Protein Alignment didum and Myo1b

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_006495827.1
• Gene: Myo1b / 17912
• MGIID: 107752
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1207
• Identity: 370/1207 - (30%)
• Similarity: 586/1207 - (48%)
• Gaps: 215/1207 - (17%)

  Fly    69 LVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAM 133
            ::|..|:..|..|:|...:.||:.|| :...||||.|.:::::|||..:|:|.|..:..||....
Mouse    14 MIGVGDMVLLEPLNEETFIDNLKKRF-DHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNF 77

  Fly   134 GDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESE-TQVERKV 197
            .:|.||||||::|||..|..::.:..|:::||||||||.::|..|.|.|||.|..:| .||:.::
Mouse    78 YELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQL 142

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.|:|::||||||||.||||||||||:..:.|..:...:   |..:..|||||||||.|.:||||
Mouse   143 LQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPL---GGVISNYLLEKSRVVKQPRGERN 204

  Fly   263 YHIFYQLCAARSK---YPELVLDHQ-DKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQ 323
            :|:||||.:..|:   | :|.|:.. .::.:|::..| ::..|.||..|.....||.::||...:
Mouse   205 FHVFYQLLSGASEELLY-KLKLERDFSRYNYLSLDSA-KVNGVDDAANFRTVRNAMQIVGFLDHE 267

  Fly   324 IADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMR 388
            ...:::::|.:|.||||:    |...|.....|...|...: .|:...:|..:....|.|....|
Mouse   268 AEAVLEVVAAVLKLGNIE----FKPESRVNGLDESKIKDKN-ELKEICELTSIDQVVLERAFSFR 327

  Fly   389 KIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSK-QCSFIGVLDIYGFE 452
            .:|:..|.|....::..|..|||||||::|::||.::|..:|:|:...:| :...:|||||||||
Mouse   328 TVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFE 392

  Fly   453 TFE--VNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-G 514
            .||  .||||||.|||.||||||.|.:...|.|||||::|.|.||.||:::|....||||:.. |
Mouse   393 IFENADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNG 457

  Fly   515 VLDLLDEECRMP-KGSDESWAGKLIGKCNKFPHFEK-----PRF--GTT----SFFIKHFSDTVE 567
            :|.:|||||..| ..:||::..||...|....|||.     .||  .||    .|.|:|::..|.
Mouse   458 ILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVL 522

  Fly   568 YDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQ 632
            |.|.||::||.|.:.::|:|.:.::..||.|.:.                             .:
Mouse   523 YQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLF-----------------------------PE 558

  Fly   633 GNDTRRRVVPSKQHRK---TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQ 694
            ||       |:|.:.|   |.||||:.|:|:|:..|....|:|:|||||||.|.|..:..:.:..
Mouse   559 GN-------PAKVNLKRPPTAGSQFKASVATLMRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCH 616

  Fly   695 QLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKW--------- 750
            |:|..|:||.||:..||:..|..|.....||::|              |:.....|
Mouse   617 QIRYLGLLENVRVRRAGYAFRQAYEPCLERYKML--------------CKQTWPHWKGPARSGVE 667

  Fly   751 -IQDE-----DKYRFGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKV 808
             :.:|     :::.||.::||.|..:..| ||.:|....:...|::|.:.|.:..|..||.:::.
Mouse   668 VLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRS 732

  Fly   809 INGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRH------SISGIQTYARGM 867
            ...|....|.|..::|.|:::.  :.|::..|.|||..|:....|:|      :.:.|..|..|.
Mouse   733 QVVIAAWYRRYAQQKRYQQIKS--SALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGT 795

  Fly   868 LARNKFHAMRD-----HYRAVQIQRFVRGALARRAYQK-----RRRNIIICQAA------IRRFL 916
            .||.:...::|     |..|| |..:..|:.|||..::     ||::.:....|      :||
Mouse   796 QARRELRRLKDEARNKHAIAV-IWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRR-- 857

  Fly   917 ARRKFKRMKAEAK----TISHMENKY-MGLENKIISMQQRIDE-------LNRDNSNLKHKTSEI 969
            ..|||.|..|..|    |:..:..|| :.::||:.|:.. ||:       |..|::   ||
Mouse   858 EYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSP-IDKNWPSRPYLFLDST---HK---- 914

  Fly   970 SVLKMKLELKKTLEA-EFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQ 1033
                   |||:.... ..|..:....|:.|||                 .||...|.|.:..:|.
Mouse   915 -------ELKRIFHLWRCKKYRDQFTDQQKLI-----------------YEEKLEASELFKDKKA 955

  Fly  1034 TWRQE-NEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFML 1097
            .:... .:..:....||....|..::....:|..::||:.|: :|.|..::.....::.|.|.:|
Mouse   956 LYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNK-INRANGKSTSRIFLLTNNNLLL 1019

  Fly  1098 ------------------KEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDL 1144
                              |..:|....|.|::|.::.|.|:|:.:                  .|
Mouse  1020 ADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGD------------------FL 1066

  Fly  1145 LSKNYSYNDSTSLVVKLRSILEEEKQKHKV-LQEQYI 1180
            .|.::....:|.|   .|:.|.:.|||..: :.::::
Mouse  1067 FSSDHLIEMATKL---YRTTLSQTKQKLNIEISDEFL 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	262/721 (36%)
		IQ	900..922	CDD:197470	7/32 (22%)
		SMC_prok_B	<942..1365	CDD:274008	51/267 (19%)
		Myo5_CBD	1424..1792	CDD:271254
Myo1b	XP_006495827.1	MYSc_Myo1	29..690	CDD:276829	262/721 (36%)
		IQ	751..773	CDD:197470	6/23 (26%)
		Myosin_TH1	943..1120	CDD:461801	32/180 (18%)