DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and smyhc2

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001096096.2 Gene:smyhc2 / 100124599 ZFINID:ZDB-GENE-070822-12 Length:1939 Species:Danio rerio


Alignment Length:2069 Identity:537/2069 - (25%)
Similarity:886/2069 - (42%) Gaps:533/2069 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGK---LKEVKLKADG 57
            |.:|.|.||      ..:.:||..::.:..|::..   :....:.:.|:.||   :|||      
Zfish    19 SDKERLEAQTRPFDMKKECFVPDPEVEYVKASVTS---RDGDKVTVETEFGKTVTVKEV------ 74

  Fly    58 SDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGP 122
             |..| :||.......|:...::||||.||.||:.|:. ..:||||.|:..|.:|||..:|:|..
Zfish    75 -DCHP-QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNQ 136

  Fly   123 SIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV--- 184
            .::.||||....:..||||::::.||..:..:..|.|::::|||||||||:.|..::|||::   
Zfish   137 EVVVAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAA 201

  Fly   185 -GGSESETQ-----VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVM-FLQGAT 242
             ||.:..:|     :|.:::..:|.:||||||||.|||||||||||.::.|    ||. .|..|.
Zfish   202 PGGKKDPSQEKKGTLEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHF----GVSGKLSSAD 262

  Fly   243 MHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVS 302
            :.|||||||||.||.:.||:||||||:.:.|.  ||     |:.::...:.:::. |..::..:.
Zfish   263 IETYLLEKSRVTYQLKAERDYHIFYQILSQRK--PELLEMLLITNNPYDYSYISQ-GETQVASID 324

  Fly   303 DAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDIFHN 363
            |.::...|.:|..||||:.::...|.|:...|:|.||::..:|..|...|    ||:|.      
Zfish   325 DRDELIATDEAFDVLGFTQEEKNSIYKLTGAIMHYGNMKFKQKQREEQAEADGTEDADK------ 383

  Fly   364 DIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGV 428
                  .|.|:.:::.||.:.|...:::..||:|....:::....:..||||.:|.|:|.::|..
Zfish   384 ------VAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVR 442

  Fly   429 LNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGIT 493
            :|:||:....:..|||||||.|||.|:.|:|||.|||:.||||||.||.|:|.||||||.||||.
Zfish   443 INQSLDTKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE 507

  Fly   494 WTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKPRF---- 552
            |..||| .|.|.||:|||..:|::.:|:|||..||.||.::..||. ....|.|:|:|||.    
Zfish   508 WEFIDFGMDLQACIELIEKPMGIMSILEEECMFPKASDATFKAKLYDNHLGKNPNFQKPRIVKGR 572

  Fly   553 GTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVD--SAK 615
            ....|.:.|::.||:|:::.:|.||:|.:::.:..:..:|         ||:.:.||..:  .|:
Zfish   573 PEAHFALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKS---------TLKLLGTLFANYAGAE 628

  Fly   616 SSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPND 680
            |:..||:.  ..|.|::|:..           :||.:..:|:|..|::.|.:|.||:|||:.||:
Zfish   629 SADSGGKG--KGGAKKKGSSF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCLIPNE 680

  Fly   681 DKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLS 742
            .|.....|...::.|||..||||.:||...|||:|.||.||..||::| ..|.:.:.   |.|..
Zfish   681 TKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRIL-NPSAIPEGQFIDNKKG 744

  Fly   743 CRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQK 807
            ...::.....|.::|:.|:|::||:||.:..||::|.:                       |:..
Zfish   745 AEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDD-----------------------RLAL 786

  Fly   808 VINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYAR 865
            :|.|||..|||.|:|...||:.|.|..|::.::       .:.|...:.|.:::..:...:|...
Zfish   787 IITGIQARARGILSRIEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKE 851

  Fly   866 GMLARNKFHAMRDHY-----RAVQIQRFVRGALARR-----AYQKRRRNII----ICQAAIR--- 913
            ....:.:|..:::.|     |..:::..:...|..:     |.|..:.|:.    .|:..|:   
Zfish   852 MANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKI 916

  Fly   914 RFLA----------------------RRKFKRMKAEAK--------TISHMENKYMGLENKIISM 948
            :|.|                      :||.:...:|.|        |::.:|.:....|||:.::
Zfish   917 QFEAKVKELTERLEDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 981

  Fly   949 -------------------------QQRIDELNRD------------------------------ 958
                                     ||.:|:|..:                              
Zfish   982 TEEMAALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKK 1046

  Fly   959 ---------------------------------NSNLKHKTSEISVLKMKLELKKTLEAEFKNVK 990
                                             ...||.|..|||.|..|:|.::.|||:.:...
Zfish  1047 IRMDLERAKRKLEGDLKLTQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQALEAQLQKKL 1111

  Fly   991 AACQDKDKLIEALNKQLEAER-----------------DEKMQLLEENGHAQEEWISQ------- 1031
            ...|.:   ||.|.::|||||                 :|..:.|||.|.|....|..       
Zfish  1112 KELQAR---IEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAE 1173

  Fly  1032 -------------------------------------------KQTWRQENEELRRQIDEIID-- 1051
                                                       ||...:|..|||.::|:::.  
Zfish  1174 FQKLRRDLEEATLQHEATASTLRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNM 1238

  Fly  1052 ----MAK-NAEVNQRNQEDRMLAEIDNRELNEAYQRAIKD----KEVIENENFMLKEEL------ 1101
                .|| |.|...|..||:|   .:.|...|..||.|.|    |..::.||..|..:|      
Zfish  1239 EQIVKAKANLEKMCRTLEDQM---SEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSL 1300

  Fly  1102 -SRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL-----DINRPPDLLSKNY----------- 1149
             |:||.|..| :.::..:...|.|::|   .|||.|     ......:||.:.|           
Zfish  1301 VSQLTRGKQS-YTQQIEDLKRQLEEEV---KAKNALAHAVQSARHDAELLREQYEEEQEAKAELQ 1361

  Fly  1150 -SYNDSTSLVVKLRSILEEEK-QKHKVLQEQYIKLSSRHKPTEDSF-----RVSELEVENEKLRS 1207
             |.:.:.|.|.:.|:..|.:. |:.:.|:|...||:.|.:..|::.     :.|.||....:|::
Zfish  1362 RSLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1426

  Fly  1208 EYDQLRTSIKHGVEINELNAQHAALQEEVR-----------RRREECIQLKAVLLQQSQSMRSLE 1261
            |.:.|.      |::...||..|||.::.|           :..|...:|::.   |.:| |||.
Zfish  1427 EIEDLM------VDVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQTELESA---QKES-RSLS 1481

  Fly  1262 PESLQMRGNDVNELMEAFHSQKLINRQLESELKAITE---EHNSKLVEMTQEIERLNNEKDELQK 1323
            .|..::: |...|.::...|.|..|:.|:.|:..:||   |....:.|:.:..::|..||.|:| 
Zfish  1482 TELFKLK-NSYEESLDHLESMKRENKNLQEEISDLTEQLGESGKNIHELEKVRKQLEQEKQEIQ- 1544

  Fly  1324 VMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKI-- 1386
               .:::|.|.|                        |..||.|:..|:|: :.|....:|.|:  
Zfish  1545 ---TALEEAEGS------------------------LEHEEGKILRAQLE-FNQVKADIERKLSE 1581

  Fly  1387 -EEEM---IRNKSNGTSADVGANVTKQKSQNPQ-GLMKFHSSDLDKILQRLLSALTPRT-VVGLL 1445
             :|||   .||:.........:..::.:|:|.. .|.|....||:::..:|..|....: ....|
Zfish  1582 KDEEMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQL 1646

  Fly  1446 PGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQY 1510
            .|...:|....::..|....:||::|.::              .:|.|          .||::  
Zfish  1647 KGLHGHLKDAQLQLDDALRGNDDLKENIA--------------IVERR----------NNLLQ-- 1685

  Fly  1511 GDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDE-- 1573
            .::||......:.:..::|....|.:        :....|.|..|...||:.|   ..|..|.  
Zfish  1686 AELDELRSLVEQTERGRKLAEQELMD--------VSERVQLLHSQNTSLLNQK---KKLEGDNTQ 1739

  Fly  1574 --------IQRGRQAHGMRSRATSIGASSS----PEHGGGPAWKQLIGQLEHFYKQFQHFGLDNC 1626
                    :|..|.|.....:|.:..|..:    .|.......:::...:|...|..|| .||. 
Zfish  1740 LQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH-RLDE- 1802

  Fly  1627 YAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVR---------SKKMSNDV 1682
             ||||                .::|.          :..:..:|..||         .:|.|:.|
Zfish  1803 -AEQI----------------AMKGG----------KKQVQKLESRVRELESEVEMEQRKASDSV 1840

  Fly  1683 LTALAPLNQVSQL-LQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESE 1735
            ........::.:| .|:.:..:::..:.||...|.    ||| ||||....|:|
Zfish  1841 KGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQ----LKV-KSYKRTAEEAE 1889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 275/742 (37%)
MYSc_Myo5 84..767 CDD:276831 264/712 (37%)
IQ 900..922 CDD:197470 7/50 (14%)
GBP_C <971..1086 CDD:303769 42/188 (22%)
coiled coil 1049..1068 CDD:293879 7/25 (28%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/127 (24%)
Myo5_CBD 1424..1792 CDD:271254 64/337 (19%)
smyhc2NP_001096096.2 Myosin_N 35..72 CDD:280832 6/39 (15%)
Myosin_head 87..769 CDD:278492 268/724 (37%)
MYSc_class_II 99..769 CDD:276951 264/712 (37%)
Myosin_tail_1 849..1926 CDD:279860 227/1162 (20%)
RILP-like 964..1097 CDD:304877 15/132 (11%)
mycoplas_twoTM 1184..>1321 CDD:275320 31/140 (22%)
MIT_CorA-like <1298..>1410 CDD:294313 27/115 (23%)
COG6 1375..>1508 CDD:303003 35/143 (24%)
TMPIT 1458..>1563 CDD:285135 31/137 (23%)
TMPIT 1743..>1828 CDD:285135 20/113 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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