Protein Alignment didum and myha

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_021332193.1
• Gene: myha / 100149148
• ZFINID: ZDB-GENE-060531-50
• Length: 1933
• Species: Danio rerio
• Alignment Length: 1890
• Identity: 488/1890 - (25%)
• Similarity: 860/1890 - (45%)
• Gaps: 408/1890 - (21%)

  Fly    29 EESYRKGAGFLKICTDSGKLKEVKLK------ADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87
            :|.|.||.  :| ..|.||:..:.|.      |...|:.|: ||.......|:..:::|:||.||
Zfish    44 KELYVKGT--IK-SRDGGKVTVITLDTKEERVAKEEDVHPM-NPPKFDKIEDMAMMTHLNEPSVL 104

  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152
            :||:.|:. ..:||||.|:....:|||..:|:|...::.||||....:..||||::::.||..:.
Zfish   105 YNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFML 168

  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAV---GGSESETQ--------VERKVLASSPIMEA 206
            .:..|.|::::|||||||||:.|..::|||.|   ||.:.:.|        :|.:::|::|::||
Zfish   169 TDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGGDKKKEQTPGKMQGSLEDQIIAANPLLEA 233

  Fly   207 FGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCA 271
            :|||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|...||.||||||:..
Zfish   234 YGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLPDERGYHIFYQMMT 295

  Fly   272 ARSKYPELV---LDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
              :..|||:   |...:.:.| :...|...:..:.|.|:...|..|:.:|||:.::...|.|...
Zfish   296 --NHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGFTGEEKMGIYKFTG 358

  Fly   333 GILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIE 391
            .:||.||::..:|..|      |:||.|..|.              ||.:::.::.:.|...:::
Zfish   359 AVLHHGNMKFKQKQREEQAEPDGTEEADKISY--------------LLGLNSAEMLKALCYPRVK 409

  Fly   392 SVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEV 456
            ..||:|....::.....:..||:|.||.::|.::|..:|:.|:...::..|||||||.|||.|:.
Zfish   410 VGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQQRNFFIGVLDIAGFEIFDF 474

  Fly   457 NSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLD 520
            ||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .|...||:|||..:|:..:|:
Zfish   475 NSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPMGIFSILE 539

  Fly   521 EECRMPKGSDESWAGKL----IGKCNKFPHFEKPR----FGTTSFFIKHFSDTVEYDVNGFLEKN 577
            |||..||.:|.|:..||    :||||.   |:|||    .....|.:.|::.||:|:|:|:|:||
Zfish   540 EECMFPKATDTSFKNKLYDQHLGKCNA---FQKPRPQKGKAEAHFSLVHYAGTVDYNVSGWLDKN 601

  Fly   578 RDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVP 642
            :|.:::.:.|:..:|::.|   :.||  ...:..|::|          ..|:|:.|:
Zfish   602 KDPLNESVVQLYQKSSVKL---LATL--YPPVVEDTSK----------KGGKKKGGS-------- 643

  Fly   643 SKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRI 707
                .:||.|||:|:|..|::.|.:|.||:|||:.||:.|.....|...:|.|||..||||.:||
Zfish   644 ----MQTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRI 704

  Fly   708 SAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAG 769
            ...|||||.||.||..||::| ..|.:.:.   |.|.:...::.....:.|:||||:|::||:||
Zfish   705 CRKGFPSRILYADFKQRYKVL-NASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAG 768

  Fly   770 QVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAG 834
            .:..||::|.......:|:.|::.|.::.||:|:                       ||.|.|..
Zfish   769 LLGTLEEMRDEKLASLVTMTQALCRAYLMRREFV-----------------------KMMERRES 810

  Fly   835 LILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQ 899
            :...:|.     .|.::.::|                 :..|:.:|:   |:..::.|...:...
Zfish   811 IYTIQYN-----IRSFMNVKH-----------------WPWMKVYYK---IKPLLKSAETEKELA 850

  Fly   900 KRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKH 964
            ..:.:.:.|:..:           :|||||.        ..||.|::::
Zfish   851 NMKEDFVKCKEDL-----------VKAEAKK--------KELEEKMVAL---------------- 880

  Fly   965 KTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNK---QLEAERDEKMQLLEENGHAQE 1026
                   |:.|.:|:..:.:|.:|:    .|.::..|.|.|   ||||:..|..:.||:......
Zfish   881 -------LQEKNDLQLAVASEAENL----SDAEERCEGLIKSKIQLEAKLKETTERLEDEEEINA 934

  Fly  1027 EWISQKQTWRQENEELRRQIDEI------IDMAKNAEVNQ-RN------QEDRMLAEI--DNREL 1076
            |..::|:....|..||::.||::      ::..|:|..|: :|      .:|..:|::  :.:.|
Zfish   935 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAKLTKEKKAL 999

  Fly  1077 NEAYQRAIKDKEVIENENFMLKEELSRL------TAGSFSLHAR---KASNASSQNEDDVGYASA 1132
            .||:|:.:.|.:..|::...|.:..::|      ..||.....:   ....|..:.|.|:..|.
Zfish  1000 QEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ- 1063

  Fly  1133 KNTLDINRPPDLLSKNYSYND-STSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSF--- 1193
            ::.:|:........:.....| .||   :|.|.:|:|:.....||::..:|.:|.:..|:..
Zfish  1064 ESIMDLENDKQQSEEKIKKKDFETS---QLLSKIEDEQSLGAQLQKKIKELQARIEELEEEIEAE 1125

  Fly  1194 RVSELEVE------------------------------NEKLRSEYDQLRTSIKHGVEINELNAQ 1228
            |.:..:||                              |:|..:|:.:||.      ::.|...|
Zfish  1126 RAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRR------DLEESTLQ 1184

  Fly  1229 HAALQEEVRRRREECIQLKAVLLQQSQSMRSL------EPESLQMRGNDVNELMEAFHSQKL--- 1284
            |.|....:|:::.:.:   |.|.:|..:::.:      |....:|..:|::..|||....|.
Zfish  1185 HEATAAALRKKQADSV---AELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLE 1246

  Fly  1285 -INRQLE---SELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDR 1345
             :.|.||   ||:|:.::|:..::.:::.:..||..|..|..:.:     |.:::.|..|.:..:
Zfish  1247 KMCRTLEDQLSEIKSKSDENLRQINDLSAQRARLQTENGEFGRQL-----EEKEALVSQLTRGKQ 1306

  Fly  1346 YLRRELQKAVAQFLLVQEELKLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVT 1407
            ...:::::...|   ::||:|..||   .:::.|.|...|..:.|||      ....|::...::
Zfish  1307 AFTQQIEELKRQ---IEEEVKAKNALAHAVQSARHDCDLLREQFEEE------QEAKAELQRGMS 1362

  Fly  1408 KQKSQNPQGLMKFHSSDLDKI--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVR 1470
            |..|:..|...|:.:..:.:.  |:.....|..|                      |..|::.:.
Zfish  1363 KANSEVAQWRTKYETDAIQRTEELEESKKKLAQR----------------------LQEAEEQIE 1405

  Fly  1471 ELLSKFVIQIKKMHRTPHPIENRVIWL--VNSITLLNLMKQYGDVDEYVKFNTEK--QNQQQLKN 1531
            .:.||.....|...|....:|:.:|.:  .||:. .||.|:..:.|:.:....:|  :.|.:|:.
Zfish  1406 AVNSKCASLEKTKQRLQGEVEDLMIDVERANSLA-ANLDKKQRNFDKVLAEWKQKYEEGQAELEG 1469

  Fly  1532 FNLFEYRRVILDL--IVNLYQALIMQIQGL------LDPKIVPAILNNDEIQRGRQAHGMRSRAT 1588
            ... |.|.:..:|  :.|.|:..:.|::.|      |..:|  :.|.....:.|:..|.:.....
Zfish  1470 AQK-EARSLSTELFKMKNSYEETLDQLETLKRENKNLQQEI--SDLTEQIGETGKSIHELEKAKK 1531

  Fly  1589 SIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDI 1653
            ::....:...   .|.::..|.|||
Zfish  1532 TVETEKAEIQ---TALEEAEGTLEH---------------------------------------- 1553

  Fly  1654 CMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQD--VQTICDLCTSLS 1716
               |...|:|..:                     .||||...:..:.:|:|  ::.|     ..:
Zfish  1554 ---EESKILRVQL---------------------ELNQVKGEIDRKLAEKDEEIEQI-----KRN 1589

  Fly  1717 TAQVLKVMKSYKLDDYESEITNVFLEKLTE-KLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSD 1779
            :.:|.:.|:|....:..|....:.::|..| .||..::|.|:::....: ||.::..:...:.:.
Zfish  1590 SQRVTEAMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAAEAQKQLRNVQSQLKDAQ 1654

  Fly  1780 IKLED 1784
            :.|:|
Zfish  1655 LHLDD 1659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	268/715 (37%)
		IQ	900..922	CDD:197470	1/21 (5%)
		SMC_prok_B	<942..1365	CDD:274008	97/496 (20%)
		Myo5_CBD	1424..1792	CDD:271254	61/379 (16%)
myha	XP_021332193.1	Myosin_N	33..78	CDD:460670	10/36 (28%)
		MYSc_class_II	101..766	CDD:276951	268/715 (37%)
		Myosin_tail_1	846..1923	CDD:460256	180/985 (18%)