DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myo-2

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_510092.2 Gene:myo-2 / 181404 WormBaseID:WBGene00003514 Length:1947 Species:Caenorhabditis elegans


Alignment Length:2076 Identity:523/2076 - (25%)
Similarity:875/2076 - (42%) Gaps:504/2076 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEML------YAQGAKIWVPHADLVWESATLEESYRKGAG-FLKICTDSGKLKEVKLKADGSD 59
            |.||||      |.....:|:|.:    |...:|....|.|| .:.:....|..|.||     .|
 Worm    15 SREEMLQDQSRAYDSKKNVWIPDS----EDGYIEGVITKTAGDNVTVSIGQGAEKTVK-----KD 70

  Fly    60 LPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
            :....||.......|::.|::|::..||:||:.|:. ..:||||.|:..|.||||..:|:|..|:
 Worm    71 VVQEMNPPKFEKTEDMSNLTFLNDASVLYNLKARYA-AMLIYTYSGLFCVVINPYKRLPIYTDSV 134

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSES 189
            .|.:.|....::.||:||:::|||..:.:.:.|.|::::||||||||.:.|..:.||||||.::.
 Worm   135 ARMFMGKRRTEMPPHLFAVSDEAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQQ 199

  Fly   190 ET-----------------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMF 237
            ||                 .:|.:::.::|::||||||||.||:||||||||.::.|..|..|  
 Worm   200 ETFGAKKAATEEDKNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRV-- 262

  Fly   238 LQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKY-----PELVLDHQDKFQFLNMGGAPE 297
             ....:..||||||||:.||.|||.||||||:.   |.|     .:|:|:...|..:........
 Worm   263 -ASCDIEHYLLEKSRVIRQAPGERCYHIFYQVF---SDYLPNLKKDLLLNKPVKDYWFIAQAELI 323

  Fly   298 IERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFH 362
            |:.::|.|:...|.:|..:|.|:..:..:..:::|.::|:||::..::..|  |:.:.|..|   
 Worm   324 IDGINDKEEHQLTDEAFDILKFTPTEKMECYRLVAAMMHMGNMKFKQRPRE--EQAEPDGTD--- 383

  Fly   363 NDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVG 427
               ..:..|....:.:::..:.|...:::..||:|....:||....|..|:||.:|:::|.::|.
 Worm   384 ---DAERAAKCFGIDSEEFLKALTRPRVKVGNEWVNKGQNIEQVNWAVGAMAKGLYSRIFNWLVK 445

  Fly   428 VLNKSLN-NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEG 491
            ..|::|: .|..:..|||||||.|||.|:.|||||..||:.||||||.||.|:|.||||||.:||
 Worm   446 KCNQTLDQKGISRDHFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREG 510

  Fly   492 ITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKP---- 550
            |.||.||| .|.|.||:|||..||::.:|||||.:||.:|.:.|.|||.: ..|.|:||||    
 Worm   511 IQWTFIDFGLDLQACIELIEKPLGIIAMLDEECIVPKATDLTLAQKLIDQHLGKHPNFEKPKPPK 575

  Fly   551 -RFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEI--DTLCVD 612
             :.....|.::|::.||.|:...:||||:|.::..:..|     |..:|:...:.|:  |....:
 Worm   576 GKQAEAHFAMRHYAGTVRYNCLNWLEKNKDPLNDTVVTV-----MKASKEHALIVEVWQDYTTQE 635

  Fly   613 SAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIK 677
            .|.::...|    :||.|::|         ......||...::|||..|::.||:|.||::|||.
 Worm   636 EAAAAAAKG----TAGAKKKG---------KSGSFMTVSMLYRESLNKLMTMLHSTHPHFIRCII 687

  Fly   678 PNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVY-RSKLDKNDMK- 740
            ||:.|.:...:...::.||...||||.:||...|||:|.|:|||..||.||.. .|.:.|.|.| 
 Worm   688 PNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYALLAADESIIGKTDAKK 752

  Fly   741 ---LSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQF 802
               |....:|.:...:|:.:|.|.|::||:||.||.||.:|.....:.||.:|:.:|.:      
 Worm   753 GSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLEDLRDQSLAQLITGLQAQIRWY------ 811

  Fly   803 LRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGM 867
                            |...||.:::.:..|..|:.:..|.|...|.::       ..:.|.:  
 Worm   812 ----------------YQTIERKRRVEKITALKIIQRNIRSWAELRTWV-------WFKLYGK-- 851

  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNI------IICQAAIRRFLARRKFKRMKA 926
                             ::..|........|:|.:..:      ::.:...:|.|.....:..|.
 Worm   852 -----------------VKPLVNSGKIEAQYEKLQETVATLKDTVVQEEEKKRQLQEGAERLNKE 899

  Fly   927 EAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLEL-----------KK 980
            .|..::.:|    ..:.....:::|:..:|.....|:.|.::.|   .|||:           ||
 Worm   900 TADLLAQLE----ASKGSTREVEERMTAMNEQKVALEGKLADAS---KKLEVEEARAVEINKQKK 957

  Fly   981 TLEAEFKNVKAACQDKDKLIEALNKQLEAERDEK---MQLLEENGHAQEEWISQKQTWRQENEEL 1042
            .:|||..::|..|||.|..:    :::|||::.|   ::.|::....|:|.||:....|:..||.
 Worm   958 LVEAECADLKKNCQDVDLSL----RKVEAEKNAKEHQIRALQDEMRQQDENISKLNKERKNQEEQ 1018

  Fly  1043 RRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNREL---NEAYQRAIKDK-------------EVIE 1091
            .:::.|.:..|:...:.....:.:::..:::.|.   .|...||..||             |.:|
 Worm  1019 NKKLTEDLQAAEEQNLAANKLKAKLMQSLEDSEQTMEREKRNRADMDKNKRKAEGELKIAQETLE 1083

  Fly  1092 N--------ENFMLKEELSRLTAGS-----------------------FSLHARKA--------- 1116
            .        ||.:.::|....|.|.                       ..||.:.|         
 Worm  1084 ELNKSKSDAENALRRKETELHTLGMKLEDEQAAVAKLQKGIQQDEARVKDLHDQLADEKDARQRA 1148

  Fly  1117 --SNASSQNE--------DDVGYASAKNTLDINRPPD----------------------LLSKNY 1149
              |.|..|.|        :|...|:|.. :::.:..|                      :|.|..
 Worm  1149 DRSRADQQAEYDELTEQLEDQARATAAQ-IELGKKKDAELTKLRRDLEESGLKFGEQLTVLKKKG 1212

  Fly  1150 S-----YNDSTSLVVKLRSILEEEK-----------------QKHKVLQEQYIK------LSSRH 1186
            |     .:|....:.|.:..:|:||                 .|.:..||:..|      |..|.
 Worm  1213 SDAIQELSDQIEQLQKQKGRIEKEKGHMQREFDESSAALDQEAKLRADQERIAKGYEVRLLELRL 1277

  Fly  1187 KPTEDSFRVSE-------LEVENEKLRSEYDQLRTSIKHGVEI-----NELNAQHAALQ-EEVRR 1238
            |..|.|.::.:       |..||..|..:.::|...|:....:     |||:  ||..| ||..|
 Worm  1278 KADEQSRQLQDFVSSKGRLNSENSDLARQVEELEAKIQAANRLKLQFSNELD--HAKRQAEEESR 1340

  Fly  1239 RREECIQLKAVLLQQSQSMR-SLEPE---------SLQMRGNDVNELMEAFHSQKLI-------- 1285
            .|:....|...|.::.:.:: |:|.|         .|.....::::....|.::.||        
 Worm  1341 ERQNLSNLSKNLARELEQLKESIEDEVAGKNEASRQLSKASVELDQWRTKFETEGLIGADEFDEV 1405

  Fly  1286 ---NRQLESELKAITEEHNSKLVEMTQEIERLNNEKD-----------------ELQKVMFESID 1330
               ..|..||::...:..|:|:|.:.....||..|.|                 :.||...:.||
 Worm  1406 KKRQNQKTSEIQDALDACNAKIVALENARSRLTAEADANRLEAEHHAQAVSSLEKKQKAFDKVID 1470

  Fly  1331 EFEDS------NVDTLRQNDRYLRRELQKAVAQFLLVQEE---LKLANAKLKAYRQD-------G 1379
            |::..      .:|..:::.|.|..|..|...|...:.::   |:..|..|....:|       |
 Worm  1471 EWKKKVDDLYLELDGAQRDARQLSGEAHKLRGQHDTLADQVEGLRRENKSLSDETRDLTESLSEG 1535

  Fly  1380 GQLEHKI----------EEEMIRNKSNGTSA----------------DVGANVTK---QKSQNPQ 1415
            |:..|.:          :||:.|......:|                .:.|.:.|   :|.:..:
 Worm  1536 GRATHALSKNLRRLEMEKEELQRGLDEAEAALESEESKALRCQIEVSQIRAEIEKRIAEKEEEFE 1600

  Fly  1416 GLMKFHSSDLDKILQRLLSALTPRT-VVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQ 1479
            ...|.|...:|.|...|.|....:: :..:.....|.:..:.|.......|::|.::.:.:::.|
 Worm  1601 NHRKVHQQTIDSIQATLDSETKAKSELFRVKKKLEADINELEIALDHANKANEDAQKNIRRYLDQ 1665

  Fly  1480 IKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTE---------------KQNQQQL 1529
            |:::.:|                          |||..|...|               ||.|::|
 Worm  1666 IRELQQT--------------------------VDEEQKRREEFREHLLAAERKLAVAKQEQEEL 1704

  Fly  1530 --KNFNLFEYRRVILDLI---------VNLYQALIMQIQGLLDPKIVPAILNNDEIQ-------- 1575
              |...|...|||:...:         :|.....:...:..||.:|  |:||:|..:        
 Worm  1705 IVKLEALERARRVVESSVKEHQEHNNELNSQNVALAAAKSQLDNEI--ALLNSDIAEAHTELSAS 1767

  Fly  1576 --RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYF 1638
              |||:|   .|.|..:......|       ::...|||.|.||.:.                  
 Worm  1768 EDRGRRA---ASDAAKLAEDLRHE-------QEQSQQLERFKKQLES------------------ 1804

  Fly  1639 ICAVALNCLMLRGDICMWETGMIIRYNIGCIED-WVRSKKMSNDVLTALAPLNQVSQLLQSRKSE 1702
                |:..|..|.|..   ...:::.....|:. ..|.|...:|:.|            :||::.
 Worm  1805 ----AVKDLQERADAA---EAAVMKGGAKAIQKAEQRLKAFQSDLET------------ESRRAG 1850

  Fly  1703 QDVQTI--CDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLNARQMQKSNSDE 1760
            :..:|:  .|........||.:..|:| ||.:        .:||||.||..::.|...::|
 Worm  1851 EASKTLARADRKVREFEFQVAEDKKNYDKLQE--------LVEKLTAKLKLQKKQLEEAEE 1903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 275/749 (37%)
MYSc_Myo5 84..767 CDD:276831 263/719 (37%)
IQ 900..922 CDD:197470 3/27 (11%)
GBP_C <971..1086 CDD:303769 31/131 (24%)
coiled coil 1049..1068 CDD:293879 1/18 (6%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 30/142 (21%)
Myo5_CBD 1424..1792 CDD:271254 73/378 (19%)
myo-2NP_510092.2 Myosin_N 31..68 CDD:280832 9/40 (23%)
Myosin_head 83..782 CDD:278492 266/731 (36%)
MYSc_class_II 95..782 CDD:276951 263/719 (37%)
Myosin_tail_1 876..1939 CDD:279860 213/1125 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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