DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh9

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_071855.2 Gene:Myh9 / 17886 MGIID:107717 Length:1960 Species:Mus musculus


Alignment Length:1936 Identity:522/1936 - (26%)
Similarity:884/1936 - (45%) Gaps:353/1936 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.:...:|.|:|:|..  |...:....::||    |:|.:..|:..: ||.......|:..|
Mouse    32 VWVPSSKNGFEPASLKEEV--GEEAIVELVENGK----KVKVNKDDIQKM-NPPKFSKVEDMAEL 89

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|:|....::.|||:|:
Mouse    90 TCLNEASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAI 153

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS----ESETQVERKVLASSPIM 204
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|    :.:.::||::|.::||:
Mouse   154 TDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPIL 218

  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269
            ||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.||.:||||.|
Mouse   219 EAFGNAKTVKNDNSSRFGKFIRINF-DVNG--YIVGANIETYLLEKSRAIRQAKEERTFHIFYYL 280

  Fly   270 CAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            .:...::  .:|:|:..:|::||: .|...|....|.:.|.||::||.::|....:...::::::
Mouse   281 LSGAGEHLKTDLLLEPYNKYRFLS-NGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVIS 344

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397
            |:|.||||...|       |.::|...:..|.. .|..:.||.::..|..|.:|..:|:...:||
Mouse   345 GVLQLGNIAFKK-------ERNTDQASMPDNTA-AQKVSHLLGINVTDFTRGILTPRIKVGRDYV 401

  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQ 461
            ....:.|.|..|.:||||..|.::|:::|..:||:|:...:| .||||:|||.|||.|::|||||
Mouse   402 QKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQ 466

  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRL---GVLDLLDEE 522
            .||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||...   |:|.|||||
Mouse   467 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEE 531

  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585
            |..||.:|:|:..|::.:....|.|:||:  .....|.|.|::..|:|..:.:|.||.|.::..:
Mouse   532 CWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596

  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLC----VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            ..:|.:|:.....::.  :::|.:.    |.....:.|.|..           .||:.:.     
Mouse   597 ATLLHQSSDKFVSELW--KDVDRIIGLDQVAGMSETALPGAF-----------KTRKGMF----- 643

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             :|||..::|.||.|::||..|.|::||||.||.:|.|.|.:...::.|||..||||.:||...|
Mouse   644 -RTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQG 707

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774
            ||:|.::.:|..||::|...| :.|.  |.|.:|..::.....|.:.||.|.:::|||||.:|.|
Mouse   708 FPNRVVFQEFRQRYEILTPNS-IPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHL 771

  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER-TQKMREARAGLILS 838
            |:.|.                       |:|..||.|.|...||||||:. .::.::..|..:|.
Mouse   772 EEERD-----------------------LKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQ 813

  Fly   839 KYA------RGWLCRRRYLRLRHSISGIQTYARGMLA--------RNKFHAMRDHYRAVQIQRFV 889
            :..      |.|...|.:.:::..::.|: :...:||        |.|..|..:....::..:..
Mouse   814 RNCAAYLRLRNWQWWRLFTKVKPLLNSIR-HEDELLAKEAELTKVREKHLAAENRLTEMETMQSQ 877

  Fly   890 RGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISH-----MEN-----KYMGLENK 944
            ..|...:..::.:....:|..|..   .|.:....|.|.:.|.|     :|.     :|:..|.|
Mouse   878 LMAEKLQLQEQLQAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKK 939

  Fly   945 IISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFK------------NVKAACQDK 996
              .|||.|.|       |:.:..|....:.||:|:| |.||:.|            |.|.|.:.|
Mouse   940 --KMQQNIQE-------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKK 995

  Fly   997 ---DKLIEALNKQLEAERDEKMQLLEENGHAQ-----EEWISQKQTWRQENEELRRQI------- 1046
               |::.|.....:|.|...|.....:|.|..     ||.:.:::..|||.|:.||::       
Mouse   996 LLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

  Fly  1047 -DEIIDM-AKNAEVNQR--NQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAG 1107
             |:|.:: |:.||:..:  .:|:.:.|.:...| .||.|:.:..|::.|     |:.::|.|.. 
Mouse  1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRE-----LETQISELQE- 1118

  Fly  1108 SFSLHARKAS-NASSQNEDDVG--YASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEK 1169
              .|.:.:|| |.:.:.:.|:|  ..:.|..|:     |.|       |||:...:|||..|:| 
Mouse  1119 --DLESERASRNKAEKQKRDLGEELEALKTELE-----DTL-------DSTAAQQELRSKREQE- 1168

  Fly  1170 QKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQE 1234
                        :|...|..||..:.                      |..:|.|:..:|:...|
Mouse  1169 ------------VSILKKTLEDEAKT----------------------HEAQIQEMRQKHSQAVE 1199

  Fly  1235 EVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELM----EAFHSQKLINRQLESELKA 1295
            |:..:.|:..::||.|   .::.::||.|..:: .|:|..|:    ::.|.:|.:..||: ||:.
Mouse  1200 ELADQLEQTKRVKATL---EKAKQTLENERGEL-ANEVKALLQGKGDSEHKRKKVEAQLQ-ELQV 1259

  Fly  1296 ITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLL 1360
            ...|......|:..::.:|..|.|.:..::.:|     ||....|.::...|..:||....   |
Mouse  1260 KFSEGERVRTELADKVTKLQVELDSVTGLLSQS-----DSKSSKLTKDFSALESQLQDTQE---L 1316

  Fly  1361 VQEE--LKLA-NAKLKAYRQDGGQLEHKI-EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFH 1421
            :|||  .||: :.|||....:......:: |||..:.......|.:.|.||..|.:...|:....
Mouse  1317 LQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLE 1381

  Fly  1422 SS---------DLDKILQRLLSALT-----PRTVVGLLPGFPAYLIFMCIRYTDLTNADD----- 1467
            ::         ||:.:.|||...:.     .:|...|.......|:.:..:...::|.:.     
Mouse  1382 TAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKF 1446

  Fly  1468 -----DVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVK-FNTEKQNQ 1526
                 :.:.:.:|:..:..:........|.:.:.|..:  |...|:|..:::...| |.||.::.
Mouse  1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA--LEEAMEQKAELERLNKQFRTEMEDL 1509

  Fly  1527 QQLKN------FNLFEYRRVILDLIVNL---YQALIMQIQGLLDPKI---VPAILNNDEIQRGRQ 1579
            ...|:      ..|.:.:|.:...:..:   .:.|..::|...|.|:   |.......:.:|..|
Mouse  1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574

  Fly  1580 AHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQ------------------------- 1619
            ....:|....               |||:.|:.....:.:                         
Mouse  1575 GRDEQSEEKK---------------KQLVRQVREMEAELEDERKQRSMAMAARKKLEMDLKDLEA 1624

  Fly  1620 HFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLT 1684
            |....|...|:...|         |..|..:...||.|           ::|    .:.|.:.:.
Mouse  1625 HIDTANKNREEAIKQ---------LRKLQAQMKDCMRE-----------LDD----TRASREEIL 1665

  Fly  1685 ALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITN------VFLEK 1743
            |.|..|:  :.|:|.::|     :..|...|:.|:..|.....:.|:...||.|      :.||:
Mouse  1666 AQAKENE--KKLKSMEAE-----MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723

  Fly  1744 LTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLD 1794
             ..:|.||..|.  .:|...:|...:......:.::::::.|.  :.|||:
Mouse  1724 -KRRLEARIAQL--EEELEEEQGNTELINDRLKKANLQIDQIN--TDLNLE 1769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 278/731 (38%)
MYSc_Myo5 84..767 CDD:276831 265/701 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 38/146 (26%)
coiled coil 1049..1068 CDD:293879 5/21 (24%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 24/112 (21%)
Myo5_CBD 1424..1792 CDD:271254 68/426 (16%)
Myh9NP_071855.2 Mediates interaction with LIMCH1. /evidence=ECO:0000250|UniProtKB:P35579 2..838 309/868 (36%)
Myosin_N 30..68 CDD:280832 12/41 (29%)
Myosin_head 83..764 CDD:278492 269/713 (38%)
Motor_domain 95..764 CDD:277568 265/701 (38%)
Actin-binding 654..676 12/21 (57%)
Myosin_tail_1 842..1921 CDD:279860 212/1063 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 6/21 (29%)
UBAN 1038..1149 CDD:301588 29/119 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1167 16/64 (25%)
RRF <1206..1261 CDD:294170 16/59 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1352 6/24 (25%)
RILP-like <1480..1587 CDD:304877 20/123 (16%)
DUF2390 <1610..1678 CDD:295281 15/93 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1768..1788 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1908
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1939..1960
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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