DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myhb

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_001339206.5 Gene:myhb / 100002040 ZFINID:ZDB-GENE-081124-1 Length:1937 Species:Danio rerio


Alignment Length:1991 Identity:517/1991 - (25%)
Similarity:875/1991 - (43%) Gaps:482/1991 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EESYRKG------AGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87
            :|.|.||      .|...:.|..||...||    ..::.|: ||.......|:..:::|:||.||
Zfish    44 KEMYLKGVLKSKEGGKATVQTLCGKTLTVK----EDEIFPM-NPPKFDKIEDMAMMTHLNEPTVL 103

  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152
            :||:.|:. ..:||||.|:..|.:|||..:|:|...::..|||....:..||||::::.||..:.
Zfish   104 YNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYDAVVVSGYRGKKRIEAPPHIFSISDNAYQFML 167

  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSESETQV--------ERKVLASSPIMEAF 207
            .:..|.||:::|||||||||:.|..::|||  ||.|.:.:..:        |.:::|::|::||:
Zfish   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAVAGKQKQEPIPGKMQGSLEDQIIAANPLLEAY 232

  Fly   208 GNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAA 272
            |||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|...||:||||||||..
Zfish   233 GNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLSAERSYHIFYQLCTG 294

  Fly   273 RSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            ..  ||     |:..:...:..::.|.. .::.::|.|:|..|..|:.:|||:.::...|.|:..
Zfish   295 HK--PELLEALLITTNPYDYPMISQGEI-TVKSINDVEEFIATDTAIDILGFNAEEKVGIYKLTG 356

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397
            .::|.||::..:|..|  |:.:.|..::...      .|.||.:::.|:.:.|...:::..||:|
Zfish   357 AVMHHGNMKFKQKQRE--EQAEPDGTEVADK------IAYLLGLNSADMLKALCYPRVKVGNEFV 413

  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQF 462
            ....::.....|..||.|.:|.|:|.::|..:|:.|:....:..|||||||.|||.|:.||.||.
Zfish   414 TKGQTVPQVNNATMALCKSVYEKMFLWMVVRINEMLDTKQPRQFFIGVLDIAGFEIFDFNSLEQL 478

  Fly   463 CINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMP 526
            |||:.||||||.||.|:|.||||||.||||.|..||| .|...||:|||..:|:..:|:|||..|
Zfish   479 CINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFP 543

  Fly   527 KGSDESWAGKL----IGKCNKFPHFEKPRFGTTS--FFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585
            |.:|.::..||    :||.|.|.. .||..|...  |.:.|::.||:|:::|:|:||:|.::..:
Zfish   544 KATDTTFKNKLHDQHLGKTNCFQK-PKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNDSV 607

  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLC-VDSAKSST---LGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            .|:..:|::.|            || :.:|.:||   .||:   ..|:|:.|:            
Zfish   608 VQLYQKSSVKL------------LCHLYAAHASTEAESGGK---KGGKKKGGS------------ 645

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
            .:||.:.|:|:|..|::.|.:|.||:|||:.||:.|.....|...:|.|||..||||.:||...|
Zfish   646 FQTVSALFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKG 710

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            ||||.||.||..||::| ..|.:.:.   |.|.:...::.....|..:|:||:|::||:||.:..
Zfish   711 FPSRILYGDFKQRYKVL-NASVIPEGQFIDNKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGT 774

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRI---QKVINGIQKHARGYLARERTQKMREARAGL 835
            ||::|.......:|:.|:|.|.:|.|::|:::   ::.|..||.:.|.::               
Zfish   775 LEEMRDEKLVILVTMTQAVCRGYVMRKEFVKMMARRESIYSIQYNIRSFM--------------- 824

  Fly   836 ILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQK 900
                ..:.|...:.|.:::..:...:|       ..:..||::::.  :::..:..|||::...:
Zfish   825 ----NVKHWPWMKLYFKIKPLLKSAET-------EKEMAAMKENFE--KMKEDLAKALAKKKELE 876

  Fly   901 RR-------RNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRD 958
            .:       :|.:..|.|              :|.:.:|..|.:..||....|.::.::.|....
Zfish   877 EKMVTLLQEKNDLQLQVA--------------SETENLSDAEERCEGLIKSKIQLEAKLKEATER 927

  Fly   959 NSNLKHKTSEISVLKMKL-----ELKKTL-----------------EAEFKNVKAACQDKDKLIE 1001
            ..:.:...:|::..|.||     ||||.:                 |.:.||:......:|::|.
Zfish   928 LEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMTSQDEVIV 992

  Fly  1002 ALNKQ--------------LEAERDEKMQL------LEENGHAQEEWISQKQTWRQENEELRRQI 1046
            .|.|:              |:||.|:...|      ||:.....|..:.|::..|.:.|..:|::
Zfish   993 KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMDLERAKRKL 1057

  Fly  1047 DEIIDMAKNAEVNQRNQEDRM--------------LAEI-DNRELNEAYQRAIKDKEVIENENFM 1096
            :..:.:|:.:.::..|.:.::              |:.| |.:.|...:|:.||:.:....|   
Zfish  1058 EGDLKLAQESLMDLENDKQQLEEKLKKKDFETSQFLSRIEDEQSLGIQFQKKIKELQARIEE--- 1119

  Fly  1097 LKEELSRLTAGSFSLH------ARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDST 1155
            |:||:....|....:.      ||:....|.:.|:..|..||:..::..|..:.           
Zfish  1120 LEEEIEAERAARAKVEKQRSDLARELEEISERLEEAGGATSAQIEMNKKREAEF----------- 1173

  Fly  1156 SLVVKLRSILEEEKQKHK-----VLQEQYIKLSSRHKPTEDSFRVSE-LEVENEKLRSEYDQLRT 1214
               .|||..|||...:|:     :.::|...::...:..::..||.: ||.|..:|:.|.|.:.:
Zfish  1174 ---QKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEVDDVSS 1235

  Fly  1215 SI-----------------------------KHGVEINELNAQHAALQEEVRRRREECIQLKAVL 1250
            |:                             :|...||:|:||.|.||.|......:        
Zfish  1236 SMEAVAKSKTNLEKMCRTLEDQLSEFKSKHDEHVRHINDLSAQKARLQTENGEMGRQ-------- 1292

  Fly  1251 LQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKA--------ITEEHNSKLVEM 1307
            |::.:|:.|....|.|.....:.||          .||:|.|:||        .:..|:..|  :
Zfish  1293 LEEKESLVSQLTRSKQAYTQQIEEL----------KRQIEEEVKAKNSLAHAVQSSRHDCDL--L 1345

  Fly  1308 TQEIERLNNEKDELQKVMFESIDEFED----SNVDTLRQNDRYLRRELQKAVAQFLL-VQEELKL 1367
            .::.|.....|.|||:.|.::..|...    ...|.:::.:..  .|.:|.:||.|. .:|.::.
Zfish  1346 REQYEEEQEAKAELQRSMSKANSEVAQWRTKYETDAIQRTEEL--EEAKKKLAQRLQDAEESIEA 1408

  Fly  1368 ANAKLKAYRQDGGQLEHKIEEEMIR-NKSNGTSADVGANVT---------KQKSQNPQG------ 1416
            .|||..:..:...:|::::|:.||. .::|..:|::.....         |||.:..|.      
Zfish  1409 VNAKCASLEKTKQRLQNEVEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEETQAELEGAQ 1473

  Fly  1417 ---------LMKFHSS---DLD---------KILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYT 1460
                     |.|..:|   .||         |.||:.::.||.:                     
Zfish  1474 KEARSLSTELFKMKNSYEETLDHLETLKRENKNLQQEITDLTEQ--------------------- 1517

  Fly  1461 DLTNADDDVREL--------LSKFVIQ--IKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDE 1515
             |......:.||        :.|..||  :::...|....|::::.:     .|.|.:..|::|.
Zfish  1518 -LGETGKTIHELEKGKKTAEIEKSEIQAALEEAEATLEHEESKILRV-----QLELNQVKGEIDR 1576

  Fly  1516 YVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKI------------VPAI 1568
              |...:.:..:|:|..:                |.:|..:|..||.::            :...
Zfish  1577 --KLAEKDEEIEQIKRNS----------------QRIIDSMQSTLDAEVRSRNDALRIKKKMEGD 1623

  Fly  1569 LNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQL---IGQLEHFYKQFQHFGLDNCY--A 1628
            ||..|||   .:|..|..|              .|.|||   .|||:.     ....||...  .
Zfish  1624 LNEMEIQ---LSHANRQAA--------------EAQKQLRNVQGQLKD-----AQLHLDEALRAQ 1666

  Fly  1629 EQIFHQLLYFICAVAL----NCLM------LRGDICMWETG----------------MIIRYNIG 1667
            |.:..|       ||:    |.||      ||..:...|.|                ::...|..
Zfish  1667 EDMKEQ-------VAMVERRNNLMQAEIEELRVALEQTERGRKVAEQELVDASERVTLLHSQNTS 1724

  Fly  1668 CIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV-QTICD-------LCTSLSTAQVLKVM 1724
            .|.   ..||:..|::.....:..|.|  ::|.:|:.. :.|.|       |.....|:..|:.|
Zfish  1725 LIN---TKKKLEADLVQIQGEMEDVVQ--EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1784

  Fly  1725 K----------SYKLDDYESEITNVFLEKLTEKLNARQMQK 1755
            |          .::||:.||         |..|...:|:||
Zfish  1785 KKNLEVTVKDLQHRLDEAES---------LAMKGGKKQLQK 1816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 275/741 (37%)
MYSc_Myo5 84..767 CDD:276831 265/711 (37%)
IQ 900..922 CDD:197470 3/28 (11%)
GBP_C <971..1086 CDD:303769 34/171 (20%)
coiled coil 1049..1068 CDD:293879 2/32 (6%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/146 (22%)
Myo5_CBD 1424..1792 CDD:271254 80/412 (19%)
myhbXP_001339206.5 Myosin_N 36..73 CDD:280832 8/28 (29%)
Myosin_head 88..768 CDD:278492 268/723 (37%)
MYSc_class_II 100..768 CDD:276951 265/711 (37%)
Myosin_tail_1 848..1925 CDD:279860 216/1112 (19%)
Uso1_p115_C 898..1011 CDD:282695 21/112 (19%)
COG6 1374..>1509 CDD:303003 27/136 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.000

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