DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpa and MCM8

DIOPT Version :9

Sequence 1:	NP_001286160.1	Gene:	dpa / 35679	FlyBaseID:	FBgn0015929	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001319512.1	Gene:	MCM8 / 820123	AraportID:	AT3G09660	Length:	801	Species:	Arabidopsis thaliana

Alignment Length:	816	Identity:	231/816 - (28%)
Similarity:	393/816 - (48%)	Gaps:	107/816 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GGGSGLEPIPEKGSETTDPVSESSQAPQLVVWGTNVVVSQCKSKFKSFIMRFIDPSAEQDEISEN 188
            ||||.....||  |...|.:.........:....|:.:.:.|.:..:.::|....|..:|.:|:
plant     5 GGGSMASGRPE--STGIDSLGIGKILAVYIKDNENLAIDEDKLQLTAELIRVFSASPGRDIVSQ- 66

  Fly   189 IDVNQ--------PLYLQKLEEIHTLEEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAIN 245
              ||:        .|.||:.::|..:|..::||         :|       .|:.|||..:.|::
plant    67 --VNEDGGGSFSLSLDLQQFKKISDIENFFINL---------ED-------NPKGVIPCMNAAVH 113

  Fly   246 EMFFERYPAALLEH--QIQVRPFN-ADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFF 307
            ::.|:::.....|:  :|.||..| .:.:.::::|....:.:|:::.|.|::.|.|.|.:.:..|
plant   114 KVLFDQWETNEFENVMKINVRLHNYPESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAF 178

  Fly   308 SCNICSFSTTVEVDRGRINQPTLCTNCNTNHC----FRLIHNRSEFTDKQLVKLQE--SPDDMAA 366
            .|..|....|.|...|:.:.|   ..|:::.|    |..|.:.::..|.|.:::||  .|:|...
plant   179 DCGKCKTGITREFTDGKFSPP---LKCDSHGCKSKTFTPIRSSAQTIDFQKIRVQELQKPEDHEE 240

  Fly   367 GQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRA--TPLKTGGLSSSVKS--VYKTHVDVVHFRKV 427
            |:.|..|......||||...|||.||||||...  ..:..||..|..|:  .|...::.|..:..
plant   241 GRVPRTVECELMEDLVDICIPGDVVTVTGIIGVINNYMDIGGGKSKTKNQGFYYLFIEAVSVKNT 305

  Fly   428 DNKRLYEDEE-----------GKDHIFPPERVELLQLLAKK--PDIYDRLARAIAPSIYENDDIK 479
            ..:..:|:.|           |..:.|....:|.:....::  .|.:.|:..::.||||.::.:|
plant   306 KRQSAFENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDTFRRILHSVCPSIYGHEIVK 370

  Fly   480 KGILLQLFGGTKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVG 544
            .||.|.||||.:|......:...|.:||:::.||||..|||:||....:.||..|..|..::..|
plant   371 AGITLSLFGGVRKHSMDRNKVPVRGDIHVIIVGDPGLGKSQLLQAAAAISPRGIYVCGNATTRAG 435

  Fly   545 LTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQL 609
            ||..|.||..|.....:.||:||||.|:|||||||||....:::| |.||||.:|:||||::..|
plant   436 LTVAVVKDSMTNDYAFEAGAMVLADGGLCCIDEFDKMTTEHQALL-EAMEQQCVSVAKAGLVASL 499

  Fly   610 NARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEIFDKRLASHLVSLY-- 672
            :||||::|||||....:|:.|.:.:|:::...|||||||:|::||..||:.||:::.|::||:
plant   500 SARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVSEHIMSLHSA 564

  Fly   673 ----------------------YVTRHEEEDTMF-----------DMS-----VLRDYIAYAREH 699
                                  |...|.|.:::.           |.|     :||.||:|||..
plant   565 SGETSPALKKFKPVNAASQNAGYANMHAEGNSLLSRLRLDSEKDDDFSPVPGQLLRKYISYARNF 629

  Fly   700 LSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAW 764
            ::|.:|.:|.:.:.:.|:.:|.............||||||:||::|.|:|.|..::.:.|..:..
plant   630 VNPKMSKDAGEIIQKFYLKLRDHNTSADSTPITARQLESLVRLAQARARVDLREEITVQDAMDVV 694

  Fly   765 RLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDI 829
            .:.:|:|.....|. .|.:|.| .:.|:|.....||. |.|..|::..::....:|......:|
plant   695 EIMKESLYDKLIDE-HGVVDFG-RSGGMSQQKEAKRF-LSALDKQSELQQKDCFSVSEMYSLAD- 755

  Fly   830 KEGSQIMITREQFEDALKEVQDEGAIVVMGKNTIRI 865
                :|.:.....:..|:.:...|.::..|..|.::
plant   756 ----RIGLRVPDIDTFLENLNIAGYLLKKGPKTYQV 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpa	NP_001286160.1	PHA03307	2..>150	CDD:223039	8/25 (32%)
		MCM_N	168..267	CDD:379644	24/108 (22%)
		MCM	270..772	CDD:214631	177/564 (31%)
MCM8	NP_001319512.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820