Protein Alignment didum and LOC100493774

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_004916275.2
• Gene: LOC100493774 / 100493774
• XenbaseID: XB-GENE-29081879
• Length: 1989
• Species: Xenopus tropicalis
• Alignment Length: 1988
• Identity: 552/1988 - (27%)
• Similarity: 889/1988 - (44%)
• Gaps: 402/1988 - (20%)

  Fly    13 KIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR------NPAILVG 71
            ::|||.....:|:|:::|             :.|:...|:|..:|..:|..:      ||.....
 Frog    35 QVWVPSEKHGFEAASIKE-------------ERGEEVIVELAENGKRVPVAKDDIQKMNPPKFTK 86

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDL 136
            ..|:..|:.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|||....::
 Frog    87 VEDMAELTCLNEASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLPIYTEQIVEMYRGKKRHEI 150

  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG-----------SESE 190
            .|||:|::|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..           |.|.
 Frog   151 PPHIYAISETAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKEHTAPSSSN 215

  Fly   191 T---QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSR 252
            |   ::|.::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||
 Frog   216 TFYGELEHQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVAG--YIVGANIETYLLEKSR 277

  Fly   253 VVYQAQGERNYHIFYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMT 315
            .:.||:.||.:|:||||.|...::  .:|:|:..::::||:.|..| |....|.|.|.||:::|.
 Frog   278 AIRQAKDERTFHVFYQLLAGAGEHMKTDLLLEGFNQYRFLSNGNLP-IPGQQDREIFQETMESMK 341

  Fly   316 VLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADD 380
            ::||:.::|..::|:::.:|..|||...|       |.::|...:..|.. .|....||.::..:
 Frog   342 IMGFNHEEIMSMLKMVSAVLQFGNIVFRK-------ERNTDQASMPDNTA-AQKLCHLLGLNVTE 398

  Fly   381 LRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIG 444
            ..|.:||.:|:...:||....:.|.|..|.:||||.:|.:||:::|..:||:|:...:| .||||
 Frog   399 FSRAILMPRIKVGRDYVQKAQTKEQADFAVEALAKALYERLFRWLVHRINKALDRTKRQGASFIG 463

  Fly   445 VLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDL 508
            :|||.|||.||:|||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||
 Frog   464 ILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIEWNFIDFGLDLQPCIDL 528

  Fly   509 IE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEY 568
            ||   :..|||.||||||..||.:|:|:..|:|.:....|.|:|||  .......|.|::..|:|
 Frog   529 IERPANPPGVLSLLDEECWFPKATDKSFVEKVIQELGNHPKFQKPRQLRDKADLCIIHYAGKVDY 593

  Fly   569 DVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQG 633
            ..:.:|.||.|.::..:..:|.:|......::.  :::|.:         :|...|...|....|
 Frog   594 KADEWLMKNMDPLNDNVATLLHQSTDKYTAELW--KDVDRI---------VGLDQVSGMGEMSFG 647

  Fly   634 NDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRA 698
            :..:.:    |...:|||..::|||:.|:|||..|.|::||||.||.:|.|.|.|...::.|||.
 Frog   648 SSYKTK----KGMFRTVGQLYKESLSKLMSTLRNTNPNFVRCIIPNHEKKAGKLEPHLVLDQLRC 708

  Fly   699 CGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGN 761
            .||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:.||.|.
 Frog   709 NGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACAIMIRALELDPNLYRIGQ 772

  Fly   762 TQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQ 826
            ::||||||.:|.||:.|.                       |:|..:|...|..|||||||....
 Frog   773 SKIFFRAGVLAHLEEERD-----------------------LKITDIIVFFQAAARGYLARRAFY 814

  Fly   827 KMREARAGL-ILSKYARGWLCRRRYLRLRH-SISGIQTYARGMLARNKFHAMRDHY---RAVQIQ 886
            |.::..:.| ::.:....      ||:||| ....:.|..:.:|...:    :|..   :.|::|
 Frog   815 KKQQQMSALKVVQRNCAA------YLKLRHWQWWRLFTKVKPLLQVTR----QDEVMQAKVVELQ 869

  Fly   887 RF------VRGALARRA--YQK--RRRNIII--CQAAIRRFL----ARRKFKRMKAEAKTISH-- 933
            :.      ....|...|  ||:  ..::|:.  .||....|.    .|.:....|.|.:.|.|
 Frog   870 KVKDTQVKTESELKEMANKYQQLFEEKSILAEQLQAETELFAEAEEMRARLASKKQELEEILHDL 934

  Fly   934 ------MENKYMGLENKIISMQQRIDELN---------RDNSNLKHKTSEISVLKMKLELKKTLE 983
                  .|.:.:.|:|:...|.|.|.:|.         |....|:..|:|..:.||:.::   |.
 Frog   935 EARVEEEEERTLQLQNEKKKMHQHIQDLEEQLEEEEGARQKLQLEKVTTESRLKKMEEDI---LL 996

  Fly   984 AEFKNVKAACQDK---DKLIEALNKQLEAERDEKMQLLEE--NGHAQ-----EEWISQKQTWRQE 1038
            .|.:|.|.|.:.|   |::.|..:..  ||.:||::.|.:  |.:..     |:.:.:::..|||
 Frog   997 LEDQNAKLAKERKLLDDRIGEFTSTM--AEEEEKVKSLNKLRNKYEAVIADLEDRLKKEEKGRQE 1059

  Fly  1039 NEELRRQID-EIIDMAKN-AEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFM--LKE 1099
            .|:::|::| |..|:... .|:.|:.:|.:........||..|..|.  |.||.:..|.:  |::
 Frog  1060 MEKMKRKLDGETTDLQDQLLELQQQIEELKQQLARKEEELQAALARV--DDEVGQKNNLLKQLRD 1122

  Fly  1100 ELSRLTAGSFSLHARKASNASSQNE-DDVG--YASAKNTLDINRPPDLLSKNYSYNDSTSLVVKL 1161
            ..|:|......|.:.||:.|.::.: .|:|  ..:.|..|:     |.|       |||:...:|
 Frog  1123 LQSQLAELHEDLESEKAARAKAEKQRRDLGEELEALKTELE-----DTL-------DSTAAQQEL 1175

  Fly  1162 RSILEEE--------KQKHKVLQEQYIKLSSRHKPTEDSFRVSE-----------LEVENEKLRS 1207
            |:..|:|        ::..||...|..::..||....:  .:||           ||...:.|.|
 Frog  1176 RAKREQEVTDLKKTIEEDVKVRDAQVTEMRQRHNQVVE--EISEQLEQARRFKGNLEKVKQTLES 1238

  Fly  1208 EYDQLRTSIKHGVEINELNAQHAALQEEVRRRR-----------------------EECIQLKAV 1249
            |...|...:|        |.|.|....|.||::                       |:..:|:|.
 Frog  1239 ENTDLIKEVK--------NLQAAKQDSEQRRKKLEQQVSEFQIRTNESEKVKFELAEKLQKLQAE 1295

  Fly  1250 LLQQSQSMRSLEPESL---------QMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLV 1305
            |...|.::.|.|.:|:         |.:..|..||::....|||   ...|.::.:.||.|: |:
 Frog  1296 LDGVSGALGSTEGKSIKLTKDLSTVQSQLQDTQELLQEETRQKL---NFSSRVRQLEEEKNN-LM 1356

  Fly  1306 EMTQEIE----RLNNEKDELQKVMFESIDEFEDSN--VDTLRQNDRYLRRELQKAVAQF------ 1358
            |..:|.|    :|:.:...||:.:.||....||..  |:.:.:..:...:||:....:|
 Frog  1357 ENLEEEESAKAQLSRQLQALQQQLLESKKRMEDQGGMVEAMEEAKKKSYKELEFLQQRFDEKHQI 1421

  Fly  1359 --------LLVQEELKLANAKLKAYRQDGGQLEHKIE--EEMIRNKSN-----GTSADVGANVTK 1408
                    ..:|:||......|...||....||.|.:  ::|:..:.|     |...|......:
 Frog  1422 NDKLEKTRNRLQQELDDLMVDLDHQRQIVSNLEKKQKKFDQMLAEEKNISARYGEERDRAEAEAR 1486

  Fly  1409 QKSQNPQGLMKF--HSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDV-- 1469
            :|......|.:.  .:.||...|.|....|.                   ....||.::.|||
 Frog  1487 EKETKALSLSRALEEAIDLKDELDRQNKQLR-------------------AEMDDLVSSKDDVGK 1532

  Fly  1470 ------------RELLSKFVIQIKKMHRTPHPIENRVIWL-VNSITLLNLMKQYGDVDEYVKFNT 1521
                        .:.:.:...||:::......||:..:.| ||    :..||        .:|..
 Frog  1533 NVHELERSKRALEQQVQEMKTQIEELEDELQAIEDGKLRLEVN----MQAMK--------AQFER 1585

  Fly  1522 EKQNQQQL---KNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGM 1583
            :.||:...   |...||:..|   ::.|.|.:....:.|.|...|.:...|.:.|.|
 Frog  1586 DLQNRDDSNDEKKKLLFKQVR---EMEVELEEERKQKSQILAAKKKLEMDLQDMESQ-------- 1639

  Fly  1584 RSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLL---YFICAVALN 1645
                     ..|...|...|.|||......|.:.::.........::||.|..   ..:.::...
 Frog  1640 ---------MDSANKGRDEAVKQLKKLQLQFKEVWREVEETRAARDEIFVQSRDNEKKLKSLEAE 1695

  Fly  1646 CLMLRGDICMWETGMIIRYNIGCIEDWVRSKK------------MSNDVLTALAPLNQ------- 1691
            .|.|:.|:...|                |:|:            :||.|....|.|::
 Frog  1696 LLQLQEDLAAAE----------------RAKRQAQQERDDLADELSNGVSGKSALLDEKRALEMR 1744

  Fly  1692 VSQLLQSRKSEQ-DVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEK-LTEKL-NARQM 1753
            :|||.:....|| :.:.|.|....| |.||            |:..|.:..|: .::|. ||||.
 Frog  1745 ISQLEEELDEEQSNTELINDRYRKL-TLQV------------ETITTELSAERSFSQKAENARQQ 1796

  Fly  1754 QKSNSDEFTI-----DQKFIQPFKVVFRYSDIKLEDIE 1786
            .:..:.|..:     |......:|:.....:.|:..:|
 Frog  1797 MERQNKELKVKLNEMDSTMRSKYKITIASLEAKISQLE 1834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	276/707 (39%)
		IQ	900..922	CDD:197470	5/29 (17%)
		SMC_prok_B	<942..1365	CDD:274008	120/519 (23%)
		Myo5_CBD	1424..1792	CDD:271254	79/411 (19%)
LOC100493774	XP_004916275.2	Myosin_N	31..76	CDD:460670	11/53 (21%)
		MYSc_Myh10	99..778	CDD:276952	276/707 (39%)
		Myosin_tail_1	855..1935	CDD:460256	231/1097 (21%)