DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myo-1

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_492053.1 Gene:myo-1 / 172471 WormBaseID:WBGene00002348 Length:1938 Species:Caenorhabditis elegans


Alignment Length:1903 Identity:497/1903 - (26%)
Similarity:862/1903 - (45%) Gaps:396/1903 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEML------YAQGAKIWVPHADLVWESATLEESYRKGAGFLK---------ICTDSGKLKEV 51
            |.|:.|      |.....:|:|.|         ||.|.:|.  :|         |.|..|  |:|
 Worm    17 SREQQLADQSRPYDSKKNVWIPDA---------EEGYIEGV--IKGPGPKADTVIVTAGG--KDV 68

  Fly    52 KLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAE 116
            .||   .|:....||.......|::.|::|::..||.|||.|:. ..:||||.|:..|.||||..
 Worm    69 TLK---KDIVQEVNPPKFEKTEDMSNLTFLNDASVLWNLRSRYA-AMLIYTYSGLFCVVINPYKR 129

  Fly   117 MPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF 181
            :|:|..|:.|.:.|....::.||:||::::||..:.:::.|.|::::||||||||.:.|..:.||
 Worm   130 LPIYTDSVARMFMGKRRTEMPPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVICYF 194

  Fly   182 AAVGGS--------ESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFL 238
            |.||.|        |.|..:|.:::.::|::||||||||.||:||||||||.::.| |:.|.  |
 Worm   195 ATVGASQKAALKEGEKEVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHF-NKHGT--L 256

  Fly   239 QGATMHTYLLEKSRVVYQAQGERNYHIFYQLCA--ARSKYPELVLDHQDKFQFLNMGGAPEIERV 301
            ....:..||||||||:.||.|||.||||||:.:  ......||:|:|.....:........|:.:
 Worm   257 ASCDIEHYLLEKSRVIRQAPGERCYHIFYQIYSDFKPQLRDELLLNHPISNYWFVAQAELLIDGI 321

  Fly   302 SDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSD-----SCDIF 361
            .|.|:|..|.:|..||.||..:..|..::::..:|:||::..::..|...|.|..     :|:::
 Worm   322 DDTEEFQLTDEAFDVLKFSPTEKMDCYRLMSAHMHMGNMKFKQRPREEQAEPDGQDEAERACNMY 386

  Fly   362 HNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIV 426
            ..|:             |...:.|:..:::...|:|....:::....|..|:||.:||::|.::|
 Worm   387 GIDV-------------DQFLKALVSPRVKVGTEWVSKGQNVDQVHWAIGAMAKGLYARVFHWLV 438

  Fly   427 GVLNKSLN-NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKE 490
            ...|.:|: .|..:..|||||||.|||.|:.|||||..||:.||||||.||.|:|.||||||.:|
 Worm   439 KKCNLTLDQKGIDRDYFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYARE 503

  Fly   491 GITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKP--- 550
            ||.||.||| .|.|.||:|||..||::.:|||||.:||.:|.:.|.||..: ..|.|:||||   
 Worm   504 GIQWTFIDFGLDLQACIELIEKPLGIISMLDEECIVPKATDMTLAQKLTDQHLGKHPNFEKPKPP 568

  Fly   551 --RFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVL--SESNMSLAK--QVMTLEEIDTL 609
              :.|...|.::|::.||.|:|..:||||:|.::..:..|:  |:.|..|.:  |..|.:|    
 Worm   569 KGKQGEAHFAMRHYAGTVRYNVLNWLEKNKDPLNDTVVSVMKASKKNDLLVEIWQDYTTQE---- 629

  Fly   610 CVDSAKSSTLGGRVVISAGRK--QQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHY 672
              ::|.::..||      |||  :.|:            ..||...::|||..|::.||.|.||:
 Worm   630 --EAAAAAKAGG------GRKGGKSGS------------FMTVSMMYRESLNKLMTMLHKTHPHF 674

  Fly   673 VRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN 737
            :|||.||:.|.:...:.|.::.||...||||.:||...|||:|..:|||..||.:|..:.....:
 Worm   675 IRCIIPNEKKQSGMIDAALVLNQLTCNGVLEGIRICRKGFPNRTQHPDFVQRYAILAAKEAKSSD 739

  Fly   738 DMKLSCRNIVM------KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRF 796
            ||| :|...::      |.:.|| ::|.|:|::||:||.||.:|.:|.:                
 Worm   740 DMK-TCAGAILQALINQKQLNDE-QFRIGHTKVFFKAGVVAHIEDLRDD---------------- 786

  Fly   797 VYRRQFLRIQKVINGIQKHARGYLA-RERTQKMREARAGLILSKYARGWLCRRR------YLRLR 854
                   ::.::|.|.|...|.|.| .:...:.::..:.:||.:..|.|...|.      :.:||
 Worm   787 -------KLNQIITGFQSAIRWYTATADAGARRKQLNSYIILQRNIRSWCVLRTWDWFLLFGKLR 844

  Fly   855 HSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARR 919
            ..:              |...|.:....:..::.|..|.|::|...|:..             ..
 Worm   845 PQL--------------KCGKMAEEMIKMAEEQKVLEAEAKKAESARKSQ-------------EE 882

  Fly   920 KFKRMKAE-AKTISHMENKYMG---LENKII---SMQQRIDE-LNRDNSNL---KHKTSEISVLK 973
            .:.::.|| :|.:..:|....|   :|.|:.   |.:|.::: ||..|..|   :.|.:::...:
 Worm   883 AYAKLSAERSKLLEALELTQGGSAAIEEKLTRLNSARQEVEKSLNDANDRLSEHEEKNADLEKQR 947

  Fly   974 MKLE-----LKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQ 1033
            .|.:     |||::||...|:..:.::|            |.::.::..|::..::|:|.|.:..
 Worm   948 RKAQQEVENLKKSIEAVDGNLAKSLEEK------------AAKENQIHSLQDEMNSQDETIGKIN 1000

  Fly  1034 TWRQENEELRRQ-IDEI-IDMAKNAEVNQ-RNQEDRMLAEIDNRELNEAYQRA--IKDKEVIENE 1093
            ..::..||..|| :|:: .:.||.|:.|: |.:.::.|.|::.....|...||  .|.|..:|.|
 Worm  1001 KEKKLLEENNRQLVDDLQAEEAKQAQANRLRGKLEQTLDEMEEAVEREKRIRAETEKSKRKVEGE 1065

  Fly  1094 NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLV 1158
            ....:|.:..|:|      .:..::||.:.::...:|......|.....:.|::....|  ...:
 Worm  1066 LKGAQETIDELSA------IKLETDASLKKKEADIHALGVRIEDEQALANRLTRQSKEN--AQRI 1122

  Fly  1159 VKLRSILEEEKQKHK-------VLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTS- 1215
            :::...||.|:|...       .||.:..:|:.|            |:.:|::|..:.|..:.. 
 Worm  1123 IEIEDELEHERQSRSKADRARAELQRELDELNER------------LDEQNKQLEIQQDNNKKKD 1175

  Fly  1216 ---IKHGVEINELNAQHAALQEEVRRRREECIQLKAV-----LLQQSQSMRSLEPESLQMRGNDV 1272
               ||...:::|.|..:......:||:..:  |:.|:     .||:|::....|...||...:|:
 Worm  1176 SEIIKFRRDLDEKNMANEDQMAMIRRKNND--QISALTNTLDALQKSKAKIEKEKGVLQKELDDI 1238

  Fly  1273 NELME----AFHSQKLINRQLE---SELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESID 1330
            |..::    :...|:.:.:|.|   :||:...:|.:.::.|.|....||:|:..:|.:    .::
 Worm  1239 NAQVDQETKSRVEQERLAKQYEIQVAELQQKVDEQSRQIGEYTSTKGRLSNDNSDLAR----QVE 1299

  Fly  1331 EFEDSNVDTLRQNDRYLRR--ELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEE--EMI 1391
            |.|.......|....:..:  |.:||....|..::|.   :|..|       .|||::::  |::
 Worm  1300 ELEIHLATINRAKTAFSSQLVEAKKAAEDELHERQEF---HAACK-------NLEHELDQCHELL 1354

  Fly  1392 RNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMC 1456
            ..:.||.. |:...:::..|:..|...::....|                ||             
 Worm  1355 EEQINGKD-DIQRQLSRINSEISQWKARYEGEGL----------------VG------------- 1389

  Fly  1457 IRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWL--VNSITLLNLMKQYGDVDEYVKF 1519
                     .:::.||..|.:.::..:.......:|:||.|  .....|........|||.::..
 Worm  1390 ---------SEELEELKRKQMNRVMDLQEALSAAQNKVISLEKAKGKLLAETEDARSDVDRHLTV 1445

  Fly  1520 NTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDP-------------KIVPAILN- 1570
            ....:.:|:            ..|.||:.::..:..||..:|.             |:..::.| 
 Worm  1446 IASLEKKQR------------AFDKIVDDWKRKVDDIQKEIDATTRDSRNTSTEVFKLRSSMDNL 1498

  Fly  1571 NDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQL---IGQLEHFYKQFQHFGLDNCYAEQIF 1632
            :::|:..|:.:.:.|:  .|...:.....||..::::   :.:||....:.|| .||...|    
 Worm  1499 SEQIETLRRENKIFSQ--EIRDINEQITQGGRTYQEVHKSVRRLEQEKDELQH-ALDEAEA---- 1556

  Fly  1633 HQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGC------IEDWVRSKKMSNDVLTALAPLNQ 1691
                      ||..          |...::|..|..      ||..::.|:              
 Worm  1557 ----------ALEA----------EESKVLRLQIEVQQIRSEIEKRIQEKE-------------- 1587

  Fly  1692 VSQLLQSRKSEQDVQTICDLCTSLST-----AQVLKVMKSYKLDDYESEI-------TNVFLEKL 1744
             .:...:||:.|  :.:..:..||.|     |::.:..|..:.|..:.||       .||..:|.
 Worm  1588 -EEFENTRKNHQ--RALESIQASLETEAKSKAELARAKKKLETDINQLEIALDHANKANVDAQKN 1649

  Fly  1745 TEKL--NARQMQKSNSDE 1760
            .:||  ..:::|....||
 Worm  1650 LKKLFDQVKELQGQVDDE 1667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 279/747 (37%)
MYSc_Myo5 84..767 CDD:276831 268/717 (37%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 28/124 (23%)
coiled coil 1049..1068 CDD:293879 5/20 (25%)
coiled coil 1077..1086 CDD:293879 3/10 (30%)
JAKMIP_CC3 <1190..1299 CDD:292653 25/124 (20%)
Myo5_CBD 1424..1792 CDD:271254 63/376 (17%)
myo-1NP_492053.1 Myosin_N 33..71 CDD:280832 13/50 (26%)
Myosin_head 86..773 CDD:278492 271/729 (37%)
MYSc_class_II 98..773 CDD:276951 268/717 (37%)
Myosin_tail_1 854..1918 CDD:279860 182/970 (19%)
P-loop_NTPase <863..>1071 CDD:304359 51/232 (22%)
DUF2213 <1074..1224 CDD:303028 31/171 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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