Protein Alignment didum and hum-5

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_497809.1
• Gene: hum-5 / 175521
• WormBaseID: WBGene00002038
• Length: 1017
• Species: Caenorhabditis elegans
• Alignment Length: 1063
• Identity: 325/1063 - (30%)
• Similarity: 515/1063 - (48%)
• Gaps: 182/1063 - (17%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..||..||.:....|:.||::|| ::..||||.|.:|||:|||.::.:|..|.:..|:|..:.:
 Worm    12 GVEDLVLLSTIDLKSVVQNLQLRF-QKGRIYTYIGEVLVAVNPYRQLGIYEKSTVDQYKGREIYE 75

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER---KV 197
            ..||:||:|:.||..::|...:..|::|||||||||.::|..|:|.||:.....:.::||   .:
 Worm    76 RAPHVFAIADAAYRSMKRFGRDSCIVISGESGAGKTETSKIIMKYLAAITNVRQQGEIERVKNVL 140

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.|:.|:||||.||||||||||||||:..:.|......:   |..:..|||||||||.|.:||||
 Worm   141 LRSNCILEAFGCAKTTRNDNSSRFGKYMHINFDYDGDPV---GGNISNYLLEKSRVVRQQEGERN 202

  Fly   263 YHIFYQLCAARS----KYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAM-TVLGFSIQ 322
            :|:||||.....    :...|..|.: ::.|||.|.:.::..::|:..|.|...|: ::..|..|
 Worm   203 FHVFYQLVNGGDDGLLRQFGLTKDAK-QYYFLNQGQSHKVASINDSRDFAEVQTALRSIHTFDKQ 266

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            .:..:..::||::||||:    :|.:|   |:|...........||..|..|.|:.|:|.:.|..
 Worm   267 DVESMWSVIAGLIHLGNV----RFIDG---ENSSGAVHIAEKAALQNAARCLNVTPDELAKSLSS 324

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNK--SLNNGSK--QCSFIGVLDI 448
            :.:.:..:.|...:.:.||...||||||.:|.:||.::|..:|:  |:.|.|:  :...||||||
 Worm   325 QVVAAHGDIVKKQHDVNAAYYTRDALAKALYERLFSWMVSKVNEAISVQNSSRYSKSHVIGVLDI 389

  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIE-SR 512
            ||||.|..|||||.||||.||||||.|.:.|.|.|||||.:|||.|..|::::|:...||:| .|
 Worm   390 YGFEIFGTNSFEQLCINYCNEKLQQLFIELVLKQEQEEYEREGIKWVKIEYFNNKVICDLVEIPR 454

  Fly   513 LGVLDLLDEEC-RMPKGSDESWAGKLIGKCNKFPHF-------EKPRFGTTSFFIKHFSDTVEYD 569
            .|:|.:|||.| .:...:|:.:.|:|..|.....|:       .....|...|.|.|::..|.|.
 Worm   455 TGILSILDEACASIGNVTDKVFLGELDKKLKSHKHYTSRNLKQSDKSMGFEEFKITHYAGDVTYS 519

  Fly   570 VNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGN 634
            |.||::||:||:.::|.::|..|...|.|         :|..|.:||..
 Worm   520 VMGFMDKNKDTLFQDLKRLLYHSKNRLVK---------SLFPDGSKSMA---------------- 559

  Fly   635 DTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRAC 699
            :..||       ..|.|..|:.|::.|:..|....|||:||||||::|.:..::..::..|:|..
 Worm   560 EVNRR-------PPTAGFLFKNSMSELVKQLAQKEPHYIRCIKPNEEKNSNVFDLERVEHQVRYL 617

  Fly   700 GVLETVRISAAGFPSRWLYPDFYMRYQLL---VYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGN 761
            |:||.||:..|||..|..|..|..||:|:   .:.:......:|.||..|:......:|..: |.
 Worm   618 GLLENVRVRRAGFAHRMPYDRFVNRYKLICASTWPNPRRGQQLKDSCMQILESAGLAQDCVQ-GR 681

  Fly   762 TQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVR----RFVYRRQFLRIQKVINGIQKH-ARGYL 820
            |:||.|:.|..| ||::|.......||.:|.:||    |..||| .|.::|:|...::: .:.|:
 Worm   682 TKIFIRSPQTVFRLEELRTEQLPNVITFLQKMVRGVQQRERYRR-MLAVRKIIGAYRRYKLKSYI 745

  Fly   821 -----ARERTQKMREA---------------------------RAGLILSK-------------- 839
                 |....::||:.                           ||..||::
 Worm   746 WQLINAFRDVRRMRDLGKSIRWPAPPLVLAQFVSRLRVMHQRWRAATILARMPPHLRASLPQKIA 810

  Fly   840 -------------YARGWLCRRRYLRLRHSI---SGIQTYARGMLARNKFHAMRDHYRAVQIQRF 888
                         |.|.|  |..||..:..:   :.:.||..|:.|..:.|.......:..:|:|
 Worm   811 AFEVLNNKKENWGYTRMW--RGDYLSQQEELELPTTVSTYHDGIQALRQSHPFGKVLFSTYVQKF 873

  Fly   889 VRGALARRAYQKRRRNIIICQAAIRRFLAR---RKFKRMK--------------AEAK--TISHM 934
                   ..:.|....::|   ...||:|:   :|||.:|              ||:.  .:.|:
 Worm   874 -------NKFNKSSLRVLI---VTDRFVAKLENKKFKLLKEPIPLQSISRISVCAESNGLFVIHV 928

  Fly   935 -ENKYMGLENKIISMQQRI-----------DELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFK 987
             :|..:|.. |....::|:           |::....|.:..:::.:..|..|....:..:||..
 Worm   929 GDNDIVGCA-KNTKNEERVGEMIGTLLAHYDKITMRRSPVLIQSAVVCTLGGKTRTIRVFDAENN 992

  Fly   988 NVKAACQDKDKLIEALNKQLEAE 1010
            ||....:.....::.:..||.|:
 Worm   993 NVPPVFKKNGNDVDLICHQLTAQ 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	254/706 (36%)
		IQ	900..922	CDD:197470	6/24 (25%)
		SMC_prok_B	<942..1365	CDD:274008	13/80 (16%)
		Myo5_CBD	1424..1792	CDD:271254
hum-5	NP_497809.1	MYSc	6..699	CDD:214580	264/731 (36%)
		Myosin_TH1	808..986	CDD:461801	33/190 (17%)