DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and rasip1

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001276809.1	Gene:	rasip1 / 102725533	ZFINID:	ZDB-GENE-120403-3	Length:	989	Species:	Danio rerio

Alignment Length:	908	Identity:	175/908 - (19%)
Similarity:	288/908 - (31%)	Gaps:	324/908 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1001 EALNKQLEAERD-EKMQ-------LLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAE 1057
            |...|:.|.||| |..|       .:...|.|:||     :..|..|.||||.|.::....:..:
Zfish   261 EEKEKEKERERDGESYQGVRWRRSRMSSGGGAEEE-----RGHRGRNSELRRSISDMNLSLRRRQ 320

  Fly  1058 VNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTA--GSFSLHARKASNAS 1120
            .|..|         |.|....|.......|.::.    |:..|...::.  |..|...|:...|
Zfish   321 GNTGN---------DPRRSGCAQNNGQDRKNIVS----MIATEGGEVSGSRGGVSESDRRTRVA- 371

  Fly  1121 SQNEDDVGYASAKNTLDI------------NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHK 1173
               |:|      |:|.|:            :||..||.:.|                  ::.|..
Zfish   372 ---EED------KDTCDLEVMSQSLILPPTDRPYFLLLQGY------------------DQSKDF 409

  Fly  1174 VLQEQYIKLSSRH----KPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQE 1234
            ||   ||.....|    |||   ||..|::.|.||......::.|.:    ...:|.|:|..:
Zfish   410 VL---YIMAGHTHVFGRKPT---FREREMDREREKKGKRPLKVDTYL----SAPDLLARHLLI-- 462

  Fly  1235 EVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEE 1299
                ||:..:.      :|........|    .||....
Zfish   463 ----RRDTAVP------EQPHGQALARP----FRGGQAT-------------------------- 487

  Fly  1300 HNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEE 1364
                          ||......:.|               |:..|      |....:.||.:..:
Zfish   488 --------------LNGAPLYREAV---------------LKPGD------LLGLGSHFLFLYRD 517

  Fly  1365 LKLANAKLKA----YRQD-------GGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLM 1418
            .::......|    ::.|       ||..:   .:||:|.....|                :.|:
Zfish   518 PRVTPVPPLALPPPWQGDMPTSFGPGGMTD---RQEMLRLYLGST----------------ESLL 563

  Fly  1419 KFHSSDLDKILQR-LLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIK- 1481
            ::.:...|.:||. :|...:|.:..|.|.  ||||:.:.|.|.......:...:||.|...|||
Zfish   564 RYQAKHADALLQEIILKNTSPDSGGGALA--PAYLLSLMIDYASKHLDPELTPQLLLKAANQIKG 626

  Fly  1482 ------KMHRTPHPIENR----------------------VIWLVNSITLLN--------LMKQY 1510
                  |.....||.:|.                      :.|:.|:..|||        |.|::
Zfish   627 IVWDKIKEFGDKHPTQNSADAEVDLPPPSAQKLSSDLRPLMFWMSNATELLNFFQVKVEALEKEW 691

  Fly  1511 -----GDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILN 1570
                 ||.......:|..:...||.:..:..:::.:..|...||             .::||:|:
Zfish   692 EFEAPGDPVLSADMDTCSEALAQLDDVIMHTFQQCVYHLTKTLY-------------SLLPALLD 743

  Fly  1571 NDEI---QRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYA---- 1628
            .:..   :|.:...|::.:..|.|.....|.|.  |....:..|...|:.......:.|.:
Zfish   744 TNPFSSEERKKAKAGVKDKTGSGGEGDEEEDGS--ALPPTVAGLVEVYRCSLQLSREACLSPPLT 806

  Fly  1629 EQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRS-----------KKMSNDV 1682
            .|.|..|.:|.....||.|:.|.::..|...:.||.|:..:.||::.           ||:|..|
Zfish   807 SQTFGYLFFFTNTSLLNTLLERDNLFSWSRAVQIRTNLDLVLDWLQGAGLGDIASEFLKKLSVTV 871

  Fly  1683 LTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKL------------------ 1729
            .....|..::.|  .|..|.|:...:      ||.:|:..::..|||
Zfish   872 NFLCIPKTRLIQ--SSWSSLQEEHPL------LSPSQLHHLLTHYKLGPTRAPPSSWAPPLGTEL 928

  Fly  1730 --DDYESEITNVFLE-------------KLTEKLNARQMQKS-----------NSDEFTIDQK 1766
              |.:||     ||:             .||:.:.:.::||.           :.||...:|:
Zfish   929 GGDIFES-----FLDHPPLILPNETPRLDLTQPIPSPELQKEVTRLRTFLWGLDQDELPANQR 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580
		MYSc_Myo5	84..767	CDD:276831
		IQ	900..922	CDD:197470
		GBP_C	<971..1086	CDD:303769	24/92 (26%)
		coiled coil	1049..1068	CDD:293879	2/18 (11%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	16/108 (15%)
		Myo5_CBD	1424..1792	CDD:271254	92/448 (21%)
rasip1	NP_001276809.1	UBQ	139..254	CDD:294102
rasip1	NP_001276809.1	Myo5p-like_CBD_Rasip1	568..945	CDD:271256	85/406 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900