DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh2

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus


Alignment Length:2070 Identity:520/2070 - (25%)
Similarity:906/2070 - (43%) Gaps:461/2070 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.:.||........:..|.|.   :||:.||      ||.:.:.|::|....||    ...:
Mouse    20 SEKERIEAQNRPFDAKTSVFVAEP---KESFVKGTIQSKDAGKVTVKTEAGATLTVK----EDQI 77

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            .|: ||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::
Mouse    78 FPM-NPPKYDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNPEVV 140

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
Mouse   141 AAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDK 205

  Fly   189 SETQ---------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            .:.:         :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
Mouse   206 KKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIE 267

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDA 304
            |||||||||.:|.:.||:||||||:.:  :|.||     |:..:...:.|::.|.. .:..:.|.
Mouse   268 TYLLEKSRVTFQLKAERSYHIFYQITS--NKKPELIEMLLITTNPYDYPFVSQGEI-SVASIDDQ 329

  Fly   305 EQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQ- 368
            |:...|..|:.:|||:..:...|.|:...::|.||::..:|..|  |:.:.|..::.....:|| 
Mouse   330 EELMATDSAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQG 392

  Fly   369 -ITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKS 432
             .:||||:.        |...:::..||||....::|....|..||||.:|.|:|.::|..:|:.
Mouse   393 LNSADLLKA--------LCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQ 449

  Fly   433 LNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMI 497
            |:....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.|
Mouse   450 LDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFI 514

  Fly   498 DF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPRF----GTTS 556
            || .|...||:|||..:|:..:|:|||..||.:|.|:..||..: ..|..:|:||:.    ....
Mouse   515 DFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 579

  Fly   557 FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGG 621
            |.:.|::.||:|::.|:|:||:|.:::.:..:..:|:      |.||..:.:....:...::.||
Mouse   580 FSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSS------VKTLAYLFSGAQTAEAEASSGG 638

  Fly   622 RVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFK 686
              ....|.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|....
Mouse   639 --AAKKGAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGA 690

  Fly   687 WETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVM 748
            .|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...::.
Mouse   691 MEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL-NASAIPEGQYIDSKKASEKLLG 754

  Fly   749 KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQ 813
            ....|..:|:||:|::||:||.:..||::|.:                       ::.::|...|
Mouse   755 SIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDD-----------------------KLAQLITRTQ 796

  Fly   814 KHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARN 871
            ...||:|||...|||.|.|..:...:|       .:.|...:.:.:::..:...:|.......:.
Mouse   797 AMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKE 861

  Fly   872 KFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFK-----RMKAEAKTI 931
            :|...:|.        ..:....|:..:::..:::             |.|     :::|||:.:
Mouse   862 EFQKTKDD--------LAKSEAKRKELEEKMVSLL-------------KEKNDLQLQVQAEAEGL 905

  Fly   932 SHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------AE 985
            :..|.:...|....|.::.:|.|:.....:.:...:|::..|.||     ||||.::      |:
Mouse   906 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 970

  Fly   986 FKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------LE 1019
            .:..|.|.::|           |:.|..|.|:              |:||.|:...|      ||
Mouse   971 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1035

  Fly  1020 ENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEA-YQRA 1083
            :.....|..:.|::..|.:.|..:|:::..:.:|:.:.::..|::.::...:..:|...: .|..
Mouse  1036 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSK 1100

  Fly  1084 IKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSK 1147
            |:|::.|..: ...:||..:|:......:.|.:||.|.::          |...|::|..:.:|:
Mouse  1101 IEDEQAIGIQLQKKIKELQARIEELEEEIEAERASRAKAE----------KQRSDLSRELEEISE 1155

  Fly  1148 NY-SYNDSTSLVVKLRSILEEEKQKHK------VLQEQYIKLSSRHKPTEDSFRVSE-------- 1197
            .. ....:||..:::....|.|.||.:      .||.:....:.|.|..:....:.|        
Mouse  1156 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1220

  Fly  1198 ---LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNAQHA 1230
               ||.|..:::.|.|.|.:::      |..:|                       ||:|..|..
Mouse  1221 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRG 1285

  Fly  1231 ALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQ-KLINRQLESELK 1294
            .||.|......:..:.:|::.|.|             ||.      :||..| :.:.||||.|:|
Mouse  1286 RLQTESGEFSRQLDEKEALVSQLS-------------RGK------QAFTQQIEELKRQLEEEVK 1331

  Fly  1295 A--------ITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFED----SNVDTLRQNDRYL 1347
            |        .:..|:..|  :.::.|.....|.|||:.:.::..|...    ...|.:::.:.. 
Mouse  1332 AKNALAHALQSSRHDCDL--LREQYEEEQESKAELQRALSKANSEVAQWRTKYETDAIQRTEEL- 1393

  Fly  1348 RRELQKAVAQFLLVQEE-LKLANAKLKAYRQDGGQLEHKIEEEMI-------------------- 1391
             .|.:|.:||.|...|| ::..|||..:..:...:|::::|:.|:                    
Mouse  1394 -EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1457

  Fly  1392 ------RNKSNGTSADVGANVTKQKSQNPQGLMKF---HSSDLDKI---------LQRLLSALTP 1438
                  :.|...|.|::.|:..:.:|...: |.|.   :...||::         ||:.:|.||.
Mouse  1458 KILAEWKQKYEETHAELEASQKEARSLGTE-LFKMKNAYEESLDQLETLKRENKNLQQEISDLTE 1521

  Fly  1439 RTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL 1503
            :...|            ..|..:|......|.:...:....:::...:....|.:::.:     .
Mouse  1522 QIAEG------------GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI-----Q 1569

  Fly  1504 LNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILD----------------------LIV 1546
            |.|.:...::|..:....|:.:|.:..:..:.|..:..||                      :.:
Mouse  1570 LELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEI 1634

  Fly  1547 NLYQALIMQIQGLLDPKIVPAILNN-----DEIQRG------------RQAHGMRSRATSIGASS 1594
            .|..:..|..:.|.:.:....||.:     |:..||            |:|:.:::....:.|: 
Mouse  1635 QLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRAT- 1698

  Fly  1595 SPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNC-LMLRGDICMWET 1658
                         :.|.|...|..:...||  .:|::  |||:......:|. ..|..||...: 
Mouse  1699 -------------LEQTERSRKIAEQELLD--ASERV--QLLHTQNTSLINTKKKLETDISQIQ- 1745

  Fly  1659 GMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDL 1711
                    |.:||.|:..:.:.:  .|...:...:.:.:..|.|||.            ||:.||
Mouse  1746 --------GEMEDIVQEARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1800

  Fly  1712 CTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNAR---------QMQKSNSD-------- 1759
            ...|..|:.| .:|..|              |..:||.||         ..||.|::        
Mouse  1801 QLRLDEAEQL-ALKGGK--------------KQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1850

  Fly  1760 -----EFTIDQKFIQPFKVVFRYSDI-------------KLEDIELPSHLNLDEF 1796
                 |.|...:  :..|.:.|..|:             :.|:.|..|:.||.:|
Mouse  1851 ERRVKELTYQTE--EDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSKF 1903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 277/739 (37%)
MYSc_Myo5 84..767 CDD:276831 266/709 (38%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 32/157 (20%)
coiled coil 1049..1068 CDD:293879 2/18 (11%)
coiled coil 1077..1086 CDD:293879 2/9 (22%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/157 (20%)
Myo5_CBD 1424..1792 CDD:271254 78/463 (17%)
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832 10/39 (26%)
Myosin_head 88..773 CDD:278492 270/721 (37%)
Motor_domain 100..773 CDD:277568 266/709 (38%)
Myosin_tail_1 853..1930 CDD:279860 210/1169 (18%)
RILP-like 968..1101 CDD:304877 24/132 (18%)
MIT_CorA-like <1302..>1414 CDD:294313 31/134 (23%)
DUF342 <1673..1770 CDD:302792 21/125 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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