DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and myo18b

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_073771313.1 Gene:myo18b / 100331349 ZFINID:ZDB-GENE-111111-8 Length:2103 Species:Danio rerio


Alignment Length:1908 Identity:398/1908 - (20%)
Similarity:714/1908 - (37%) Gaps:477/1908 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGS-------DLPPLR 64
            ::.:..::|..|.|    ..||....:...|..::  ..|::: |:|.:|.|       ::..| 
Zfish   190 VWYEAGQVWFTHKD----GYTLATQLKPDEGTPEL--PDGRVR-VRLSSDQSIHDVSQYEIEKL- 246

  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYR 129
            ||..|....||:.|..::|...||.|..| .:..:..|:.|..|:|:.|    |:  .|..:::|
Zfish   247 NPPELDLCEDLSDLVSVNESSALHTLSSR-AKAHLPLTHAGPNLLALWP----PV--SSSTKSFR 304

  Fly   130 G------HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAK-YAMRYFAAVGGS 187
            .      .|.|.|:    |:..:.|..:..:..:.:::..|.||:|||.:.: :::......|.:
Zfish   305 SRRWESWEAPGPLQ----AVVRKVYVSMLGQRRDQTLVALGRSGSGKTTACQSFSLELLKQAGTA 365

  Fly   188 ESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSR 252
            .....:|| :.|...::.:||...:|.::.||||.....:.| |..|:  ...|.:.|.||||.|
Zfish   366 GGSLTLER-LQAVFTVLRSFGCVSSTHSEASSRFAMVLSVDF-NHAGL--AAAAHLQTMLLEKWR 426

  Fly   253 VVYQAQGERNYHIFYQLCAARSK--YPELVLDHQDKFQFLNMGGAPEI-ERVSDAEQFNETVQAM 314
            |..:..||.|:.:|.|:.:..|.  ..||.|....:..|..:....:: |:...|..|.:.:.||
Zfish   427 VCQRPDGESNFLVFSQMLSGLSSDLRTELQLHQLKEHNFFGITCPTKVDEKQRAAVGFGKLLAAM 491

  Fly   315 TVLGFSIQQIADIVKILAGILHL---GNIQVSKK----FNEGSEEEDSDSCDIFHNDIHLQITAD 372
            ..||||..:...|.::||||.||   |..:|.:|    |:..........|:  ..::|..:...
Zfish   492 NTLGFSSDEQKAIWRVLAGIYHLGVAGTCKVGRKQFMSFDSAQTASAMLGCE--GEELHTAVFKH 554

  Fly   373 LLRVSADDLRRWLLMRKIESVNEYVLIPN-----SIEAAQAARDALAKHIYAKLFQYIVGVLNKS 432
            .|        |.||.|....:.|......     .:.|||.. :.:|..:|.:||..:|.::|::
Zfish   555 HL--------RQLLQRASGGIRERQTAEQHDDGPKLTAAQCV-EGMAAGLYEELFTAVVSLINRT 610

  Fly   433 LNNGSKQCSFIGVLDIYGFET------FEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEG 491
            |.:.....:.:.|:|..|...      .....|.:.|.||..|:|.:....|.|....:.|.:||
Zfish   611 LCSQQLTLASVMVVDAPGLRNPRHSAEERAAGFSELCHNYLQERLLEHHYTHTFTQTLDRYTQEG 675

  Fly   492 ITWTMIDFYD------------NQPCIDL----IESRLGVLDLLDEECRMPKGSDES-------- 532
            :.   :||..            :||.:.:    .:|| |:|.:||||. ...||.||        
Zfish   676 VP---VDFSAPESSPSEVVCAIDQPGLQVRGPEADSR-GLLWVLDEEL-STAGSSESVVLERVCQ 735

  Fly   533 WAGKLIGKCNKFPHFEKPRFGTTSFFIKHF--SDTVEYDVNGF--LEKNRDTVSKELTQVLSESN 593
            :....:.:|      |:|    ....|.|.  ||.|.||::|:  |.:|..::....:.:.:.|:
Zfish   736 YFSSTVRQC------EQP----LQCEIAHLMGSDAVRYDLSGWFSLLQNNPSLLNASSLLHNSSH 790

  Fly   594 MSLAKQVMTLEEIDTLC-----VDSAKSSTL----GGRVVISAGRKQQGNDTRRRVVPSKQHRKT 649
            ||:.........:..||     |:.....:|    ..|..:|||           :...::|...
Zfish   791 MSVKALFGPRASVPPLCRGLGGVEGGSQRSLERSGAVRKTLSAG-----------MAALRRHSHC 844

  Fly   650 VGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPS 714
            :..:.|..  :|:|.:....|.:::|:....|...|.....:|  ||.:..:|.|:::...|:|.
Zfish   845 ISIKLQAD--ALLSVIRRARPVFLQCLSVKTDGGGFDVPALRI--QLNSTHLLPTLQLYRTGYPE 905

  Fly   715 RWLYPDFYMRYQLLV------YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            .....||..|:|.|.      |.|.....|.:.:...:::....|:.....|.:::|.:.|.:..
Zfish   906 HMSLSDFRCRFQALSAPVMKRYGSVFITPDERKAVEELLIDLDLDKKSVVLGASRVFMKRGVLRS 970

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            |:|.|..|                                                       ||
Zfish   971 LDQQRDQL-------------------------------------------------------LS 980

  Fly   839 KYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQ-IQRFVR--GALARRAYQK 900
                |||.:            :|....|.|.|.|:..|:....||: :||.||  .|::|.::.|
Zfish   981 ----GWLVQ------------LQASCLGHLGRLKYRRMKVQQMAVRCVQRNVRVLSAVSRWSWWK 1029

  Fly   901 RRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHK 965
                 ::|:  :|..|                                     ::|.|:..|:.|
Zfish  1030 -----LLCR--VRPLL-------------------------------------DVNMDDQRLRSK 1050

  Fly   966 TSEISVLKMKL--------ELKKT---LEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLE 1019
            ..||:.|:.:|        ||::|   ||.:...|.:...|:....||:::.|:|||.|:::|.:
Zfish  1051 EDEITALRRRLEKSEKERNELRQTADNLETKVTAVISELSDERFRGEAMSQALDAERTERLRLAK 1115

  Fly  1020 ENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAE----VNQRNQEDRML------AEIDNR 1074
            |:...|    |:.:..:...|.|.||::|.....||.|    |...::....|      .|...|
Zfish  1116 ESKELQ----SRVEQSKVSLEALERQLEEEKQKVKNKEALCGVATESELQLQLECAQTEVEFLRR 1176

  Fly  1075 ELNEAYQRAIKDKE---VIENENFMLKEEL--SRLTAGSFSLHARKASNASSQNEDDVGYASAKN 1134
            .|.:..:|...:||   ::|.:...|:.:|  |:.|......|.|:.::       |:..|....
Zfish  1177 RLRQTEERLEGEKEGRQLLETKVQDLQSQLDQSKRTVTELKRHCRRLTS-------DLQDARVLT 1234

  Fly  1135 TLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELE 1199
            ....:|..:|..|...::  :.|...|.....|.:||.:|:.|. ..|.:.......:.:.||.|
Zfish  1235 DSLQSRAHELDRKQRRFD--SELTQALTHADNEREQKERVIHEN-TTLGAEIFTLRKTLKESETE 1296

  Fly  1200 VEN-----EKLRSEYDQLRTSIK-HGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMR 1258
            |::     |:|..:...|...:| ....:.||......|:...:.|.||..|:.|.:.|..|...
Zfish  1297 VQHLQQLKEELSCQIRDLSVPLKLTSDSVPELKKHLRELESRDKERSEEISQMTARITQHEQMHL 1361

  Fly  1259 SLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQK 1323
            ..|.|.         |.|:..|.::|.::  :.||:.:.:....:|.::..::|:   |.:|.|.
Zfish  1362 RFEMEM---------ERMKQIHQKELEDK--DEELEDVQKSSQRRLRQLEMQLEQ---EYEEKQM 1412

  Fly  1324 VMFESIDEFEDSNVDTLRQN--------DRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGG 1380
            |:.|..|  .:..:.||.:.        ::.|||:|::..|  ||...:|.|:..:......|.|
Zfish  1413 VVHEKHD--LEGLIATLCEQVGHRDFDVEKRLRRDLKRTHA--LLSDAQLLLSTVEQPGQGHDPG 1473

  Fly  1381 ----------QLEHKIEEEMIRNKSNGTSADVGA----------NVTKQKSQNPQGL--MKFHSS 1423
                      |||   :.|..|.::.|....:.|          |:.||||...:.|  :::..:
Zfish  1474 AQEQLQRLRCQLE---DSEARRLEAEGVQKTLAAELENAQIELENICKQKSLADEDLSQLRYERT 1535

  Fly  1424 DLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPH 1488
            ||.|.|:                                 ...:|:.||:.|             
Zfish  1536 DLMKRLE---------------------------------EDQEDLNELMKK------------- 1554

  Fly  1489 PIENRVIWLVNSITLLNLMKQYGDVDEYVK--FNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQA 1551
               ::.:...:|..:..:.:...:::|..|  ...:|:.|..:......|...|... ||:..:|
Zfish  1555 ---HKALIAQSSSDISQIRELQAEMEELKKQRQTLQKELQTSVSRVQFLESSTVSRS-IVSKQEA 1615

  Fly  1552 LIMQIQGLLDPKIVPAILNNDEIQRGR----QAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLE 1612
            .|..::            |..|.|||:    |...:|.|.:.:......|...            
Zfish  1616 RICDLE------------NKLEFQRGQVKRFQVLVLRLRDSVVRLGEELEQAA------------ 1656

  Fly  1613 HFYKQFQHFGLDNC-YAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSK 1676
                |.:....:|| |.:|....:           .|...|:            .|..:|   |.
Zfish  1657 ----QAEARERENCRYYQQRLEDM-----------RMEMEDL------------TGREQD---SS 1691

  Fly  1677 KMSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFL 1741
            :...::...:..|:.|.|.||: ..|..::.|.||..:|...:        ..||.::|.....:
Zfish  1692 RRRMELEMQVEELSAVRQTLQA-DLETSIRRIVDLQAALEEVE--------SSDDSDTESVQTAV 1747

  Fly  1742 EKLTEKLNARQMQKSNSDEFTID 1764
            |..:.|.:...:....|...|.|
Zfish  1748 ESFSRKRDLDSLSSVGSSVGTED 1770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 173/753 (23%)
IQ 900..922 CDD:197470 4/21 (19%)
SMC_prok_B <942..1365 CDD:274008 105/462 (23%)
Myo5_CBD 1424..1792 CDD:271254 56/348 (16%)
myo18bXP_073771313.1 None

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