DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM4

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_015344.1	Gene:	MCM4 / 856130	SGDID:	S000006223	Length:	933	Species:	Saccharomyces cerevisiae

Alignment Length:	946	Identity:	390/946 - (41%)
Similarity:	552/946 - (58%)	Gaps:	131/946 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SQDVETPMRMGPGRAVRPSDNISLPPTSPGNISLP--ATSPARGLGANMSEIDL----------- 79
            ||...:|.:         .||.|..|..|...|:|  .:|||....::.|:.|:
Yeast     2 SQQSSSPTK---------EDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQ 57

  Fly    80 ----------SSPLNYGTPSS--------------MGSIRTPRSGIRGTPLRARPDIRTDKRI-- 118
                      |||||:  |||              .|.||:..|....:  |...|:|:|:.:
Yeast    58 GEGNIRAAIGSSPLNF--PSSSQRQNSDVFQSQGRQGRIRSSASASGRS--RYHSDLRSDRALPT 118

  Fly   119 -----------------------------RQVAIGGGSGLEPIPEKGSETTDPVSESSQAPQLVV 154
                                         |.|.....||:..:..  |.::.|.||:|: |..::
Yeast   119 SSSSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDT--SSSSAPPSEASE-PLRII 180

  Fly   155 WGTNVVVSQCKSKFKSFIMRF-------IDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLN 212
            |||||.:.:|.:.|::|:|.|       :|   |::|...|....:..|:::|.|:..|....||
Yeast   181 WGTNVSIQECTTNFRNFLMSFKYKFRKILD---EREEFINNTTDEELYYIKQLNEMRELGTSNLN 242

  Fly   213 LNCAHLKTFDQ--DLYRQLICYPQEVIPGFDMAINEMFFERYPAALLEHQI--------QVRPFN 267
            |:..:|..:.|  |||.||:.||||||...|..|.:..........|::.:        :|||:|
Yeast   243 LDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYN 307

  Fly   268 ADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLC- 331
            ....:.||.|||.|:|:||::.|:|:||:.|||:|:.|||.||:|..:..||:|||.|.:|..|
Yeast   308 VGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCE 372

  Fly   332 -TNCNTNHCFRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTG 395
             .:||..:...|||||..|.|||::||||:||.:..|||||::.|..:::|||..:.|||:.|||
Yeast   373 RIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTG 437

  Fly   396 IYRATPLKTGGLSSSVKSVYKTHVDVVHFRKVDNKRL------YEDEEGKDHIFPPERVELLQL- 453
            .:|:.|::.......:||:|||:|||||.:||.:|||      .|.|..::.:...|..|:.|:
Yeast   438 TFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQIT 502

  Fly   454 ---------LAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLL 509
                     :|.:.|:|..|||:|||||||.:|:||||||||||||.|.....||  :|.:|::|
Yeast   503 DQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGR--YRGDINIL 565

  Fly   510 LCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCC 574
            |||||.|||||:||||..:.||..||||:||||||||||:|:|.:|:||||::|||||:|.||||
Yeast   566 LCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCC 630

  Fly   575 IDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLP 639
            |||||||:|||||||||||||||:||||||||..||||:||||:|||..|::|....:.:|:.||
Yeast   631 IDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLP 695

  Fly   640 HTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTR--HEEEDTMFDMSVLRDYIAYAREHLSP 702
            ..|||||||::||||..||..|:.||.||.:||...:  |..:|.:..:..|..||:||:||:.|
Yeast   696 PPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHP 760

  Fly   703 TLSDEAQQRLIQAYVDMRKVG----AGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEA 763
            .:::.|:..|::|||.|||:|    :...:|:|..|||||:|||:|||||::|.|.|||.||:||
Yeast   761 IITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEA 825

  Fly   764 WRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSD 828
            .||.|.|:|..||||.:||||:.::.||.|...||.:.||...|...||.:... ::.:.:|...
Yeast   826 VRLIRSAIKDYATDPKTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASD-SMSFNELIKQ 889

  Fly   829 IKEGSQIMITREQFEDALKEVQDEGAIVVMGKNTIR 864
            |.|.||..:.....::||..:|.|..::|:|:...|
Yeast   890 INEHSQDRVESSDIQEALSRLQQEDKVIVLGEGVRR 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	40/189 (21%)
		MCM_N	168..267	CDD:379644	34/115 (30%)
		MCM	270..772	CDD:214631	277/525 (53%)
MCM4	NP_015344.1	MCM_N	194..306	CDD:405270	33/114 (29%)
MCM4	NP_015344.1	MCM	310..834	CDD:214631	277/525 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343925
Domainoid	1	1.000	285	1.000	Domainoid score	I247
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40496
Inparanoid	1	1.050	645	1.000	Inparanoid score	I112
Isobase	1	0.950	-	0	Normalized mean entropy	S595
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005010
OrthoInspector	1	1.000	-	-		oto98926
orthoMCL	1	0.900	-	-		OOG6_101805
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R694
SonicParanoid	1	1.000	-	-		X3542
TreeFam	1	0.960	-	-
	15	14.730