DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM7

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_009761.4	Gene:	MCM7 / 852501	SGDID:	S000000406	Length:	845	Species:	Saccharomyces cerevisiae

Alignment Length:	767	Identity:	251/767 - (32%)
Similarity:	388/767 - (50%)	Gaps:	139/767 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 ESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFID-----PSAEQDEISENIDV--------NQPLY 196
            :.:||..||     ..:.|..:.|.....|.||     |:.|.|...:.:||        |:.:.
Yeast    95 QGTQADDLV-----SAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERML 154

  Fly   197 LQKLEEIH------TLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAA 255
            ..:..||.      |..:|..::|         |..|:::....|:.|              |..
Yeast   155 SDRTNEIRSENLMDTTMDPPSSMN---------DALREVVEDETELFP--------------PNL 196

  Fly   256 LLEHQIQVRPFN------------ADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFS 308
            ...:.:..:|.:            :.|..::|.:..:.:.|||::.|::.|.|:|.|.:....::
Yeast   197 TRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYT 261

  Fly   309 CNICSFSTTVEVDRGRINQPTLCTN--CNTNHC---FRLIHNRSEFTDKQLVKLQESPDDMAAGQ 368
            |:.|.:....||:.......:.||:  |:.|..   ..:....|:|:..|..|:||....:..|.
Yeast   262 CDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGH 326

  Fly   369 TPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATP------LKTGGLSSSVKSVYKTHVDV----VH 423
            .|.::.::.:..||..:.|||.|.||||:...|      ||.|.|:       :|:::.    .|
Yeast   327 IPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLT-------ETYLEAQFVRQH 384

  Fly   424 FRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSIYENDDIKKGILLQLFG 488
            .:|..:..|..|.|        |||  ::|:. ..|:|:|||::|||.||.|.|:||.:||.|.|
Yeast   385 KKKFASFSLTSDVE--------ERV--MELIT-SGDVYNRLAKSIAPEIYGNLDVKKALLLLLVG 438

  Fly   489 GTKKKHATLG-RQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKD 552
            |..|:   :| ....|.:|::.|.||||.:|||:|:.:..:.||..||:|:|||.|||||.|.||
Yeast   439 GVDKR---VGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKD 500

  Fly   553 PETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQLNARTSILA 617
            |.|.:::|:.|||||||||:|||||||||::|.|:.:||||||||:||:||||...|||||||||
Yeast   501 PVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILA 565

  Fly   618 AANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLYYVTRHEEED- 681
            ||||...::|.|.:.:||:.||..||||||::||:||......|::||.|:.   ||..|.::.
Yeast   566 AANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVT---YVHMHNKQPD 627

  Fly   682 ---TMFDMSVLRDYIAYAREHLSPTLSDEAQQRLIQAYVDMR---------KVGAGRGQISAYPR 734
               |..:.|.:|:|||||:.. .|.:|:.....::|||:.:|         |...|:    |.||
Yeast   628 LDFTPVEPSKMREYIAYAKTK-RPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQ----ATPR 687

  Fly   735 QLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHR---EALKQSATDPLSGKIDVGILTTGLSTAA 796
            .|..:||||:|.||:||::.|::.|||||.||.|   |:|.|.               |..|...
Yeast   688 TLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQE---------------TNKSKED 737

  Fly   797 RKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQIMITREQFEDALKE 848
            ......:...||:.|::.|| .|:.|:.:...::.....|:   |..:.::|
Yeast   738 ESPTTKIFTIIKKMLQETGK-NTLSYENIVKTVRLRGFTML---QLSNCIQE 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	1/4 (25%)
		MCM_N	168..267	CDD:379644	21/117 (18%)
		MCM	270..772	CDD:214631	211/533 (40%)
MCM7	NP_009761.4	MCM_N	52..>123	CDD:405270	8/32 (25%)
MCM7	NP_009761.4	MCM	223..724	CDD:214631	210/529 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810