DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and nmy-1

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_508504.2 Gene:nmy-1 / 180581 WormBaseID:WBGene00003776 Length:1963 Species:Caenorhabditis elegans


Alignment Length:2062 Identity:531/2062 - (25%)
Similarity:897/2062 - (43%) Gaps:476/2062 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 YAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLK-----EVKLK-ADGS-------D 59
            :||....|||.               :..|||     .|.:|     ||.:: .|.|       |
 Worm    23 WAQRKLCWVPD---------------QNEGFL-----IGSIKRETNDEVLVELVDTSRQVTISRD 67

  Fly    60 LPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
            .....||.......|::.|:||:|..|||||:.|:.. .:||||.|:..|.||||.::|:|...:
 Worm    68 DVQKANPPKFDKIEDMSELTYLNEASVLHNLKDRYYS-SLIYTYSGLFCVVINPYKKLPIYSEDL 131

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSES 189
            |..::|....::.|||||:|:.||..:.:|..:.||:.:||||||||.:.|..::|.|.|.|:..
 Worm   132 IEEFKGKKRHEMPPHIFAIADTAYRSMLQEREDQSILCTGESGAGKTENTKKVIQYLAHVAGATR 196

  Fly   190 ET---------------------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQM 233
            ..                     ::|.::|.::||:|||||:||.:||||||||||.::.| :..
 Worm   197 NKSLNAAAQQNIVQKPDVRNPIGELEHQLLQANPILEAFGNSKTVKNDNSSRFGKFIRINF-DMS 260

  Fly   234 GVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL---CAARSKYPELVLDHQDKFQFLNMGGA 295
            |  ::.||.:..||||||||:.|||.||::|||||:   |:|:.| .|.:|:..|.::||...|.
 Worm   261 G--YISGANIEFYLLEKSRVLRQAQDERSFHIFYQILRGCSAKEK-SEYLLEGVDNYRFLVNRGI 322

  Fly   296 PEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDI 360
             .:..|.|.::|:.|:.:|.::||:..:|:.|:::::.:|.|||:       |.::|:.||.. :
 Worm   323 -TLPNVDDVQEFHSTINSMRIMGFADDEISSIMRVVSAVLLLGNL-------EFTQEKKSDQA-M 378

  Fly   361 FHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYI 425
            ..:|..:|....||.:...:|::..|..:|:...|:|....:.|.|:.|.:|:||..|.:||:::
 Worm   379 LQDDRVIQKVCHLLGLPVIELQKAFLRPRIKVGREFVNKAQNQEQAEFAVEAIAKASYERLFKWL 443

  Fly   426 VGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLK 489
            |..:||||:...:| .||||:|||.|||.|::|||||.||||.||||||.||..:|.||||||.:
 Worm   444 VTRINKSLDRTHRQGASFIGILDIAGFEIFDINSFEQICINYTNEKLQQLFNNTMFILEQEEYQR 508

  Fly   490 EGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG 553
            |||.|..||| .|.||.|||||..:|||.||||||..||.:|:|:..||....||.|.|..|...
 Worm   509 EGIEWDFIDFGLDLQPTIDLIEKPMGVLALLDEECLFPKANDKSFVEKLQKTHNKHPKFIVPDMR 573

  Fly   554 TTSFF-IKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSS 617
            :.|.| :.|::..|:|..:.:|.||.|.:::.:..::..|.......:....|...:|......:
 Worm   574 SKSHFAVVHYAGRVDYSADQWLMKNMDPLNENVVGLMQNSTDPFVAGIWKDAEFAGICAAEMNET 638

  Fly   618 TLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDK 682
            ..|.|             :|:.:.      :||....:|.|..|::||..|:||:||||.||.:|
 Worm   639 AFGMR-------------SRKGMF------RTVSQLHKEQLTKLMTTLRNTSPHFVRCIIPNHEK 684

  Fly   683 VAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRN 745
            .:.|..:..:::|||..||||.:||...|||:|..:.:|..||::|. ...:.||  |.|.|.|.
 Worm   685 KSGKINSNLVLEQLRCNGVLEGIRICRQGFPNRVPFQEFRHRYEILT-PDVIPKNFIDGKESVRK 748

  Fly   746 IVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVIN 810
            ::.....|.:.||.|.:::|||.|.:|.||:.|.                       |::..:|.
 Worm   749 MITALDIDTNLYRIGQSKVFFRTGVLAHLEEERD-----------------------LKLTALIM 790

  Fly   811 GIQKHARGYLARE---RTQKMREA-----RAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGM 867
            ..|...||:|:|.   |.|:...|     |.||...| .|.|...|.:.:::..:...:|     
 Worm   791 NFQAQCRGFLSRRLYTRRQQQSSAIRIIQRNGLAYLK-LRNWQWWRLFTKVKPLLQVTRT----- 849

  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTI- 931
              .::..|..|..||.: :|.::.....|..:|:...:|:.:|.|:..|.:.  ....||...| 
 Worm   850 --DDEIRAKDDELRATK-ERLLKMEHDFRENEKKLDQVIVERAVIQEQLQQE--SENSAELDDIR 909

  Fly   932 SHMENKYMGLENKIISMQQRIDELNRDNS--------------NLKHKTSEISVLKMKLELKKT- 981
            ..::.:...||..:..|:.|:.|..:.|.              :|:.:..:....:.||.|.|| 
 Worm   910 GRLQTRNQELEYIVNDMRDRLSEEEQQNEKNNDERRKQMETVRDLEEQLEQEEQARQKLLLDKTN 974

  Fly   982 LEAEFKNVK---AACQDK-DKL----------IEALNKQLEAERDEKMQ-------LLEENGHAQ 1025
            ::...:|::   ...||. |||          :|.|..|| .:.:|:.:       .||...|..
 Worm   975 VDQRLRNLEERLVELQDAYDKLLKEKRLLEEKVEGLTTQL-LDHEERAKHGVKAKGRLENQLHEL 1038

  Fly  1026 EEWISQKQTWRQENEELRRQI--------DEIID-MAKNAEVN----QRNQE-DRMLAEIDNREL 1076
            |:.:::::.::.|.|:.:|::        |.:.: |.|..|:|    :|::| ...|...|....
 Worm  1039 EQDLNRERQYKSELEQHKRKLLAELEDSKDHLAEKMGKVEELNNQLMKRDEELQHQLTRYDEESA 1103

  Fly  1077 N-EAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDI-- 1138
            | ...|:.::|.:...:|   |:|::..         .|.|.|.:.....:|.....|...|:  
 Worm  1104 NVTLMQKQMRDMQTTIDE---LREDMET---------ERNARNKAEMTRREVVAQLEKVKGDVLD 1156

  Fly  1139 -----NRPPDLLSKNYSYNDSTSLVVK-----LRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSF 1193
                 ....||:|:.....::|...::     :...:||:|.|.....|:......:||......
 Worm  1157 KVDEATMLQDLMSRKDEEVNATKRAIEQIQHTMEGKIEEQKAKFSRQVEELHDQIEQHKKQRSQL 1221

  Fly  1194 RVSELEVENEKL------------RSEYDQLRTSIKHGVEINELNAQHA-------ALQEEVRRR 1239
            ...:.:.:.|:.            |::.|:.|..  |...:.|:.|..|       .|.:::.|.
 Worm  1222 EKQQNQADQERADMAQEIALLQASRADIDKKRKI--HEAHLMEIQANLAESDEHKRTLIDQLERS 1284

  Fly  1240 REECIQLKAVLLQQSQSMRSLEPESLQMRG--NDVNELMEAFHSQKLIN----RQLESELKAITE 1298
            |:|...|..|..::..:..:::.......|  .::||.::.....|:.|    ||||.|..|:.:
 Worm  1285 RDELDHLNRVREEEEHAFANMQRRLATAEGQIQELNEQIQEETRLKIANINRARQLEDEKNALLD 1349

  Fly  1299 E---------HNSKLV----------------EMTQEIERLNNEK----DELQKVMFES------ 1328
            |         |..|.:                .:.|::|.|..:.    :.|||.:.||      
 Worm  1350 EKEEAEGLRAHLEKEIHAARQGAGEARRKAEESVNQQLEELRKKNLRDVEHLQKQLEESEVAKER 1414

  Fly  1329 --------IDEFEDSNVDTLRQNDRYLRRELQK--------------AVAQFLL----VQEELKL 1367
                    ..|.|||:::.  :|.|...|:.:|              ||.:.||    :.:||:.
 Worm  1415 ILQSKKKIQQELEDSSMEL--ENVRASHRDSEKRQKKFESQMAEERVAVQKALLDRDAMSQELRD 1477

  Fly  1368 ANAK----------LKAYRQDGGQLEHKIEEEM---IRNKSNGTSADVGANV-----TKQKSQNP 1414
            ...:          :|.:.::..::...:::|:   |.||.     |.|.||     .|:..:..
 Worm  1478 RETRVLSLLNEVDIMKEHLEESDRVRRSLQQELQDSISNKD-----DFGKNVHELEKAKRSLEAE 1537

  Fly  1415 QGLMKFHSSDLDKILQ-----RLLSALTPRTVVGLLPGFPAYLIFMCIRYTD--LTNADDDVREL 1472
            ...|:....:|:..||     ||...:|.:.:..               .:|  ::|.|.:..|.
 Worm  1538 LNDMRVQMEELEDNLQIAEDARLRLEVTNQALKS---------------ESDRAISNKDVEAEEK 1587

  Fly  1473 LSKFVIQIKKM----------------HRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNT 1521
            ....:.||:.:                ||  ..|||::..|...:.:.|.:|     :||.|  .
 Worm  1588 RRGLLKQIRDLENELENEKRGKSGAVSHR--KKIENQIGELEQQLEVANRLK-----EEYNK--Q 1643

  Fly  1522 EKQNQQQLKNFNL--FEYRRVILDLIVNLYQA-------------------LIMQIQGLLDPKIV 1565
            .|:|||.:|.:.:  .|.|:...|:...|.:|                   .:||.:..|:    
 Worm  1644 LKKNQQIIKEYQIECEEARQAKEDIAALLREADRKFRAVEAEREQLREANEGLMQARKQLE---- 1704

  Fly  1566 PAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQ 1630
               |.|||::..|...|        |.||..:.    ..:..|.|||...::.|.          
 Worm  1705 ---LENDELEELRAKGG--------GISSEEKR----RLEAKIAQLEEELEEEQS---------- 1744

  Fly  1631 IFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQL 1695
                          ||.:                   .|:...:::.....:.|.|:....::|.
 Worm  1745 --------------NCEL-------------------AIDKQRKAQVQLEQITTDLSMERTLNQK 1776

  Fly  1696 LQSRK-----SEQDVQT-ICDL---CTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNAR 1751
            .::.|     |.:|.:. |.:|   ..|.:.||:..:  ..|:...|.::.....||......||
 Worm  1777 TEAEKQSLERSNRDYKAKITELESGAQSRARAQMAAL--EAKVQYLEDQLNVEGQEKTAANRAAR 1839

  Fly  1752 QMQKSNSD---EFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDE 1795
            :::|..:|   :|..:::..:..|.:...|::|..::    ...|||
 Worm  1840 RLEKRLNDTTQQFEDEKRANEQAKELLEKSNLKNRNL----RRQLDE 1882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 281/741 (38%)
MYSc_Myo5 84..767 CDD:276831 268/711 (38%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 34/151 (23%)
coiled coil 1049..1068 CDD:293879 6/24 (25%)
coiled coil 1077..1086 CDD:293879 2/9 (22%)
JAKMIP_CC3 <1190..1299 CDD:292653 25/133 (19%)
Myo5_CBD 1424..1792 CDD:271254 76/423 (18%)
nmy-1NP_508504.2 Myosin_N 27..65 CDD:280832 12/57 (21%)
Myosin_head 80..770 CDD:278492 273/723 (38%)
MYSc_class_II 92..770 CDD:276951 268/711 (38%)
Myosin_tail_1 847..1919 CDD:279860 217/1160 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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