Protein Alignment didum and myo-5

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_505094.1
• Gene: myo-5 / 179190
• WormBaseID: WBGene00019064
• Length: 1974
• Species: Caenorhabditis elegans
• Alignment Length: 1995
• Identity: 504/1995 - (25%)
• Similarity: 873/1995 - (43%)
• Gaps: 401/1995 - (20%)

  Fly     2 SSEEMLYAQGAK------IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.|::|.|...|      :||...:..:.:|.::.|  || ..:.:.|..|..|.:| |.|...:
 Worm    15 SPEQLLAATTKKFDSKKNVWVADPEEGFIAAEIKSS--KG-DTVVVVTSKGVEKTIK-KDDAQQM 75

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
                ||.......|:..|::|::..||||||.|:.. .:||||.|:..|.||||..:|:|..|:.
 Worm    76 ----NPPKYEKTEDMANLTFLNDASVLHNLRQRYYS-MMIYTYSGLFCVVINPYKRLPIYSESVC 135

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE-- 188
            :.|.|....::.||:||:::|||..:..:..|.|::::||||||||.:.|..:.|||.||.|:
 Worm   136 QMYLGKRRNEMPPHLFAVSDEAYRNMTNDRENQSMLITGESGAGKTENTKKVISYFAMVGASQQS 200

  Fly   189 ---------SETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
                     ::..:|.:::.::|::||||||||.||:||||||||.::.| |..|.  :.||.:.
 Worm   201 NKKKSKKDKAQVSLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHF-NTGGK--VAGADIE 262

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLC--AARSKYPELVLDHQDK-FQFLNMGGAPEIERVSDAEQ 306
            .||||||||:.||.|||:||||||:.  |.:....:|.|....| :.|::.... .|:.|.|.|:
 Worm   263 HYLLEKSRVIKQAPGERSYHIFYQIYSDAVKGLREKLFLTRPIKEYTFVSQAEV-TIDGVDDKEE 326

  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITA 371
            ...|.:|..::.|:..:.:::..|.|||:|:|.:    ||.:...||.::    .......::..
 Worm   327 MLITDEAFDIMKFTATEKSELFAITAGIMHMGEL----KFKQRPREEQAE----LEEGKEGELAC 383

  Fly   372 DLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNG 436
            .|..|.::.....||..:::...|:|....:::....|..||||.::|::|.:::...||:|:
 Worm   384 KLYCVESEKFINALLKPRVKVGTEWVNKGQNLDQVNWAVGALAKALFARMFSWLIRRCNKTLD-- 446

  Fly   437 SKQCS---FIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMID 498
            ::..|   |||||||.|||.|::|||||..||:.||||||.||.|:|.||||||.:|||.|..||
 Worm   447 AQDLSRDFFIGVLDIAGFEIFDLNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYKREGIQWEFID 511

  Fly   499 F-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPR-----FGTTS 556
            | .|.|.||:|||..||::.:|||||.:||.||.:.|.||..: ..|.|:|:|||     .....
 Worm   512 FGLDLQACIELIEKPLGIVSMLDEECIVPKASDLTLASKLNDQHLGKHPNFQKPRPPKGKQAEAH 576

  Fly   557 FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVL--SESNMSLA---KQVMTLEEIDTLCVDSAKS 616
            ..|.|::.||.|:|.|:||||:|.::.....||  ::.|..:|   ....|.|::.....|..|
 Worm   577 LAIVHYAGTVRYNVKGWLEKNKDPLNDTAVTVLKANKGNQLMADLWADYATQEDVAAAAKDGKK- 640

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
                     :.|:|:          .......||...::|||..|:..||.|.||::|||.||:.
 Worm   641 ---------AVGKKK----------GKSASFMTVSMMYRESLNKLMHMLHQTHPHFIRCIIPNEL 686

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNI 746
            |.|...:...::.||...||||.:||...|||:|..:.||..||.:|...:.....|.|.:...|
 Worm   687 KKAGMIDANLVLNQLTCNGVLEGIRICRKGFPNRMPFLDFKQRYAVLAADAAKAGKDPKDAGEKI 751

  Fly   747 VMKWIQD----EDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQK 807
            ....|:|    :::::.|.|::||:||.:|.||::|..                       .:.|
 Worm   752 SAALIKDGSLKQEEFQCGLTKVFFKAGVLAHLEELRDE-----------------------ALGK 793

  Fly   808 VINGIQKHARGYLARERTQKMREARAGLI-LSKYARGWLCRRRYLRLRHSISGIQTYARGMLARN 871
            ::...|...|.|||:...::..:.:.||| |.:..|.| |..|..........::...:|.....
 Worm   794 IMAKFQCACRHYLAQCEYKRKLDQKVGLIVLQRNIRAW-CTLRSWSWFKLFGRVKPLIKGSKKNE 857

  Fly   872 KFHAMRDHYRAV-----QIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARR------KFKRMK 925
            :|.|:...::.:     |.:|..:...|..|..:..:..::.|....|..:..      |....|
 Worm   858 EFEALEKKFKVLEEEKTQEERKRKDMEAENARLEAEKQALLIQLEQERDSSAEGEERSAKLLAQK 922

  Fly   926 AE-AKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI-SVLKMKLELKKTLEAEFKN 988
            |: .|.:::|.::....|.|..::.::..::.:||..||...|:: :.:|.:...|:..:.:.::
 Worm   923 ADLEKQMANMNDQLCDEEEKNAALTKQKKKIEQDNEGLKKTVSDLETTIKKQESEKQAKDHQIRS 987

  Fly   989 VKAACQDKDKLIEALNKQ--------------LEAERDEKMQL------LEENGHAQEEWISQKQ 1033
            ::...|.:|::|..|||:              ::||.|:...|      ||......|:.:.:::
 Worm   988 LQDEIQSQDEVISKLNKEKKHQEEVNRKLLEDIQAEEDKVNHLNKTKAKLESTLDELEDTLEREK 1052

  Fly  1034 TWRQENEELRRQIDEIIDMAKN--AEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFM 1096
            ..||:.|:.||:::..:.:|:.  .|:|:...|...:.:..:.||:....|...::.::......
 Worm  1053 RGRQDCEKQRRKVEGELKIAQELIEELNRHKHEQEQVIKKKDIELSSIQSRLEDEQSLVAKLQRQ 1117

  Fly  1097 LKEELSRLTAGSFSLHARKASNASSQ---NE------------DDVGYAS--------------A 1132
            :||.|:|:......|.|.:.|.:.::   ||            |:.|.|:              |
 Worm  1118 IKELLARIQELEEELDAERNSRSKAEKARNEMQMELEELGDRLDEAGGATQAQIELNKKREAELA 1182

  Fly  1133 KNTLD-----INRPPDLLSKNYSYNDSTS-------LVVKLRSILEEEK-----QKHKVLQEQYI 1180
            |...|     ||....:.:....:||:.:       .:.|:|..||.||     :..::.|...:
 Worm  1183 KLRQDLEDAAINSETSMAALRKKHNDAVAELSDQLDTIQKMRGKLEREKNDKQREVDELQQSADV 1247

  Fly  1181 KLSSRH------------------KPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNA 1227
            :...|.                  |..|.:..:.||.:...|:.:|...|..      ::.:..|
 Worm  1248 EAKQRQNCERMAKQLEAQLTDMTLKSDEQARLIQELTMGKNKVHNENQDLNR------QLEDAEA 1306

  Fly  1228 QHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESE 1292
            |..||....:::..:..:||..|.|:::..:||                   ||| :.|.|||.|
 Worm  1307 QLCALNRIKQQQHSQLEELKRTLDQETRERQSL-------------------HSQ-VSNYQLECE 1351

  Fly  1293 --LKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFED---SNVDTLRQNDRYLRRELQ 1352
              .:::.||.::| .::.:::.:.|:|..:.:.       :||.   |..:.|.:..|.|..::|
 Worm  1352 QFRESLEEEQDAK-TDVQRQLSKANSEIQQWRA-------KFEGEGVSRAEELEETRRKLTHKVQ 1408

  Fly  1353 KAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGL 1417
            :       :||:|:.||.|:....::..:|.|.:|:..:       .||...::.....:..:|
 Worm  1409 E-------MQEQLENANQKIGTLEKNKQRLAHDLEDAQV-------DADRANSIASSLEKKQKG- 1458

  Fly  1418 MKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK 1482
                   .||:|                                     |:.|......|.::::
 Worm  1459 -------FDKVL-------------------------------------DEWRRKCEALVAEVEQ 1479

  Fly  1483 MHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF------------NLF 1535
            ..|     |.|.. ...:..|.|.:::.|:..|.|| ...|...|:||:.            :|.
 Worm  1480 SQR-----ETRAA-ATETFRLRNQLEESGEQTEAVK-RENKALAQELKDIADQLGEGGKSVHDLQ 1537

  Fly  1536 EYRRVILDLIVNLYQAL--------------------IMQIQGLLDPKIVPAILNNDEIQRGRQA 1580
            :.||.:......|.|||                    :.||:..::.::..   ..:|.:..|:.
 Worm  1538 KMRRRLEIEKEELQQALDEAECALEAEEAKVMRAQIEVSQIRSEIEKRLQE---KEEEFENTRKN 1599

  Fly  1581 HG--MRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVA 1643
            |.  :.|...|:...|..........|:|.|.:........|....|...::...:|
 Worm  1600 HSRTIESMQVSLETESRGRAELLKTKKKLEGDVNELEIALDHSNKLNVDGQKSMKKL-------- 1656

  Fly  1644 LNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQS---------- 1698
                        .:|...::|.   :|:..||...|.|... ||  .:.||:||.
 Worm  1657 ------------QDTIRELQYQ---VEEEQRSLSESRDHAN-LA--ERRSQVLQQEKEDLAIIYE 1703

  Fly  1699 ------RKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDD----YESEITNVFLEKLT--EKLNAR 1751
                  |::|.::..:.|....||.:..|.:....|::.    .:|||.....:..|  ||....
 Worm  1704 QSERTRRQAELELAEVKDSVNELSNSNSLLLATKRKVEGDLQLLQSEIEEAMSDAKTSDEKAKKA 1768

  Fly  1752 QMQKSN-SDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDE 1795
            .|..|. :||...:|:.........:..:.:::|::    :.|||
 Worm  1769 IMDASKLADELRSEQEHASNLNQSKKTLESQVKDLQ----MRLDE 1809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	262/715 (37%)
		IQ	900..922	CDD:197470	3/27 (11%)
		SMC_prok_B	<942..1365	CDD:274008	100/514 (19%)
		Myo5_CBD	1424..1792	CDD:271254	72/424 (17%)
myo-5	NP_505094.1	Myosin_N	28..71	CDD:460670	11/46 (24%)
		MYSc_class_II	95..776	CDD:276951	262/715 (37%)
		Myosin_tail_1	853..1933	CDD:460256	198/1090 (18%)