DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh4

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_034985.2 Gene:Myh4 / 17884 MGIID:1339713 Length:1939 Species:Mus musculus


Alignment Length:2093 Identity:535/2093 - (25%)
Similarity:886/2093 - (42%) Gaps:564/2093 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQG------AKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.:.||.      :.::|..|...:..||::.  |:| |.:...|:.|....||     .|.
Mouse    20 SEKERIEAQNKPFDAKSSVFVVDAKESYVKATVQS--REG-GKVTAKTEGGATVTVK-----DDQ 76

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            ....||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::
Mouse    77 VFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNPEVV 140

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
Mouse   141 AAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDK 205

  Fly   189 SETQ---------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            .:.:         :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
Mouse   206 KKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIE 267

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAE 305
            |||||||||.:|.:.||:||||||:.:  :|.|||:   |...:.:.|..:. |...:..:.|.|
Mouse   268 TYLLEKSRVTFQLKAERSYHIFYQIMS--NKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQE 330

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQIT 370
            :...|..|:.:||||..:...|.|:...::|.||::..:|..|  |:.:.|..::...      .
Mouse   331 ELMATDTAVDILGFSADEKVAIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------A 387

  Fly   371 ADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNN 435
            |.|..:::.||.:.|...:::..||||....:::....:..||||.:|.|:|.::|..:|:.|:.
Mouse   388 AYLTSLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALAKSMYEKMFLWMVTRINQQLDT 452

  Fly   436 GSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF- 499
            ...:..|||||||.|||.|:.|:.||.|||:.||||||.||.|:|.||||||.||||.|..||| 
Mouse   453 KQPRQYFIGVLDIAGFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFG 517

  Fly   500 YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR----FGTTS 556
            .|...||:|||..:|:..:|:|||..||.:|.|:..||    :||.|   :|:||:    .....
Mouse   518 MDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSN---NFQKPKPAKGKAEAH 579

  Fly   557 FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCV-----DSAKS 616
            |.:.|::.||:|::.|:|:||:|.:::.:..:..:|.:.            ||..     .:|::
Mouse   580 FSLVHYAGTVDYNIIGWLDKNKDPLNETVVGLYQKSGLK------------TLAFLFSGGQAAEA 632

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
            ...||:    .|.|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.
Mouse   633 EGGGGK----KGGKKKGSSF-----------QTVSALFRENLNKLMTNLKSTHPHFVRCLIPNET 682

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSC 743
            |.....|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:.
Mouse   683 KTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL-NASAIPEGQFIDSKKAS 746

  Fly   744 RNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKV 808
            ..::.....|..:|:||:|::||:||.:..||::|.....:.||..|:|                
Mouse   747 EKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAV---------------- 795

  Fly   809 INGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQT---- 862
                   .||||.|...:||.|.|..:...:|       .:.|...:.|.:::..:...:|    
Mouse   796 -------CRGYLMRVEFKKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEM 853

  Fly   863 --------YARGMLARN---------KFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIII--- 907
                    .|:..||::         |..|:......:|:|  |:......|..:.|.:.:|   
Mouse   854 ANMKEDFEKAKEDLAKSEAKRKELEEKMVALMQEKNDLQLQ--VQAEADGLADAEERCDQLIKTK 916

  Fly   908 --CQAAIRRFLAR---------------RKFKRMKAEAK--------TISHMENKYMGLENKIIS 947
              .:|.|:....|               ||.:...:|.|        |::.:|.:....|||:.:
Mouse   917 IQLEAKIKELTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981

  Fly   948 M-------------------------QQRIDELNRD----NSNLKHKTS---------------- 967
            :                         ||.:|:|..:    |:..|.||.                
Mouse   982 LTEEMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEK 1046

  Fly   968 ----EISVLKMKLE-----------------------LKKTLEAEFKNVKAACQDKDKL------ 999
                ::...|.|||                       |||. |.|..|:::..:|:..|      
Mouse  1047 KLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK-EFEMSNLQSKIEDEQALGMQLQK 1110

  Fly  1000 --------IEALNKQLEAER-----------------DEKMQLLEENGHAQEEWISQ-------- 1031
                    ||.|.:::||||                 :|..:.|||.|.|....|..        
Mouse  1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF 1175

  Fly  1032 ------------------------------------------KQTWRQENEELRRQID------E 1048
                                                      ||...:|..||:.:||      |
Mouse  1176 QKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNME 1240

  Fly  1049 IIDMAK-NAEVNQRNQEDRMLAEIDNRELNEAYQRAIKD----KEVIENENFMLKEEL------- 1101
            .:..|| |.|...|..||: |:|:..:|  |..||.|.:    |..:..|:.....:|       
Mouse  1241 TVSKAKGNLEKMCRTLEDQ-LSEVKTKE--EEQQRLINELSTQKARLHTESGEFSRQLDEKDAMV 1302

  Fly  1102 SRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL-----DINRPPDLLSKNY------------ 1149
            |:|:.|. ....::......|.|::   :.|||.|     ......|||.:.|            
Mouse  1303 SQLSRGK-QAFTQQIEELKRQLEEE---SKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQR 1363

  Fly  1150 SYNDSTSLVVKLRSILEEEK-QKHKVLQEQYIKLSSRHKPTED-----SFRVSELEVENEKLRSE 1208
            :.:.:.|.|.:.|:..|.:. |:.:.|:|...||:.|.:..|:     :.:.:.||...::|::|
Mouse  1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNE 1428

  Fly  1209 YDQLRTSIKHGVEINELNAQHAALQEEVR-------RRREECIQLKAVLLQQSQSMRSLEPESLQ 1266
            .:.|.      :::...||..|||.::.|       ..:::..:.:|.|....:..|||..|..:
Mouse  1429 VEDLM------IDVERSNAACAALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487

  Fly  1267 MRGNDVNELMEAFHSQKLINRQLESELKAITEE--HNSKLVEMTQEIER-LNNEKDELQKVMFES 1328
            :: |...|.::...:.|..|:.|:.|:..:||:  ...|.:...::|:: ::.||.|||..:.|:
Mouse  1488 VK-NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEA 1551

  Fly  1329 IDEFE---------------------------DSNVDTLRQNDRYLRRELQKAVAQFLLVQEELK 1366
            ....|                           |..:|.|::|...:...:|..      :..|::
Mouse  1552 EASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHLRVVESMQST------LDAEIR 1610

  Fly  1367 LANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQR 1431
            ..|..|:..::..|.|.   |.|:..|.:|..:|:...|:     :|.||::|.....||     
Mouse  1611 SRNDALRIKKKMEGDLN---EMEIQLNHANRQAAEAIRNL-----RNTQGMLKDTQLHLD----- 1662

  Fly  1432 LLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIW 1496
                                         |.....||::|.|:.              :|.|.  
Mouse  1663 -----------------------------DALRGQDDLKEQLAM--------------VERRA-- 1682

  Fly  1497 LVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFE-YRRVIL-----DLIVNLYQAL--- 1552
                    |||:  .:::|......:.:..:::....|.: ..||.|     ..::|..:.|   
Mouse  1683 --------NLMQ--AEIEELRASLEQTERSRRVAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737

  Fly  1553 IMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSS----PEHGGGPAWKQLIGQLEH 1613
            |.||||.::          |.:|..|.|.....:|.:..|..:    .|.......:::...:|.
Mouse  1738 ISQIQGEME----------DIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1792

  Fly  1614 FYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKM 1678
            ..|..|| .||.  |||                |.|:|.          :..|..:|  .|.:::
Mouse  1793 TVKDLQH-RLDE--AEQ----------------LALKGG----------KKQIQKLE--ARVREL 1826

  Fly  1679 SNDV-------LTALAPL----NQVSQL-LQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDD 1731
            .|:|       :.|:..|    .:|.:| .|:.:..::|..:.||...|.|.     :|:||...
Mouse  1827 ENEVENEQKRNIEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTK-----VKAYKRQA 1886

  Fly  1732 YES-EITNVFLEK 1743
            .|: |.:||.|.|
Mouse  1887 EEAEEQSNVNLAK 1899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 274/744 (37%)
MYSc_Myo5 84..767 CDD:276831 263/714 (37%)
IQ 900..922 CDD:197470 7/41 (17%)
GBP_C <971..1086 CDD:303769 48/225 (21%)
coiled coil 1049..1068 CDD:293879 7/19 (37%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 25/120 (21%)
Myo5_CBD 1424..1792 CDD:271254 67/346 (19%)
Myh4NP_034985.2 Myosin_N 35..73 CDD:308391 9/40 (23%)
MYSc_Myh4 100..770 CDD:276879 263/714 (37%)
Actin-binding. /evidence=ECO:0000250 659..681 10/21 (48%)
Actin-binding. /evidence=ECO:0000250 761..775 7/13 (54%)
SMC_N 850..1927 CDD:330553 227/1187 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1147 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1172 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1276..1299 3/22 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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