DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh7

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001348536.1 Gene:Myh7 / 140781 MGIID:2155600 Length:1935 Species:Mus musculus


Alignment Length:1958 Identity:507/1958 - (25%)
Similarity:861/1958 - (43%) Gaps:492/1958 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||      ...::||.....:..|.:..  |:| |.:...|::||...||     .|.
Mouse    19 SEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVS--REG-GKVTAETENGKTVTVK-----EDQ 75

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            ...:||.......|:..|::||||.||:||:.|:.. .:||||.|:..|.:|||..:|:|...::
Mouse    76 VMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAS-WMIYTYSGLFCVTVNPYKWLPVYNAEVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGS 187
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::||   ||:|..
Mouse   140 AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR 204

  Fly   188 ESETQ------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTY 246
            ..:.|      :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |..|.:.||
Mouse   205 SKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIETY 266

  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQ 306
            |||||||::|.:.||:||||||:.:  :|.||     |:.::...:.|::. |...:..:.|:|:
Mouse   267 LLEKSRVIFQLKAERDYHIFYQILS--NKKPELLDMLLITNNPYDYAFISQ-GETTVASIDDSEE 328

  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDI 365
            ...|..|..||||:.::...|.|:...|:|.||::..:|..|      |:||.|.          
Mouse   329 LMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADK---------- 383

  Fly   366 HLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN 430
                :|.|:.:::.||.:.|...:::..||||....:::....|..||||.:|.|:|.::|..:|
Mouse   384 ----SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRIN 444

  Fly   431 KSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT 495
            .:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||||.||
Mouse   445 ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509

  Fly   496 MIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR---- 551
            .||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :||.|   :|:|||    
Mouse   510 FIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSN---NFQKPRNVKG 571

  Fly   552 FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKS 616
            .....|.:.|::.||:|::.|:|:||:|.:::.:..:..:|::.|...:...........|..| 
Mouse   572 KQEAHFSLVHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPADKGK- 635

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
                       |:.::|:..           :||.:..:|:|..|::.|.:|.||:||||.||:.
Mouse   636 -----------GKAKKGSSF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNET 678

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--------- 737
            |.....:...::.|||..||||.:||...|||:|.||.||..||::|        |         
Mouse   679 KSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL--------NPAAIPEGQF 735

  Fly   738 -DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQ 801
             |.:.....::.....|.::|:||:|::||:||.:..||::|..                     
Mouse   736 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE--------------------- 779

  Fly   802 FLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISG 859
              |:.::|..||..:||.|:|...:|:.|.|..|::.::       .:.|...:.|.:::..:..
Mouse   780 --RLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKS 842

  Fly   860 IQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRM 924
            .:|.......:.:|..::|                                |:.:..||||    
Mouse   843 AETEKEMATMKEEFGRVKD--------------------------------ALEKSEARRK---- 871

  Fly   925 KAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNV 989
                           .||.|::|:                       |:.|.:|:..::||..|:
Mouse   872 ---------------ELEEKMVSL-----------------------LQEKNDLQLQVQAEQDNL 898

  Fly   990 KAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEI---- 1049
            ..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||:|.||::    
Mouse   899 ADAEERCDQLIK--NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961

  Fly  1050 --IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKD----------------- 1086
              ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|                 
Mouse   962 AKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK 1026

  Fly  1087 ---------------KEV------------------------IENENFMLKEELSRLTAGSFSLH 1112
                           |:|                        :||:...|.|   ||....|.|:
Mouse  1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE---RLKKKDFELN 1088

  Fly  1113 ARKASNASSQNEDDVGYASAKNTLDIN-RPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQ 1176
               |.||..::|..:|....|...::. |..:|..:..:...:.:.|.||||.|..|      |:
Mouse  1089 ---ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE------LE 1144

  Fly  1177 EQYIKLSSRHKPTEDSFRVSELEVE-NEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRR 1240
            |    :|.|   .|::...:.:::| |:|..:|:.::|.      ::.|...||.|....:|::.
Mouse  1145 E----ISER---LEEAGGATSVQIEMNKKREAEFQKMRR------DLEEATLQHEATAAALRKKH 1196

  Fly  1241 EECIQLKAVLLQQSQSMRSL------EPESLQMRGNDVNELMEAFHSQKL----INRQLESELKA 1295
            .:.:   |.|.:|..:::.:      |....::..:||...||.....|.    :.|.||.::  
Mouse  1197 ADSV---AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM-- 1256

  Fly  1296 ITEEHNSKLVEMTQEIERLNNEKDELQK---VMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQ 1357
              .||.||..|..:.:..|.:::.:||.   .:...:|| :::.:..|.:......::|:....|
Mouse  1257 --NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE-KEALISQLTRGKLTYTQQLEDLKRQ 1318

  Fly  1358 FLLVQEELKLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMK 1419
               ::||:|..||   .|::.|.|...|..:.|||      ....|::...::|..|:..|...|
Mouse  1319 ---LEEEVKAKNALAHALQSARHDCDLLREQYEEE------TEAKAELQRVLSKANSEVAQWRTK 1374

  Fly  1420 FHSSDLDKI--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKK 1482
            :.:..:.:.  |:.....|..|                      |.:|::.|..:.:|    ...
Mouse  1375 YETDAIQRTEELEEAKKKLAQR----------------------LQDAEEAVEAVNAK----CSS 1413

  Fly  1483 MHRTPHPIENRVIWLVNSITLLN-----LMKQYGDVD--------EYVKFNTEKQNQQQLKNFNL 1534
            :.:|.|.::|.:..|:..:...|     |.|:..:.|        :|.:..:|.::.|:      
Mouse  1414 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK------ 1472

  Fly  1535 FEYRRVILDL--IVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPE 1597
             |.|.:..:|  :.|.|:..:..::...        ..|..:|  .:...:..:..|.|.|    
Mouse  1473 -EARSLSTELFKLKNAYEESLEHLETFK--------RENKNLQ--EEISDLTEQLGSTGKS---- 1522

  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMII 1662
                      |.:||...||.:        ||::..|........:|.          .|.|.|:
Mouse  1523 ----------IHELEKIRKQLE--------AEKLELQSALEEAEASLE----------HEEGKIL 1559

  Fly  1663 RYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQD----------VQTICDLCTSL-- 1715
            |                     |....||:...::.:.:|:|          ::.:..|.|||  
Mouse  1560 R---------------------AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDA 1603

  Fly  1716 ---STAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFR 1776
               |..:.|:|.|                 |:...||..::|.|:::....: ||.::..:.:.:
Mouse  1604 ETRSRNEALRVKK-----------------KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651

  Fly  1777 YSDIKLED 1784
            .:.|:|:|
Mouse  1652 DTQIQLDD 1659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 276/751 (37%)
MYSc_Myo5 84..767 CDD:276831 264/721 (37%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 40/130 (31%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 23/119 (19%)
Myo5_CBD 1424..1792 CDD:271254 64/394 (16%)
Myh7NP_001348536.1 COG5022 37..1432 CDD:227355 449/1624 (28%)
MYSc_class_II 99..766 CDD:276951 264/721 (37%)
Actin-binding 655..677 11/21 (52%)
Actin-binding 757..771 7/13 (54%)
SMC_prok_B 1173..1930 CDD:274008 112/623 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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