DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh3

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001093105.1 Gene:Myh3 / 17883 MGIID:1339709 Length:1940 Species:Mus musculus


Alignment Length:2037 Identity:523/2037 - (25%)
Similarity:912/2037 - (44%) Gaps:469/2037 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EESYRKGA------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87
            :|.|.||.      |.:.:.|:..:...||    ..|:..: ||.......|:..|::|:||.||
Mouse    44 KEEYVKGKIKSSQDGKVTVETEDSRTLVVK----PEDVYAM-NPPKFDKIEDMAMLTHLNEPAVL 103

  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152
            :||:.|:.. .:||||.|:..|.:|||..:|:|.|.::..|||....:..||||::::.||..:.
Mouse   104 YNLKDRYTS-WMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFML 167

  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---------SESETQVERKVLASSPIMEAFG 208
            .:..|.||:::|||||||||:.|..::|||.:..         |:.:..:|.::::::|::||||
Mouse   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFG 232

  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273
            ||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|.:.||:||||||:.:  
Mouse   233 NAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLKAERSYHIFYQILS-- 292

  Fly   274 SKYPE-----LVLDHQDKFQFLNMGGAPEI--ERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331
            :|.||     |:..:...:.|::.|   ||  ..:.|||:...|..|:.:|||:.::.:.:.|:.
Mouse   293 NKKPELIELLLITTNPYDYPFISQG---EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLT 354

  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396
            ..::|.||::..:|..|  |:.:.|..::...      ||.|:.:::.||.:.|...:::..|||
Mouse   355 GAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------TAYLMGLNSSDLLKALCFPRVKVGNEY 411

  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQ 461
            |....:::....|.:||:|.:|.|||.::|..:|:.|:....:..|||||||.|||.||.||.||
Mouse   412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQ 476

  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRM 525
            .|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||..
Mouse   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMF 541

  Fly   526 PKGSDESWAGKL----IGKCNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582
            ||.:|.|:..||    :||.|   :|:||:.    ....|.:.|::.||:|.|:|:||||:|.::
Mouse   542 PKATDTSFKNKLYDQHLGKSN---NFQKPKVVKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLN 603

  Fly   583 KELTQVLSE-SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            :.:..:..: ||..||....|.          |.:...||:..::   |::|:..          
Mouse   604 ETVVGLYQKSSNRLLAHLYATF----------ATTDADGGKKKVA---KKKGSSF---------- 645

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             :||.:.|:|:|..|:|.|..|.||:||||.||:.|.....|.:.::.|||..||||.:||...|
Mouse   646 -QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKG 709

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            ||:|.||.||..||::| ..|.:.:.   |.|.:|..::.....|..:|:||:|::||:||.:..
Mouse   710 FPNRILYGDFKQRYRVL-NASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGT 773

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            ||::|.....|.||..|:|                       .||:|.|...|||.:.|..:...
Mouse   774 LEEMRDERLAKLITRTQAV-----------------------CRGFLMRVEFQKMMQRRESIFCI 815

  Fly   839 KY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896
            :|       .:.|...:.:.:::..:...:|.......:.:|...:|.                 
Mouse   816 QYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE----------------- 863

  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK------YMGLENKIISMQQRIDEL 955
                               ||:.:.||.:.|.|.::.::.|      .......::..::|.|:|
Mouse   864 -------------------LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909

  Fly   956 NRDNSNLKHK--------------TSEISVLKMKL-----ELKKTLE------AEFKNVKAACQD 995
            .:....|:.|              .:|::..|.||     ||||.::      |:.:..|.|.::
Mouse   910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974

  Fly   996 K-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQ----KQTWRQENEELRRQ 1045
            |           |:.|..|.::.:|.::...|.|::. .|:|:.::.    |....|:.::|...
Mouse   975 KVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDL-QAEEDKVNSLSKLKSKLEQQVDDLESS 1038

  Fly  1046 IDEIIDMAKNAEVNQRNQE-DRMLA-------EIDNRELNEAYQRAIKDKEV------IENENFM 1096
            :::...:..:.|.|:|..| |..||       |.|.::|:|..::  ||.|.      :|:|..:
Mouse  1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK--KDFEYSQLQSKVEDEQTL 1101

  Fly  1097 -------LKEELSRL----------------TAGSFSLHARKASNASSQNEDDVGYASAKNTLDI 1138
                   :||..:|:                |....|.:||:....|.:.|:..|..|.:..|:.
Mouse  1102 SLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166

  Fly  1139 NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSE------ 1197
            .|..:.|              |||..|||     ..||.:....:.|.|..:.:..::|      
Mouse  1167 KREAEFL--------------KLRRDLEE-----ATLQHEATVATLRKKHADSAAELAEQIDNLQ 1212

  Fly  1198 -----LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNAQ 1228
                 ||.|..:.:.|.|.|.:|:      |..:|                       ::||..|
Mouse  1213 RVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEEMQRSLSELTTQ 1277

  Fly  1229 HAALQEEVRRRREECIQLKAVLLQQSQS-----------MRSLEPE---------SLQMRGNDVN 1273
            .:.||.|......:..:.::::.|.|:|           .|.||.|         :||...:|.:
Mouse  1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCD 1342

  Fly  1274 ELMEAFHSQKLINRQLESEL-KAITE------EHNSKLVEMTQEIE--------RLNNEKDELQK 1323
            .|.|.:..::....:|:..| ||.:|      ::.:..::.|:|:|        ||.:.:::::.
Mouse  1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

  Fly  1324 VMFE--SID--------EFEDSNVDTLRQN------DRYLRRELQKAVAQFLL----VQEELKLA 1368
            |..:  |::        |.||..||..|.|      |: .:|...|.:|::..    .|.||:.|
Mouse  1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK-KQRNFDKVLAEWKTKCEESQAELEAA 1471

  Fly  1369 NAKLKAYRQDGGQLEHKIEE-----EMIRNKSNGTSADVGANVTKQKSQNPQGL---------MK 1419
            ..:.::...:..:|::..||     |.::.::.....:: |::|:|.::|.:.:         |:
Mouse  1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI-ADLTEQIAENGKSIHELEKSRKQME 1535

  Fly  1420 FHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK--FVIQIKK 1482
            ...:|:...|:...:||...         .|.::.:.:..|.:.:..|  |::..|  .:.|:|:
Mouse  1536 LEKADIQMALEEAEAALEHE---------EAKILRIQLELTQVKSEID--RKIAEKDEEIEQLKR 1589

  Fly  1483 MH-RTPHPIENRVIWLVNS----ITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF-NLFEYRRVI 1541
            .: ||...::..:...|.|    |.|...|:  ||::| ::......|:|..:.. :|...:..:
Mouse  1590 NYQRTVETMQGALDAEVRSRNEAIRLKKKME--GDLNE-IEIQLSHANRQAAETIKHLRSVQGQL 1651

  Fly  1542 LDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQ 1606
            .|..::|..||    :|..|.|...||:.       |:|:.:::....:.|:             
Mouse  1652 KDTQLHLDDAL----RGQEDLKEQLAIVE-------RRANLLQAEVEELRAT------------- 1692

  Fly  1607 LIGQLEHFYKQFQHFGLDNCYAEQIFH----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIG 1667
             :.|.|...|..:...||:....|:.|    .|::....:..:...|:.:               
Mouse  1693 -LEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSE--------------- 1741

  Fly  1668 CIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQV 1720
             :||..|..:.:.:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.
Mouse  1742 -VEDACRDARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803

  Fly  1721 LKVMKSYK-LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSD----- 1779
            |.:....| :...|:.|..:..|...|       ||.|::.....:|:.:..|.:...|:     
Mouse  1804 LALKGGKKQIQKLETRIRELEFELEGE-------QKRNTESVKGLRKYERRVKELTYQSEEDRKN 1861

  Fly  1780 -IKLEDIELPSHLNLDEFLTKI 1800
             ::|:|:       :|:...|:
Mouse  1862 VLRLQDL-------VDKLQVKV 1876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 281/741 (38%)
MYSc_Myo5 84..767 CDD:276831 270/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 33/148 (22%)
coiled coil 1049..1068 CDD:293879 5/19 (26%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/175 (19%)
Myo5_CBD 1424..1792 CDD:271254 73/398 (18%)
Myh3NP_001093105.1 Myosin_N 35..73 CDD:367160 6/28 (21%)
MYSc_Myh3 100..767 CDD:276878 270/711 (38%)
Actin-binding. /evidence=ECO:0000250 656..678 12/21 (57%)
Actin-binding. /evidence=ECO:0000250 758..772 7/13 (54%)
Myosin_tail_1 847..1924 CDD:366712 216/1161 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 6/28 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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