Protein Alignment didum and nmy-1

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_508504.2
• Gene: nmy-1 / 180581
• WormBaseID: WBGene00003776
• Length: 1963
• Species: Caenorhabditis elegans
• Alignment Length: 2062
• Identity: 531/2062 - (25%)
• Similarity: 897/2062 - (43%)
• Gaps: 476/2062 - (23%)

  Fly     8 YAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLK-----EVKLK-ADGS-------D 59
            :||....|||.               :..|||     .|.:|     ||.:: .|.|       |
 Worm    23 WAQRKLCWVPD---------------QNEGFL-----IGSIKRETNDEVLVELVDTSRQVTISRD 67

  Fly    60 LPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
            .....||.......|::.|:||:|..|||||:.|:.. .:||||.|:..|.||||.::|:|...:
 Worm    68 DVQKANPPKFDKIEDMSELTYLNEASVLHNLKDRYYS-SLIYTYSGLFCVVINPYKKLPIYSEDL 131

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSES 189
            |..::|....::.|||||:|:.||..:.:|..:.||:.:||||||||.:.|..::|.|.|.|:..
 Worm   132 IEEFKGKKRHEMPPHIFAIADTAYRSMLQEREDQSILCTGESGAGKTENTKKVIQYLAHVAGATR 196

  Fly   190 ET---------------------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQM 233
            ..                     ::|.::|.::||:|||||:||.:||||||||||.::.| :..
 Worm   197 NKSLNAAAQQNIVQKPDVRNPIGELEHQLLQANPILEAFGNSKTVKNDNSSRFGKFIRINF-DMS 260

  Fly   234 GVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL---CAARSKYPELVLDHQDKFQFLNMGGA 295
            |  ::.||.:..||||||||:.|||.||::|||||:   |:|:.| .|.:|:..|.::||...|.
 Worm   261 G--YISGANIEFYLLEKSRVLRQAQDERSFHIFYQILRGCSAKEK-SEYLLEGVDNYRFLVNRGI 322

  Fly   296 PEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDI 360
             .:..|.|.::|:.|:.:|.::||:..:|:.|:::::.:|.|||:       |.::|:.||.. :
 Worm   323 -TLPNVDDVQEFHSTINSMRIMGFADDEISSIMRVVSAVLLLGNL-------EFTQEKKSDQA-M 378

  Fly   361 FHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYI 425
            ..:|..:|....||.:...:|::..|..:|:...|:|....:.|.|:.|.:|:||..|.:||:::
 Worm   379 LQDDRVIQKVCHLLGLPVIELQKAFLRPRIKVGREFVNKAQNQEQAEFAVEAIAKASYERLFKWL 443

  Fly   426 VGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLK 489
            |..:||||:...:| .||||:|||.|||.|::|||||.||||.||||||.||..:|.||||||.:
 Worm   444 VTRINKSLDRTHRQGASFIGILDIAGFEIFDINSFEQICINYTNEKLQQLFNNTMFILEQEEYQR 508

  Fly   490 EGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG 553
            |||.|..||| .|.||.|||||..:|||.||||||..||.:|:|:..||....||.|.|..|...
 Worm   509 EGIEWDFIDFGLDLQPTIDLIEKPMGVLALLDEECLFPKANDKSFVEKLQKTHNKHPKFIVPDMR 573

  Fly   554 TTSFF-IKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSS 617
            :.|.| :.|::..|:|..:.:|.||.|.:::.:..::..|.......:....|...:|......:
 Worm   574 SKSHFAVVHYAGRVDYSADQWLMKNMDPLNENVVGLMQNSTDPFVAGIWKDAEFAGICAAEMNET 638

  Fly   618 TLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDK 682
            ..|.|             :|:.:.      :||....:|.|..|::||..|:||:||||.||.:|
 Worm   639 AFGMR-------------SRKGMF------RTVSQLHKEQLTKLMTTLRNTSPHFVRCIIPNHEK 684

  Fly   683 VAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRN 745
            .:.|..:..:::|||..||||.:||...|||:|..:.:|..||::|. ...:.||  |.|.|.|.
 Worm   685 KSGKINSNLVLEQLRCNGVLEGIRICRQGFPNRVPFQEFRHRYEILT-PDVIPKNFIDGKESVRK 748

  Fly   746 IVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVIN 810
            ::.....|.:.||.|.:::|||.|.:|.||:.|.                       |::..:|.
 Worm   749 MITALDIDTNLYRIGQSKVFFRTGVLAHLEEERD-----------------------LKLTALIM 790

  Fly   811 GIQKHARGYLARE---RTQKMREA-----RAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGM 867
            ..|...||:|:|.   |.|:...|     |.||...| .|.|...|.:.:::..:...:|
 Worm   791 NFQAQCRGFLSRRLYTRRQQQSSAIRIIQRNGLAYLK-LRNWQWWRLFTKVKPLLQVTRT----- 849

  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTI- 931
              .::..|..|..||.: :|.::.....|..:|:...:|:.:|.|:..|.:.  ....||...|
 Worm   850 --DDEIRAKDDELRATK-ERLLKMEHDFRENEKKLDQVIVERAVIQEQLQQE--SENSAELDDIR 909

  Fly   932 SHMENKYMGLENKIISMQQRIDELNRDNS--------------NLKHKTSEISVLKMKLELKKT- 981
            ..::.:...||..:..|:.|:.|..:.|.              :|:.:..:....:.||.|.||
 Worm   910 GRLQTRNQELEYIVNDMRDRLSEEEQQNEKNNDERRKQMETVRDLEEQLEQEEQARQKLLLDKTN 974

  Fly   982 LEAEFKNVK---AACQDK-DKL----------IEALNKQLEAERDEKMQ-------LLEENGHAQ 1025
            ::...:|::   ...||. |||          :|.|..|| .:.:|:.:       .||...|..
 Worm   975 VDQRLRNLEERLVELQDAYDKLLKEKRLLEEKVEGLTTQL-LDHEERAKHGVKAKGRLENQLHEL 1038

  Fly  1026 EEWISQKQTWRQENEELRRQI--------DEIID-MAKNAEVN----QRNQE-DRMLAEIDNREL 1076
            |:.:::::.::.|.|:.:|::        |.:.: |.|..|:|    :|::| ...|...|....
 Worm  1039 EQDLNRERQYKSELEQHKRKLLAELEDSKDHLAEKMGKVEELNNQLMKRDEELQHQLTRYDEESA 1103

  Fly  1077 N-EAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDI-- 1138
            | ...|:.::|.:...:|   |:|::..         .|.|.|.:.....:|.....|...|:
 Worm  1104 NVTLMQKQMRDMQTTIDE---LREDMET---------ERNARNKAEMTRREVVAQLEKVKGDVLD 1156

  Fly  1139 -----NRPPDLLSKNYSYNDSTSLVVK-----LRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSF 1193
                 ....||:|:.....::|...::     :...:||:|.|.....|:......:||......
 Worm  1157 KVDEATMLQDLMSRKDEEVNATKRAIEQIQHTMEGKIEEQKAKFSRQVEELHDQIEQHKKQRSQL 1221

  Fly  1194 RVSELEVENEKL------------RSEYDQLRTSIKHGVEINELNAQHA-------ALQEEVRRR 1239
            ...:.:.:.|:.            |::.|:.|..  |...:.|:.|..|       .|.:::.|.
 Worm  1222 EKQQNQADQERADMAQEIALLQASRADIDKKRKI--HEAHLMEIQANLAESDEHKRTLIDQLERS 1284

  Fly  1240 REECIQLKAVLLQQSQSMRSLEPESLQMRG--NDVNELMEAFHSQKLIN----RQLESELKAITE 1298
            |:|...|..|..::..:..:::.......|  .::||.::.....|:.|    ||||.|..|:.:
 Worm  1285 RDELDHLNRVREEEEHAFANMQRRLATAEGQIQELNEQIQEETRLKIANINRARQLEDEKNALLD 1349

  Fly  1299 E---------HNSKLV----------------EMTQEIERLNNEK----DELQKVMFES------ 1328
            |         |..|.:                .:.|::|.|..:.    :.|||.:.||
 Worm  1350 EKEEAEGLRAHLEKEIHAARQGAGEARRKAEESVNQQLEELRKKNLRDVEHLQKQLEESEVAKER 1414

  Fly  1329 --------IDEFEDSNVDTLRQNDRYLRRELQK--------------AVAQFLL----VQEELKL 1367
                    ..|.|||:::.  :|.|...|:.:|              ||.:.||    :.:||:.
 Worm  1415 ILQSKKKIQQELEDSSMEL--ENVRASHRDSEKRQKKFESQMAEERVAVQKALLDRDAMSQELRD 1477

  Fly  1368 ANAK----------LKAYRQDGGQLEHKIEEEM---IRNKSNGTSADVGANV-----TKQKSQNP 1414
            ...:          :|.:.::..::...:::|:   |.||.     |.|.||     .|:..:..
 Worm  1478 RETRVLSLLNEVDIMKEHLEESDRVRRSLQQELQDSISNKD-----DFGKNVHELEKAKRSLEAE 1537

  Fly  1415 QGLMKFHSSDLDKILQ-----RLLSALTPRTVVGLLPGFPAYLIFMCIRYTD--LTNADDDVREL 1472
            ...|:....:|:..||     ||...:|.:.:..               .:|  ::|.|.:..|.
 Worm  1538 LNDMRVQMEELEDNLQIAEDARLRLEVTNQALKS---------------ESDRAISNKDVEAEEK 1587

  Fly  1473 LSKFVIQIKKM----------------HRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNT 1521
            ....:.||:.:                ||  ..|||::..|...:.:.|.:|     :||.|  .
 Worm  1588 RRGLLKQIRDLENELENEKRGKSGAVSHR--KKIENQIGELEQQLEVANRLK-----EEYNK--Q 1643

  Fly  1522 EKQNQQQLKNFNL--FEYRRVILDLIVNLYQA-------------------LIMQIQGLLDPKIV 1565
            .|:|||.:|.:.:  .|.|:...|:...|.:|                   .:||.:..|:
 Worm  1644 LKKNQQIIKEYQIECEEARQAKEDIAALLREADRKFRAVEAEREQLREANEGLMQARKQLE---- 1704

  Fly  1566 PAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQ 1630
               |.|||::..|...|        |.||..:.    ..:..|.|||...::.|.
 Worm  1705 ---LENDELEELRAKGG--------GISSEEKR----RLEAKIAQLEEELEEEQS---------- 1744

  Fly  1631 IFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQL 1695
                          ||.:                   .|:...:::.....:.|.|:....::|.
 Worm  1745 --------------NCEL-------------------AIDKQRKAQVQLEQITTDLSMERTLNQK 1776

  Fly  1696 LQSRK-----SEQDVQT-ICDL---CTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNAR 1751
            .::.|     |.:|.:. |.:|   ..|.:.||:..:  ..|:...|.::.....||......||
 Worm  1777 TEAEKQSLERSNRDYKAKITELESGAQSRARAQMAAL--EAKVQYLEDQLNVEGQEKTAANRAAR 1839

  Fly  1752 QMQKSNSD---EFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDE 1795
            :::|..:|   :|..:::..:..|.:...|::|..::    ...|||
 Worm  1840 RLEKRLNDTTQQFEDEKRANEQAKELLEKSNLKNRNL----RRQLDE 1882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	268/711 (38%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	109/571 (19%)
		Myo5_CBD	1424..1792	CDD:271254	76/423 (18%)
nmy-1	NP_508504.2	Myosin_N	26..69	CDD:460670	13/62 (21%)
		MYSc_class_II	92..770	CDD:276951	268/711 (38%)
		Myosin_tail_1	847..1919	CDD:460256	217/1160 (19%)