Protein Alignment didum and Myo7a

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_011239990.1
• Gene: Myo7a / 17921
• MGIID: 104510
• Length: 2250
• Species: Mus musculus
• Alignment Length: 1683
• Identity: 467/1683 - (27%)
• Similarity: 725/1683 - (43%)
• Gaps: 384/1683 - (22%)

  Fly    20 DLVWESATLEESYRKGAG-FLKICTDSGKLKEVKLKADGSD------------LPPLRNPAILVG 71
            |.||......:.:....| .:|:| |||:::.|    |..|            :.|: :|..:.|
Mouse    37 DYVWMDLKSGQEFDVPIGAVVKLC-DSGQIQVV----DDEDNEHWISPQNATHIKPM-HPTSVHG 95

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYC------GIILVAINPYAEMPLYGPSIIRAYRG 130
            ..|:..|..|:|.|:|.||.:|:.: .:|||.|      |.||||:|||..:.:|.|..||.|..
Mouse    96 VEDMIRLGDLNEAGILRNLLIRYRD-HLIYTSCGGRTYTGSILVAVNPYQLLSIYSPEHIRQYTN 159

  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER 195
            ..:|::.|||||:|:..|..::|.|.:...|:|||||||||.|.|..:::.||:.|..|  .:|:
Mouse   160 KKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHS--WIEQ 222

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260
            :||.::||:||||||||.||||||||||:..:.| |:.|.  ::||.:..||||||||..||..|
Mouse   223 QVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHF-NKRGA--IEGAKIEQYLLEKSRVCRQAPDE 284

  Fly   261 RNYHIFYQLCAARSKYPE----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSI 321
            ||||:||  |.......|    |.|.....:.:|.||.....|...|::::.....||.||.|:.
Mouse   285 RNYHVFY--CMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTD 347

  Fly   322 QQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386
            .:..:|.|:||.|||:||:|.     |....|:.|:|::..:. .|...|.||.|:..||...|.
Mouse   348 TENWEISKLLAAILHMGNLQY-----EARTFENLDACEVLFSP-SLATAASLLEVNPPDLMSCLT 406

  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL--------NNGSKQCSFI 443
            .|.:.:..|.|..|.|.|.|...|||..|.||.:||.:||..:|.::        .|..:.   |
Mouse   407 SRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPPLEVKNSRRS---I 468

  Fly   444 GVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDL 508
            |:|||:|||.|.||||||.|||:|||.|||.|.:||||||||||..|.|.|..|:|.|||..:|:
Mouse   469 GLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDM 533

  Fly   509 IESR-LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG-TTSFFIKHFSDTVEYDVN 571
            |.:| :.|:.|:|||.:.|||:|.:...||..:.....::..|:.. .|.|.|.||:..|.|:..
Mouse   534 IANRPMNVISLIDEESKFPKGTDATMLHKLNSQHKLNANYVPPKNSHETQFGINHFAGVVYYESQ 598

  Fly   572 GFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDT 636
            |||||||||:..::.|::..|.....||:..        .|.|                 .|.:|
Mouse   599 GFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ--------ADVA-----------------MGAET 638

  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701
            |:|       ..|:.|||:.||..|:.||.|..|.:|||||||:.|....::....::|||..|:
Mouse   639 RKR-------SPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGM 696

  Fly   702 LETVRISAAGFPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQI 764
            :||:||..||:|.|:.:.:|..||::|:  .:....:.|::.:|:.:....:...|.::.|.|:|
Mouse   697 METIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKI 761

  Fly   765 FFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMR 829
            |.:......||..|.......:.::|.|:|.|..|..|||::.....||:|.||:
Mouse   762 FLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGH---------- 816

  Fly   830 EARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALA 894
                           .||:.|..:|.....:|...|......::...|.  |.::.|...|..|.
Mouse   817 ---------------HCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQ--RIIEFQARCRAYLV 864

  Fly   895 RRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDN 959
            |:|::.|...:|..||..|..:|||..:|::.|.:.....|...:..|.|
Mouse   865 RKAFRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEK--------------- 914

  Fly   960 SNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHA 1024
                        |:.::..||..|                        ||||..:.:|.:.....
Mouse   915 ------------LRKEMSAKKAKE------------------------EAERKHQERLAQLARED 943

  Fly  1025 QEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNR--------------E 1075
            .|..:.:|:..|::.|.|     |.::.|::..:|..:..|:|...:...              |
Mouse   944 AERELKEKEEARRKKELL-----EQMEKARHEPINHSDMVDKMFGFLGTSGSLPGQEGQAPSGFE 1003

  Fly  1076 LNEAYQRAIKDKEV-----IENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNT 1135
            ..|..:|.:.:::|     :.:|:   :|:||......|:                ..|.....|
Mouse  1004 DLERGRREMVEEDVDAALPLPDED---EEDLSEYKFAKFA----------------ATYFQGTTT 1049

  Fly  1136 LDINRPPDLLSKNYSYNDS-----TSLVV--------------KLRSILEEEKQKHKVLQEQYIK 1181
            ....|.|  |.:...|:|.     .:|.|              |..:.:.:..:|..|:.:.|..
Mouse  1050 HSYTRRP--LKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYET 1112

  Fly  1182 LSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRR---REEC 1243
            |..:....|    :..|:.|.|....| .|.:||::|.: ::....:.:.|.|||.:|   .|..
Mouse  1113 LGKKTYKRE----LQALQGEGETQLPE-GQKKTSVRHKL-VHLTLKKKSKLTEEVTKRLNDGEST 1171

  Fly  1244 IQLKAVLLQQSQSMRSLEPESLQ-MRGNDV--NELMEAFHSQKLINRQLESELKAITEEHN-SK- 1303
            :|..::|..:..|    ..|.|. :.||.:  ..|.:..:.|  |::||         .|| ||
Mouse  1172 VQGNSMLEDRPTS----NLEKLHFIIGNGILRPALRDEIYCQ--ISKQL---------THNPSKS 1221

  Fly  1304 -------LVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLV 1361
                   ||.:...              .|...::|.           :|||..:.
Mouse  1222 SYARGWILVSLCVG--------------CFAPSEKFV-----------KYLRNFIH--------- 1252

  Fly  1362 QEELKLANAKLKAYRQDGGQLEHK--IEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSD 1424
                             ||...:.  .||.:.|...|||.....:.:..|.:::.:.:| ...:.
Mouse  1253 -----------------GGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIM-LPVTF 1299

  Fly  1425 LDKILQRLL--SALTPRTVVGLLP---------GFPAYLIFMCIRYTDLTNADDDVRELLSK--- 1475
            :|...:.||  ||.|.|.:...|.         ||..| |.:..:.:.|.:..|.|.:.:|:
Mouse  1300 MDGTTKTLLTDSATTARELCNALADKISLKDRFGFSLY-IALFDKVSSLGSGSDHVMDAISQCEQ 1363

  Fly  1476 -------------FVIQIKKMHRTP--HPIENRVIWLVNSITLLNLMKQYGDVDEYVKFN----- 1520
                         :.:..:|...||  :|.|:.|        ..||:  |..|...|||.
Mouse  1364 YAKEQGAQERNAPWRLFFRKEVFTPWHNPSEDNV--------ATNLI--YQQVVRGVKFGEYRCE 1418

  Fly  1521 -----TEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDE 1573
                 .|..:||...::.    ..:||:.:::|....|.      |.:|.|  |.|.|
Mouse  1419 KEDDLAELASQQYFVDYG----SEMILERLLSLVPTYIP------DREITP--LKNLE 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	274/704 (39%)
		IQ	900..922	CDD:197470	8/21 (38%)
		SMC_prok_B	<942..1365	CDD:274008	82/475 (17%)
		Myo5_CBD	1424..1792	CDD:271254	42/189 (22%)
Myo7a	XP_011239990.1	MYSc_Myo7	108..764	CDD:276832	274/704 (39%)
		IQ	801..822	CDD:197470	8/45 (18%)
		PTZ00121	<838..>1010	CDD:173412	41/229 (18%)
		MAP7	<892..>970	CDD:461709	21/133 (16%)
		MyTH4	1052..1288	CDD:214535	59/309 (19%)
		FERM1_F1_Myosin-VII	1292..1390	CDD:340612	20/99 (20%)
		B41	1294..1509	CDD:214604	43/195 (22%)
		FERM_C1_MyoVII	1503..1639	CDD:270019
		SH3_MYO7A	1640..1704	CDD:212814
		MyTH4	1782..1931	CDD:214535
		FERM2_F1_Myosin-VII	1936..2033	CDD:340613
		B41	1938..2150	CDD:214604
		FERM_C2_MyoVII	2146..2241	CDD:270020