Protein Alignment didum and myh8

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_012824466.1
• Gene: myh8 / 100379877
• XenbaseID: XB-GENE-5954541
• Length: 1935
• Species: Xenopus tropicalis
• Alignment Length: 2045
• Identity: 527/2045 - (25%)
• Similarity: 896/2045 - (43%)
• Gaps: 488/2045 - (23%)

  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGA------GFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||.......:...|.::   :|.|.||.      |.:.:.||.|....||   |....
 Frog    19 SDKERLEAQSRPFDAKNTVFVDDA---KELYVKGMVTARDNGKVTVKTDDGNTVTVK---DTQIY 77

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            |  :||.......|:..:::|:|..||:||:.|:. ..:||||.|:....:|||..:|:|.|.::
 Frog    78 P--QNPPKFDKIEDMAMMTHLNEASVLYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYNPEVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVG----- 185
            ..|||....:..||||:|::.||..:..:..|.|::::|||||||||:.|..::|||.:.
 Frog   140 AGYRGKKRVEAPPHIFSLSDNAYQAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDP 204

  Fly   186 GSESETQ------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            |.:.|..      :|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
 Frog   205 GKKKEPSNSLKGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LSSADIE 266

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAE 305
            |||||||||.:|...||:||||||:..  :|.||:|   |...:.:.:.::. |...::.:.|.|
 Frog   267 TYLLEKSRVTFQLSAERSYHIFYQMMT--NKKPEIVEMCLITTNPYDYPSISQGEIVVKSIDDEE 329

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDIFHNDIH 366
            :...|..|:.:|||:..:...|.|:...::|.||::..:|..|...|    ||:|.
 Frog   330 ELMATDSAIDILGFNQDEKVGIYKLTGAVMHHGNMKFKQKQREEQAEPDGTEDADK--------- 385

  Fly   367 LQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNK 431
               .|.|:.:::.||.:.|...:::..||:|....::.....:..||.|.::.|||.::|..:|:
 Frog   386 ---IAYLMGLNSADLLKALCYPRVKVGNEFVTKGQTVPQVNNSVGALCKSVFEKLFLWMVIRINQ 447

  Fly   432 SLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTM 496
            .|:....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.|..
 Frog   448 QLDTKQPRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEF 512

  Fly   497 IDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFG--- 553
            ||| .|...||:|||..:|:..:|:|||..||.:|.|:..||    :|||.   :||||:.|
 Frog   513 IDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKCK---NFEKPKPGKGK 574

  Fly   554 -TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSS 617
             ...|.:.|::.||:|:::|:|:||:|.:::.:.|:..:|::.|         :..|....|.|.
 Frog   575 AEAHFSLVHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKL---------LALLFSSHAASE 630

  Fly   618 TLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDK 682
            ...|:    .|:|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.|
 Frog   631 ADSGK----GGKKKKGSSF-----------QTVSALFRENLNKLMTNLKSTHPHFVRCLIPNETK 680

  Fly   683 VAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRN 745
            .....:...||.|||..||||.:||...|||||.||.||..||::|...:..|..  |.|.:|..
 Frog   681 TPGIMDNHLIIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPDGQFIDSKKACEK 745

  Fly   746 IVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVIN 810
            ::.....|..:|:||:|::||:||.:..||::|.....:.||..|::
 Frog   746 LLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITCTQAL------------------ 792

  Fly   811 GIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGML 868
                 .||:|.|...:||.|.|..:.:.:|       .:.|...:.|.:::..:...:|......
 Frog   793 -----CRGFLMRVEFKKMMERREAIYVIQYNLRSFMNVKHWPWMKLYFKIKPLLQSAETEKEMQN 852

  Fly   869 ARNKFHAMRDHYRAVQIQ-RFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTIS 932
            .:.:|...::.....:.: :.:.|.:....::|   |.::.|              :::|::|::
 Frog   853 MKEEFEKTKEALAKAETKAKDLEGKMVALLHEK---NELVLQ--------------VQSESETLA 900

  Fly   933 HMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------AEF 986
            ..|.:..||....|.|:.:|.||.....:.:...:|::..|.||     ||||.::      |:.
 Frog   901 DSEERCEGLIKSKIQMESKIKELTERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKV 965

  Fly   987 KNVKAACQDK-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENE 1040
            :..|.|.::|           |:.|..|:|:.:|.::...|.|::. .|:|:.:|   :..:...
 Frog   966 EKEKHATENKVKNLTEEMATLDENISKLSKEKKALQEAHQQTLDDL-QAEEDKVS---SLTKAKT 1026

  Fly  1041 ELRRQIDEI---IDMAKNAEVN------------QRNQEDRMLAEIDNRELNEAYQRAIKDKEV- 1089
            :|.:|:|::   ::..|...::            :.:||..|..|.:.::..|..::  ||.|:
 Frog  1027 KLEQQVDDLEGSLEQEKKLRLDLERAKRKLEGDLKLSQETVMDLENEKQQAEEKLKK--KDFEIS 1089

  Fly  1090 -----IENENFM-------LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPP 1142
                 ||:|..:       :||..:|:......:.|.:|:.|..:          |...|::|..
 Frog  1090 QLQGKIEDEQSLGIQLQKKIKELQARIEELEEEIEAERAARAKIE----------KQRADLSREL 1144

  Fly  1143 DLLSKNY-SYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFR------VSE--- 1197
            :.:|:.. ....:||..:::....|.|.||   |:....:.:.:|:.|..:.|      |:|
 Frog  1145 EEISERLEEAGGATSAQIEMNKKREAEFQK---LRRDLEEATLQHEATAGALRKKHADSVAELGE 1206

  Fly  1198 -----------LEVENEKLRSEYDQLRTSI-----------------------------KHGVEI 1222
                       ||.|..:|:.|.|.|.:::                             :|...:
 Frog  1207 QIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEKVNRVVEDQLSEVKAKDDEHQRLL 1271

  Fly  1223 NELNAQHAALQE---EVRRRREECIQL-------KAVLLQQSQSMRSLEPESLQMRGNDVNELME 1277
            |:|:||.|.||.   |:.|:.||...|       |....||.:.::....|..:.:....:.|..
 Frog  1272 NDLSAQKARLQTENGELSRQLEEKESLISQLSRGKQGFTQQVEELKRQLEEETKAKNALAHGLQS 1336

  Fly  1278 AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIE--RLNNEKDELQKVMFESIDEFEDSNVDTL 1340
            |.|...|:..|.|.|.:|..|...| |.:...|:.  |...|.|.:|:.     :|.|::.
 Frog  1337 ARHDCDLLREQFEEEQEAKAELQRS-LSKANGEVAQWRTKYETDAIQRT-----EELEEAK---- 1391

  Fly  1341 RQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR-NKSNGTSA---- 1400
                :.|.:.||.|       :|:::..|:|..:..:...:|:.::|:.|:. .::|..:|
 Frog  1392 ----KKLAQRLQDA-------EEQVEAVNSKCASLEKTKQRLQSEVEDLMVDVERANSAAASLDK 1445

  Fly  1401 -----DVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYT 1460
                 |...:..|||.:..|       ::|:..|:...|..|.              ||
 Frog  1446 KQRNFDKVLSEWKQKYEEGQ-------AELEAALKEARSLSTE--------------IF------ 1483

  Fly  1461 DLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYV-------- 1517
            .:.||.::..|       |::.:.|     ||:           ||.::..|:.|.:
 Frog  1484 KMKNAYEEALE-------QVETLKR-----ENK-----------NLQQEISDLTEQIGEGSKSIN 1525

  Fly  1518 KFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQA----------------LIMQIQGLLDPKIVP 1566
            :....|:..:|.||           ||...|.:|                .:.|::..:|.||..
 Frog  1526 ELEKSKKQVEQEKN-----------DLQAALEEAEGSLEHEEAKILRIQLELNQVKSEVDRKIAE 1579

  Fly  1567 AILNNDEIQRGRQA----------HGMRSRATSIGASSSPE-----------HG---GGPAWKQL 1607
            .....::::|..|.          ..:|||..::......|           |.   .|.|.|||
 Frog  1580 KDEEIEQLKRNSQRSIDTMQSTLDSEIRSRNDALRLKKKMEGDLNELEIQLSHANRQAGEAQKQL 1644

  Fly  1608 IGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRG-DICMWETGMI---------- 1661
             ..::..||..| ..||:.                      ||| |....:..:|
 Frog  1645 -RNVQAQYKDTQ-LQLDDA----------------------LRGHDDLKEQVAVIERRNNLQQAE 1685

  Fly  1662 IRYNIGCIEDWVRSKKMS-NDVLTALAPL----NQVSQLLQSRKS-EQDV--------------- 1705
            |..|...:|...||:|:: .::|.:...|    :|.:.|:.|:|. |.|:
 Frog  1686 IEENRSALEQTERSRKIAEQELLDSSERLQLLHSQNTSLINSKKKLESDIGQLQNEAEEAVQEAR 1750

  Fly  1706 -------QTICD-------LCTSLSTAQVLKVMKSYKLDDYESEITNVF--LEKLTEKLNARQMQ 1754
                   :.|.|       |.....|:..|:.||. .|:....::.|..  .|:|..|...:|:|
 Frog  1751 NAEEKAKKAITDAALMAEELKKEQDTSAHLERMKK-NLEQTVKDLQNRLDEAEQLAMKGGKKQLQ 1814

  Fly  1755 KSNS------DEFTIDQK-FIQPFKVVFRY 1777
            |..|      :|...:|| .::..|.|.:|
 Frog  1815 KLESRVRELENELDNEQKRGVEAVKGVRKY 1844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	263/712 (37%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	111/534 (21%)
		Myo5_CBD	1424..1792	CDD:271254	87/457 (19%)
myh8	XP_012824466.1	Myosin_N	32..76	CDD:460670	12/49 (24%)
		MYSc_class_II	99..767	CDD:276951	263/712 (37%)
		Myosin_tail_1	847..1924	CDD:460256	220/1141 (19%)