Protein Alignment didum and LOC100495968

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_002935256.2
• Gene: LOC100495968 / 100495968
• XenbaseID: XB-GENE-29082907
• Length: 1941
• Species: Xenopus tropicalis
• Alignment Length: 2107
• Identity: 524/2107 - (24%)
• Similarity: 893/2107 - (42%)
• Gaps: 574/2107 - (27%)

  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.:.||.......:...:.::.||   :.||      ...:.:.|:.|:.:.|.........
 Frog    20 SEKERIEAQNKPFDAKNTVYIDDTNTL---FVKGFITARDGDKITVKTEDGRTETVTESQIYQQN 81

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            ||..:..     .|:..:::|:||.||.||:.|:. ..:||||.|:..:.:|||..:|:|.|.::
 Frog    82 PPKYDKI-----EDMAMMTHLNEPSVLFNLKERYA-AWMIYTYSGLFCITVNPYKWLPVYNPEVV 140

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGS 187
            ..|||....:..||||::::.||..:..:..|.|::::|||||||||:.|..::||   ||:|.:
 Frog   141 AGYRGKKRVEAPPHIFSISDNAYQSMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAAIGDA 205

  Fly   188 ESETQ--------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            ..:.|        :|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
 Frog   206 GKKKQADNNLKGTLEDQIIQANPLLEAFGNAKTLRNDNSSRFGKFIRIHF-GTTGK--LSSADIE 267

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAE 305
            |||||||||.:|...||:||||||:..  :|.|||:   |...:.:.:..:. |..:::.:.|.:
 Frog   268 TYLLEKSRVTFQLSAERSYHIFYQILT--NKIPELIEMLLLTTNPYDYPTISQGELKVKSIDDED 330

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQIT 370
            :|..|..|:.||||:.::...|.|:...::|.||::..:|..|  |:.:.|..::
 Frog   331 EFMATESAIEVLGFNAEERVSIYKMTGAVMHHGNMKFKQKQRE--EQAEPDGTEV---------- 383

  Fly   371 AD----LLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNK 431
            ||    |:.:::.||.:.|...:::..||:|....::.....:..||.|.:|.|||.::|..:|:
 Frog   384 ADKISYLMGLNSADLLKALCYPRVKVGNEFVTKSQTVPQVCNSVGALCKSVYEKLFLWMVTRINQ 448

  Fly   432 SLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTM 496
            .|:....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|..|||||.||||.|..
 Frog   449 QLDTKQPRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVQEQEEYKKEGIEWEF 513

  Fly   497 IDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFG--- 553
            ||| .|...||:|||..:|:..:|:|||..||.::.|:..||    :|||.   :||||:.|
 Frog   514 IDFGMDLAACIELIEKPMGIFSILEEECMFPKATETSFKNKLYEQHLGKCK---NFEKPKPGKGK 575

  Fly   554 -TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDS-AKS 616
             ...|.:.|::..|:|:::|:|:||:|.::..:.|:..:|::.|...:.:    .....|| :.|
 Frog   576 AEAHFSLVHYAGIVDYNISGWLDKNKDPLNDSVVQLYQKSSVKLLSFLYS----SYASADSGSDS 636

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
            |:.||      |:|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.
 Frog   637 SSKGG------GKKKKGSSF-----------QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNET 684

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCR 744
            |.....:...||.|||..||||.:||...|||||..|.||..||::|...:..|..  |.|.:..
 Frog   685 KTPGIMDNYLIIHQLRCNGVLEGIRICTKGFPSRIQYGDFKQRYKILNASAIPDGQFIDSKKAAE 749

  Fly   745 NIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVI 809
            .::.....|.::||||:|::||:||.:..||::|..:                       :..||
 Frog   750 KLLGSIDVDHNQYRFGHTKVFFKAGLLGTLEEMRDEM-----------------------LAHVI 791

  Fly   810 NGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGM 867
            ..||.:.||||.|...:||...|..|.:.:|       .:.|...:.|.:::..:...:|
 Frog   792 TRIQSYCRGYLMRIEFKKMNSRREALFVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSAET----- 851

  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIII-----------------------CQ 909
              ..:...:::.|.  :|:..:..|.||:...:.:..:::                       |:
 Frog   852 --EKEMANIKEEYE--KIKEALEKAEARKKELEEKMVVLLQEKNDLMLQAQAESETLADAEERCE 912

  Fly   910 AAIR-RFLARRKFKRMK------------------------AEAK--------TISHMENKYMGL 941
            :.|: :.....|.|.|.                        :|.|        |:|.:|.:....
 Frog   913 SLIKGKIQLESKIKEMTERLEDEEESNAELSAKKRKLEDECSELKKDIDELEITLSKVEKEKHAT 977

  Fly   942 ENKIISM-------------------------QQRIDELNRDNSNLKHKTSEISVLKMKLE---- 977
            |||:.::                         ||.:|:|..:    :.|.:.:|..|.|||
 Frog   978 ENKVKNLTEDMAALDDNISKVTKEKKSLQEAHQQTLDDLQTE----EDKVNTLSKAKSKLEQQVD 1038

  Fly   978 --------------------------LKKTLEA--EFKNVKAACQD----KDKLIEALNKQLEAE 1010
                                      ||.|.|.  :|:|.|...::    ||..|..|..::|.|
 Frog  1039 DLEGSLEQEKKLRLDLERTKRKLECDLKLTQETVLDFENDKQQAEERLKKKDYEISQLLSKIEDE 1103

  Fly  1011 R------DEKMQLLEENGHAQEEWISQKQTWRQENEELR----RQIDEIIDMAKNA--------E 1057
            :      .:|::.|:......||.|..::|.|.:.|:.|    |:::||.:..:.|        |
 Frog  1104 QALSSQLQKKIKELQARTEELEEEIEAERTVRAKAEKQRALITRELEEISERLEEAGGATAVQIE 1168

  Fly  1058 VNQRNQED-----RMLAEIDNR-----------------ELNEAYQRAIKDKEVIENENFMLKEE 1100
            :|::.:.:     |.|.|.:.|                 ||.|......:.|:.:|.|...||.|
 Frog  1169 MNKKRENEFQKMRRDLEEANLRHETIACNLRKKHADTVAELGEQLDNLQRIKQKLEKEKSELKME 1233

  Fly  1101 LSRLTAGSFSLHARKASNASSQN---EDDVGYASAK--------NTLDINRPPDLLSKNYSYN-- 1152
            :... |.:....::..:|....|   ||.:..|.||        |.|..:: ..|||:|...:
 Frog  1234 IDDF-ASNLDNTSKLKANFEKLNHVLEDQLSEAKAKGEEQQRLLNDLTTHK-ARLLSENGELSRQ 1296

  Fly  1153 --DSTSLVVKL---------------RSILEEEKQK----HKV---------LQEQY-------- 1179
              :..||:.:|               |.:.||.|.|    |.|         |:||:
 Frog  1297 GEEKESLISQLSRGKQAFIQQIEELKRQLEEETKAKNALAHAVQSARHDCDLLREQFEEEQEAKS 1361

  Fly  1180 -----------------------------------IKLSSRHKPTED-----SFRVSELEVENEK 1204
                                               .||:...:..||     :.:.:.||...::
 Frog  1362 ELQRSLSKANNEVSQWRNKYETDAIQRTEELEEAKKKLAQHLQEAEDQVAAVNSKCASLEKTKQR 1426

  Fly  1205 LRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLK-------AVLLQQSQSMRSLEP 1262
            |:||.|.|.      :::...|...|||.::.|...:..::.|       |.|....:..|||..
 Frog  1427 LQSEVDDLM------IDVERSNNAAAALDKKQRNFDKVLVEWKQKYGEGQAELEAALKECRSLST 1485

  Fly  1263 ESLQMRGNDVNELMEAFHSQKLINRQLESELKAITE---EHNSKLVEMTQEIERLNNEKDELQKV 1324
            |..:|| |...|.:|...:.|..|:.|:.|:..:||   |....:.|:.:..:::..:|:|:|..
 Frog  1486 EIFKMR-NAYEEALELTETLKRENKNLQQEITDLTEHIGESGKSINELDKARKQVEQQKNEMQAA 1549

  Fly  1325 MFESIDEFE---------------------------DSNVDTLRQNDRYLRRELQKAVAQFLLVQ 1362
            :.|:....|                           |..::.|::|::.....||..      :.
 Frog  1550 LEEAEGSLEHEETKFLRIQLELNQVKSEMDKKIAEKDEEIEQLKRNNQRATDTLQTT------LD 1608

  Fly  1363 EELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSD-LD 1426
            .|::..|..|:..::..|.|.   |.|:..|::|..:|:....:...::||...|::..:.: ::
 Frog  1609 SEIRSRNEALRLKKKMEGDLN---ELEIQLNQANRQAAEAQKQLRNVQTQNKDTLLQLDNKERIE 1670

  Fly  1427 KILQRLLSALTPRTVVGL--LPGFPAYLIFM---CIRYTDLTNADDDVRELLSKFVIQIKKMHRT 1486
            ..|:..::.|..||.:.|  :....|.|..:   | :..:...||...|       :|:.:.|.|
 Frog  1671 SDLKEQIAVLERRTALQLAEIEEIRAALEMLDRSC-KVAEQELADSSER-------LQLLRSHNT 1727

  Fly  1487 PHPIENRVIWLVNSITLL--NLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLY 1549
            .         |.||...|  ::.:...:|:|.::   |.:|.::       :.::.|.|
 Frog  1728 S---------LTNSKKKLESDVSQLQSEVEESIQ---EARNTEE-------KAKKAITD------ 1767

  Fly  1550 QALIMQIQGLLDPKIVPAILNNDEIQRGR--QAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLE 1612
                             |.|..:|:::.:  .||.:|.:.                      .||
 Frog  1768 -----------------AALMAEELKKEQDTSAHLVRMKK----------------------NLE 1793

  Fly  1613 HFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVR--S 1675
            ...|..|| .||.  |||                |.|:|.          :..:..:|..||  .
 Frog  1794 QTVKDLQH-RLDE--AEQ----------------LALKGG----------KKQLQKLETRVRELE 1829

  Fly  1676 KKMSNDVLTALAPLNQVSQ--------LLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDY 1732
            .::.|:....:..:..|.:        ..|:.:..::|..:.||...|.    ||| |:||....
 Frog  1830 NELENEQKRGVEAVKGVRKYERRMKELTYQNEEDRKNVLRLQDLVDKLQ----LKV-KAYKRQAE 1889

  Fly  1733 ESEITNVFLEKLTEKLNA-----RQMQ 1754
            |:|          |:.||     |:||
 Frog  1890 EAE----------EQANAHMARYRKMQ 1906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	263/713 (37%)
		IQ	900..922	CDD:197470	3/45 (7%)
		SMC_prok_B	<942..1365	CDD:274008	127/651 (20%)
		Myo5_CBD	1424..1792	CDD:271254	67/356 (19%)
LOC100495968	XP_002935256.2	Myosin_N	33..77	CDD:460670	7/46 (15%)
		MYSc_class_II	100..772	CDD:276951	263/713 (37%)
		Myosin_tail_1	852..1929	CDD:460256	222/1195 (19%)