DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh6

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_006518740.1 Gene:Myh6 / 17888 MGIID:97255 Length:1939 Species:Mus musculus


Alignment Length:1964 Identity:511/1964 - (26%)
Similarity:858/1964 - (43%) Gaps:485/1964 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLK 54
            |.:|.|.||      ..:.:||..         :|.|.|.      .|.:...|::||...:|  
Mouse    19 SEKERLEAQTRPFDIRTECFVPDD---------KEEYVKAKVVSREGGKVTAETENGKTVTIK-- 72

  Fly    55 ADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPL 119
               .|....:||.......|:..|::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:
Mouse    73 ---EDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPV 133

  Fly   120 YGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV 184
            |...::.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||::
Mouse   134 YNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASI 198

  Fly   185 G--GSESETQ--------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQ 239
            .  |..|:.:        :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |.
Mouse   199 AAIGDRSKKENPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LA 260

  Fly   240 GATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIE 299
            .|.:.|||||||||::|.:.|||||||||:.:  :|.||     ||.::...:.|::.|.. .:.
Mouse   261 SADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDYAFVSQGEV-SVA 322

  Fly   300 RVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDI 360
            .:.|:|:...|..|..||.|:.::.|.:.|:...|:|.||::..:|..|...|    ||:|.   
Mouse   323 SIDDSEELLATDSAFDVLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADK--- 384

  Fly   361 FHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYI 425
                     :|.|:.:::.||.:.|...:::..||||....|::....:..||||.:|.|:|.::
Mouse   385 ---------SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWM 440

  Fly   426 VGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKE 490
            |..:|.:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||
Mouse   441 VTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKE 505

  Fly   491 GITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKP 550
            ||.|..||| .|.|.||||||..:|::.:|:|||..||.||.::..||    :||.|   :|:||
Mouse   506 GIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSN---NFQKP 567

  Fly   551 R----FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSL-AKQVMTLEEIDTLC 610
            |    .....|.:.|::.||:|::.|:||||:|.:::.:..:..:|::.| |....|....||  
Mouse   568 RNVKGKQEAHFSLVHYAGTVDYNIMGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADT-- 630

  Fly   611 VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRC 675
            .||.|..          |.|::|:..           :||.:..:|:|..|::.|..|.||:|||
Mouse   631 GDSGKGK----------GGKKKGSSF-----------QTVSALHRENLNKLMTNLKTTHPHFVRC 674

  Fly   676 IKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--- 737
            |.||:.|.....:...::.|||..||||.:||...|||:|.||.||..||::|        |   
Mouse   675 IIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL--------NPAA 731

  Fly   738 -------DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRR 795
                   |.:.....::.....|.::|:||:|::||:||.:..||::|..               
Mouse   732 IPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE--------------- 781

  Fly   796 FVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRL 853
                    |:.::|..||..|||.|.|...:|:.|.|..|::.::       .:.|...:.|.::
Mouse   782 --------RLSRIITRIQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKI 838

  Fly   854 RHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLAR 918
            :..:...:|.......:.:|..::|                                |:.:..||
Mouse   839 KPLLKSAETEKEMANMKEEFGRVKD--------------------------------ALEKSEAR 871

  Fly   919 RKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLE 983
            ||                   .||.|::|:                       |:.|.:|:..::
Mouse   872 RK-------------------ELEEKMVSL-----------------------LQEKNDLQLQVQ 894

  Fly   984 AEFKNVKAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQID 1047
            ||..|:..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||::.||
Mouse   895 AEQDNLNDAEERCDQLIK--NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDID 957

  Fly  1048 EI------IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENENFML 1097
            ::      ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:..|      
Mouse   958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEE------ 1016

  Fly  1098 KEELSRLTAGSFSLHARKASNASSQNEDDVGYA---SAKNTLDINRPPDLLSKNYSY-------- 1151
             ::::.||.....|         .|..||:..:   ..|..:|:.|....|..:...        
Mouse  1017 -DKVNTLTKSKVKL---------EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071

  Fly  1152 -NDSTSLVVKL-RSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENE---KLRSEYDQ 1211
             ||...|..|| :...:..:|..|:..||.:.|..:.|..|:..|:.|||.|.|   ..|::.::
Mouse  1072 ENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEK 1136

  Fly  1212 LRTSIKHGVEINELNAQ------HAALQEEVRRRREECIQ-----LKAVLLQQSQSMRSLEPESL 1265
            ||:.:..  |:.|::.:      ..::|.|:.::||...|     |:...||...:..:|.    
Mouse  1137 LRSDLSR--ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR---- 1195

  Fly  1266 QMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV------ 1324
            :...:.|.||.|...:.:.:.::||.|    ..|...:|.::|..:|::...|..|:||      
Mouse  1196 KKHADSVAELGEQIDNLQRVKQKLEKE----KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED 1256

  Fly  1325 -----------MFESIDEFEDSNVDTLRQNDRYLRR--ELQKAVAQFL---------------LV 1361
                       ...|:::|.........:|....|:  |.:..::|..               .:
Mouse  1257 QANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL 1321

  Fly  1362 QEELKLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSS 1423
            :||.|..||   .|::.|.|...|..:.||||      ...|::...::|..|:..|...|:.:.
Mouse  1322 EEEGKAKNALAHALQSSRHDCDLLREQYEEEM------EAKAELQRVLSKANSEVAQWRTKYETD 1380

  Fly  1424 DLDKI--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRT 1486
            .:.:.  |:.....|..|                      |.:|::.|..:.:|    ...:.:|
Mouse  1381 AIQRTEELEEAKKKLAQR----------------------LQDAEEAVEAVNAK----CSSLEKT 1419

  Fly  1487 PHPIENRVIWLVNSITLLN-----LMKQYGDVD--------EYVKFNTEKQNQQQLKNFNLFEYR 1538
            .|.::|.:..|:..:...|     |.|:..:.|        :|.:..:|.::.|:       |.|
Mouse  1420 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK-------EAR 1477

  Fly  1539 RVILDL--IVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGG 1601
            .:..:|  :.|.|:..:..::..                 .|:...::...:.:  :.....|| 
Mouse  1478 SLSTELFKLKNAYEESLEHLETF-----------------KRENKNLQEEISDL--TEQLGEGG- 1522

  Fly  1602 PAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNI 1666
                :.:.:||...||.:        .|::..|........:|.          .|.|.|:|   
Mouse  1523 ----KNVHELEKIRKQLE--------VEKLELQSALEEAEASLE----------HEEGKILR--- 1562

  Fly  1667 GCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQD----------VQTICDLCTSL-----S 1716
                              |....||:...::.:.:|:|          ::.:..|.|||     |
Mouse  1563 ------------------AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRS 1609

  Fly  1717 TAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDI 1780
            ..:.|:|.|                 |:...||..::|.|.::....: ||.::..:...:.:.:
Mouse  1610 RNEALRVKK-----------------KMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQL 1657

  Fly  1781 KLEDIELPSHLNLD 1794
            :|:|   ..|.|.|
Mouse  1658 QLDD---AVHANDD 1668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 283/751 (38%)
MYSc_Myo5 84..767 CDD:276831 271/721 (38%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 39/130 (30%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/122 (23%)
Myo5_CBD 1424..1792 CDD:271254 60/400 (15%)
Myh6XP_006518740.1 Myosin_N 34..72 CDD:367160 9/46 (20%)
MYSc_class_II 99..768 CDD:276951 271/721 (38%)
Myosin_tail_1 848..1925 CDD:366712 195/1045 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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