Protein Alignment didum and Myo7b

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_115770.2
• Gene: Myo7b / 17922
• MGIID: 107709
• Length: 2113
• Species: Mus musculus
• Alignment Length: 1697
• Identity: 478/1697 - (28%)
• Similarity: 735/1697 - (43%)
• Gaps: 369/1697 - (21%)

  Fly    46 GKLKEVKLK-------------ADGSDLPPLR--NPAILVGQNDLTTLSYLHEPGVLHNLRVRFC 95
            |.:||.||.             ....||..||  :|....|.:|:..|..|:|.||:|||.:|:
Mouse    26 GIVKETKLGKTLIEDDEGKEHWVHAEDLSTLRPMHPNSAQGVDDMIRLGDLNEAGVVHNLLIRY- 89

  Fly    96 ERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSI 160
            ::..||||.|.||||:||:..:|||....::.|....||:|.|||||:|...|..:::...:...
Mouse    90 QQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCC 154

  Fly   161 IVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFT 225
            |:|||||||||.:.|..:::.|.|.|..|  .:|::||.::||:||||||||.||||||||||:.
Mouse   155 IISGESGAGKTETTKLILQFLATVSGQHS--WIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYI 217

  Fly   226 KLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE----LVLDHQDK 286
            .:.| |..||  ::||::..:|||||||..||..||||||||  |......||    |.|....:
Mouse   218 DIHF-NSSGV--IEGASIEHFLLEKSRVCRQAPEERNYHIFY--CMLMGMSPEEKQMLSLGMPSE 277

  Fly   287 FQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQ-VSKKFNEGS 350
            :.:|.||.....|.:|||:.:.....||.:|.||..:..||.|:||.||||||:. ::..|
Mouse   278 YHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFMAAVF---- 338

  Fly   351 EEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAK 415
              |:.||.|:..... ..:...||.|....||..|:...|..:.|:|..|.:|..|...|||..|
Mouse   339 --ENLDSSDVMETPA-FPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQATDRRDAFVK 400

  Fly   416 HIYAKLFQYIVGVLNKSLNNGSKQ-----CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQF 475
            .||.:|||:||..:|.::.....|     ...||:|||:|||.|:.|||||.|||:|||.|||.|
Mouse   401 GIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCINFANEHLQQFF 465

  Fly   476 NQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDEECRMPKGSDESWAGKL-- 537
            .:|||.:||||||.|.|||..|.:.||||.:|::..: :.::.|||||.|.|:|:|.:...||
Mouse   466 VKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGTDVTMLQKLNS 530

  Fly   538 IGKCNKFPHFEKPR-FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVM 601
            |...||  .|..|| ...|.|.|.||:..|.|...||||||||.:|.::..::..|.....|::.
Mouse   531 IHANNK--SFLSPRSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSKNKFLKEIF 593

  Fly   602 TLEEIDTLCVDSAKSSTLGGRVV-ISAGRKQ-QGNDTRRRVVPSKQHRKTVGSQFQESLASLIST 664
            .        |||:::....|.:. :.||.:. :.:|:.:|.|       |:.|||::||..|:..
Mouse   594 N--------VDSSQTKLGHGTICQVKAGSQLFKSSDSIKRPV-------TLASQFKQSLDQLMRI 643

  Fly   665 LHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLV 729
            |....|::|||||||:.|....::....|||||..|::|||.|..:|||.|:.:.:|..|:::|:
Mouse   644 LTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLL 708

  Fly   730 -------YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYIT 787
                   :::|  ...|.|...::.:.  .|:| ::.|.|:||.:..|...||..|:........
Mouse   709 PSPERMQFQNK--PRQMTLHIADLCLG--TDKD-WKVGKTKIFLKDHQDTVLEIRRSQALDGAAI 768

  Fly   788 IVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLR 852
            .:|.|:|...||::|||.::....:|...|||..|:..:        |||..:.|
Mouse   769 RIQRVLRGHKYRKEFLRQRRAAVTLQAGWRGYSQRKNFK--------LILVGFER---------- 815

  Fly   853 LRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLA 917
                   :|..||..|...:|.|||.  |.||:|...||.|.|:..|.:||.::|.||..|..:.
Mouse   816 -------LQAIARSHLLMRQFQAMRQ--RIVQLQARCRGYLVRQQVQAKRRAVVIIQAHARGMVV 871

  Fly   918 RRKFKRMKA-----------EAKTISH---------------MENKYMGLENKIISMQQ-----R 951
            |:.:.:.|:           :|:...|               |..|..|....:|..|:     |
Mouse   872 RKSYWQQKSTGPQVILAKEPKAQVAVHERKRKSIYDTVTDTAMVEKVFGFLPAMIGGQEGPAPTR 936

  Fly   952 IDELNRDNSNLKHKTSEISVLKMKL---ELKKTLEAEFKNVKAACQDKDKLIEALNKQL------ 1007
            .::|......| |:....:|..|.:   |:....|..|.........|......:.|.|
Mouse   937 FEDLEVKTQKL-HEVDLDTVPMMAMPEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLY 1000

  Fly  1008 -EAERDEKMQL------LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQED 1065
             |.:.|....|      |...|...|..:..:.:  .....:.|||.:  .:.|:: |.|.|:..
Mouse  1001 HENDTDHSAALDVWIIILRFMGDLPEPVVYGRNS--LTGSSVMRQIHD--KLGKDS-VTQHNRSS 1060

  Fly  1066 RMLAEIDNRELNEAYQRAIKDKEV--IENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVG 1128
            ::.::::..|....:...|.|:.:  :|..:|:                              ||
Mouse  1061 QVASQLNFGEEAFKFDGPISDRPMSNLEKVHFI------------------------------VG 1095

  Fly  1129 YASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHK------ 1187
            ||..:        |.|..:.|.                   |..|.|.|.| |.|||.:
Mouse  1096 YAIMR--------PGLRDEIYC-------------------QICKQLSENY-KTSSRARGWILLS 1132

  Fly  1188 ------PTEDSFRVSELEVENEKLRSEY-----DQLRTSIKHGVEIN-----ELNA----QHAAL 1232
                  |..:.|....|...::...| |     ::|:.:..:||...     ||.|    :|..:
Mouse  1133 LCLGCFPPSERFMKYLLNFISQGPPS-YGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPI 1196

  Fly  1233 Q-------------EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMR--------GNDVNELM 1276
            |             :.....||.|..     :.|.|.:|.....|||:.        |:..:.||
Mouse  1197 QVILATGRSLTISVDSASTSREICQH-----VAQKQGLRDNLGFSLQVAVYDKFWSLGSGCDHLM 1256

  Fly  1277 EAF-HSQKLINRQLESELKA----------ITEEHNSKLVEMTQEI-----------ERLNNEKD 1319
            :|. ..::|...:.||:.:|          .|..|:|:...::.|:           ...|.||:
Mouse  1257 DAVAQCEQLARERGESQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYNFEKE 1321

  Fly  1320 ELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEH 1384
            |                             ||.:.:|:...||..   |..|..|.::   .|..
Mouse  1322 E-----------------------------ELVELLARHCYVQLG---ATVKSNAVQE---LLPS 1351

  Fly  1385 KIEEEMIRNKSNG------TSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSA--LTPRTV 1441
            .:..::.|.||..      |:|...|..|:.|: .|..:.: .:.:..::|..||.:  ....|:
Mouse  1352 CVPSKLYRTKSPEKWASLVTAAHAKAQYTQSKA-TPLAVRE-QTVEAARLLWPLLFSRLFEVTTL 1414

  Fly  1442 VGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNL 1506
            .|  |..|...:.:.|.:..:...|...|.||.....::..:      :.||.......:.|..|
Mouse  1415 SG--PRLPKTQLVLAINWKGMYFLDQKERTLLGLSFAEVMGL------VANRDAPGGKKLLLATL 1471

  Fly  1507 MKQY------------------GDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALI 1553
            .::|                  |.:.|...|....|:::...:..|..:::.  ||::      :
Mouse  1472 QEEYEFVSPSSVAIAEMVALFLGGLKERSVFAMALQDRRATDDITLLPFKKG--DLLI------L 1528

  Fly  1554 MQIQGLL 1560
            .:.||||
Mouse  1529 TKKQGLL 1535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	280/705 (40%)
		IQ	900..922	CDD:197470	7/21 (33%)
		SMC_prok_B	<942..1365	CDD:274008	91/514 (18%)
		Myo5_CBD	1424..1792	CDD:271254	28/157 (18%)
Myo7b	NP_115770.2	MYSc_Myo7	79..748	CDD:276832	280/705 (40%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	637..659		10/21 (48%)
		IQ	785..807	CDD:197470	6/21 (29%)
		Mediates interaction with ANKS4B. /evidence=ECO:0000269|PubMed:26812017	962..1578		124/696 (18%)
		MyTH4	989..1189	CDD:214535	47/263 (18%)
		FERM1_F1_Myosin-VII	1193..1291	CDD:340612	20/102 (20%)
		B41	1196..1409	CDD:214604	47/254 (19%)
		FERM_C1_MyoVII	1403..1499	CDD:270019	17/103 (17%)
		Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250|UniProtKB:Q6PIF6	1497..2113		10/47 (21%)
		SH3	1500..1560	CDD:473055	9/44 (20%)
		MyTH4	1641..1788	CDD:214535
		FERM2_F1_Myosin-VII	1795..1892	CDD:340613
		B41	1797..2009	CDD:214604
		FERM_C2_MyoVII	2005..2100	CDD:270020