...:...|..:.|:         |||.|
  Rat   931 GRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLL 995

  Fly   620 GGRVV------------ISAGRKQQGNDT----RRRVVPSKQHRKTVGSQFQESLASLISTLHAT 668
            ..|:.            :|...|::|..|    ..|..|:     |..||..:|||.:.:.|...
  Rat   996 SKRIASSMVGVNKNYLELSKLLKKKGTCTFLQRLERGDPA-----TTASQLTKSLADITAKLQKG 1055

  Fly   669 TPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL--VYR 731
            :||::.|:|||..::...::...:..||:..|||..||:...|:|.|..:.||..||:.|  |..
  Rat  1056 SPHFILCVKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRYGYPVRPSFEDFLSRYEPLASVLL 1120

  Fly   732 SKLDKNDMKLSCRNIVMK-----WIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQS 791
            .:......:..||.::.:     |       :.|..::|.:..||..|..:...:::|.:|
  Rat  1121 GEKKGQPAEERCRLVLQRCKLQGW-------QMGVHKVFLKYWQVDQLGDLWLQMQRKIVT---- 1174

  Fly   792 VVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHS 856
                         .||||       ||:|||:.                    |.:|..:: :..
  Rat  1175 -------------CQKVI-------RGFLARQH--------------------LLQRMSIK-QQE 1198

  Fly   857 ISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKF 921
            ::.|:::    |...:..|::. |.|:.||   ..:...|.:.:.|:.:   .||..|.......
  Rat  1199 VTSIKSF----LQSTEDMALKT-YDALVIQ---NASDIAREHDRLRKEV---HAAYHRNRQEEGT 1252

  Fly   922 KRMKAEAKTISHMENKYMGLENKIISMQQRI-----------DELNRDNSNLKHKTSEISVLKMK 975
            ||.:.:. ...|..:..:.:...:.|:.|.:           ...:.|:|.......:....|.|
  Rat  1253 KRAEDQG-GCRHAHSNSVPVPMAVDSLAQALAGPSSRSPSLHSVFSMDDSTGLPSPRKQPPPKPK 1316

  Fly   976 LELKKTLEAEFKNVKAACQ-DKDKLIEALN------------KQLEAERDEKMQLLEENGHAQEE 1027
            .:....|.|.::.|.|... .||...|||.            |::...:.::....:.:|..:|.
  Rat  1317 RDPNTRLSASYEAVSACLSATKDAASEALTRPRPHSDDYSTMKKIPPRKPKRSPHTKLSGSYEEI 1381

  Fly  1028 WISQKQ-----------------TWRQENE--ELRRQI------------DE----IIDMAKNAE 1057
            |..:..                 .|...:.  :...|:            |:    .|:|..||
  Rat  1382 WGPRPSGTMGQVGKHHAPGTLGVQWASPDSMPQCTPQLPLHLPLPQGDYDDDGEPVYIEMVGNA- 1445

  Fly  1058 VNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEE------LSRLTAG-SFSLHARK 1115
                       |.....|.:...|    .:.|.|...::|.||      |:.|.|. ...|..||
  Rat  1446 -----------ARAGGSETDSPDQ----GESVYEEMKYVLPEEGCGPGMLTFLPASPPLFLETRK 1495

  Fly  1116 -----ASNASSQNEDDVGYASAKNTLDI---------NRPPDLL--------SKNYSYNDSTSLV 1158
                 |...|.|        ..|:|.||         :|||.|:        |.....:..|.|.
  Rat  1496 AIILEAGEGSCQ--------PLKDTCDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLE 1552

  Fly  1159 VKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRS 1207
            ||...:| |...|:.|..|....||.::...:..        ||::|.|
  Rat  1553 VKKLPVL-ETNLKYPVQSEGSSPLSPQYSKAQKG--------ENDQLTS 1592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	211/750 (28%)
		IQ	900..922	CDD:197470	4/21 (19%)
		SMC_prok_B	<942..1365	CDD:274008	67/354 (19%)
		Myo5_CBD	1424..1792	CDD:271254
Myo16	XP_008769606.1	ANKYR	81..332	CDD:440430	6/19 (32%)
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		MYSc_Myo16	437..1154	CDD:276844	211/750 (28%)
		NYAP_N	1236..1603	CDD:464717	74/394 (19%)