Protein Alignment didum and nmy-2

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_492186.3
• Gene: nmy-2 / 172562
• WormBaseID: WBGene00003777
• Length: 2003
• Species: Caenorhabditis elegans
• Alignment Length: 1855
• Identity: 468/1855 - (25%)
• Similarity: 815/1855 - (43%)
• Gaps: 400/1855 - (21%)

  Fly     3 SEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPA 67
            ||:..:|.||.|..||||...:...:|...|:                 ::.:|....|   ||.
 Worm    39 SEKDGFALGAVIGEPHADGTIDIELMETGERQ-----------------RVSSDDCQKP---NPP 83

  Fly    68 ILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHA 132
            ......|::.|:.|:|..|||||:.|:.. .:.|||.|:..|.||||..:|:|..:|...::...
 Worm    84 KYDKCEDMSMLTCLNEASVLHNLKQRYFS-NLYYTYSGLFCVVINPYKRIPIYTDTIAEQFKCKK 147

  Fly   133 MGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS---------- 187
            ..::.|||||:|:|||..:.:|..:.||:.:||||||||.:.|..::|.|.|...
 Worm   148 RKEMPPHIFAVADEAYRSMLQERDDQSILCTGESGAGKTENTKKVIQYLAYVANRSMVKNRKTSV 212

  Fly   188 --ESET-----QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHT 245
              ::.|     |:|.::|.::||:|||||:||.:||||||||||.::.| :..|.  :.||.:..
 Worm   213 DLDTSTNRIMGQLEEQLLQANPILEAFGNSKTVKNDNSSRFGKFIRVHF-DSTGC--ISGANIEF 274

  Fly   246 YLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE---LVLDHQDKFQFLNMGGAPEIERVSDAEQF 307
            ||||||||:.||..||::||||||....||...   |:.|...|::|::.|.: ::..|.|..:.
 Worm   275 YLLEKSRVLKQAPNERSFHIFYQLLKGLSKVQREHYLLEDSLSKYKFVSNGDS-KLAGVDDGAEM 338

  Fly   308 NETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITAD 372
            .||:.||:::|.:.::|..|:::::.::..||::.|      .|.:::|.. :..||...|..|.
 Worm   339 KETLNAMSIMGLNDEEIGGILRVVSAVMLFGNLEFS------HENKNNDQA-VLLNDAVAQKIAS 396

  Fly   373 LLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGS 437
            ||.|:..:|.|..|..||:...:.|....|::....:..|:||..|.:||:::|..|||||:...
 Worm   397 LLGVNVTELMRAFLKPKIKVQRDLVHRAQSVDQVNFSVGAIAKASYERLFRWLVHRLNKSLDRTR 461

  Fly   438 KQ-CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYD 501
            :| .||||:|||.|||.||.|||||.||||.||||||.||..:|..||:|||.||:.|..:||..
 Worm   462 QQSVSFIGILDIAGFEIFETNSFEQLCINYTNEKLQQLFNNTMFVREQQEYLDEGLEWKFLDFGL 526

  Fly   502 N-QPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTS-FFIKHFSD 564
            | ||.||||:..:|::..||:.|..|:|:|:|:..:|....::.|.:..|...:.| |.:.|::.
 Worm   527 NLQPTIDLIDKPMGIMSTLDDVCLFPQGNDQSFVQRLNNTHSQHPKYVVPEIRSRSDFAVVHYAG 591

  Fly   565 TVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSST-----LGGRVV 624
            .|:|...|:..||.|.:::.:..||..|..||.  |...::|..:|..||..||     .|.|
 Worm   592 RVDYQSEGWRVKNMDPLNENVIDVLKTSKESLI--VDMWKDIADVCSLSAADSTSDTGVFGSR-- 652

  Fly   625 ISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWET 689
                            ||.|...:||...::|.||.|:|||:.|.||:||||.||.:|.......
 Worm   653 ----------------VPKKGMFRTVSQLYKEQLARLMSTLNNTNPHFVRCIIPNHEKKHGVLNA 701

  Fly   690 AKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMK----LSCRNIVMKW 750
            ..::.|||..||||.:||...|||:|..:.:|..||:      ||...|:.    :..:|.|.:.
 Worm   702 HLVLDQLRCNGVLEGIRICRQGFPTRLPFQEFRQRYE------KLLAPDVNPAGFMDGKNAVYRI 760

  Fly   751 IQ----DEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811
            :|    |.:.:|.|.::||||:|.:|..|::|..                       ::..:|..
 Worm   761 VQYLEVDANLFRIGQSKIFFRSGVIAEFEEMRDQ-----------------------KLSALIES 802

  Fly   812 IQKHARGYLARERTQKMREARAGL-ILSKYARGWLCRRRYL------------------------ 851
            .|...||:|.|....:.||....: ||.:....|:..|.:.
 Worm   803 FQAQCRGWLGRRVMVRRREQEVAIKILQRNGLAWMRLREWQWWRLLTKVKPLLEVTNKDELIAER 867

  Fly   852 ---------RLRHSISGIQTYARGM--------LARNKFHAMRDHYRAVQIQRFVRGALARRAYQ 899
                     :||.|...|..|.:.|        :.:.:..|.......:..:|      :|.|.:
 Worm   868 EQELKVTAEKLRRSEVFISDYKQQMEKMDEERLVLKTRLDAESSERAEIFEER------SRMAAR 926

  Fly   900 KRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHM------------------------------ 934
            :.....|:.:.:.|..:..:|.|:..:|::.::.|
 Worm   927 RDELEGILEEVSKRLEIEEQKAKKADSESRKLTEMVRHLEENLEDEERSRQKLLLEKNSIESRLK 991

  Fly   935 ENKYMGLE-----NKII----SMQQR--------IDELNRDNSNLKHKTS-EISVLKMKLELKK- 980
            |.:..|||     ||:.    ::::|        |||:.|....:|.|.. |.:|.::..||:|
 Worm   992 ELEAQGLELEDSGNKLSKEKKALEERCEDLSSRLIDEVERSKQLVKAKARLEATVAEINDELEKE 1056

  Fly   981 ------------TLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQ 1033
                        ..|.:.:..:.:|.:|.:..|.|..||..:..|..|:...|    :|.::.:|
 Worm  1057 KQQRHNAETARRAAETQLREEQESCLEKTRKAEELTNQLMRKESELSQISIRN----DEELAARQ 1117

  Fly  1034 TWRQENEELRRQIDEII------------------DMAKNAEVNQRNQED---------RMLAEI 1071
            ...:|..|:|.|:|:.|                  |||:..|..::..|:         ::.|:.
 Worm  1118 QLEREIREIRAQLDDAIEETNKEKAARQKAEKARRDMAEELESYKQELEESNDKTVLHSQLKAKR 1182

  Fly  1072 DN-------------------------------RELNEAYQR-------AIKDKEVIENENFMLK 1098
            |.                               .||||...:       |.|.|...|::|...:
 Worm  1183 DEEYAHLQKQLEETVKSSEEVVEEMKAQNQKKIEELNETIDQLKRQKISADKAKSSAESDNENFR 1247

  Fly  1099 EELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRS 1163
            .|||.:.:.......::.:..:|..|.|......::.||     ||::|....|:....:.|.:|
 Worm  1248 AELSNIASARLEAEKKRKAAETSLMEKDHKMREMQSNLD-----DLMAKLSKMNNELESIQKAKS 1307

  Fly  1164 ILEEEKQKHKVLQEQY---IKLSSRHKPTEDSFR--------VSELEVE--------------NE 1203
              .:|.....:|::..   ::||...:.:|:..|        :.:||.:              .|
 Worm  1308 --ADETLNSNLLKKNASLDMQLSELTEASEEDRRTRATLNNKIRQLEEDLAVAVEARDDALDAQE 1370

  Fly  1204 KLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQL---KAVLLQQSQSMRSLEPESL 1265
            |:..|..::::.:....:  :|:.::..:.||:|:::|:.:..   :|.:.:|::.......:..
 Worm  1371 KIEKEVKEVKSLLAEARK--KLDEENREVMEELRKKKEKELSAEKERADMAEQARDKAERAKKKA 1433

  Fly  1266 QMRGNDV-NELMEAFHSQKLINRQLESELKAITEEHNSKLV---------EMTQEIER----LNN 1316
            .....|| .||.:...:.:.:.|::....:.:.||.|:.|:         :|.::.|.    |:|
 Worm  1434 IQEAEDVQKELTDVVAATREMERKMRKFDQQLAEERNNTLLAQQERDMAHQMLRDAETKALVLSN 1498

  Fly  1317 EKDELQKVMFESIDEFE--------------------DSNVDTLRQNDRYLRRELQKAVAQFLLV 1361
            |..|.:.:    :|:.|                    ..||..|.:..|.|..||.:|..|.:.:
 Worm  1499 ELSEKKDI----VDQLEKDKRTLKLEIDNLASTKDDAGKNVYELEKTKRRLDEELSRAEQQIIEL 1559

  Fly  1362 QEELKLAN-------AKLKAYRQD-GGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLM 1418
            ::.|:||:       ..::|.|.: ..||..:.|:|..|.|  |.::.: .|:|::.....:...
 Worm  1560 EDALQLADDARSRVEVNMQAMRSEFERQLASREEDEDDRKK--GLTSKI-RNLTEELESEQRARQ 1621

  Fly  1419 KFHSSDLDKILQRLLSALTPRTVVGL--LPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIK 1481
            ...::  .|.::..:|.||.:....|  :......|....:.:.||.....:.|..:...:...:
 Worm  1622 AAIAN--KKKIESQISELTEKNEASLRQIEDLSRQLRKAQLGWKDLQLDVTEARAAMEDALAGQR 1684

  Fly  1482 KMHRTPHPIENRVIWLVNSITLLNLMKQYGDV--DEYVKFNTEKQNQQQLKNFNLFEYRRVILDL 1544
            ...:.....|:.:..|...|..::..|:..:.  ||.:    |:.:..:..:|:..|.||:
 Worm  1685 DAEKRARASEDEIKRLTADIQAVSSSKRKAEAERDELI----EEVSSLRASSFSNEEKRRL---- 1741

  Fly  1545 IVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQ 1579
                 :|.::.::..||.:.....|..:::::.:|
 Worm  1742 -----EAKVIDLEDQLDEEASANELAQEKVRKSQQ 1771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	265/718 (37%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	107/580 (18%)
		Myo5_CBD	1424..1792	CDD:271254	25/160 (16%)
nmy-2	NP_492186.3	MYSc_class_II	100..781	CDD:276951	265/718 (37%)
		Myosin_tail_1	858..1934	CDD:460256	165/955 (17%)