Protein Alignment didum and hum-6

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_508420.1
• Gene: hum-6 / 180539
• WormBaseID: WBGene00002039
• Length: 2098
• Species: Caenorhabditis elegans
• Alignment Length: 2252
• Identity: 534/2252 - (23%)
• Similarity: 845/2252 - (37%)
• Gaps: 729/2252 - (32%)

  Fly    14 IWVPHADLVW-ESATLEESYRKGA-------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILV 70
            :.|...|.:| |....|.|...||       |.||:..|.|  .|..|.||..  ..|.:|..:.
 Worm     2 VLVSKGDFIWIEPGKTEGSIPIGARVIDQDHGRLKVIDDLG--NEQWLSADRR--VRLMHPTSVQ 62

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..|:..|...||..:|.||.:|:.|: :||.|.|.||:|:|||.::.:|....||.|:...:|:
 Worm    63 GVEDMCQLGDFHESAILRNLFIRYREK-LIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGE 126

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLAS 200
            |.|||||:|:.|||.:.||..|.|:|:|||||||||.|.|..:::.|.:.|..|  .:|::||.:
 Worm   127 LPPHIFAIADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHS--WIEQQVLEA 189

  Fly   201 SPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            :|::||||||||.||||||||||:..:.| |:.|  .::||.:..|||||||:|.|::.||||||
 Worm   190 NPVLEAFGNAKTIRNDNSSRFGKYIDVHF-NESG--SIEGAKIEQYLLEKSRIVTQSENERNYHI 251

  Fly   266 FYQLCA--ARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIV 328
            ||.|.|  :|.:..||.|.....:.:|..|.....|...||....|...||.||..:.|:|..|.
 Worm   252 FYCLLAGLSREEKSELELGTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIF 316

  Fly   329 KILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESV 393
            |:||.:||:|||:..:..|:..|     |.|:......::| |.||::...:|...:..:.:.:.
 Worm   317 KLLASLLHIGNIRFRQNTNDNME-----SVDVADPSTLVRI-AKLLQLHEQNLLDAITTKSLVTR 375

  Fly   394 NEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSK-QCSFIGVLDIYGFETFEVN 457
            .|.|:...:.:.|..|||||||.||.|||.:||..:|.::...|: :.:.||:|||:|||.||.|
 Worm   376 EERVISRLNGQQAVDARDALAKAIYGKLFIHIVRRVNDAIYKPSQSRRTSIGILDIFGFENFESN 440

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDE 521
            ||||.|||:|||.|||.|..||||:||:||.:|.|.|..|.|.|||..:|||..| |.:|.|:||
 Worm   441 SFEQLCINFANETLQQFFVHHVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDE 505

  Fly   522 ECRMPKGSDESWAGKLIGKCNKFPHFEKPR------FGTTSFFIKHFSDTVEYDVNGFLEKNRDT 580
            |...|||:|::...||.....:...:.:|:      ||.|     ||:..|.|:..||||||||:
 Worm   506 ESIFPKGTDKTMLLKLHSTHGRNELYLQPKSELQRAFGVT-----HFAGNVFYNTRGFLEKNRDS 565

  Fly   581 VSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQ 645
            .|.:|:.::|.|.|....::....|.||                          .:|::|
 Worm   566 FSADLSVLISSSKMPFLARLFDDIEYDT--------------------------SSRKKV----- 599

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
               |||:||:.||..|:|.|..|.|.::||||||:.|.|...:...:::|||..|::||::|..:
 Worm   600 ---TVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNEMKRALVMDRDLVLRQLRYSGMMETIKIRRS 661

  Fly   711 GFPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            |:|.|..|..|..||::||  .:..:::.|:..:.:.|....:.....|:.|.|::|.:......
 Worm   662 GYPIRHDYYPFVFRYRVLVSSIQGPVNRIDLHDAAKKICHMILGTNADYQLGKTKVFLKDKHDLV 726

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            |||....:.|....::|..|||::.|:.|.:.::....||...||:..|:|.::        |:|
 Worm   727 LEQEYYRILKDKAIVIQKNVRRWLVRKDFEKQRQAAVTIQTAWRGFDQRKRYRQ--------IIS 783

  Fly   839 KYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAY-QKRR 902
            .::|    .:..||.|..:|..||..:.:               :|.|...||:|.||.. :||:
 Worm   784 GFSR----LQAVLRSRQLVSHYQTLRKTI---------------IQFQAVCRGSLVRRQVGEKRK 829

  Fly   903 RNIIICQAAIRRFLARRKFKRMKAEAKTIS--------HM------ENKYMGLENKIISMQQ--- 950
            |.            .:.....:.:.|..||        |:      :.|..|.||......:
 Worm   830 RG------------EKAPLTEVSSTASVISDSHEELVGHLFDFLPSDGKDSGNENDSADSSRRGS 882

  Fly   951 ----------------RIDE-LNRDNSNL---KHKTSEISVLKMKLELKKTLE------------ 983
                            |:|. ::.|.|..   |:..:..........:||.|:
 Worm   883 YSRLHTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQAQATATHVKKPLKTALLTHTEPSAQ 947

  Fly   984 --------------AEFKNVK------AACQDKD----KLIEALNKQLEAERDEKMQLLEENGHA 1024
                          .:..:||      :...||.    ||...|.|:..|...|:..|..|.|.|
 Worm   948 LAALTAWTTILRFMGDLADVKPGSTNGSEVYDKTPVMIKLYATLGKKFSAHDLEEAMLSSEYGGA 1012

  Fly  1025 QEEWISQKQTWRQENEELRRQID-EIIDMA--KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKD 1086
                           :.|::.:. ::|.|.  :..::|..:     .:.|.:..:..::...:::
 Worm  1013 ---------------KTLKKGMGRKLISMTLKRKGKINGSD-----TSSISSDSVYSSFNAMLEN 1057

  Fly  1087 KEVIENENF-------MLKEEL----------------SRLTA-----------GSFSLHAR--- 1114
            |.:...:..       :|:|:|                |:|:|           |.|:...|
 Worm  1058 KPMTSLDKLHYIIGLGILREDLRDEIYCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPSERFIK 1122

  Fly  1115 -----------KASNASSQNEDDVGYASAKNTLDINRPPDL--LSKNYSYN-------------- 1152
                       ..:..|...||.:.......|.  ::||..  |..|.|..
 Worm  1123 YLFCFIRERGPAGTGYSKYIEDRLRRTQVNGTR--HQPPSYVELQANKSQKPVVLAVTFMDGSVK 1185

  Fly  1153 ----DSTSLVVKLRSILEE---------------------------EKQKHKVLQ-EQYIKLSSR 1185
                ||.:...:|...|.|                           :.....:.| |||.|...|
 Worm  1186 TLCADSATTAAELCKQLAEKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKEQGR 1250

  Fly  1186 -------------------HKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAA 1231
                               |.|.:|....:.:          |.|:...||:|
 Worm  1251 QERNAPWRLFFRKEIFSPWHDPRDDPVSTNLI----------YQQVIRGIKYG------------ 1293

  Fly  1232 LQEEVRRRREECIQLKAVLLQQ------SQSMRSLE---PESL---QMRGNDVNELMEAFHSQKL 1284
               |.|..::|  :|.|:..||      :..:..||   |..|   :|.|.::
 Worm  1294 ---EYRCDKDE--ELAAICAQQYYIDEGTMDVNKLENNLPSYLPDFEMSGKEM------------ 1341

  Fly  1285 INRQLESELKAITEEHNSKL-------VEMTQEIERLNNEK------------------------ 1318
               .||...:.|..::..|.       :|:.:.:..:...|
 Worm  1342 ---ALEKWTQTIMHQYRKKFTGRLPSQIEVKENVVSVAKTKWPLLFSRFYEALKFAGPPLPKNEV 1403

  Fly  1319 ------------DELQKVMFE-SIDEF--------EDSNVDTLR----QNDRYLRR-----ELQK 1353
                        |:.:.||.| |..|.        :.|..||..    ..|.|..:     ::..
 Worm  1404 IIAVNWTGVYVVDDREHVMLEFSFPEISTAYYGKGKRSTTDTCTVRTVVGDEYTFQSPNADDITN 1468

  Fly  1354 AVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLM 1418
            .:..||   |.||..:..|.|                               :..||.......:
 Worm  1469 LIVMFL---EGLKKRSRYLVA-------------------------------IKSQKGDEKNNFL 1499

  Fly  1419 KFHSSDL----------DKILQRLLSALTPRT-VVGLLPGFPAYLIFMCIRYT------------ 1460
            :|...||          ..:.:.::.....|| :.||:.....|::...::.:
 Worm  1500 EFEKGDLLILVNEFTGNTLLTESVVKGENSRTCLFGLIRAENVYVLPTLVKPSKNTLQIFPKDMD 1564

  Fly  1461 ---DLTNADDDVRELLSKFVIQIKKMHRTPHPIEN--------RVIWLVNSITLLNLMKQYGDVD 1514
               ||.|.:..|         .:...:..|:.:||        :|..:.:.|:|:.|.|:...:
 Worm  1565 LSLDLFNNNKQV---------TVVDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQI- 1619

  Fly  1515 EYVKFNTEKQNQQQLKNFN---------------LFEY--------RRVILDLIVNLYQALIMQI 1556
            |..:|:.|..:|..||..|               :.:|        .|:...|..:::: |.:.:
 Worm  1620 ECWRFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPSKRSRLGTHLTDHIFK-LPISM 1683

  Fly  1557 QGLLDP---KIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQF 1618
            :.|.|.   ::|..:..|..|....:...:...||.:.|.|:          .|..::.||.|..
 Worm  1684 EALRDELYCQLVKQLTLNPSIMSEERGWELLWMATGLFAPSA----------ALAKEISHFLKSR 1738

  Fly  1619 QH-FGLDNCY---------------------------AEQIFHQLLY---FICAVALNCLMLRGD 1652
            .| ..|| |.                           ..||||::.:   ...|:.::......|
 Worm  1739 PHPIALD-CQNRMQKLAKGGSRKYPPHLVEVEAIQHKTTQIFHKVFFPDNTDEAIEVDSATRARD 1802

  Fly  1653 ICMWETGMIIRYNIG-------------------------------CIEDWVRS----------- 1675
            .|     ..|.|.:|                               .:.|||.:
 Worm  1803 FC-----HKIGYRLGLKSSDGFSLFVKIKDKVLAVPESEFFFDYVRSLSDWVHTNHATQKDATMI 1862

  Fly  1676 ------------------------------------------KKMSNDV--LTAL---------- 1686
                                                      |...|||  |.||
 Worm  1863 PINYQVYFMRKLWYNFVAGADPQADIIFHYHQESQKYLLGYHKTTKNDVIELAALILRSMTKDGK 1927

  Fly  1687 -APLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNA 1750
             |||.|:.|||.....:..                   :|.|...::...|:|.:
 Worm  1928 NAPLAQIPQLLDEIIPKDS-------------------LKMYSASEWRKTISNAY---------- 1963

  Fly  1751 RQMQKSNSDEFTID--------QKFIQPFKVVFRYSDIKLED 1784
            .:::...||:..|:        ..|...|..|.:|||:.|.|
 Worm  1964 ARIEHLKSDQAKIEFLNYICRWPTFGSAFFPVSQYSDLNLPD 2005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	273/694 (39%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	100/672 (15%)
		Myo5_CBD	1424..1792	CDD:271254	89/557 (16%)
hum-6	NP_508420.1	MYSc_Myo7	76..720	CDD:276832	273/694 (39%)
		CBD_MYO6-like	738..>808	CDD:409646	21/81 (26%)
		IQ	757..779	CDD:197470	6/21 (29%)
		MyTH4	929..1168	CDD:214535	39/260 (15%)
		FERM1_F1_Myosin-VII	1172..1270	CDD:340612	11/97 (11%)
		B41	1174..1388	CDD:214604	38/255 (15%)
		FERM_C1_MyoVII	1382..1480	CDD:270019	16/100 (16%)
		SH3	1481..1544	CDD:473055	11/93 (12%)
		MyTH4	1624..1772	CDD:214535	27/159 (17%)
		FERM2_F1_Myosin-VII	1777..1875	CDD:340613	13/102 (13%)
		B41	1779..1993	CDD:214604	33/247 (13%)
		FERM_C2_MyoVII	1989..2087	CDD:270020	7/17 (41%)