DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and Mhc

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_061510840.1 Gene:Mhc / 1279567 VectorBaseID:AGAMI1_010506 Length:1964 Species:Anopheles gambiae


Alignment Length:1949 Identity:509/1949 - (26%)
Similarity:861/1949 - (44%) Gaps:354/1949 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 WVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLS 79
            |||...   |...|.|........:.:....|:.|:.|     .||....||.......|::.|:
Mosquito    40 WVPEEK---EGYVLGEIKATKGELVTVALPGGETKDFK-----KDLVSQVNPPKYEKCEDMSNLT 96

  Fly    80 YLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALA 144
            ||::..||||||.|:..: :||||.|:..|.||||...|||.....:.|||....::.||:||::
Mosquito    97 YLNDASVLHNLRQRYYAK-LIYTYSGLFCVVINPYKRYPLYTNRCAKMYRGKRRNEVPPHLFAVS 160

  Fly   145 EEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-------ESETQVERKVLASSP 202
            :.||..:...:.|.|::::||||||||.:.|..:.|||.:|.|       |.:..:|.:|:.::|
Mosquito   161 DGAYVNMLTNHENQSMLITGESGAGKTENTKKVIAYFATIGASGKKDENAEKKGSLEDQVVQTNP 225

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            ::||||||||.|||||||||||.::.|   .|...|.||.:.||||||:||:.|...||:|||||
Mosquito   226 VLEAFGNAKTVRNDNSSRFGKFIRIHF---TGSGKLAGADIETYLLEKARVISQQTLERSYHIFY 287

  Fly   268 QLCAARSK-YPELVLDHQDKFQFLNMG-GAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKI 330
            |:.:...| ..|:.....|.:.:.::. |...|..|.|.|:...|.:|..||||:.::..:|.:|
Mosquito   288 QIMSGSVKGLKEMCFLSNDIYDYNSVSQGKITIPNVDDGEECLLTDEAFNVLGFTQEEKDNIYRI 352

  Fly   331 LAGILHLGNIQVSKKFNEGSEE----EDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIE 391
            .:.::|:|.:|..:|..|...|    ||.|.            .|.||.|..|||.:.||..:|:
Mosquito   353 TSAVMHMGRMQFKQKGREEQAEADGTEDGDR------------VAKLLGVGTDDLYKNLLKPRIK 405

  Fly   392 SVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEV 456
            ..||:|....:.:....:..||.|.|:.:||:::|...|::|:...|:..|||||||.|||.|:.
Mosquito   406 VGNEFVTKGQNKDQVTNSVGALCKGIFDRLFKWLVKKCNETLDTKQKRAQFIGVLDIAGFEIFDF 470

  Fly   457 NSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLD 520
            |.|||.|||:.||||||.||.|:|.||||||.||||.|..||| .|...|::|||..:|:|.:|:
Mosquito   471 NGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGINWAFIDFGMDLLACVELIEKPMGILSILE 535

  Fly   521 EECRMPKGSDESWAGKL----IGKCNKF--PHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRD 579
            ||...||.:|:::|.||    :||...|  |...||......|.|.|::..|.|::.|:||||:|
Mosquito   536 EESMFPKATDQTFAEKLMTNHLGKSAPFMKPRPPKPGIPAGHFAIGHYAGVVSYNITGWLEKNKD 600

  Fly   580 TVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSK 644
            .::..:.....:.:.:|..::..    |.....:..::..|||     |:|..|           
Mosquito   601 PLNDTVVDQFKKGSNALMVEIFA----DHPGQSADPAAAKGGR-----GKKGAG----------- 645

  Fly   645 QHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISA 709
              ..||.|.::|.|.:|::||.:|.||:||||.||:.|.|...:...::.||...||||.:||..
Mosquito   646 --FATVSSSYKEQLNNLMTTLKSTQPHFVRCIIPNEMKTAGVVDAHLVMHQLTCNGVLEGIRICR 708

  Fly   710 AGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQ----DEDKYRFGNTQIFFRAGQ 770
            .|||:|.:||||.:||::|..:: :|..|::...|.|....|:    :.|:||.|.|::|||||.
Mosquito   709 KGFPNRMMYPDFKLRYKILNPKA-VDGLDVEKEGRKIAQLIIEAVGLNADQYRLGMTKVFFRAGV 772

  Fly   771 VAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGL 835
            :..:|:.|..                       |:.|:::.:|...||||:|:..:||:|.|..|
Mosquito   773 LGQMEEFRDE-----------------------RLSKIMSWMQAWCRGYLSRKEFKKMQEQRVSL 814

  Fly   836 -ILSKYARGWLCRRRYLRLRHSISGIQTYARGML---ARNKFHAMRDHYRAVQIQRFVRGALARR 896
             |:.:..      |:||:||       |:|...|   .:...:..|...:..:::.  :...|:.
Mosquito   815 EIVQRNL------RKYLKLR-------TWAWWKLWQKVKPLLNVSRVEDQIAKLEE--KATKAQE 864

  Fly   897 AYQKRRRNIIICQAAIRRFLARR------------KFKRMKAEAKTISHMENKYMGLENKIISMQ 949
            ||:|..:.....:|...:.||.:            ..:..:.:|..::..:|   .|||::...|
Mosquito   865 AYEKEEKLRKELEALNSKLLAEKTALLDSLSGEKGALQEYQEKAAKLTAQKN---DLENQLRDTQ 926

  Fly   950 QRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEK 1014
            :|:.: ..|..|...:|            ||.||.|..:.|...:|.:..|:.: :|.:|.:|.:
Mosquito   927 ERLAQ-EEDARNQLFQT------------KKKLEQEIGSQKKDAEDLELQIQKI-EQDKASKDHQ 977

  Fly  1015 MQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEA 1079
            ::.|.:....|:|.|::.      |:|.:.|          .||||:..|:...||.....||:.
Mosquito   978 IRNLNDEIAHQDELINKL------NKEKKMQ----------GEVNQKTAEELQAAEDKVNHLNKV 1026

  Fly  1080 YQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVG-YASAKNTLD---INR 1140
              :|..::.:.|.|:.:.:|:..|   |......||........::.|. ....|..|:   :.:
Mosquito  1027 --KAKLEQTLDELEDSLEREKKLR---GDVEKAKRKVEGDLKLTQEAVADLERNKKELEQTVLRK 1086

  Fly  1141 PPDLLSKNYSYNDSTSLVVKLRSILEE----------------------EKQKHKVLQEQYIKLS 1183
            ..::.:.:....|..|||.||:..::|                      |||:..:.:|    |.
Mosquito  1087 DKEISALSAKLEDEQSLVGKLQKQIKELQARIEELEEEVEAERQARAKAEKQRADLARE----LE 1147

  Fly  1184 SRHKPTEDSFRVSELEVE-NEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLK 1247
            ...:..|::...:..::| |:|..:|..:||.      ::.|.|.||......:|::..:.:   
Mosquito  1148 ELGERLEEAGGATSAQIELNKKREAELAKLRR------DLEEANIQHEGTLANLRKKHNDAV--- 1203

  Fly  1248 AVLLQQSQSMRSLEPESLQMRGNDVNEL------MEAFHSQKLINRQLESELKAITEEHNSKLVE 1306
            |.:.:|...:..|:.::...|.|..|||      .:....:|....::..:|:....|..|||.|
Mosquito  1204 AEMAEQVDQLNKLKTKAEHDRANMYNELNNTRTACDQLSREKAAQEKIAKQLQHTLNEVQSKLDE 1268

  Fly  1307 MTQEIERLNNEKDELQKVMFESIDEFED--SNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLAN 1369
            ..:.:...:..|.:|.....:.:.:.||  |.|..|.:....|.::|:....   |..||.:...
Mosquito  1269 TNRTLNDFDASKKKLSIENSDLLRQLEDAESQVSQLSKIKISLTQQLEDTKR---LADEEARERA 1330

  Fly  1370 AKLKAYRQDGGQLEHKIE--EEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKI--LQ 1430
            ..|..:|    .|||.::  .|.:..::.| ..|:...::|..::......|:.|..:.:.  |:
Mosquito  1331 TLLGKFR----NLEHDLDNLREQVEEEAEG-KGDIQRQLSKANAEAQLWRSKYESEGVARAEELE 1390

  Fly  1431 RLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVI 1495
            .....|..|                      |..|::.:..|..|.:...|...|....:|:..:
Mosquito  1391 EAKRKLQAR----------------------LAEAEETIESLNQKCIALEKTKQRLATEVEDLQL 1433

  Fly  1496 WLVNSITLLNLM--------KQYGD----VDEYV-----------KFNTE--------KQNQQQL 1529
            .:..:.::.|..        |..|:    ||:..           .::||        ::.|:||
Mosquito  1434 EVDRASSIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1498

  Fly  1530 -----KNFNLFEYRRVILDLI----VNLY----------------QALIMQIQGLLDP---KIVP 1566
                 :|.||.:..:.:||.|    .|::                ||.:.:.:..|:.   |::.
Mosquito  1499 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKSRKRLEAEKDELQAALEEAEAALEQEENKVLR 1563

  Fly  1567 AIL---------------NNDEIQRGRQAH--GMRSRATSIGASSSPEHGGGPAWKQLIGQLEHF 1614
            |.|               ..:|.:..|:.|  .:.|...|:.|.:..:.......|:|...:...
Mosquito  1564 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1628

  Fly  1615 YKQFQHFGLDNCYAE---QIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSK 1676
            .....|....|..|:   :.:.|.|..:.:........|.|         .|..:|..|.  |:.
Mosquito  1629 EIALDHANKANAEAQKNIKRYQQQLKDVQSALEEEQRARDD---------AREQLGISER--RAN 1682

  Fly  1677 KMSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFL 1741
            .:.|::..:...|.|..:  ..|::||::....:....:|...........||   |||:..:..
Mosquito  1683 ALQNELEESRTLLEQADR--GRRQAEQELSDAHEQLNEVSAQNASIAAAKRKL---ESELQTLHS 1742

  Fly  1742 ---EKLTEKLNARQMQKSN-------SDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLDE 1795
               |.|.|..|:.:..|..       :||...:|...|..:.:.:..:.::::::    :.|||
Mosquito  1743 DLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQ----VRLDE 1802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 270/706 (38%)
IQ 900..922 CDD:197470 4/33 (12%)
SMC_prok_B <942..1365 CDD:274008 95/457 (21%)
Myo5_CBD 1424..1792 CDD:271254 73/458 (16%)
MhcXP_061510840.1 None

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