DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and hum-6

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_508420.1 Gene:hum-6 / 180539 WormBaseID:WBGene00002039 Length:2098 Species:Caenorhabditis elegans


Alignment Length:2252 Identity:534/2252 - (23%)
Similarity:845/2252 - (37%) Gaps:729/2252 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVW-ESATLEESYRKGA-------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILV 70
            :.|...|.:| |....|.|...||       |.||:..|.|  .|..|.||..  ..|.:|..:.
 Worm     2 VLVSKGDFIWIEPGKTEGSIPIGARVIDQDHGRLKVIDDLG--NEQWLSADRR--VRLMHPTSVQ 62

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..|:..|...||..:|.||.:|:.|: :||.|.|.||:|:|||.::.:|....||.|:...:|:
 Worm    63 GVEDMCQLGDFHESAILRNLFIRYREK-LIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGE 126

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLAS 200
            |.|||||:|:.|||.:.||..|.|:|:|||||||||.|.|..:::.|.:.|..|  .:|::||.:
 Worm   127 LPPHIFAIADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHS--WIEQQVLEA 189

  Fly   201 SPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            :|::||||||||.||||||||||:..:.| |:.|  .::||.:..|||||||:|.|::.||||||
 Worm   190 NPVLEAFGNAKTIRNDNSSRFGKYIDVHF-NESG--SIEGAKIEQYLLEKSRIVTQSENERNYHI 251

  Fly   266 FYQLCA--ARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIV 328
            ||.|.|  :|.:..||.|.....:.:|..|.....|...||....|...||.||..:.|:|..|.
 Worm   252 FYCLLAGLSREEKSELELGTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIF 316

  Fly   329 KILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESV 393
            |:||.:||:|||:..:..|:..|     |.|:......::| |.||::...:|...:..:.:.:.
 Worm   317 KLLASLLHIGNIRFRQNTNDNME-----SVDVADPSTLVRI-AKLLQLHEQNLLDAITTKSLVTR 375

  Fly   394 NEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSK-QCSFIGVLDIYGFETFEVN 457
            .|.|:...:.:.|..|||||||.||.|||.:||..:|.::...|: :.:.||:|||:|||.||.|
 Worm   376 EERVISRLNGQQAVDARDALAKAIYGKLFIHIVRRVNDAIYKPSQSRRTSIGILDIFGFENFESN 440

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDE 521
            ||||.|||:|||.|||.|..||||:||:||.:|.|.|..|.|.|||..:|||..| |.:|.|:||
 Worm   441 SFEQLCINFANETLQQFFVHHVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDE 505

  Fly   522 ECRMPKGSDESWAGKLIGKCNKFPHFEKPR------FGTTSFFIKHFSDTVEYDVNGFLEKNRDT 580
            |...|||:|::...||.....:...:.:|:      ||.|     ||:..|.|:..||||||||:
 Worm   506 ESIFPKGTDKTMLLKLHSTHGRNELYLQPKSELQRAFGVT-----HFAGNVFYNTRGFLEKNRDS 565

  Fly   581 VSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQ 645
            .|.:|:.::|.|.|....::....|.||                          .:|::|     
 Worm   566 FSADLSVLISSSKMPFLARLFDDIEYDT--------------------------SSRKKV----- 599

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
               |||:||:.||..|:|.|..|.|.::||||||:.|.|...:...:::|||..|::||::|..:
 Worm   600 ---TVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNEMKRALVMDRDLVLRQLRYSGMMETIKIRRS 661

  Fly   711 GFPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            |:|.|..|..|..||::||  .:..:::.|:..:.:.|....:.....|:.|.|::|.:......
 Worm   662 GYPIRHDYYPFVFRYRVLVSSIQGPVNRIDLHDAAKKICHMILGTNADYQLGKTKVFLKDKHDLV 726

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            |||....:.|....::|..|||::.|:.|.:.::....||...||:..|:|.::        |:|
 Worm   727 LEQEYYRILKDKAIVIQKNVRRWLVRKDFEKQRQAAVTIQTAWRGFDQRKRYRQ--------IIS 783

  Fly   839 KYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAY-QKRR 902
            .::|    .:..||.|..:|..||..:.:               :|.|...||:|.||.. :||:
 Worm   784 GFSR----LQAVLRSRQLVSHYQTLRKTI---------------IQFQAVCRGSLVRRQVGEKRK 829

  Fly   903 RNIIICQAAIRRFLARRKFKRMKAEAKTIS--------HM------ENKYMGLENKIISMQQ--- 950
            |.            .:.....:.:.|..||        |:      :.|..|.||......:   
 Worm   830 RG------------EKAPLTEVSSTASVISDSHEELVGHLFDFLPSDGKDSGNENDSADSSRRGS 882

  Fly   951 ----------------RIDE-LNRDNSNL---KHKTSEISVLKMKLELKKTLE------------ 983
                            |:|. ::.|.|..   |:..:..........:||.|:            
 Worm   883 YSRLHTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQAQATATHVKKPLKTALLTHTEPSAQ 947

  Fly   984 --------------AEFKNVK------AACQDKD----KLIEALNKQLEAERDEKMQLLEENGHA 1024
                          .:..:||      :...||.    ||...|.|:..|...|:..|..|.|.|
 Worm   948 LAALTAWTTILRFMGDLADVKPGSTNGSEVYDKTPVMIKLYATLGKKFSAHDLEEAMLSSEYGGA 1012

  Fly  1025 QEEWISQKQTWRQENEELRRQID-EIIDMA--KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKD 1086
                           :.|::.:. ::|.|.  :..::|..:     .:.|.:..:..::...:::
 Worm  1013 ---------------KTLKKGMGRKLISMTLKRKGKINGSD-----TSSISSDSVYSSFNAMLEN 1057

  Fly  1087 KEVIENENF-------MLKEEL----------------SRLTA-----------GSFSLHAR--- 1114
            |.:...:..       :|:|:|                |:|:|           |.|:...|   
 Worm  1058 KPMTSLDKLHYIIGLGILREDLRDEIYCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPSERFIK 1122

  Fly  1115 -----------KASNASSQNEDDVGYASAKNTLDINRPPDL--LSKNYSYN-------------- 1152
                       ..:..|...||.:.......|.  ::||..  |..|.|..              
 Worm  1123 YLFCFIRERGPAGTGYSKYIEDRLRRTQVNGTR--HQPPSYVELQANKSQKPVVLAVTFMDGSVK 1185

  Fly  1153 ----DSTSLVVKLRSILEE---------------------------EKQKHKVLQ-EQYIKLSSR 1185
                ||.:...:|...|.|                           :.....:.| |||.|...|
 Worm  1186 TLCADSATTAAELCKQLAEKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKEQGR 1250

  Fly  1186 -------------------HKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAA 1231
                               |.|.:|....:.:          |.|:...||:|            
 Worm  1251 QERNAPWRLFFRKEIFSPWHDPRDDPVSTNLI----------YQQVIRGIKYG------------ 1293

  Fly  1232 LQEEVRRRREECIQLKAVLLQQ------SQSMRSLE---PESL---QMRGNDVNELMEAFHSQKL 1284
               |.|..::|  :|.|:..||      :..:..||   |..|   :|.|.::            
 Worm  1294 ---EYRCDKDE--ELAAICAQQYYIDEGTMDVNKLENNLPSYLPDFEMSGKEM------------ 1341

  Fly  1285 INRQLESELKAITEEHNSKL-------VEMTQEIERLNNEK------------------------ 1318
               .||...:.|..::..|.       :|:.:.:..:...|                        
 Worm  1342 ---ALEKWTQTIMHQYRKKFTGRLPSQIEVKENVVSVAKTKWPLLFSRFYEALKFAGPPLPKNEV 1403

  Fly  1319 ------------DELQKVMFE-SIDEF--------EDSNVDTLR----QNDRYLRR-----ELQK 1353
                        |:.:.||.| |..|.        :.|..||..    ..|.|..:     ::..
 Worm  1404 IIAVNWTGVYVVDDREHVMLEFSFPEISTAYYGKGKRSTTDTCTVRTVVGDEYTFQSPNADDITN 1468

  Fly  1354 AVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLM 1418
            .:..||   |.||..:..|.|                               :..||.......:
 Worm  1469 LIVMFL---EGLKKRSRYLVA-------------------------------IKSQKGDEKNNFL 1499

  Fly  1419 KFHSSDL----------DKILQRLLSALTPRT-VVGLLPGFPAYLIFMCIRYT------------ 1460
            :|...||          ..:.:.::.....|| :.||:.....|::...::.:            
 Worm  1500 EFEKGDLLILVNEFTGNTLLTESVVKGENSRTCLFGLIRAENVYVLPTLVKPSKNTLQIFPKDMD 1564

  Fly  1461 ---DLTNADDDVRELLSKFVIQIKKMHRTPHPIEN--------RVIWLVNSITLLNLMKQYGDVD 1514
               ||.|.:..|         .:...:..|:.:||        :|..:.:.|:|:.|.|:...: 
 Worm  1565 LSLDLFNNNKQV---------TVVDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQI- 1619

  Fly  1515 EYVKFNTEKQNQQQLKNFN---------------LFEY--------RRVILDLIVNLYQALIMQI 1556
            |..:|:.|..:|..||..|               :.:|        .|:...|..:::: |.:.:
 Worm  1620 ECWRFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPSKRSRLGTHLTDHIFK-LPISM 1683

  Fly  1557 QGLLDP---KIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQF 1618
            :.|.|.   ::|..:..|..|....:...:...||.:.|.|:          .|..::.||.|..
 Worm  1684 EALRDELYCQLVKQLTLNPSIMSEERGWELLWMATGLFAPSA----------ALAKEISHFLKSR 1738

  Fly  1619 QH-FGLDNCY---------------------------AEQIFHQLLY---FICAVALNCLMLRGD 1652
            .| ..|| |.                           ..||||::.:   ...|:.::......|
 Worm  1739 PHPIALD-CQNRMQKLAKGGSRKYPPHLVEVEAIQHKTTQIFHKVFFPDNTDEAIEVDSATRARD 1802

  Fly  1653 ICMWETGMIIRYNIG-------------------------------CIEDWVRS----------- 1675
            .|     ..|.|.:|                               .:.|||.:           
 Worm  1803 FC-----HKIGYRLGLKSSDGFSLFVKIKDKVLAVPESEFFFDYVRSLSDWVHTNHATQKDATMI 1862

  Fly  1676 ------------------------------------------KKMSNDV--LTAL---------- 1686
                                                      |...|||  |.||          
 Worm  1863 PINYQVYFMRKLWYNFVAGADPQADIIFHYHQESQKYLLGYHKTTKNDVIELAALILRSMTKDGK 1927

  Fly  1687 -APLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNA 1750
             |||.|:.|||.....:..                   :|.|...::...|:|.:          
 Worm  1928 NAPLAQIPQLLDEIIPKDS-------------------LKMYSASEWRKTISNAY---------- 1963

  Fly  1751 RQMQKSNSDEFTID--------QKFIQPFKVVFRYSDIKLED 1784
            .:::...||:..|:        ..|...|..|.:|||:.|.|
 Worm  1964 ARIEHLKSDQAKIEFLNYICRWPTFGSAFFPVSQYSDLNLPD 2005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 282/724 (39%)
MYSc_Myo5 84..767 CDD:276831 273/694 (39%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 22/153 (14%)
coiled coil 1049..1068 CDD:293879 3/20 (15%)
coiled coil 1077..1086 CDD:293879 0/8 (0%)
JAKMIP_CC3 <1190..1299 CDD:292653 22/120 (18%)
Myo5_CBD 1424..1792 CDD:271254 89/557 (16%)
hum-6NP_508420.1 MYSc 57..731 CDD:214580 282/724 (39%)
MYSc_Myo7 76..720 CDD:276832 273/694 (39%)
IQ 757..779 CDD:197470 6/21 (29%)
MyTH4 929..1168 CDD:214535 39/260 (15%)
B41 1174..1388 CDD:214604 38/255 (15%)
FERM_B-lobe 1278..1378 CDD:271216 23/141 (16%)
FERM_C1_MyoVII 1382..1480 CDD:270019 16/100 (16%)
SH3 1481..1544 CDD:302595 11/93 (12%)
MyTH4 1624..1772 CDD:214535 27/159 (17%)
B41 1779..1993 CDD:214604 33/247 (13%)
FERM_B-lobe 1890..1985 CDD:271216 21/123 (17%)
FERM_C2_MyoVII 1989..2087 CDD:270020 7/17 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.