DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myo5a

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_006510890.1 Gene:Myo5a / 17918 MGIID:105976 Length:1880 Species:Mus musculus


Alignment Length:1936 Identity:767/1936 - (39%)
Similarity:1118/1936 - (57%) Gaps:192/1936 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRN 65
            |::.| ||.:.|::|:|..:.||:||.|.:.|:.|...|.:..:.||..|.:|.....:||.|||
Mouse     1 MAASE-LYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTGELPHLRN 64

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRG 130
            |.||||:||||.|||||||.|||||||||.:.::|||||||:|||||||.::|:||..||.||.|
Mouse    65 PDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 129

  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER 195
            ..|||::|||||:|||||.::.|:..|.||||||||||||||||||||||||.|.||.||..||.
Mouse   130 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEE 194

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260
            |||||:||||:.||||||||||||||||:.::.|..:..::   ||.|.||||||||||:||:.|
Mouse   195 KVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRII---GANMRTYLLEKSRVVFQAEEE 256

  Fly   261 RNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            |||||||||||: :|.||   |.|.:.|.|.:...||:|.||.|.||::...|.||.|:||.|..
Mouse   257 RNYHIFYQLCAS-AKLPEFKMLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISES 320

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            ....|.:||||||||||:        |....|||||.|......|.|..||:.|..:::..||..
Mouse   321 YQMGIFRILAGILHLGNV--------GFASRDSDSCTIPPKHEPLTIFCDLMGVDYEEMCHWLCH 377

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFE 452
            ||:.:..|..:.|.|...|..||||||||||||||.:||..:|::|::..||.||||||||||||
Mouse   378 RKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDHVNQALHSAVKQHSFIGVLDIYGFE 442

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLD 517
            |||:||||||||||||||||||||.||||||||||:||.|.||:||||||||||:||||:||:||
Mouse   443 TFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILD 507

  Fly   518 LLDEECRMPKGSDESWAGKLIG-KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            ||||||:||||:|::||.||.. ..||...|||||....:|.||||:|.|||...||||||:|||
Mouse   508 LLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLEKNKDTV 572

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP---- 642
            .:|..:||..|..   |.:..|.:.|...: |..|:|..||..:          ||..|.|    
Mouse   573 FEEQIKVLKSSKF---KMLPELFQDDEKAI-SPTSATSSGRTPL----------TRVPVKPTKGR 623

  Fly   643 ----SKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLE 703
                :|:|:||||.||:.||..|:.||:||||||||||||||.|..|.::..:.:||||||||||
Mouse   624 PGQTAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLE 688

  Fly   704 TVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRA 768
            |:|||||||||||.|.:|:.||::|: :.|....|.|.:|:|::.|.|.|:|||:||.|:|||||
Mouse   689 TIRISAAGFPSRWTYQEFFSRYRVLM-KQKDVLGDRKQTCKNVLEKLILDKDKYQFGKTKIFFRA 752

  Fly   769 GQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARA 833
            ||||:||::||:..:.....:|..:|.::.|:::|.:|:....:|::.|||.||...:.:|..:|
Mouse   753 GQVAYLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKA 817

  Fly   834 GLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAY 898
            ...:.||.|.::.||||...|.:...||:|.||.|.||::..:...|:||.||:.|||.|||..|
Mouse   818 ATTIQKYWRMYVVRRRYKIRRAATIVIQSYLRGYLTRNRYRKILREYKAVIIQKRVRGWLARTHY 882

  Fly   899 QKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLK 963
            ::..:.|:..|...||.:|:|:.|::|.||:::...:..::|:||||:.:|:::||.|:|...|.
Mouse   883 KRTMKAIVYLQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLM 947

  Fly   964 HK--------TSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEE 1020
            .|        .||...|:..:|..:..|.|.|..........:.|..|.|.||..|.||..:.|.
Mouse   948 EKLTNLEGVYNSETEKLRNDVERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEER 1012

  Fly  1021 NGHAQEEWISQKQTWRQENEELRRQID----EIIDMAKN-AEVNQRN--QEDRMLAEIDNRELNE 1078
            ....::|........::||..|:::.:    .|::.||. .|..:|.  :|.:.| |:|..:...
Mouse  1013 ADKYKQETDQLVSNLKEENTLLKQEKETLNHRIVEQAKEMTETMERKLVEETKQL-ELDLNDERL 1076

  Fly  1079 AYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASA-KNTLDI-NRP 1141
            .||..:.:...:|.....||||::.:.......|.|..|..|| ||.:..::|. ..|.|| .|.
Mouse  1077 RYQNLLNEFSRLEERYDDLKEEMTLMLNVPKPGHKRTDSTHSS-NESEYTFSSEFAETEDIAPRT 1140

  Fly  1142 PDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIK-----LSSRHKPTE----------- 1190
            .:.:.|....:  .||.:||:..:.|.:|:.:::|::..:     ..|:.|..|           
Mouse  1141 EEPIEKKVPLD--MSLFLKLQKRVTELEQEKQLMQDELDRKEEQVFRSKAKEEERPQIRGAELEY 1203

  Fly  1191 DSFRVSELEVENEKLRSEYDQLRTSI--KHGVEINE--------LNAQHAALQEEVRRRREECIQ 1245
            :|.:..|||.||:||::|.::||.::  |...|:..        |..|..::.||:..|:||.:.
Mouse  1204 ESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLI 1268

  Fly  1246 LKAVLLQQSQSMRSLEP--------------ESLQMRG-----------------------NDVN 1273
            |::.|:.|.::::..:.              :.::.:|                       |:..
Mouse  1269 LRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSTMDYQELNEDG 1333

  Fly  1274 ELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESID-------- 1330
            ||...:...|..||.|||:|::....|.::...:..||:.|..|.:..|:::.:::.        
Mouse  1334 ELWMVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIE 1398

  Fly  1331 ---------------EFEDSNVDTLRQNDRY----------LRRELQKAVAQFLLVQEELKLANA 1370
                           .||:...|..::...|          |..:|:|.......::::||:...
Mouse  1399 ASLQHEITRLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAK 1463

  Fly  1371 KLKAYRQDGGQLEH----KIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQR 1431
            |:.  ..:.||:|:    :|.:|.||          ..|:.: |.::.||::::...|..|:::.
Mouse  1464 KIG--ELEVGQMENISPGQIIDEPIR----------PVNIPR-KEKDFQGMLEYKREDEQKLVKN 1515

  Fly  1432 LLSALTPRTV-VGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK-MHRTPHPIENRV 1494
            |:..|.||.| |.|:||.|||::|||:|:.|..|.|..||.||:..:..||| :.:.....|...
Mouse  1516 LILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDDFETVS 1580

  Fly  1495 IWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGL 1559
            .||.|:...|:.:|||...:.::|.||.:||:..|.||:|.|||:|:.||.:.:||.|:..::.:
Mouse  1581 FWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENI 1645

  Fly  1560 LDPKIVPAILNNDEIQ--RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFG 1622
            |.|.||..:|.::.||  .|.:..|:|.|.:||...      |......::.||..|:......|
Mouse  1646 LQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADE------GTYTLDSILRQLNSFHSVMCQHG 1704

  Fly  1623 LDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSND-VLTAL 1686
            :|....:|:..|:.|.:.|:.||.|:||.|:|.|..||.||||:..:|:|:|.|.:.|. ....|
Mouse  1705 MDPELIKQVVKQMFYIVGAITLNNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETL 1769

  Fly  1687 APLNQVSQLLQ-SRKSEQDVQTICDLCTSLSTAQVLKVMKSY-KLDDYESEITNVFLEKLTEKLN 1749
            .||.|.:|||| .:|::.|.:.||.:|.:|:|||::||:..| .::::|..::..|:..:..:|.
Mouse  1770 EPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLR 1834

  Fly  1750 ARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDEFLTKI 1800
            .|:    :|.:..:|.|.|.|....|..|.:.||.|::|:.|.|. |:.::
Mouse  1835 DRK----DSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLG-FIARV 1880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 425/724 (59%)
MYSc_Myo5 84..767 CDD:276831 400/694 (58%)
IQ 900..922 CDD:197470 6/21 (29%)
GBP_C <971..1086 CDD:303769 29/121 (24%)
coiled coil 1049..1068 CDD:293879 6/21 (29%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 35/166 (21%)
Myo5_CBD 1424..1792 CDD:271254 131/374 (35%)
Myo5aXP_006510890.1 COG5022 7..1448 CDD:227355 616/1471 (42%)
MYSc_Myo5 83..751 CDD:276831 400/694 (58%)
Myo5a_CBD 1506..1880 CDD:271262 134/384 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 763 1.000 Domainoid score I81
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20100
Inparanoid 1 1.050 1254 1.000 Inparanoid score I175
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52542
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm43121
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4210
SonicParanoid 1 1.000 - - X244
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.870

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