DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM6

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_011314.2	Gene:	MCM6 / 852673	SGDID:	S000003169	Length:	1017	Species:	Saccharomyces cerevisiae

Alignment Length:	979	Identity:	288/979 - (29%)
Similarity:	428/979 - (43%)	Gaps:	217/979 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PGRAVRPSDNISLPPTSPGNISLPATSPARGLGANMSEID--LSSPLNYGTPSSMGSIRTPRSG- 100
            |..|..||.|      .|.|.|.|.:|...|.|:: |.:|  :.|.|::.: ||...:...::|
Yeast     4 PFPADTPSSN------RPSNSSPPPSSIGAGFGSS-SGLDSQIGSRLHFPS-SSQPHVSNSQTGP 60

  Fly   101 -IRGTPLRARPDIRTDKRIRQVAIGGGSGLEPIPEKGSETTD-----PV-SESSQAPQLVVWGTN 158
             :..:...:...::||                    ||.|.|     |. |..|:|...|....:
Yeast    61 FVNDSTQFSSQRLQTD--------------------GSATNDMEGNEPARSFKSRALNHVKKVDD 105

  Fly   159 VVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTLEEPYLNL----NCAHLK 219
            |...:.:..|:.|:..|...|.:..|: |.: ....:...|:.:::|:...|.:|    |.|...
Yeast   106 VTGEKVREAFEQFLEDFSVQSTDTGEV-EKV-YRAQIEFMKIYDLNTIYIDYQHLSMRENGALAM 168

  Fly   220 TFDQDLYRQLIC-----------YPQEVIPGFD-------------------------------- 241
            ...:..||.|..           |..|::...|
Yeast   169 AISEQYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSG 233

  Fly   242 -----------MAINEMFFERYPAALLEHQIQVRPFNADKTRNMRSLNPEDMDQLISISGMVIRS 295
                       ||...:.....|.. .|...|:..||......:|.:..|.:..|:||||.|.|:
Yeast   234 SSAAPGNGTSAMATRSITTSTSPEQ-TERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRT 297

  Fly   296 SNVIPEMREAFFSCNIC---------SFSTTVEVDRGRINQPTLCTN--CNTNHCFRLIHNRSEF 349
            |.|.||:.:|.|:|::|         ||..|         :||.|.|  |.....:.|...||.|
Yeast   298 SEVRPELYKASFTCDMCRAIVDNVEQSFKYT---------EPTFCPNPSCENRAFWTLNVTRSRF 353

  Fly   350 TDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATP------------- 401
            .|.|.|::||:.:::..|..|..:.:....|.|::.:||||...||:....|
Yeast   354 LDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPS 418

  Fly   402 --LKTGGLSSSVKSV----------------YKTHVDVVHFRKV------------DNKR----- 431
              |.|.|:|.:.:.:                ||......|...:            .|.|
Yeast   419 STLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQ 483

  Fly   432 ---------LYEDEEGKDHIF----PPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGIL 483
                     :|:|.|....:|    ..:.:..|:.:.|...|||:|.|:|||:::.::.:|||||
Yeast   484 MAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGIL 548

  Fly   484 LQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAY 548
            ||:.||..|  :|:.....|.:|::.:.|||.|||||.|:||....|||.||||:.|||.||||.
Yeast   549 LQMLGGVHK--STVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAA 611

  Fly   549 VTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNART 613
            |.:|.|.....::.|||:|||||:|||||||||:.|.:..:||.|||||:|||||||...|||||
Yeast   612 VVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNART 676

  Fly   614 SILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHE 678
            ||||||||...::|::.::..|:.:...::|||||.|::||..:|..|..||||:|.| ::.|.|
Yeast   677 SILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDL-HMKRDE 740

  Fly   679 EEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMRK---VGAGRGQISAYPRQLESLI 740
            ..:..|....||.||.|||. ..|.|:.||:..|::.|.::||   .|..|.......|||||:|
Yeast   741 AIEPPFSAEQLRRYIKYART-FKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMI 804

  Fly   741 RLSEAHAKVRLSNQVELLDVEEAWRLHREAL----------------KQSATDPLSGKIDVGILT 789
            |||||.|:....:::....:.||:.|.|:::                .:|.:...||..|.....
Yeast   805 RLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDDVEMDEEFDNIESQSHAASGNNDDNDDG 869

  Fly   790 TGLSTAARKKRADLVAAIKENLKKKG----KVLTVPYQKLFSDIKEGSQIMITREQFEDALKEVQ 850
            ||......:..||:.....|...:.|    |..||.|.|..|.:.     ||.|:     :.||.
Yeast   870 TGSGVITSEPPADIEEGQSEATARPGTSEKKKTTVTYDKYVSMMN-----MIVRK-----IAEVD 924

  Fly   851 DEGA 854
            .|||
Yeast   925 REGA 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	28/120 (23%)
		MCM_N	168..267	CDD:379644	23/156 (15%)
		MCM	270..772	CDD:214631	208/592 (35%)
MCM6	NP_011314.2	MCM_N	112..205	CDD:405270	18/94 (19%)
		MCM	272..836	CDD:214631	208/576 (36%)
		MCM6_C	900..1007	CDD:408078	14/39 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810