Protein Alignment didum and spe-15

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_490856.1
• Gene: spe-15 / 171712
• WormBaseID: WBGene00004969
• Length: 1219
• Species: Caenorhabditis elegans
• Alignment Length: 1335
• Identity: 387/1335 - (28%)
• Similarity: 606/1335 - (45%)
• Gaps: 310/1335 - (23%)

  Fly    74 DLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMGDLE 137
            |...|.:|:|..:|:|.|:|:...: ||||...||::||||..:. ||.|..|:.|||.::|.:|
 Worm    68 DNCALVHLNEATLLNNCRLRYANGK-IYTYVANILISINPYQLIDGLYSPETIKEYRGKSLGQME 131

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSP 202
            |||||:|::||.::.|...:.|||||||||||||.|.|..::|.....|::: ..:::::|.::|
 Worm   132 PHIFAIADKAYREMRRIKTSQSIIVSGESGAGKTESQKAVLKYLCENWGTDA-GPIQQRLLETNP 195

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            |:||||||||.||:||||||||.::.|.:...|   .|..:..||||.|||..||.|||||||||
 Worm   196 ILEAFGNAKTLRNNNSSRFGKFVQIHFSDNGTV---AGGFVSHYLLETSRVCRQAAGERNYHIFY 257

  Fly   268 QLCAARSK--YPELVLDHQDKFQFLNMGGA-----------PEIER------------VSDAEQF 307
            ||.|..|.  |.:|.|.....|.:|..|..           .:..|            :||.:.|
 Worm   258 QLIAGSSPDLYKKLRLAPASSFNYLKHGATLFFVNSKSSLKTDASRFSETNSSVSDSIISDIDDF 322

  Fly   308 NETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDS---CDIFH-NDIHLQ 368
            .:..:|:.:.|.|..:...|...:|||||||||:.        ||..|||   |.|.. .:..|.
 Worm   323 AKLERALALSGVSDDEKMFIWSTVAGILHLGNIEF--------EENASDSRGGCMITSGTENSLM 379

  Fly   369 ITADLLRVSADDLRRWLLMRKIESV-----NEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGV 428
            ..|:||.:..::::..|..|.:::.     ...:.:|.....|.|.||||||.||:|||.::|..
 Worm   380 AAAELLGLEPEEMKLGLCARIMQTTKGGVKGTLIRVPLKAHEASAGRDALAKAIYSKLFDWLVAQ 444

  Fly   429 LNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGIT 493
            :|||: ...|...:|||||:.|||.|.||||||||||:.|||||..||:.:.|.|||.|..||:.
 Worm   445 INKSI-PFEKSTGYIGVLDVAGFEYFAVNSFEQFCINFCNEKLQHFFNERILKQEQEMYEAEGLN 508

  Fly   494 WTMIDFYDNQPCIDLIESRL-GVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHF--EKPRFGTT 555
            ...|:|.||..||:|.|.:. |:.||||||.::|:.:.:.:..: ..:.|| .||  :.||....
 Worm   509 IQKIEFTDNLDCIELFEKKASGLFDLLDEEAKLPRATFQHFTQR-AHESNK-NHFRLDAPRKSKV 571

  Fly   556 ----------SFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLC 610
                      ...|:|::.||.|:...|:|||.|.:...|..::.:|:..|...:.|.|     .
 Worm   572 KSHREMRDDEGLLIRHYAGTVCYETRYFVEKNNDQLHNSLEMLIEQSSFPLVVSLFTSE-----A 631

  Fly   611 VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRC 675
            ..:.|:   |||:               :.|       :||::|:..|:||:..|:.|..|:|||
 Worm   632 TGAVKT---GGRL---------------KAV-------SVGAKFKSQLSSLLDKLNNTGTHFVRC 671

  Fly   676 IKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMK 740
            :|||....|:.::.:.|:.||:..|:...:|:...|||||..:.|.|..|:..:..| |.:.|.:
 Worm   672 VKPNSQMKAWHFDGSAILGQLQCAGMASVLRLMQEGFPSRTSFADLYAMYEKNLPPS-LARLDPR 735

  Fly   741 LSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRI 805
            |..:.:......|::.::||||::||.||:.|..:|:   :::...|:::             .|
 Worm   736 LFSKCLFHALGLDQNDFQFGNTKVFFTAGKFAEFDQM---MKQDPETVME-------------LI 784

  Fly   806 QKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLAR 870
            .||.:        :|.:.|.:|::.....:|..|        .:.|.....|..||.:.||.|.|
 Worm   785 SKVTD--------WLVKARWRKVQYGAWSVIKLK--------NKILYRAEKIKKIQAWIRGYLVR 833

  Fly   871 NKFHAMRDHYRAVQIQRFVRGALARRA---YQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTIS 932
            .:||.              |.|:.|:|   .:..|....|    :.|.....:.|..:|...|..
 Worm   834 KRFHK--------------RLAIFRKACALLENSREMTDI----LARMNESSQDKWREAADSTTG 880

  Fly   933 HMENKYMGLENKIISMQQRIDELNRD--------NSNLKHKTSEISVLKMKLELKKTLEAEFKNV 989
            .::.....::|         |:||.:        ...:|...|.|:.||::||
 Worm   881 ELDELVKTIKN---------DDLNTEIDRAVKCYEDCVKRVDSIIADLKLQLE------------ 924

  Fly   990 KAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMA- 1053
                  .|:|.|....:.||| |::.:..||...|::|.|            |||:::|..:.|
 Worm   925 ------NDELAEVERARKEAE-DKERREAEEKAAAEQEKI------------LRRKMEEEREKAQ 970

  Fly  1054 KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAG---------SF 1109
            |..|:....|:.::.||.:               |.::..|   |||..||.|.         ..
 Worm   971 KEYELQLEMQKQKLAAEAE---------------EEVKRRN---KEERDRLDAAVSSRLASSDGV 1017

  Fly  1110 SLHARKASNA--SSQNEDDVG---YASAKNTLDINRPPDLLSKNYSYNDSTSLVV-------KLR 1162
            :|.|::||.|  ..|::.|:|   ||..::.::.:            ||...||.       :||
 Worm  1018 ALVAQEASAAPPKQQSKYDLGNWKYADLRDAINTS------------NDMELLVACKEEFHRRLR 1070

  Fly  1163 SILEEEKQKHKVLQE-----QYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEI 1222
             |..|.|.|:...::     ..:.:.::.||:..|..||.::.
 Worm  1071 -IYNEWKSKNSANRDVPPTRAPLTVYNQQKPSSSSMMVSRVQA---------------------- 1112

  Fly  1223 NELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINR 1287
                |.|                |...|.||.....|...::.:..|...:.:..|..:.:.|.|
 Worm  1113 ----APH----------------LNPALTQQRYFKVSFATDNKKKNGGSQSGMWYAHFNGQYIRR 1157

  Fly  1288 QLESELKAITEEHNSKLVEMTQEIERLNNEKDELQ 1322
            ||              .:..:|:.:.|...||:||
 Worm  1158 QL--------------TIRPSQKPQLLVAGKDDLQ 1178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	264/730 (36%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	85/416 (20%)
		Myo5_CBD	1424..1792	CDD:271254
spe-15	NP_490856.1	Myosin_N	10..55	CDD:460670
		MYSc_Myo6	78..761	CDD:276833	263/729 (36%)
		CBD_MYO6-like	773..923	CDD:409646	38/205 (19%)
		MAP7	<924..1000	CDD:461709	27/124 (22%)
		MyUb_Myo6	1033..1073	CDD:439319	11/52 (21%)
		Myosin-VI_CBD	1123..1211	CDD:465157	14/70 (20%)