Protein Alignment didum and hum-7

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001248880.1
• Gene: hum-7 / 171650
• WormBaseID: WBGene00002040
• Length: 1880
• Species: Caenorhabditis elegans
• Alignment Length: 1980
• Identity: 479/1980 - (24%)
• Similarity: 800/1980 - (40%)
• Gaps: 579/1980 - (29%)

  Fly    74 DLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAY-RGHAMGDLE 137
            ||..|..|.|..:|.|||.||.... ||||.|.||||:||:...|:|.|...|.| :...:|.|.
 Worm   171 DLCNLPELTEQTLLDNLRERFANGH-IYTYIGPILVAVNPFCFFPIYNPKYARLYFQSKRLGSLP 234

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESE-TQVERKVLASS 201
            |||||:|:..|..:.|...|..:::|||||:|||.|..:.|.:..::....|. ...|:.:|::.
 Worm   235 PHIFAIADVCYHNMLRIKENQCVVISGESGSGKTESTNHLMSHLISLSQKGSTGCSTEQTLLSAG 299

  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLFR-NQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHI 265
            |::||||||.|..|:||||||||.|:.:| |.|    :.||.:..|||||||:::|.:||||||:
 Worm   300 PVLEAFGNAVTLTNNNSSRFGKFIKINYRENGM----VSGANVEIYLLEKSRIIFQTKGERNYHV 360

  Fly   266 FYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIA 325
            ||.|...     |.||  .:|...| :::||......:|.|::..:|:....||:.:||..:...
 Worm   361 FYYLLEGADEEERKKY--FLLKPHD-YKYLNQNEPFALEGVNERNEFDRLRHAMSSVGFCAKTQQ 422

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
            .|..|::.:|.||||...|:....|:|.     ....|:..:.:.|:||.:..|.|.:.|.|::.
 Worm   423 TIFGIISAVLLLGNITYIKRHGYHSDES-----GYIENEEVVDLVANLLHIKTDTLMQALTMKRH 482

  Fly   391 ESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIV-----GVLNKSLNNGSKQCSFIGVLDIYG 450
            ....|.|::..|:..|...|||:||.||..||.|||     .:|.|..:.|...  :||:|||:|
 Worm   483 VMKTETVVLRYSVSEATNTRDAMAKCIYNSLFHYIVLRINQALLKKDFSAGKGY--YIGILDIFG 545

  Fly   451 FETF--EVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR- 512
            ||..  :.|||||.||||||||||..||||:|:.||||||||||:||.|::.||..|:.|.:|:
 Worm   546 FEDVGSQCNSFEQLCINYANEKLQSYFNQHIFQFEQEEYLKEGISWTNIEYTDNTECVQLFQSKP 610

  Fly   513 LGVLDLLDEECRMPKGSDESWAGKLIGKCNKF----PHFEKPRFGTTSFFIKHFSDTVEYDVNGF 573
            .|:|.|:|||..:..|:|:|    ::.|.|:|    .::|.|:....:|.:.|::..|:|.:.||
 Worm   611 YGILRLVDEESNINNGTDDS----MLAKLNQFLKNNEYYETPQKKEPAFIVAHYAGKVKYQITGF 671

  Fly   574 LEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCV--------------------------- 611
            .|||:|.:.:::...|..|..|:.|   ||..||.:.|
 Worm   672 REKNKDLMRQDVLNALKSSTSSVMK---TLLGIDPVAVHRWNVLRSVFRAMNAFKQSTRKLQKSE 733

  Fly   612 -------------------DSAKSSTLGGR----------------VVISAGRKQQG-NDTRRRV 640
                               |||.|:.|.|.                :...|.|...| :|.:..:
 Worm   734 SAGHLRVMDSIVTSPRRGSDSALSAFLRGELRCEVPDFCDTSMFNTIRNQARRTPAGKSDDKMSL 798

  Fly   641 VPSKQHRK-------------TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKI 692
            :.|.|..|             :|..||:.||..|:|||...||:::||||.|:||:|..::...|
 Worm   799 LKSLQILKEAIGGRRLAKKPSSVSKQFEYSLTRLMSTLANATPYFIRCIKSNNDKIANHFDDNII 863

  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDK--NDMKLSCRNIVMKWIQ--- 752
            ::|||..|:||||||..||:..|..||.|..:|::|: |:..|.  :|:|        ::|.
 Worm   864 LRQLRYTGMLETVRIRRAGYSVRIEYPSFVQQYRILL-RNGRDSTVDDVK--------EYIHSHA 919

  Fly   753 --DEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKH 815
              |.|..::|..:||.|..:...|:.   :|.:   ||:||:.
 Worm   920 SIDNDNIQYGTNKIFMRDAEKLILDD---HLHR---TIMQSID---------------------- 956

  Fly   816 ARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHY 880
                                .|.::.|..|.|:||||::..|
 Worm   957 --------------------TLQRWFRTMLARKRYLRMKEGI----------------------- 978

  Fly   881 RAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKI 945
              ::||..:||:.||...:|:.......|...:::..|:|:..::   :::..:::.|.|
 Worm   979 --IKIQALIRGSFARAEVRKKALAAQTIQCNWKKYKQRQKYLSIR---ESVIALQSAYRG----- 1033

  Fly   946 ISMQQRIDELNRDNSNLKHKTSEISVLKM------KLELK--KTLEAEFKNVKAACQDK---DKL 999
            .|:::|:.|:.:.|..|..|.|...|.|:      |.:|.  .:|.|...:...:..||   |.|
 Worm  1034 ASVRKRVGEIPKGNGALNVKKSPFRVRKVHAVNLTKFDLSDPSSLAAFALSDDDSDSDKSTQDGL 1098

  Fly  1000 IEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQE 1064
            .:.::::.:|.:|             ::.:....|:..|:.:|:        :.:.|:::...::
 Worm  1099 DDDISEESDAFQD-------------DDAVDVDATFILEDTKLK--------LIEGADLSHHRRQ 1142

  Fly  1065 DRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSL---HARKASNASSQNEDD 1126
            .  ||...:....:..:||    ...|:.||    .:||.. .||:|   |::|...|..
 Worm  1143 S--LAPTASTTKLKMLRRA----NSTESNNF----SMSRCD-DSFTLSPTHSKKKGGAGK----- 1191

  Fly  1127 VGYASAKNTL--------DINRP-----------PDL-LSKNYSYNDSTSLVVKLRSILEEE--- 1168
            :|:..||..|        |.:.|           ||: ::|::.:        |:..:..:|
 Worm  1192 LGFQKAKKNLKALFGRNEDEDEPSPGPSFASELTPDVFVAKDHQF--------KMSRLHRQEICA 1248

  Fly  1169 ----------KQKHK-------VLQEQYIKLSS-------------------------RHK---- 1187
                      .|.||       :.:|.::..||                         .||
 Worm  1249 LCNRHLTNFISQAHKCQRCKMCLHKECFVFASSIPCNPTSPVRSPTRLHSPKRPWDLMPHKQRQS 1313

  Fly  1188 ----PTEDSFRVS----ELEVENEKLRSEYDQLRTSI------KHGVEINELNAQH-----AALQ 1233
                |:..:|.::    :::..|..:.|..|..:.||      :|   :||.||:.     |..:
 Worm  1314 SSPIPSTGTFSLTKTKQQIDPGNMLVESTDDLRQFSIFIFNKTRH---LNESNAKRDTVVDAVFK 1375

  Fly  1234 EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLE-------S 1291
            :.:|....|.:..:|||        |:|...|:.|  ||..:.|...::..:...:.       :
 Worm  1376 KSLRAFHMELLGYEAVL--------SVEQSVLKYR--DVITMFEGLLTKVCLEESVSFPTTLGVN 1430

  Fly  1292 ELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVA 1356
            ..:....|:    |.:..:.:|...:...::||..:.:    .|:|..:....|:....:.  |.
 Worm  1431 AFRGFLNEY----VHVQSKKKRGKEKSSMIKKVGKKRV----KSDVAAVHAGHRFRAEAVH--VP 1485

  Fly  1357 QFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFH 1421
            .:..|..:|...:.||...                          |...::..|...|:
 Worm  1486 TYCEVCNQLIWHHEKLYTC--------------------------VACRISCHKKCQPK------ 1518

  Fly  1422 SSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDD--VRELLSKFVIQIKKMH 1484
               :....|....|:.|:|..|..  |.|.|:.:         .|||  |..||.:...
 Worm  1519 ---VTHPCQMTGKAIDPKTNGGRF--FGASLVSI---------VDDDHTVPTLLDRLFF------ 1563

  Fly  1485 RTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLY 1549
                .||.|.:::.      .:.::.|.:.:........::.....:.||.:....:|..:|..:
 Worm  1564 ----AIETRALFVE------GVYRKSGSLPQVRSIRKVIESTADADSVNLEDIGVHVLTTLVKAF 1618

  Fly  1550 QALIMQIQGLLDPKIV----PAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQ 1610
                  .:.|.:|.|:    ...||..|:    :..|.|.|..|:.....|:..
 Worm  1619 ------FRELAEPIIIFDLYENFLNVSEV----EDMGERVRCLSVMIELLPKPN----------- 1662

  Fly  1611 LEHFYKQFQHFGLDNCYAEQIFHQLLYFICAV----ALNCLMLRGDICMWETGMIIRYNIGCIED 1671
                              ..:..:|:|.:..|    |:|                   .:||
 Worm  1663 ------------------RAVLDRLMYHLARVADQEAVN-------------------KMGC--- 1687

  Fly  1672 WVRSKKMSNDVLTALAPL---NQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYE 1733
                    |::.....|.   .|.|...|.:.::...||.|           ::.:...||..|:
 Worm  1688 --------NNLALIFGPCVLRRQDSAHAQEQLNDVARQTGC-----------VQTLIEEKLKQYK 1733

  Fly  1734 SEITNVF-LEKLTEKLNAR----QMQKSNSD-------------------EFTIDQK-----FIQ 1769
            :.|.|:. ||..::|::|.    :..:.||:                   ||...||     .:.
 Worm  1734 ATIHNIVELEDASQKVSANLRKIEEHRRNSEPSKFSPNIGTAKQLFEEQLEFLGKQKERLLQELP 1798

  Fly  1770 PFKVVFRYSDIKLED---IELPSHLNLDEF 1796
            |...|....|:...|   |...|.|:::|:
 Worm  1799 PLAPVASSEDLSSSDENAIHASSSLSVEEY 1828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	277/785 (35%)
		IQ	900..922	CDD:197470	4/21 (19%)
		SMC_prok_B	<942..1365	CDD:274008	92/531 (17%)
		Myo5_CBD	1424..1792	CDD:271254	69/412 (17%)
hum-7	NP_001248880.1	RA	28..134	CDD:214612
		MYSc_Myo9	181..936	CDD:276836	277/785 (35%)
		C1	1234..1284	CDD:410341	8/57 (14%)
		C1_Myosin-IX	1472..1527	CDD:410368	10/91 (11%)
		RhoGAP	1540..1727	CDD:470621	43/291 (15%)