DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh8

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_012824466.1 Gene:myh8 / 100379877 XenbaseID:XB-GENE-5954541 Length:1935 Species:Xenopus tropicalis


Alignment Length:2045 Identity:527/2045 - (25%)
Similarity:896/2045 - (43%) Gaps:488/2045 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGA------GFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||.......:...|.::   :|.|.||.      |.:.:.||.|....||   |....
 Frog    19 SDKERLEAQSRPFDAKNTVFVDDA---KELYVKGMVTARDNGKVTVKTDDGNTVTVK---DTQIY 77

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            |  :||.......|:..:::|:|..||:||:.|:. ..:||||.|:....:|||..:|:|.|.::
 Frog    78 P--QNPPKFDKIEDMAMMTHLNEASVLYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYNPEVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVG----- 185
            ..|||....:..||||:|::.||..:..:..|.|::::|||||||||:.|..::|||.:.     
 Frog   140 AGYRGKKRVEAPPHIFSLSDNAYQAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDP 204

  Fly   186 GSESETQ------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            |.:.|..      :|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
 Frog   205 GKKKEPSNSLKGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LSSADIE 266

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAE 305
            |||||||||.:|...||:||||||:..  :|.||:|   |...:.:.:.::. |...::.:.|.|
 Frog   267 TYLLEKSRVTFQLSAERSYHIFYQMMT--NKKPEIVEMCLITTNPYDYPSISQGEIVVKSIDDEE 329

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDIFHNDIH 366
            :...|..|:.:|||:..:...|.|:...::|.||::..:|..|...|    ||:|.         
 Frog   330 ELMATDSAIDILGFNQDEKVGIYKLTGAVMHHGNMKFKQKQREEQAEPDGTEDADK--------- 385

  Fly   367 LQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNK 431
               .|.|:.:::.||.:.|...:::..||:|....::.....:..||.|.::.|||.::|..:|:
 Frog   386 ---IAYLMGLNSADLLKALCYPRVKVGNEFVTKGQTVPQVNNSVGALCKSVFEKLFLWMVIRINQ 447

  Fly   432 SLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTM 496
            .|:....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.|..
 Frog   448 QLDTKQPRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEF 512

  Fly   497 IDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFG--- 553
            ||| .|...||:|||..:|:..:|:|||..||.:|.|:..||    :|||.   :||||:.|   
 Frog   513 IDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKCK---NFEKPKPGKGK 574

  Fly   554 -TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSS 617
             ...|.:.|::.||:|:::|:|:||:|.:::.:.|:..:|::.|         :..|....|.|.
 Frog   575 AEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKL---------LALLFSSHAASE 630

  Fly   618 TLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDK 682
            ...|:    .|:|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.|
 Frog   631 ADSGK----GGKKKKGSSF-----------QTVSALFRENLNKLMTNLKSTHPHFVRCLIPNETK 680

  Fly   683 VAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRN 745
            .....:...||.|||..||||.:||...|||||.||.||..||::|...:..|..  |.|.:|..
 Frog   681 TPGIMDNHLIIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPDGQFIDSKKACEK 745

  Fly   746 IVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVIN 810
            ::.....|..:|:||:|::||:||.:..||::|.....:.||..|::                  
 Frog   746 LLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITCTQAL------------------ 792

  Fly   811 GIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGML 868
                 .||:|.|...:||.|.|..:.:.:|       .:.|...:.|.:::..:...:|......
 Frog   793 -----CRGFLMRVEFKKMMERREAIYVIQYNLRSFMNVKHWPWMKLYFKIKPLLQSAETEKEMQN 852

  Fly   869 ARNKFHAMRDHYRAVQIQ-RFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTIS 932
            .:.:|...::.....:.: :.:.|.:....::|   |.::.|              :::|::|::
 Frog   853 MKEEFEKTKEALAKAETKAKDLEGKMVALLHEK---NELVLQ--------------VQSESETLA 900

  Fly   933 HMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------AEF 986
            ..|.:..||....|.|:.:|.||.....:.:...:|::..|.||     ||||.::      |:.
 Frog   901 DSEERCEGLIKSKIQMESKIKELTERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKV 965

  Fly   987 KNVKAACQDK-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENE 1040
            :..|.|.::|           |:.|..|:|:.:|.::...|.|::. .|:|:.:|   :..:...
 Frog   966 EKEKHATENKVKNLTEEMATLDENISKLSKEKKALQEAHQQTLDDL-QAEEDKVS---SLTKAKT 1026

  Fly  1041 ELRRQIDEI---IDMAKNAEVN------------QRNQEDRMLAEIDNRELNEAYQRAIKDKEV- 1089
            :|.:|:|::   ::..|...::            :.:||..|..|.:.::..|..::  ||.|: 
 Frog  1027 KLEQQVDDLEGSLEQEKKLRLDLERAKRKLEGDLKLSQETVMDLENEKQQAEEKLKK--KDFEIS 1089

  Fly  1090 -----IENENFM-------LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPP 1142
                 ||:|..:       :||..:|:......:.|.:|:.|..:          |...|::|..
 Frog  1090 QLQGKIEDEQSLGIQLQKKIKELQARIEELEEEIEAERAARAKIE----------KQRADLSREL 1144

  Fly  1143 DLLSKNY-SYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFR------VSE--- 1197
            :.:|:.. ....:||..:::....|.|.||   |:....:.:.:|:.|..:.|      |:|   
 Frog  1145 EEISERLEEAGGATSAQIEMNKKREAEFQK---LRRDLEEATLQHEATAGALRKKHADSVAELGE 1206

  Fly  1198 -----------LEVENEKLRSEYDQLRTSI-----------------------------KHGVEI 1222
                       ||.|..:|:.|.|.|.:::                             :|...:
 Frog  1207 QIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEKVNRVVEDQLSEVKAKDDEHQRLL 1271

  Fly  1223 NELNAQHAALQE---EVRRRREECIQL-------KAVLLQQSQSMRSLEPESLQMRGNDVNELME 1277
            |:|:||.|.||.   |:.|:.||...|       |....||.:.::....|..:.:....:.|..
 Frog  1272 NDLSAQKARLQTENGELSRQLEEKESLISQLSRGKQGFTQQVEELKRQLEEETKAKNALAHGLQS 1336

  Fly  1278 AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIE--RLNNEKDELQKVMFESIDEFEDSNVDTL 1340
            |.|...|:..|.|.|.:|..|...| |.:...|:.  |...|.|.:|:.     :|.|::.    
 Frog  1337 ARHDCDLLREQFEEEQEAKAELQRS-LSKANGEVAQWRTKYETDAIQRT-----EELEEAK---- 1391

  Fly  1341 RQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR-NKSNGTSA---- 1400
                :.|.:.||.|       :|:::..|:|..:..:...:|:.::|:.|:. .::|..:|    
 Frog  1392 ----KKLAQRLQDA-------EEQVEAVNSKCASLEKTKQRLQSEVEDLMVDVERANSAAASLDK 1445

  Fly  1401 -----DVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYT 1460
                 |...:..|||.:..|       ::|:..|:...|..|.              ||      
 Frog  1446 KQRNFDKVLSEWKQKYEEGQ-------AELEAALKEARSLSTE--------------IF------ 1483

  Fly  1461 DLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYV-------- 1517
            .:.||.::..|       |::.:.|     ||:           ||.::..|:.|.:        
 Frog  1484 KMKNAYEEALE-------QVETLKR-----ENK-----------NLQQEISDLTEQIGEGSKSIN 1525

  Fly  1518 KFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQA----------------LIMQIQGLLDPKIVP 1566
            :....|:..:|.||           ||...|.:|                .:.|::..:|.||..
 Frog  1526 ELEKSKKQVEQEKN-----------DLQAALEEAEGSLEHEEAKILRIQLELNQVKSEVDRKIAE 1579

  Fly  1567 AILNNDEIQRGRQA----------HGMRSRATSIGASSSPE-----------HG---GGPAWKQL 1607
            .....::::|..|.          ..:|||..::......|           |.   .|.|.|||
 Frog  1580 KDEEIEQLKRNSQRSIDTMQSTLDSEIRSRNDALRLKKKMEGDLNELEIQLSHANRQAGEAQKQL 1644

  Fly  1608 IGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRG-DICMWETGMI---------- 1661
             ..::..||..| ..||:.                      ||| |....:..:|          
 Frog  1645 -RNVQAQYKDTQ-LQLDDA----------------------LRGHDDLKEQVAVIERRNNLQQAE 1685

  Fly  1662 IRYNIGCIEDWVRSKKMS-NDVLTALAPL----NQVSQLLQSRKS-EQDV--------------- 1705
            |..|...:|...||:|:: .::|.:...|    :|.:.|:.|:|. |.|:               
 Frog  1686 IEENRSALEQTERSRKIAEQELLDSSERLQLLHSQNTSLINSKKKLESDIGQLQNEAEEAVQEAR 1750

  Fly  1706 -------QTICD-------LCTSLSTAQVLKVMKSYKLDDYESEITNVF--LEKLTEKLNARQMQ 1754
                   :.|.|       |.....|:..|:.||. .|:....::.|..  .|:|..|...:|:|
 Frog  1751 NAEEKAKKAITDAALMAEELKKEQDTSAHLERMKK-NLEQTVKDLQNRLDEAEQLAMKGGKKQLQ 1814

  Fly  1755 KSNS------DEFTIDQK-FIQPFKVVFRY 1777
            |..|      :|...:|| .::..|.|.:|
 Frog  1815 KLESRVRELENELDNEQKRGVEAVKGVRKY 1844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 273/742 (37%)
MYSc_Myo5 84..767 CDD:276831 263/712 (37%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 30/151 (20%)
coiled coil 1049..1068 CDD:293879 3/33 (9%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 35/167 (21%)
Myo5_CBD 1424..1792 CDD:271254 87/457 (19%)
myh8XP_012824466.1 Myosin_N 34..72 CDD:367160 9/40 (23%)
MYSc_class_II 99..767 CDD:276951 263/712 (37%)
Myosin_tail_1 847..1924 CDD:366712 220/1141 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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