Protein Alignment didum and myo5c

DIOPT Version :9

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_012815050.1
• Gene: myo5c / 100495210
• XenbaseID: XB-GENE-1004095
• Length: 1721
• Species: Xenopus tropicalis
• Alignment Length: 1893
• Identity: 692/1893 - (36%)
• Similarity: 1047/1893 - (55%)
• Gaps: 291/1893 - (15%)

  Fly    13 KIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTT 77
            ::|:|.|:.||.||.:.:..:.|...|.:|.:.|...:..::.:...|||||||.||||:||||.
 Frog    15 RVWIPDAEEVWRSAEITKDLKIGDTVLHLCLEDGTHLKYPVEPEKQVLPPLRNPDILVGENDLTA 79

  Fly    78 LSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFA 142
            |||||||.|||||:|||.|..:||||.||||||||||.|:|:||.:||.||.|..|||::|||||
 Frog    80 LSYLHEPAVLHNLKVRFVESNVIYTYSGIILVAINPYKELPIYGDAIIHAYSGQNMGDIDPHIFA 144

  Fly   143 LAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAF 207
            :|||||.::.|.|.|.||||||||||||||||:|.|||||.|..:.|:..||.|||||:||.||.
 Frog   145 VAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYTMRYFATVSKTSSKAHVEDKVLASNPITEAI 209

  Fly   208 GNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAA 272
            ||||||||||||||||:|::.|..:..::   ||.:.||||||||||:|::.||||||||||||:
 Frog   210 GNAKTTRNDNSSRFGKYTEISFDRRYKII---GANLRTYLLEKSRVVFQSENERNYHIFYQLCAS 271

  Fly   273 RSK--YPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGIL 335
            .:|  :..|.|...::|.:.:|||...|..|.|.:...:|.:...:||.......|:.|::|.||
 Frog   272 ANKPEFEHLHLTRAEEFNYTSMGGCTVITGVDDKKDMLDTQKTFALLGLGTDFQMDVFKVVAAIL 336

  Fly   336 HLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIP 400
            ||||:::.:      ..:|..|.|:  ||.||:|..|||.:.|..:.:||..|:|.:|::.|:.|
 Frog   337 HLGNVEIKR------VSDDRSSVDV--NDKHLKIFCDLLNLEASKVAQWLCNRRIVTVSDTVIKP 393

  Fly   401 NSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCIN 465
            .:.:.|..|||||||.||:.||.|::..:|.:|....||.:||||||||||||||:|||||||||
 Frog   394 MTKQQADNARDALAKKIYSHLFDYVIDKINNALQYPGKQHTFIGVLDIYGFETFEINSFEQFCIN 458

  Fly   466 YANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECRMPKGSD 530
            |||||||||||.||||||||||:||.|.||:|||||||..|||||:::|:||||||||.:|:|:|
 Frog   459 YANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQIVIDLIEAKMGILDLLDEECLLPQGTD 523

  Fly   531 ESWAGKLIGK-CNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNM 594
            |:|..||... .||.|.|||||....||.|:||:|.|||..:||||||||||...|..:|..|..
 Frog   524 ENWLQKLYNNYLNKNPLFEKPRMSNRSFIIQHFADKVEYKCDGFLEKNRDTVYDVLIDLLRTSKF 588

  Fly   595 SLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLA 659
            .|......        .:::||:.....:.:.:.|....:.       :|:.|.||||:|:.||.
 Frog   589 QLCSSFFQ--------DNTSKSAQFSSGIQVKSARPAIKSS-------NKEFRMTVGSKFRNSLC 638

  Fly   660 SLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMR 724
            .|:.||:||||||||||||||.|:.|:::..:::|||||||||||:||||..:||||.|.:|:.|
 Frog   639 LLMETLNATTPHYVRCIKPNDLKLPFEFDAKRVVQQLRACGVLETIRISAQSYPSRWTYIEFFGR 703

  Fly   725 YQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIV 789
            |.:|:.:.:|..||.|..|:.::.:.|||.::|:||.|:|||||||||:||::|::..:....|:
 Frog   704 YSILMTQQELSLNDKKYICKIVLQRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRSDKLRNACVII 768

  Fly   790 QSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERT---QKMREARAGLILSKYARGWLCRRRYL 851
            |..||.:|.:::|.|.::....||::.||..|..:.   :.::.|.|.:|:.||.||:|.||.|.
 Frog   769 QKSVRGWVQKKKFSRARRSAIVIQQYFRGQRAVRQAISGKALKHAWAAIIIQKYVRGFLVRRIYQ 833

  Fly   852 RLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFL 916
            .:..:...||::.||.|||.::|.||:.::|:.:|::.|..||||.:|..||.::..|
 Frog   834 LILVATVTIQSFTRGYLARKRYHKMREEHKALILQKYARAWLARRRFQNVRRFVLNIQ------- 891

  Fly   917 ARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKT 981
                                    |..::..:|:::::.|::|..|..:.:.::
 Frog   892 ------------------------LSYRVQRLQKKLEDQNKENHGLLERLTSLA----------- 921

  Fly   982 LEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQI 1046
                    .:...|.|| :..|..:||....:|.. |:|.|...:|...:|.|..|
 Frog   922 --------SSHTHDVDK-VHKLESELEKISSQKKH-LDEKGKKYKEEAEEKMTKLQ--------- 967

  Fly  1047 DEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSL 1111
                  |:|||:                 |.:.:|..:|    :|.:...:|:::.:||...|:
 Frog   968 ------AQNAEL-----------------LEQKHQMEVK----LETKTQEMKDQMDQLTNQLFT- 1004

  Fly  1112 HARKASNASSQNEDDVGYASAKNTLDINRPPD---LLSKNY--SYNDSTSLVVKLRSILEEEKQK 1171
                                     |:.:...   .|.|::  ...:..:::.||:..::..|::
 Frog  1005 -------------------------DVEKEEKQRMKLEKHFEAQVTEFDTMIEKLKDEIQVLKER 1044

  Fly  1172 HKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKH------GVEI--NELNAQ 1228
            :|.|.:|                ..|.::.|:.||.|.|||...:|.      .:|:  |:....
 Frog  1045 NKHLLKQ----------------AEEEQLVNDGLREEIDQLSIQVKKIPTFQTDIELLENQKRDL 1093

  Fly  1229 HAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMR------GNDVNE------------- 1274
            ...|||:.|..||:..::      ..|.:.|.|.|.::.|      || :||
 Frog  1094 EHQLQEQKREMREKLDEM------AKQLLNSFEIEDVKARLAEEELGN-LNEDGEIWFAYEGLKK 1151

  Fly  1275 ---LMEA-FHSQK--------LIN---RQLESELKAI----TEEHNSKLVEMTQEIERLNNEKDE 1320
               ::|| |.:|:        |:|   ..|..::|.|    .||.:|| ..:|.|:|||.:: ::
 Frog  1152 ATRILEAHFQTQRENYEKDIELLNFKVEHLHDDIKQIQNSYMEEKDSK-ESITLEVERLRSD-NK 1214

  Fly  1321 LQKVMFESIDEFEDSNVD--------TLRQNDRYLRRELQKAVAQFLLV----QEELKLANAKLK 1373
            :.|.:.:.:.|.|:.|:|        |::..::..||:......:..|.    |.|..:||.|::
 Frog  1215 VVKDLRKKLAELEEQNMDLQGRLYEQTMKLPEKSNRRKNYPDEDEVSLKLWNGQRENDMANVKIQ 1279

  Fly  1374 AYRQDGGQLEHKIE------EEMI--RNKSNGTSADVGANVTKQKSQNPQ-----------GLMK 1419
            |.:.|...::.:.|      ||.:  ::::.....|....:||...::.:           |:::
 Frog  1280 AIQTDNMYMKEQNEADTRDFEEQVDMKDRTIRKLQDQIKALTKSIEKDDEVRVPTVFKDYLGMLE 1344

  Fly  1420 FHSSDLDKILQRLLSALTPR-TVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKM 1483
            |.|.|..|:::.|:..|.|| .||.::||.||:::|||:||||..|..:.::.|::..:..||::
 Frog  1345 FASEDESKLIRNLILDLKPRGVVVNMIPGLPAHIMFMCVRYTDYINNAERIKSLMNASINSIKQV 1409

  Fly  1484 HRT-PHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVN 1547
            .:. ....|....||.|....||.:|||...:|::|:|...||:..||||:|.|||::|.||.:.
 Frog  1410 IKEHADDFEMLSFWLSNVHHFLNCLKQYSGEEEFMKYNQPLQNKNCLKNFDLSEYRQIISDLAIR 1474

  Fly  1548 LYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGM--------RSRATSIGASSSPEHGGGPAW 1604
            :|...|..::..|.|.|||.:|..:.:      ||:        |.|::||..:.|      ...
 Frog  1475 IYHQFITVMENNLQPMIVPGMLEYESL------HGISVSKPTGFRKRSSSIDDTDS------YTM 1527

  Fly  1605 KQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCI 1669
            ..::.||.:||......|:|....:|...||.:.|..|.:|.|.||.|:|....||.||.||..:
 Frog  1528 TSILQQLSYFYTTMCQHGMDPELLKQTMKQLFFLIATVTINSLFLRKDMCSCRKGMQIRCNISYL 1592

  Fly  1670 EDWVRSKKMSNDVLTA---LAPLNQVSQLLQSRK-SEQDVQTICDLCTSLSTAQVLKVMKSY-KL 1729
            |:|::.|.:..  .||   |.||:|.:.|||.:| ::.|.:.|.:.||:||:.|::|::.|| .:
 Frog  1593 EEWLQGKNLQG--ATAKETLEPLSQAAWLLQVKKITDDDAKEIYERCTALSSVQIVKILNSYTPI 1655

  Fly  1730 DDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDI--KLEDIELPSHLN 1792
            ||:|..:|..|:.|:...||.|:    :..:..:|.|::  |:|.|.:|..  .||.|::||.|.
 Frog  1656 DDFEKRVTPSFVRKVQSMLNNRE----DCSQLMLDSKYL--FQVTFPFSPSPHALEMIQIPSSLK 1714

  Fly  1793 LDEFLTKI 1800
            |. |||:|
 Frog  1715 LG-FLTRI 1721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	387/715 (54%)
		MYSc_Myo5	84..767	CDD:276831	362/685 (53%)
		IQ	900..922	CDD:197470	3/21 (14%)
		GBP_C	<971..1086	CDD:303769	20/114 (18%)
		coiled coil	1049..1068	CDD:293879	4/18 (22%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	35/154 (23%)
		Myo5_CBD	1424..1792	CDD:271254	129/384 (34%)
myo5c	XP_012815050.1	MYSc	67..757	CDD:214580	387/715 (54%)
		MYSc_Myo5	86..746	CDD:276831	362/685 (53%)
		IQ	815..833	CDD:197470	9/17 (53%)
		SYCE1	894..1051	CDD:291886	38/239 (16%)
		COG1340	895..1142	CDD:224259	65/352 (18%)
		Prefoldin	989..1113	CDD:298833	30/171 (18%)
		Myo5c_CBD	1348..1715	CDD:271260	130/386 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52542
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930