DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myo-3

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_506065.2 Gene:myo-3 / 179676 WormBaseID:WBGene00003515 Length:1969 Species:Caenorhabditis elegans


Alignment Length:1966 Identity:513/1966 - (26%)
Similarity:889/1966 - (45%) Gaps:384/1966 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 WVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLS 79
            |:|..:..:.:|.::.:..:.   :.:.|..|....||     .|.....||.......|:..|:
 Worm    39 WIPDPEDGFVAAEIQSTTGEQ---VTVVTVKGNQITVK-----KDQCQEMNPPKFDKTEDMANLT 95

  Fly    80 YLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALA 144
            :|:|..||.||:.|: :..:||||.|:..|.||||..:|:|..|:|:.:.|....::.||:||::
 Worm    96 FLNEASVLGNLKDRY-KDLMIYTYSGLFCVVINPYKRLPIYSESVIKHFMGKRRNEMPPHLFAVS 159

  Fly   145 EEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESET-----------QVERKVL 198
            :|||..:.::..|.|::::||||||||.:.|..:.|||.||.:::.:           .:|.:::
 Worm   160 DEAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAASGKEAKDGKKGGTLEEQIV 224

  Fly   199 ASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNY 263
            .::|::||||||||.||:||||||||.:..|   .|...|.|..:..|||||||||.||.|||.|
 Worm   225 QTNPVLEAFGNAKTVRNNNSSRFGKFIRTHF---SGSGKLAGGDIEHYLLEKSRVVRQAPGERCY 286

  Fly   264 HIFYQLCAAR--SKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIAD 326
            |||||:.:..  |...:|.|.:...:..........||.:.|.|:...|.:|..::||...:..|
 Worm   287 HIFYQIMSGNDPSLRGKLKLSNDITYYHFCSQAELTIEGMDDKEEMRLTQEAFDIMGFEDNETMD 351

  Fly   327 IVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIE 391
            :.:..|||:|:|.::..::..|...|.|.:. |..:       .|.:|.:.|::..:.|...::.
 Worm   352 LYRSTAGIMHMGEMKFKQRPREEQAEPDGEE-DALN-------AAAMLGIQAEEFLKALTKPRVR 408

  Fly   392 SVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCS---FIGVLDIYGFET 453
            ...|:|....::|....|...|||.|||::|::|:...||:|:  :|:..   |||||||.|||.
 Worm   409 VGTEWVNKGQNLEQVNWAVSGLAKAIYARMFKWIITRCNKTLD--AKEIERKHFIGVLDIAGFEI 471

  Fly   454 FEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLD 517
            |::|||||..||:.||:|||.||.|:|.||||||.:|||.||.||| .|.|.||:|||..||::.
 Worm   472 FDLNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKREGIAWTFIDFGLDLQACIELIEKPLGIIS 536

  Fly   518 LLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKP-----RFGTTSFFIKHFSDTVEYDVNGFLEK 576
            :|||||.:||.:|.::|.||:.: ..|.|:|:||     :.|...|.|.|::.||.|:...||||
 Worm   537 ILDEECIVPKATDMTYAQKLLDQHLGKHPNFQKPKPPKGKQGDAHFAIVHYAGTVRYNATNFLEK 601

  Fly   577 NRDTVSKELTQVLSESN-----MSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDT 636
            |:|.::.....:|..|.     :.:.:...|.||    ..::||:....|      |::.:.:..
 Worm   602 NKDPLNDTAVALLKHSTDNSLMLDIWQDYQTQEE----AAEAAKAGQTAG------GKRGKSSSF 656

  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701
                       .||...::|||.:|::.|:.|.||::|||.||:.|.:...::|.::.||...||
 Worm   657 -----------ATVSMIYRESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALVLNQLTCNGV 710

  Fly   702 LETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQD----EDKYRFGNT 762
            ||.:||...|||:|.|||||..||.:|. .....::|.|.:...|:.|...|    :::::.|.|
 Worm   711 LEGIRICRKGFPNRMLYPDFKHRYAILA-ADAAKESDPKKASVGILDKISVDGNLTDEEFKVGET 774

  Fly   763 QIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQK 827
            :|||:||.:|.||.:|..:..:.:|:.||.:                       |.|||:...::
 Worm   775 KIFFKAGVLAKLEDLRDEILSRIVTMFQSRI-----------------------RSYLAKAEVRR 816

  Fly   828 MREARAG-LILSKYARGWLCRR--RYLRLRHSI-----SGIQTYARGMLARNKFHAMRDHYRAVQ 884
            ..|.:.| |::.:..|.|...|  .:.:|...:     :|.:..|.|.|             ||:
 Worm   817 RYEQQTGLLVVQRNVRAWCTLRTWEWFKLFGKVKPMLKAGKEQEAMGEL-------------AVK 868

  Fly   885 IQRF----VRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISH--------MENK 937
            ||:.    .||.:||...:.:..:::..:.|:  ||:....|...|:|:..:.        :|:|
 Worm   869 IQKLEEAVQRGEIARSQLESQVADLVEEKNAL--FLSLETEKANLADAEERNEKLNQLKATLESK 931

  Fly   938 YMGLENKIISMQQRIDELNRDNSNLKHKT-SEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIE 1001
            ...:..::..||:|    |.|.:..|.|| .|:|..|..::   .||...:..:...|.:|..|.
 Worm   932 LSDITGQLEDMQER----NEDLARQKKKTDQELSDTKKHVQ---DLELSLRKAEQEKQSRDHNIR 989

  Fly  1002 ALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDR 1066
            :|..:: |.:||.:..|.:....|||      :.|:.||:|:.:.|::..:.|     .||:.::
 Worm   990 SLQDEM-ANQDEAVAKLNKEKKHQEE------SNRKLNEDLQSEEDKVNHLEK-----IRNKLEQ 1042

  Fly  1067 MLAEIDNRELNEAYQRA--IKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGY 1129
            .:.|::.....|...|.  .|.|..:|.:..:.:|.:..:|.     ..........:.|:|:.:
 Worm  1043 QMDELEENIDREKRSRGDIEKAKRKVEGDLKVAQENIDEITK-----QKHDVETTLKRKEEDLHH 1102

  Fly  1130 ASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQY-IKLSSRHKPTEDSF 1193
            .:||           |::|      .|::.||:.:::|...::..|:|:. .:.:||.|  .|..
 Worm  1103 TNAK-----------LAEN------NSIIAKLQRLIKELTARNAELEEELEAERNSRQK--SDRS 1148

  Fly  1194 RVSELEVENEKLRSEYD--------QLRTSIKHGVEINELNAQ-------HAALQEEVRRRREEC 1243
            | ||.|.|.|:|....:        ||..:.|...||.:|..:       |......:|:|..:.
 Worm  1149 R-SEAERELEELTERLEQQGGATAAQLEANKKREAEIAKLRREKEEDSLNHETAISSLRKRHGDS 1212

  Fly  1244 IQLKAVLLQQSQSMRSLEPES------LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHN- 1301
            :   |.|.:|.::::.|:.:|      ||   .|:.|...|..|:....:.||..||.|..::: 
 Worm  1213 V---AELTEQLETLQKLKAKSEAEKSKLQ---RDLEESQHATDSEVRSRQDLEKALKTIEVQYSE 1271

  Fly  1302 --SKLVEMTQEIE-------RLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQ 1357
              :|..|.:::::       |||||..:|.:    |::|. |:.:::|.:....|:.:|.:....
 Worm  1272 LQTKADEQSRQLQDFAALKNRLNNENSDLNR----SLEEM-DNQLNSLHRLKSTLQSQLDETRRN 1331

  Fly  1358 FLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHS 1422
            :.....|.:...|..|....:...|...::||.      .:.||:...::|..::..|...:|.|
 Worm  1332 YDEESRERQALAATAKNLEHENTILREHLDEEA------ESKADLTRQISKLNAEIQQWKARFDS 1390

  Fly  1423 SDLDKI---------LQRLLSALTPRTVVGLLPGFPAYLIFMCIRY---TDLTNADDDVRELLSK 1475
            ..|:|:         ||..:..||. |..||   |........:|:   .||.:|..||.:..::
 Worm  1391 EGLNKLEEIEAAKKALQLKVQELTD-TNEGL---FAKIASQEKVRFKLMQDLDDAQSDVEKAAAQ 1451

  Fly  1476 FVIQIKKMHRTPHPI-------------------ENRVIWLVNSITLLNLMKQYGDVDEYVKFNT 1521
            .....|...:....|                   :||.:    |..|........::.||:. :|
 Worm  1452 VAFYEKHRRQFESIIAEWKKKTDDLSSELDAAQRDNRQL----STDLFKAKTANDELAEYLD-ST 1511

  Fly  1522 EKQNQ---QQLKNF---------NLFEYRRVILDLIV---NLYQAL------------------- 1552
            .::|:   |::|:.         ::.|.::::..|.|   .|.:||                   
 Worm  1512 RRENKSLAQEVKDLTDQLGEGGRSVAELQKIVRKLEVEKEELQKALDEAEAALEAEEAKVLRAQI 1576

  Fly  1553 -IMQIQGLLDPKIVPAILNNDEIQRGRQAH--GMRSRATSIGASSSPEHGGGPAWKQLIGQLEHF 1614
             :.||:..::.:|..   ..:|.:..|:.|  .:.|...::.|.:..:.......|:|...:...
 Worm  1577 EVSQIRSEIEKRIQE---KEEEFENTRRNHQRALESMQATLEAETKQKEEALRIKKKLESDINDL 1638

  Fly  1615 YKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMS 1679
            .....|.......|::...:.:                    ||...:::.   ||:..|.|...
 Worm  1639 EIALDHANRAYADAQKTIKKYM--------------------ETVQELQFQ---IEEEQRQKDEI 1680

  Fly  1680 NDVLTALAPLNQVSQLLQSRKSE------------QDVQTIC--------DLCTSLS--TAQVLK 1722
            .:...|....|.:   |||.|.|            ::.:..|        ||...:|  |.|..|
 Worm  1681 REQFLASEKRNAI---LQSEKDELAQQAEAAERARRNAEAECIELREQNNDLNAHVSALTGQRRK 1742

  Fly  1723 VMKSYKLDDYESEI--TNVFLEKLTEKL-NA-RQMQKSNSDEFTIDQKFIQP------------- 1770
            :         |.|:  .:..||::..:| || .|.||:::|...:.::..|.             
 Worm  1743 L---------EGELLAAHAELEEIANELKNAVEQGQKASADAARLAEELRQEQEHSMHIERIRKG 1798

  Fly  1771 FKVVFRYSDIKLEDIE 1786
            .::..:...|:|:|.|
 Worm  1799 LELQIKEMQIRLDDAE 1814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 274/744 (37%)
MYSc_Myo5 84..767 CDD:276831 262/714 (37%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 25/116 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/10 (20%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/129 (26%)
Myo5_CBD 1424..1792 CDD:271254 82/470 (17%)
myo-3NP_506065.2 Myosin_N 36..73 CDD:280832 5/36 (14%)
Myosin_head 88..779 CDD:278492 266/726 (37%)
MYSc_class_II 100..779 CDD:276951 262/714 (37%)
Myosin_tail_1 857..1937 CDD:279860 215/1081 (20%)
DUF4795 932..1090 CDD:292662 40/181 (22%)
SPEC 1186..1391 CDD:295325 45/221 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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