DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Aspm

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_033921.3	Gene:	Aspm / 12316	MGIID:	1334448	Length:	3122	Species:	Mus musculus

Alignment Length:	1399	Identity:	246/1399 - (17%)
Similarity:	490/1399 - (35%)	Gaps:	464/1399 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 IKHFSD------TVEYDVNGFLEKNR--DTVSKELT------QVLSESNMSLAKQVMTLEEIDTL 609
            :||..:      .::..|..||.:.|  ..||..|.      :|.::..:.:.|.    |::..|
Mouse  1254 LKHHQERDKAARVIQSVVLNFLSRRRLQKNVSAALVIQKCWRRVSAQRKLRMLKN----EKLAKL 1314

  Fly   610 CVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLA--SLISTLHATTP-- 670
            ...||        |:|.|..::.  .||:|.:..|.:...:.|:.:..:|  |....|.||..
Mouse  1315 QNKSA--------VLIQAYWRRY--STRKRFLRLKHYSVILQSRIRMKIALTSYKRYLWATVTIQ 1369

  Fly   671 -HYVRCIKPNDDKVAF---------------KWETAKIIQQLRACGVLETVRISAAGFPSRWLYP 719
             |:...:....|:..|               :|:..|:..|.:|...|:..            :.
Mouse  1370 RHWRAYLSRKRDQQIFRKLKSSSLVIQFMFRRWKRRKLQLQTKAAVTLQRA------------FR 1422

  Fly   720 DFYMRYQL-----LVYRS------KLDKNDMKLSCRNIVMKWI---QDEDKYRFGNTQIF----- 765
            ::::|.|:     :|.:|      :|.|.....||..::.:.:   |.:..|:.....|.
Mouse  1423 EWHLRKQIRERSAVVIQSWYRMHRELQKYIYIRSCVIVIQRRVRCFQAQKLYKRRKDAILTLQKH 1487

  Fly   766 FRA---GQVAFLEQVRANLRKKYITI-VQSVVR----RFVYRRQ-------------------FL 803
            :||   |::|..:.    |:|:..|| :|:..|    |..||.|                   ||
Mouse  1488 YRARQKGKLAHADY----LQKRAATIRLQAAFRGMKARHSYRLQIGAACVLQSYWRMRQERVRFL 1548

  Fly   804 RIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRR----YLRLRHSISGIQTYA 864
            .::|::..:|.|.|.|...::.:|::  :|.:.:..:.|..:..||    |.:.|.|:..:|:..
Mouse  1549 NLKKMVIKLQAHIRKYQQLQKYKKIK--KAAITIQTHFRASISARRVLASYQKTRSSVIVLQSAC 1611

  Fly   865 RGMLARNKF-HAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEA 928
            |||.||..| ||:..   .::||.:.|..:.|:.:|..:...|..|:.::...:|:::.:::|.|
Mouse  1612 RGMQARKAFRHALAS---VIKIQSYYRAYICRKTFQNFKNATIKLQSIVKMKQSRKQYLQIRAAA 1673

  Fly   929 ----------KTISHMENKYMGLENKIISMQQRIDE-LNRDNSNLKHKT---------------- 966
                      |..|....:|:.:....|.:|..... |.|....|:.|.
Mouse  1674 LFIQRWYRSQKLASQKRKEYIQVRESCIKLQSHFRGCLVRKQLRLQCKAAISLQSYFRMRTARQR 1738

  Fly   967 -------------------SEISVLKMKLELKKT---LEAEFKNVKAACQDKDKLIEALNKQL-- 1007
                               ::||..|..|::|:.   |:|.::..|...|.|.:...|:..|.
Mouse  1739 YLKMCKAALVIQSFYCAYRAQISQRKNFLQVKRAAICLQAAYRGCKVRRQIKQQSTAAVTIQRVF 1803

  Fly  1008 --EAERDEKMQLLEENGHAQEEWISQK-----------------------QTWRQENEELRRQID 1047
              .::|.:...:|:.....|..:.:||                       :.| |..::||||.:
Mouse  1804 RGHSQRMKYQTMLQSAVKIQRWYRAQKVAYDMRIQFLKTREAVVCLQSAYRGW-QVRQQLRRQHE 1867

  Fly  1048 EIIDMAKNAEVNQRNQEDRM----------------------LAEIDNRELNEAYQRAIKDKEVI 1090
            ..:.:.....:....|:.::                      ||.|..|.....:|.|.|.|
Mouse  1868 AAVKIQSTFRMAVAQQQYKLLRAAAAVIQQHVRARAAGKRQHLAYIQLRHAALVFQAAWKGK--- 1929

  Fly  1091 ENENFMLKEELSR------LTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNY 1149
                 ||:.:::|      |....:.:|.::                               :.:
Mouse  1930 -----MLRRQIARQHQCAALIQSYYRMHIQR-------------------------------RKW 1958

  Fly  1150 SYNDSTSLVVKL--RSILEEEKQKHKVLQEQ--YIKLSSRHKPTEDSFRVSELEVENEKLRSEYD 1210
            |...:.:|.::|  |:....::|:|..|:.:  .:.|.|.::..:...||:|.......::|::.
Mouse  1959 SIMKTAALQIQLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRGMKVRKRVAECHKAAVTIQSKFR 2023

  Fly  1211 QLRTSIKH---------------GVEINE------LNAQHAALQEEVR------RRREECIQLKA 1248
            ..||..|:               .::|..      ||.:.||:|.:..      |||.:.:.:.|
Mouse  2024 AYRTQKKYTTYRTSAIVIQRWYRNIKITTQQHQEYLNLRRAAVQVQAAYRGIRVRRRIQHMHMAA 2088

  Fly  1249 VLLQQSQSMRSLEPESLQMR--GNDVNELMEAFHSQKLINRQLESELKAI-TEEHNSKLVEMTQE 1310
            .|::....||......|:||  ...:.....|::..|:.:.:....|||| |.:...:...:.:.
Mouse  2089 TLIEAMFKMRQSRVRYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRRT 2153

  Fly  1311 IERL--------NNEKDELQKVMF------------------ESIDEFEDSNVDTLRQN------ 1343
            :.::        ::.:...|:..|                  |...||:  ....||::
Mouse  2154 VRKMHFAATLIQSHFRGHRQQTYFHRLRKAATMVQQRYRAVKEGSAEFQ--RYSRLRRSVLLIQA 2216

  Fly  1344 -------DRYLRRE------LQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHK-------IEE 1388
                   .|:|:..      :|:....|.:.::.|.|....:...||...:|..|       :|:
Mouse  2217 AFRGLRTRRHLKAMHLAATLIQRRFRTFAMRRKFLSLRKTAIWIQRQYRARLYAKYSRQQLLLEK 2281

  Fly  1389 EMIRNKSN---------------------GTSADVGANVTKQKSQNPQGLMKFH-SSDLDK---- 1427
            .:|:.:|:                     .|....||.:..|..:....:::.| :::|.:
Mouse  2282 AVIKIQSSYRGWVVRKRVQKMHRAATVIQATFRMHGAYMRYQHLKRASVVIQVHTAAELQRQKHA 2346

  Fly  1428 --ILQRLLSALTPRTVVGLLPG--------FPAYLI---FMCIR--------------------- 1458
              |||..:..:..|:.:..:..        |.|:::   |:.:|
Mouse  2347 AVILQAAVRGMKTRSHLKTMHSSATLIQSQFRAFIVRRRFIALRKAAIFVQRKFRATLYAKHKLH 2411

  Fly  1459 -YTDLTNADDDVRELLSKFVIQ--IKKMHRTPHPIE-----NRV-----IWLVNSITLLNLMKQY 1510
             :..|..|...::....:.::|  :::|||....|:     :|.     ||...||.:....:.|
Mouse  2412 QFLQLRKAAITIQSSYRRLMVQKKLQEMHRAAALIQATFRMHRTYVAFHIWKCASIRIQQCYRTY 2476

  Fly  1511 GDVD-EYVKFNTEKQN------QQQLKNFN---LFEYRRVILDLIVNLYQA-------------- 1551
            ..:. :..|...|:|:      |...:.:.   .::.||....:|...|:|
Mouse  2477 RTIKLQKEKLIREEQHSAAVLIQSTYRMYRQRCFYQQRRWAAKVIQKTYRANKRRQDLLYVCKEE 2541

  Fly  1552 ---LIMQIQGLLDPKIVPAILNNDEIQRGRQAHG 1582
               |.|..|||            :..::|||.||
Mouse  2542 TPLLQMHFQGL------------NTAKQGRQQHG 2563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	51/274 (19%)
		MYSc_Myo5	84..767	CDD:276831	47/260 (18%)
		IQ	900..922	CDD:197470	3/21 (14%)
		GBP_C	<971..1086	CDD:303769	28/166 (17%)
		coiled coil	1049..1068	CDD:293879	1/40 (3%)
		coiled coil	1077..1086	CDD:293879	2/8 (25%)
		JAKMIP_CC3	<1190..1299	CDD:292653	30/138 (22%)
		Myo5_CBD	1424..1792	CDD:271254	41/237 (17%)
Aspm	NP_033921.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		ASH	29..126	CDD:292408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..169
		Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000269\|PubMed:28436967	289..388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..600
		CH	928..1024	CDD:294029
		CH	1082..>1135	CDD:278723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900