DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh11

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_006521906.1 Gene:Myh11 / 17880 MGIID:102643 Length:1979 Species:Mus musculus


Alignment Length:2006 Identity:548/2006 - (27%)
Similarity:907/2006 - (45%) Gaps:410/2006 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|:|:::|  .||...:....::||    |:.....|:..: ||.......|:..|
Mouse    36 VWVPSEKQGFEAASIKE--EKGDEVVVELVENGK----KVTVGKDDIQKM-NPPKFSKVEDMAEL 93

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..||||||.|:.. .:||||.|:..|.:|||..:|:|...|:..|:|....::.|||:|:
Mouse    94 TCLNEASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMPPHIYAI 157

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS------ESETQ--------VE 194
            |:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|      .|.||        :|
Mouse   158 ADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQGPSFAYGELE 222

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
            :::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.
Mouse   223 KQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAIRQARD 284

  Fly   260 ERNYHIFYQLCA-ARSKY-PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ||.:||||.|.| |:.|. .:|:|:..:.:.||:.|..| |....|.|.|.||::||:::||:.:
Mouse   285 ERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNGFVP-IPAAQDDEMFQETLEAMSIMGFNEE 348

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            :...|:|:::.:|.|||| |.||      |.::|...:..|.. .|....|:.::..|..|.:|.
Mouse   349 EQLAILKVVSSVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVCHLVGINVTDFTRAILT 405

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGF 451
            .:|:...:.|....:.|.|..|.:||||..|.:||::|:..:||:|:...:| .||:|:|||.||
Mouse   406 PRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGF 470

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE---SR 512
            |.||||||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||:|||   :.
Mouse   471 EIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNP 535

  Fly   513 LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLE 575
            .|||.||||||..||.:|:|:..||..:....|.|:||:  ...|.|.|.|::..|:|:.:.:|.
Mouse   536 PGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLT 600

  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTL-EEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRR 639
            ||.|.::..:|.:|   |.|..|.|..| :::|              |:|   |..|....|...
Mouse   601 KNMDPLNDNVTSLL---NASSDKFVADLWKDVD--------------RIV---GLDQMAKMTESS 645

  Fly   640 VVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700
            :..:.:.:|    |||..::|.|..|::||..|||::||||.||.:|.:.|.:...:::|||..|
Mouse   646 LPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNG 710

  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQ 763
            |||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:.||.|.::
Mouse   711 VLEGIRICRQGFPNRIVFQEFRQRYEILA-ANAIPKGFMDGKQACILMIKALELDPNLYRIGQSK 774

  Fly   764 IFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER-TQK 827
            ||||.|.:|.||:.|.                       |:|..||...|...||||||:. |::
Mouse   775 IFFRTGVLAHLEEERD-----------------------LKITDVIMAFQAMCRGYLARKAFTKR 816

  Fly   828 MREARAGLILSKYARGWLCRR--RYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVR 890
            .::..|..::.:....:|..|  ::.||...:..:....|   ...:..|..:..:.::.::...
Mouse   817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR---QEEEMQAKEEEMQKIKERQQKA 878

  Fly   891 GALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMEN-------KYMGLENKIISM 948
            ....:...||.      .|.|..:.|.:   ::::||.:..:..|.       |...||..:..|
Mouse   879 ETELKELEQKH------TQLAEEKTLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

  Fly   949 QQRIDE--------------LNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFKNVK---AACQD 995
            :.|::|              :.:...:|:.:..|....:.||:|:| |.||:.|.::   ....|
Mouse   935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDD 999

  Fly   996 KDKLIEALNKQLE----------AERDEKMQLLEENGHAQEEWISQ-------KQTWRQENEELR 1043
            ::..:....|.||          ||.:||.:.|.:.....|..||:       ::..|||.|:|:
Mouse  1000 QNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLK 1064

  Fly  1044 RQI--------DEIIDM-AKNAEVNQR--NQEDRM---LAEIDNRELNEAYQR--AIKDKEVIEN 1092
            |::        ::|.|: |:.||:..:  .:|:.:   ||.:|    .|..|:  |:|....:|.
Mouse  1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD----EEIAQKNNALKKIRELEG 1125

  Fly  1093 ENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVG--YASAKNTLDINRPPDLLSKNYSYNDST 1155
            ....|:|:|.         ..|.|.|.:.:.:.|:|  ..:.|..|:     |.|       |||
Mouse  1126 HISDLQEDLD---------SERAARNKAEKQKRDLGEELEALKTELE-----DTL-------DST 1169

  Fly  1156 SLVVKLRSILEEE----------------------KQKHKVLQEQYIKLSSRHKPTEDSFRVSE- 1197
            :...:||:..|:|                      :|||....|:..:...:.|..:.:...|: 
Mouse  1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQ 1234

  Fly  1198 -LEVENEKLRSE---YDQLRTSIKH-----GVEINELNAQ-------HAALQEEVRRRREECIQL 1246
             ||.||..|..|   ..|.:..::|     .|::.:|.::       .|.|.::|.:.:.|...:
Mouse  1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESV 1299

  Fly  1247 KAVLLQQSQSMRSLEPE--SLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQ 1309
            ..:|.:.......|..:  ||..:..|..||::....|||   .:.::|:.:.:|.||...::.:
Mouse  1300 TGMLNEAEGKAIKLAKDVASLGSQLQDTQELLQEETRQKL---NVSTKLRQLEDERNSLQDQLDE 1361

  Fly  1310 EIE---RLNNEKDELQKVMFESIDEFED--SNVDTLRQNDRYLRREL--------QKAVAQFLL- 1360
            |:|   .|......|...:.:|..:.:|  |.::.:.:..:.|::|:        :||.|...| 
Mouse  1362 EMEAKQNLERHVSTLNIQLSDSKKKLQDFASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLE 1426

  Fly  1361 -----VQEELKLANAKLKAYRQDGGQLEHK--------IEEEMIRNK----SNGTSADVGANVTK 1408
                 :|:||......|...||....||.|        .||:.|.:|    .:...|:.....||
Mouse  1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

  Fly  1409 QKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDD----V 1469
            ..|             |.:.|:..|.|.........:         :.....||.::.||    |
Mouse  1492 ALS-------------LARALEEALEAKEELERTNKM---------LKAEMEDLVSSKDDVGKNV 1534

  Fly  1470 REL----------LSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQY-GDVDEYVKFNTEK 1523
            .||          :.:...|::::.......|:..:.|  .:.:..|..|: .|:....:.|.||
Mouse  1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEK 1597

  Fly  1524 QNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRAT 1588
            :.|.|.:   |.||...:.|  ....:||....:..|:..:....|..|...:||:         
Mouse  1598 RRQLQRQ---LHEYETELED--ERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE--------- 1648

  Fly  1589 SIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYA--EQIFHQLLYFICAVA----LNCL 1647
                         .|.||| .:|:...|.||. .||:..|  ::||        |.:    ....
Mouse  1649 -------------EAIKQL-RKLQAQMKDFQR-ELDDARASRDEIF--------ATSKENEKKAK 1690

  Fly  1648 MLRGDICMWETGMIIRYNIGCIEDWVRSKK--------MSNDVLTALAPLN-----------QVS 1693
            .|..|:      |.::.::...|   |::|        ::.::.::|:..|           :::
Mouse  1691 SLEADL------MQLQEDLAAAE---RARKQADLEKEELAEELASSLSGRNTLQDEKRRLEARIA 1746

  Fly  1694 QLLQSRKSEQ-DVQTICD---------------LCTSLSTAQ-----------VLKVMKSYKLDD 1731
            ||.:..:.|| :::.:.|               |.|..||||           ..|.::| ||.:
Mouse  1747 QLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLQE 1810

  Fly  1732 YESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIEL 1787
            .|..: ...|:.....|.|:..|.....|....:|  |......:..|.||:::.|
Mouse  1811 VEGAV-KAKLKSTVAALEAKIAQLEEQVEQEAREK--QAATKSLKQKDKKLKEVLL 1863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 295/742 (40%)
MYSc_Myo5 84..767 CDD:276831 283/712 (40%)
IQ 900..922 CDD:197470 4/21 (19%)
GBP_C <971..1086 CDD:303769 38/151 (25%)
coiled coil 1049..1068 CDD:293879 6/24 (25%)
coiled coil 1077..1086 CDD:293879 3/10 (30%)
JAKMIP_CC3 <1190..1299 CDD:292653 26/127 (20%)
Myo5_CBD 1424..1792 CDD:271254 82/431 (19%)
Myh11XP_006521906.1 Myosin_N 33..71 CDD:367160 11/40 (28%)
MYSc_class_II 99..778 CDD:276951 283/712 (40%)
Myosin_tail_1 855..1935 CDD:366712 223/1123 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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