DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and unc-15

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001379131.1	Gene:	unc-15 / 172491	WormBaseID:	WBGene00006754	Length:	872	Species:	Caenorhabditis elegans

Alignment Length:	850	Identity:	168/850 - (19%)
Similarity:	340/850 - (40%)	Gaps:	189/850 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   813 QKHARGYLARER----------TQKMREAR----AGLILSKYARGWLCRRRYLRLRHSISGIQTY 863
            ::..|..:.|||          |.::.:|.    :.:..::...|.|.:.|.|.....:....
Worm    52 ERELRNRVERERADLSVQVIALTDRLEDAEGTTDSQIESNRKREGELSKLRKLLEESQLESED-- 114

  Fly   864 ARGMLARNKFHAMRDHYRAV-QIQRFVRGALARRAYQKRRRNIIICQAAI-----RRFLARRKFK 922
            |..:|.:....:..|:...: |:|:  :.|...|..|:.:..:|...|.|     .:..|.:..:
Worm   115 AMNVLRKKHQDSCLDYQDQIEQLQK--KNAKIDRERQRVQHEVIELTATIDQLQKDKHTAEKAAE 177

  Fly   923 RMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLE----LKKTLE 983
            |.:|:|   :.:.||...|...:..:.|:...|..:|::|   ..|:...|::|:    :|.||.
Worm   178 RFEAQA---NELANKVEDLNKHVNDLAQQRQRLQAENNDL---LKEVHDQKVQLDNLQHVKYTLA 236

  Fly   984 AEFKNVKAACQDKDKLIEALNKQL---EAERDEKMQLLEENGHAQ---EEWISQKQT----WRQE 1038
            .:.:..:...:|.::....|..||   :.|.|.....|:|...|:   |..::...|    |:.:
Worm   237 QQLEEARRRLEDAERERSQLQSQLHQVQLELDSVRTALDEESIARSDAEHKLNLANTEITQWKSK 301

  Fly  1039 -NEELRRQIDEIIDMAKNAEVNQRNQEDR---MLAEIDNRE-----LNEAYQRAIKDKEVIENEN 1094
             :.|:....:|:.|:.|.....|...|::   ||.:|...|     |....:..|.|.|..:|..
Worm   302 FDAEVALHHEEVEDLRKKMLQKQAEYEEQIEIMLQKISQLEKAKSRLQSEVEVLIVDLEKAQNTI 366

  Fly  1095 FML---KEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL-DINRPPDLLSKNYSYNDST 1155
            .:|   :|:|.| ..|...:..         :|..|...:|:..| .:|  .:|....:.|..:
Worm   367 ALLERAREQLER-QVGELKVRI---------DEITVELEAAQRELRAVN--AELQKMKHLYEKA- 418

  Fly  1156 SLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGV 1220
              |.:..::..|.|:.|..|.|....|:..::      ::.||::||.:|..|..:|:|::|
Worm   419 --VEQKEALARENKKLHDELHEAKEALADANR------KLHELDLENARLAGEIRELQTALK--- 472

  Fly  1221 EINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGN---DVNELMEAFHSQ 1282
               |.:||....:...:|...|   |:|:.::..:.::..|.|...:|.|   :::.|:.|....
Worm   473 ---EADAQRRDAENRAQRALAE---LQALRIEMERRLQEKEEEMEALRKNLQFEIDRLIAALADA 531

  Fly  1283 KLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVM---FESIDEFEDSNVDTLRQND 1344
            :   .:::||:..:.:::.:::.|:...::.||....|.||.:   .|.:...:.|..||
Worm   532 E---ARMKSEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKILQASLEDT----- 588

  Fly  1345 RYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKI----EEEMIRNKSNGTSAD---V 1402
               :|:||:.:.|:.|.|.::...:|:|:..:.   .|::.|    :.|:...::||..:|   :
Worm   589 ---QRQLQQVLDQYALAQRKVAALSAELEECKT---ALDNAIRARKQAEVDLEEANGRISDLISI 647

  Fly  1403 GANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADD 1467
            ..|:|..|::....| ....:|||::.:                              :|..||:
Worm   648 NNNLTSIKNKLETEL-STAQADLDEVTK------------------------------ELHAADE 681

  Fly  1468 DVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF 1532
            .....|:.....::::|....          :|:.:..|.|   .::|.|     ||.|.|::..
Worm   682 RANRALADAARAVEQLHEEQE----------HSMKIDALRK---SLEEQV-----KQLQVQIQEA 728

  Fly  1533 N---LFEYRRVILDL---IVNLYQAL--------------------IMQIQGLLDPKIVPAILNN 1571
            .   |...:|||..|   |.:|..||                    |.::|.|:|.:....::..
Worm   729 EAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEVQQLVDEEHKNFVMAQ 793

  Fly  1572 DEIQR 1576
            |...|
Worm   794 DTADR 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580
		MYSc_Myo5	84..767	CDD:276831
		IQ	900..922	CDD:197470	4/26 (15%)
		GBP_C	<971..1086	CDD:303769	29/137 (21%)
		coiled coil	1049..1068	CDD:293879	4/21 (19%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	24/111 (22%)
		Myo5_CBD	1424..1792	CDD:271254	31/178 (17%)
unc-15	NP_001379131.1	Myosin_tail_1	<32..839	CDD:396244	167/849 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910