Protein Alignment didum and Myo1f

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_444444.2
• Gene: Myo1f / 17916
• MGIID: 107711
• Length: 1098
• Species: Mus musculus
• Alignment Length: 962
• Identity: 306/962 - (31%)
• Similarity: 495/962 - (51%)
• Gaps: 157/962 - (16%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |.:|:..|..:.|..::.|||.||.: ..|:||.|.:|:::||:.:||.:....|..|:|.|..:
Mouse    18 GVDDMVLLPQITEDAIVSNLRKRFMD-DYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYE 81

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV-GGSESETQVERKVLA 199
            ..|||:||.:..|..:..:..|..:|:||||||||||:|||.|.|.:.| ||.:....|:..:|.
Mouse    82 NPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQ 146

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            |:|::||||||||.||:|||||||:.::.| ::.|..  .|..:..:||||||||.|.:.|||:|
Mouse   147 SNPLLEAFGNAKTVRNNNSSRFGKYFEIQF-SRGGEP--DGGKISNFLLEKSRVVMQNENERNFH 208

  Fly   265 IFYQLC--AARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF--SIQQIA 325
            |:|||.  |::.:...|.|...|.:.:||.....::|...|...|:||:.||.|:|.  |:||:
Mouse   209 IYYQLLEGASQEQQQNLGLMTPDYYYYLNQSDTYKVEGTDDRSDFSETLSAMQVIGIPTSVQQL- 272

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
             :::::|||||||||...::.|....|    |.|:      |...|.||.:.:..|:..|..||:
Mouse   273 -VLQLVAGILHLGNISFCEEGNYARVE----SVDL------LAFPAYLLGIDSGRLQEKLTSRKM 326

  Fly   391 ESV----NEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGF 451
            :|.    :|.:.:..::|.|...||||||.:||:||.::|..:|:::....::.| |||||||||
Mouse   327 DSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYS-IGVLDIYGF 390

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL--- 513
            |.|:.|.|||||||:.||||||.|.:...|.|||||::|||.||.|::::|:...||||::|
Mouse   391 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKLSPP 455

  Fly   514 GVLDLLDEECRMPK----GSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFL 574
            |::.:||:.|....    |:|::...||........||..   .:..|.|.|::..|.|||:||.
Mouse   456 GIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS---WSAGFVIHHYAGKVSYDVSGFC 517

  Fly   575 EKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVD-SAKSSTLGGRVVISAGRKQQGNDTRR 638
            |:|||.:..:|.:::..|:....:.:..    :.|.:| ..:.||.|.::      |:|.||
Mouse   518 ERNRDVLFSDLIELMQSSDQDFLRMLFP----EKLNIDKKGRPSTAGSKI------KKQAND--- 569

  Fly   639 RVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLE 703
                                  |:|||...||||:||||||:.|....||.:::..|:...|:.|
Mouse   570 ----------------------LVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRE 612

  Fly   704 TVRISAAGFPSRWLYPDFYMRYQLLVYRS-KLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFR 767
            .:|:..|||..|..:..|..||.:|...: ...:.|.:...::::.....:.|:|:.|:|::|.:
Mouse   613 NIRVRRAGFAYRRQFSKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVK 677

  Fly   768 AGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREA 831
            ..:..| ||::|.              |:|   ..|.|.      |||..|.::|..:.::|||.
Mouse   678 NPESLFLLEEMRE--------------RKF---DGFART------IQKAWRRHVAVRKYEEMREE 719

  Fly   832 RAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896
            .:.::|:|..          |.|:||:           ||                ||...|...
Mouse   720 ASNILLNKKE----------RRRNSIN-----------RN----------------FVGDYLGLE 747

  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSN 961
            .           :..:|:|||:|  :|:.. |.:::..:.::..::..:|...:.:..:.|:...
Mouse   748 E-----------RPELRQFLAKR--ERVDF-ADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVK 798

  Fly   962 LKHKTSEI-SVLKMKLELKKTLEAEFKNVKAACQDKDKLI---EALNKQLEA 1009
            ...:...: .|||.||:::     ..:.|..:.:..|..|   ||.:..||:
Mouse   799 RGPEKGLVREVLKKKLDIQ-----ALRGVSLSTRQDDFFILQEEAADSFLES 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	254/700 (36%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	14/72 (19%)
		Myo5_CBD	1424..1792	CDD:271254
Myo1f	NP_444444.2	MYSc_Myo1	31..677	CDD:276829	254/700 (36%)
		Myosin_TH1	717..915	CDD:461801	34/185 (18%)
		PHA03247	<920..1043	CDD:223021
		SH3_MyoIe_If_like	1045..1097	CDD:212761