Protein Alignment didum and LOC100493121

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_012809641.1
• Gene: LOC100493121 / 100493121
• XenbaseID: XB-GENE-29081519
• Length: 1935
• Species: Xenopus tropicalis
• Alignment Length: 2056
• Identity: 522/2056 - (25%)
• Similarity: 897/2056 - (43%)
• Gaps: 488/2056 - (23%)

  Fly    29 EESYRKGAGFLKICTDSGK-------LKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGV 86
            ::.|.||....|   :.||       :..|.:|.|  ::.|: ||.......|:..:::|:||.|
 Frog    43 KQMYVKGIVQSK---EGGKATVKKEDMSTVTVKDD--EIFPM-NPPKYDKIEDMAMMTHLNEPSV 101

  Fly    87 LHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKL 151
            |:||:.|:. ..:||||.|:....:|||..:|:|.|.::.||||....:..||||::::.||..:
 Frog   102 LYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYNPEVVNAYRGKKRQEAPPHIFSISDNAYQYM 165

  Fly   152 ERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGSESET--------QVERKVLASSPIME 205
            ..:..|.|::::|||||||||:.|..::||   ||:|..:.|.        .:|.:::.::|::|
 Frog   166 LTDRENQSVLITGESGAGKTVNTKRVIQYFATIAAIGDKKKEEAAPGKIQGTLEDQIIQANPLLE 230

  Fly   206 AFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC 270
            |||||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|...||:||||||:.
 Frog   231 AFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LSSADIETYLLEKSRVTFQLSAERSYHIFYQIM 292

  Fly   271 AARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKI 330
            :  :|.||     |:..:...|.:::.|.. .:..:.|.|:...|..|:.:|||:..:...|.|:
 Frog   293 S--NKRPELIDMLLITTNPYDFPYVSQGEI-TVASIDDQEELMATDSAIDILGFNNDEKNGIYKL 354

  Fly   331 LAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNE 395
            ...::|.||::..:|..|  |:.:.|..::...      .|.|:.:::.||.:.|...:::..||
 Frog   355 TGAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------AAYLMGLNSADLLKALCYPRVKVGNE 411

  Fly   396 YVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFE 460
            :|....:::....:..||.|.:|.|:|.::|..:|:.|:....:..|||||||.|||.|:.||.|
 Frog   412 FVTKGQTVQQVYNSVGALGKSVYEKMFLWMVIRINQQLDTKQPRQHFIGVLDIAGFEIFDFNSLE 476

  Fly   461 QFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECR 524
            |.|||:.||||||.||.|:|.||||||.||||.|..||| .|...||:|||..:|:..:|:|||.
 Frog   477 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECM 541

  Fly   525 MPKGSDESWAGKL----IGKCNKFPHFEKPRFG----TTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            .||.:|.|:..||    :||.|   :|:||:.|    ...|.:.|::.||:|:::|:|:||:|.:
 Frog   542 FPKATDTSFKNKLYDQHLGKSN---NFQKPKPGKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPL 603

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSST---LGGRVVISAGRKQQGNDTRRRVVPS 643
            ::.:..:..:|::.|...:.           ||.|.|   .||:    .|.|::|:..
 Frog   604 NETVIGLYQKSSVKLLSFLY-----------SAYSGTDADTGGK----KGGKKKGSSF------- 646

  Fly   644 KQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRIS 708
                :||.:.|:|:|..|::.|.:|.||:|||:.||:.|.....:...::.|||..||||.:||.
 Frog   647 ----QTVSALFRENLNKLMANLRSTHPHFVRCLIPNETKTPGAMDHYLVMHQLRCNGVLEGIRIC 707

  Fly   709 AAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQ 770
            ..|||||.||.||..||::| ..|.:.:.   |.|.:...::.....|..:|:||:|::||:||.
 Frog   708 RKGFPSRILYGDFKQRYKIL-NASAIPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFKAGL 771

  Fly   771 VAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGL 835
            :..||::|..                       |:.::|...|...||||.|...::|.|.|..:
 Frog   772 LGTLEEMRDE-----------------------RLAQLITRTQAMCRGYLMRVEFRQMMERRESI 813

  Fly   836 ILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGAL 893
            ...:|       .:.|...:.|.:::..:...::.......:.:|...::             ||
 Frog   814 FCIQYNVRSFMNVKHWPWMKLYFKIKPLLKSAESEKEMQNMKEEFEKTKE-------------AL 865

  Fly   894 ARRAYQKR---RRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDEL 955
            |:...:::   .:.:.|.|......|      ::.:|:::::..|.:..||....|.::.:|.|.
 Frog   866 AKSEAKRKELEEKMVAILQEKNDLHL------QVTSESESLADAEERCEGLIKAKIQLEAKIKEF 924

  Fly   956 NRDNSNLKHKTSEISVLKMKL-----ELKKTLE------AEFKNVKAACQDK-----------DK 998
            |....:.:...:|::..|.||     ||||.::      |:.:..|.|.::|           |:
 Frog   925 NERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAILDE 989

  Fly   999 LIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEI---IDMAKNAEVNQ 1060
            .|..|.|:.:|.::...|.|::. .|:|:.::   |..:...:|.:|:|::   ::..|...::.
 Frog   990 TIAKLTKEKKALQEAHQQTLDDL-QAEEDKVN---TLTKAKTKLEQQVDDLEGSLEQEKKLRMDM 1050

  Fly  1061 RN------------QEDRMLAEIDNRELNEAYQRAIKDKEV------IENENFM-------LKEE 1100
            ..            ||..|..|.|.::|:|..::  |:.|:      ||:|..:       :||.
 Frog  1051 ERAKRKLEGDLKLAQESTMDLENDRQQLDEKVKK--KEFEISQLQSKIEDEQALAAQLQKKIKEL 1113

  Fly  1101 LSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNY-SYNDSTSLVVKLRSI 1164
            .:|:......:.|.:|:.|.::          |...|::|..:.:|:.. ....:||..:::...
 Frog  1114 QARIEELEEEIEAERAARAKAE----------KQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1168

  Fly  1165 LEEEKQKHK------VLQEQYIKLSSRHKPTEDSFRVSE-----------LEVENEKLRSEYDQL 1212
            .|.|.||.:      .||.:....:.|.|..:....:.|           ||.|..:|:.|.|.|
 Frog  1169 REAEFQKMRRDLEEATLQHEATASALRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDL 1233

  Fly  1213 RTSI------KHGVE-----------------------INELNAQHAALQE---EVRRRREE--- 1242
            .:::      |..:|                       ||::|||.|.|..   |..|:.||
 Frog  1234 ASNMESVSKAKSNLEKMCRTLEDQFSEVKTKEEEHLRVINDINAQRARLHTENGEFSRQLEEKES 1298

  Fly  1243 ----CIQLKAVLLQQSQSM-RSLEPES---------LQMRGNDVNELMEAFHSQKLINRQLESEL 1293
                ..:.|....||::.: |.||.|:         ||...:|.:.|.|.:..::....:|:..|
 Frog  1299 MISQLSRAKQAFTQQTEELKRQLEEETKAKNALAHGLQSARHDCDLLREQYEEEQEAKGELQRSL 1363

  Fly  1294 KAIT---------------------EEHNSKLVEMTQE----IERLNNEKDELQKVMFESIDEFE 1333
            ....                     ||...||.:..||    ||.:|::...|:|......:|.|
 Frog  1364 SKANSEVSQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQNEVE 1428

  Fly  1334 DSNVDTLRQN-------------DRYL---RRELQKAVAQFLLVQEE--------LKLANA---- 1370
            |..||..|.|             |:.|   :::.:::.|:....|:|        .|:.|:
 Frog  1429 DLMVDVERSNSACAALDKKQKNFDKVLADWKQKFEESQAELEASQKESRSLSTEVFKMKNSYEEA 1493

  Fly  1371 --KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLL 1433
              :|:..:::...|:.:|.:...:...:|.:..   .:.|.|.|..|     ..|||...|:.
 Frog  1494 LDQLETLKRENKNLQQEISDLTEQIAESGKTIH---EIEKAKKQIEQ-----EKSDLQSALEE-- 1548

  Fly  1434 SALTPRTVVGLLPGFPAYLIFMCIRYTD--------LTNADDDVRELLSKFVIQIKKMHRT-PHP 1489
                   ..|.|....|.::.:.:....        :...|:::.:|.......::.|..| ...
 Frog  1549 -------AEGSLEHEEAKVLRIQLELNQVKGEVDRKIAEKDEEIEQLKRNSQRALESMQSTLDAE 1606

  Fly  1490 IENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIM 1554
            |.:|     |....|. .|..||::| ::......|:|..::                  |..:.
 Frog  1607 IRSR-----NDALRLK-KKMEGDLNE-MEIQLSHANRQAAES------------------QKQLR 1646

  Fly  1555 QIQGLL-DPKIVPAILNNDEIQRGR-------------------QAHGMRSRATSIGASSSPEHG 1599
            .:|||| |.:     |:.|:.|||.                   :...|||      |....|.|
 Frog  1647 NVQGLLKDTQ-----LHLDDAQRGNDDLKEQLAIVERRNNLMTAEIEEMRS------ALEQTERG 1700

  Fly  1600 GGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNC-LMLRGDICMWETGMIIR 1663
            ...|.::||...|..                   |||:......:|. ..:..|:...::.
 Frog  1701 RKVAEQELIDVTERV-------------------QLLHSQNTSLINTKKKIESDVSQLQSE---- 1742

  Fly  1664 YNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLS 1716
                 :|:.|:..:.:::  .|...:...:.:.:..|.|||.            ||:.||...|.
 Frog  1743 -----VEEAVQEARNADE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1800

  Fly  1717 TAQVLKVMKSYK--LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKV------ 1773
            .|:.| .||..|  |...|:.:     .:|..:|:|.  ||..||.....:||.:..|.
 Frog  1801 EAEQL-AMKGGKKQLQKLEARV-----RELENELDAE--QKRGSDAIKGVRKFERRVKELSYQSE 1857

  Fly  1774 -----VFRYSDI-------------KLEDIELPSHLNLDEF 1796
                 |||..|:             :.||||..::::|..|
 Frog  1858 EDKKNVFRLQDLVDKLQLKVKTYKRQTEDIEEQANVHLSRF 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	260/713 (36%)
		IQ	900..922	CDD:197470	3/24 (13%)
		SMC_prok_B	<942..1365	CDD:274008	120/588 (20%)
		Myo5_CBD	1424..1792	CDD:271254	83/435 (19%)
LOC100493121	XP_012809641.1	Myosin_N	32..76	CDD:460670	9/37 (24%)
		Motor_domain	99..768	CDD:473979	260/713 (36%)
		Myosin_tail_1	848..1925	CDD:460256	227/1177 (19%)