Protein Alignment didum and LOC100485637

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_002939061.1
• Gene: LOC100485637 / 100485637
• XenbaseID: XB-GENE-29077903
• Length: 1937
• Species: Xenopus tropicalis
• Alignment Length: 2107
• Identity: 530/2107 - (25%)
• Similarity: 895/2107 - (42%)
• Gaps: 540/2107 - (25%)

  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||      ...|:||.....:..|.:..  |:|.   ||..::...|.|.:|    |.
 Frog    19 SDKERLEAQTRVFDLKKNIYVPDDKEEFVKALVVS--REGE---KITAETEHGKSVVVK----DT 74

  Fly    61 PPL-RNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
            ..: :||.......|:..|::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|...:
 Frog    75 QVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNTEV 138

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGG 186
            :.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::||   |:||.
 Frog   139 VAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAYIASVGE 203

  Fly   187 SESETQ------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHT 245
            .:.:|.      :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |..|.:.|
 Frog   204 RKKDTSSAGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIET 265

  Fly   246 YLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAE 305
            ||||||||::|.:.||:||||||:.:  :|.||     |:.::...:.:::. |...:..:.||:
 Frog   266 YLLEKSRVIFQLKSERDYHIFYQILS--NKKPELLEMLLITNNPYDYSYVSQ-GETTVASIDDAD 327

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNE------GSEEEDSDSCDIFHND 364
            :...|..|..||||:.::...|.|:...|:|.||::..:|..|      |:||.|.
 Frog   328 ELMATDSAFDVLGFTQEEKNSIYKLTGAIMHCGNMRFKQKQREEQAEPDGTEEADK--------- 383

  Fly   365 IHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVL 429
                 .|.|..:::.||.:.|...:::..||||....::|....|..||||.:|.|:|.::|..:
 Frog   384 -----AAYLKGLNSADLLKGLCHPRVKVGNEYVTRGQTVEQVNYATGALAKSVYEKMFLWMVVRI 443

  Fly   430 NKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITW 494
            |.:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||||.|
 Frog   444 NATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEW 508

  Fly   495 TMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKPR----FG 553
            ..||| .|.|.||||||..:|::.:|:|||..||.||.::..||. ....|..:|:|||    ..
 Frog   509 VFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDTTFKAKLYDNHLGKSANFQKPRNIKGKP 573

  Fly   554 TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSST 618
            ...|.:.|::.||:|::..:|.||:|.:::.:..:..:|::.|...:..    :....||....|
 Frog   574 EAHFALVHYAGTVDYNILNWLTKNKDPLNETVVGLYQKSSLKLLAVLFA----NYAGADSVDPGT 634

  Fly   619 LGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKV 683
                   ..|.|::|:..           :||.:..:|:|..|::.|.:|.||:||||.||:.|.
 Frog   635 -------KKGTKKKGSTF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKA 681

  Fly   684 AFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNI 746
            ....:...::.|||..||||.:||...|||:|.||.||..||::|...:..|..  |.:.....:
 Frog   682 PGVMDNRLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPDGQFIDSRKGAEKL 746

  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811
            :.....|..:|:||:|::||:||.:..||::|..                       |:.::|..
 Frog   747 LASLEIDHTQYKFGHTKVFFKAGLLGQLEEMRDE-----------------------RLARIITR 788

  Fly   812 IQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLA 869
            ||..:||.|:|...:||.|.|..|::.::       .:.|...:.|.:::..:...:|.......
 Frog   789 IQAQSRGVLSRIEFKKMVERRDALLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMQNM 853

  Fly   870 RNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHM 934
            :.:|..:::                                |:.:..||||    :.|.|.:|.:
 Frog   854 KEEFQRLKE--------------------------------ALEKSEARRK----ELEEKMVSLL 882

  Fly   935 ENK------YMGLENKIISMQQRIDELNRDNSNLKHK--------------TSEISVLKMKL--- 976
            :.|      ....::.:...::|.::|.::..||:.|              .:|::..|.||
 Frog   883 QEKNDLQLQVQAEQDNLEDAEERCEQLIKNKINLEAKLKEQTERLEDEEEMNAELTAKKRKLEDE 947

  Fly   977 --ELKKTLE------AEFKNVKAACQDK-----------DKLIEALNKQLEAERDEKMQLLEENG 1022
              ||||.::      |:.:..|.|.::|           |::|..|.|:.:|.::...|.|::.
 Frog   948 CSELKKDIDDLELTLAKVEKEKHATENKVKNMTEEMAALDEIIAKLTKEKKALQEAHQQALDDL- 1011

  Fly  1023 HAQEEWISQKQTWRQENEELRRQIDEI---IDMAKNAEVN------------QRNQEDRMLAEID 1072
            .|:|:.::   :..:...:|.:|:|::   ::..|...::            :..||..|..|.|
 Frog  1012 QAEEDKVN---SLTKSKAKLEQQVDDLEGSLEQEKKVRMDLERVKRKLEGDLKLTQESLMDLEND 1073

  Fly  1073 NRELNEAYQRAIKDKEV------IENENFM-------LKEELSRLTAGSFSLHARKASNAS---- 1120
            .::|.|..::  ||.|:      ||:|..:       |||..:|:......|.|.:|:.|.
 Frog  1074 KQQLEEKLKK--KDFEISQMNTKIEDEQNVASQLLKKLKELQARIEELEEELEAERAARAKVEKL 1136

  Fly  1121 -----------SQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV 1174
                       |:..::.|.|::.. |::|:..::            ..:|||..|||     ..
 Frog  1137 RSDLSRELEEISERLEEAGGATSVQ-LELNKKREI------------EFLKLRRDLEE-----ST 1183

  Fly  1175 LQEQYIKLSSRHKPTEDSFRVSE-----------LEVENEKLRSEYDQLRTSIKHGVE------- 1221
            ||.:....:.|.|..:....:||           ||.|..:|:.|.|.:.::::..::
 Frog  1184 LQSEATAAALRKKHADSVAELSEQIDNLQRVKQKLEKEKSELKLELDDVASNMEQVIKGKANLEK 1248

  Fly  1222 ----------------------INELNAQHAALQE---EVRRRREECIQL-------KAVLLQQS 1254
                                  .|:|:.|.|.||.   |:.||.:|...|       |....||.
 Frog  1249 LCRTLEDQANEYRTKSEETQRTANDLSTQRAKLQTENGELTRRLDEKEALVSQLTRGKQTYTQQL 1313

  Fly  1255 QSM-RSLEPES---------LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQ 1309
            :.: |.||.||         ||...:|.:.|.|.:..:    ::.::||:.|..:.||::.:.
 Frog  1314 EDLKRQLEEESKAKNALAHALQSARHDCDLLREQYEEE----QEAKAELQRILSKANSEVAQW-- 1372

  Fly  1310 EIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKA 1374
               |...|.|.:|:.     :|.|::.        :.|.:.||:|       :|.::..|||..:
 Frog  1373 ---RTKYETDAIQRT-----EELEEAK--------KKLAQRLQEA-------EEAVEAVNAKCSS 1414

  Fly  1375 YRQDGGQLEHKIEEEMI-RNKSNGTSA---------DVGANVTKQKSQNPQGLMKFHSSDLDKIL 1429
            ..:...:|:::||:.|: ..:||..:|         |...:..|||.:..|..::....:...:.
 Frog  1415 LEKTKHRLQNEIEDLMVDLERSNAAAAALDKKQRNFDKILSEWKQKFEESQAELESSQKEARSLS 1479

  Fly  1430 QRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRV 1494
            ..|..                           |.|:.::..|.|..|..:.|.:..
 Frog  1480 TELFK---------------------------LKNSYEESLEHLETFKRENKNLQE--------- 1508

  Fly  1495 IWLVNSITLLNLMKQYGD----VDEYVKFNTE-KQNQQQLKNF-----NLFEYR-----RVILDL 1544
                   .:.:|.:|.|:    :.|..|...: :|.:.:|::.     ...|:.     ||.|:|
 Frog  1509 -------EISDLTEQLGESGKSIHELEKVRKQLEQEKMELQSALEEAEGSLEHEEGKILRVQLEL 1566

  Fly  1545 IVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIG 1609
                     .||:...:.|:.......|:.:|..| ..:.:...|:.|.:...:......|::.|
 Frog  1567 ---------QQIKAEFERKLSEKDEEFDQAKRNNQ-RAVDTLQASLEAETRSRNEALRVKKKMEG 1621

  Fly  1610 QLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWE-----TGMIIRYNI--- 1666
            .|.   :...|....|..|.:...||......:....|.|...:.:.|     |.::.|.|.
 Frog  1622 DLN---EMEIHLSQANRIASEAQKQLKNLQGVLKDTQLQLDDTLRINEDLKENTAIVERRNTLLQ 1683

  Fly  1667 -------GCIEDWVRS-----------------------------KKMSNDVL------------ 1683
                   ..:|...||                             |||.||:.
 Frog  1684 AELEELRSILEQTERSRKLAEQELIETNERVQLLHSQNTSLINQKKKMENDLSQLQGEVEEAVQE 1748

  Fly  1684 ------TALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK-- 1728
                  .|...:...:.:.:..|.|||.            |||.||...|..|:.: .||..|
 Frog  1749 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQQRLDEAEQI-AMKGGKKQ 1812

  Fly  1729 LDDYESEITNVFLEKLTEKLNARQMQKSNS-----------DEFTIDQKFIQPFKVVFRYSDI-- 1780
            |...|:.:     .:|..:|.|.|.:.:.|           .|.|...:  :..|.:.|..|:
 Frog  1813 LQKLEARV-----RELDNELEAEQKRNAESVKGMRKYERRIKELTYQTE--EDRKNLIRLQDLVD 1870

  Fly  1781 -----------KLEDIELPSHLNLDEF 1796
                       :.|:.|..|::||..|
 Frog  1871 KLQLKVKGYKRQAEEAEEQSNMNLSRF 1897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	263/710 (37%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	114/561 (20%)
		Myo5_CBD	1424..1792	CDD:271254	79/482 (16%)
LOC100485637	XP_002939061.1	COG5022	37..1432	CDD:227355	435/1558 (28%)
		MYSc_class_II	99..767	CDD:276951	263/710 (37%)
		SMC_prok_B	1215..>1928	CDD:274008	143/776 (18%)